scholarly journals A miRNA-PEPTIDE FUSION AS A VACCINE CANDIDATEAGAINST THE NOVEL CORONAVIRUS (COVID-19)

2020 ◽  
Keyword(s):  
In Silico ◽  
Published Data ◽  
Inhibiting Activity ◽  
The Novel ◽  
Antiviral Action ◽  
Preventive Vaccine ◽  
Immune Factor ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus

A new coronavirus named COVID-19 was reported in Wuhan, China in December 2019. The COVID-19 epidemic is spreading rapidly all over the world, (Sun P. and col, 2020). Based on published data on COVID-19, we have designed a preventive vaccine in Silico aimed to protect against COVID-19 infection and transmission (Cascella M. and col, 2020). One aim of this is to better understand potential dormant repositories of outbreaks and potential spread of those repositories, together with potential geogenic terrain factors (Wang Z., 2019). Here, we present to the miRNA-peptide fusion more stable as antiviral (Waterhouse A. and col 2018). As RNA target we used primers from Kemp V. “miRNA repertoire and host immune factor regulation upon avian coronavirus infection in eggs”: primers Biolegio, Nijmegen, The Netherlands (Kemp V. and col, 2019). Our analysis identified a miRNA-peptide with theorical fusion value stability FS=64.28, to treat COVID-19, named LCR_2020_B008-1. Additionally, peptide LCR_2020_B008 can be used in solutions as disinfectant and antiviral, having a fast-hygienic utility to avoid contagion or the propagation of the Covid-19 disease. With respect to antiviral action, the candidate manifests LCR_2020_B008-1, in Silico, manifesting partial inhibiting activity on the VIH-1, and therefore readjustments on this chimera miRNA-peptide could reach a representative antiviral activity against the VIH-1.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

scholarly journals Cutaneous manifestations in children with the new coronavirus infection COVID-19

2021 ◽  
Vol 25 (1) ◽  
pp. 16-24
Author(s):  
O. B. Tamrazova ◽  
A. S. Stadnikova ◽  
E. V. Rudikova
Keyword(s):  
Literature Review ◽  
Viral Infection ◽  
Causative Agent ◽  
The Novel ◽  
Cutaneous Manifestations ◽  
Skin Manifestations ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus

In late 2019, a new viral infection appeared in China, which spread around the world, causing a pandemic. The causative agent of the new coronavirus infection COVID-19 is the SARS-CoV-2 coronavirus. The review presents modern data on the epidemiology, pathogenesis and course of the novel coronavirus infection COVID-19 in children. Chinese, American and European scientists have described a variety of cutaneous manifestations in children with COVID-19. The article provides a literature review of the cutaneous manifestations of COVID-19 coronavirus infection in children. During our own observation of 301 patients with coronavirus infection COVID-19 caused by SARS-CoV-2 at the Bashlyaevs Children Hospital in Moscow from May 17 to November 16, 2020, it was revealed that 39 (13 %) patients had skin manifestations. The article presents a classification of skin manifestations characteristic of COVID-19. A brief description of each group is given.

In Silico Approaches for Novel Drug Discovery Against Coronavirus by Employing the Hybrid Molecular Technique: A Review

2021 ◽  
pp. 1-8
Author(s):  
Noor ul Amin Mohsin ◽  
Muhammad Irfan ◽  
Muhammad Naeem Aamir
Keyword(s):  
In Silico ◽  
Antiviral Agent ◽  
Molecular Technique ◽  
The Novel ◽  
Hybrid Molecules ◽  
The World ◽  
Being There ◽  
Novel Coronavirus ◽  
Novel Drug ◽  
Day By Day

The coronavirus disease (COVID-19) is causing havoc all around the world. The number of active cases and deaths is increasing day by day. The novel coronavirus (CoV) is the causative agent of this disease. For the time being, there is no specific antiviral agent for the cure of COVID-19. A variety of drugs are being repurposed to counteract this disease. Scientists all over the world are striving to get some ideal molecules against this pandemic. Some hybrid molecules have been designed by coupling the privileged scaffolds of known antiviral and antimalarial drugs. This review deals with the hybrid molecules that have been designed and evaluated against the known targets of CoV by in silico techniques.

IMPACT OF THE PANDEMIC ON INSURANCE IN THE TOURIST INDUSTRY

2020 ◽  
Vol 2 (10) ◽  
pp. 87-91
Author(s):  
Yu. E. KLISHINA ◽  
◽  
O. N. UGLITSKIKH ◽  
Keyword(s):  
Tourism Industry ◽  
The Novel ◽  
Tourist Industry ◽  
Travel Agents ◽  
Foreign Travel ◽  
Russian Economy ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
The Impact

The article provides an overview of the impact of the coronavirus pandemic on the tourism industry. The contribution of the tourism industry to GDP and employment of the population is also considered. In particular, the impact of the pandemic on insurance in tourism was considered. The tourism industry is one of those sectors of the Russian economy that was among the first to be hit by the novel coronavirus infection. We are talking about a blow not only viral, medical – after all, the first outbreak in Russia was a consequence of the return of citizens from foreign travel, but also a financial blow – due to the spread of COVID-19 around the world, current tours had to be interrupted, and those planned at a later date – cancel or reschedule. In such conditions, tour operators, travel agents, carriers and other participants in the tourist services market suffered serious losses.

Possibilities of using amantadines in the setting of the novel coronavirus infection in patients with Parkinson's disease

2021 ◽  
Vol 13 (6) ◽  
pp. 67-72
Author(s):  
E. A. Katunina ◽  
Yu. N. Bezdolnyi ◽  
N. N. Shipilova
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Odds Ratio ◽  
Small Sample ◽  
The Novel ◽  
Antiviral Action ◽  
Clinical Observations ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Amantadine Sulfate

The novel coronavirus infection pandemic prompted not only the development of vaccines, but also the study of the effectiveness of already known drugs with antiviral activity. These drugs include adamantanes.Objective: to assess possible mechanisms of antiviral action of amantadine and memantine.Patients and methods. The study included 75 patients with Parkinson's disease (PD): 49 (65.3%) women and 26 (34.7%) men. The age of the patients ranged from 37 to 88 years (mean age: 65±7 years). The duration of the disease varied from 1 to 25 years (mean 12±7 years). Among the monitored PD patients, 22 (29.3%) had a novel coronavirus infection. Of 22 patients with coronavirus infection, 8 (36.4%) patients received adamantanes (four – amantadine sulfate, three – amantadine hydrochloride, one – memantine) in the complex therapy of PD for at least 3 months. On average, the duration of adamantane administration was 8±5 months.Results and discussion. PD patients who received adamantanes were less likely to develop COVID-19 than those who did not take adamantanes (p<0.05). At the same time, there were no significant differences in gender, age, duration of the disease and concomitant pathology in the com pared groups (p>0.05). Among patients who received adamantanes, the disease proceeded more easily, the number of cases of pneumonia was 3 times less (odds ratio 3; 95% confidence interval 0.44–20.3). In this group, no lethal outcomes were recorded, however, due to the small sample of patients, the differences between the groups were not statistically significant (÷2=1.99; p>0.05).Conclusion. The results of a retrospective study showed that the use of amantadine and memantine in patients with PD may have an effect on reducing morbidity and mortality in the novel coronavirus infection. This is consistent with published clinical observations suggesting a possible protective effect of amantadine and memantine against coronavirus infection.

scholarly journals COVID-19 and children

2020 ◽  
Vol 30 (5) ◽  
pp. 609-628
Author(s):  
L. S. Namazova-Baranova ◽  
A. A. Baranov
Keyword(s):  
Clinical Studies ◽  
Severe Disease ◽  
Severe Infection ◽  
Vulnerable Population ◽  
Routine Practice ◽  
The Novel ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Empirical Search

In December 2019, the world became aware of an epidemic of a very severe infection caused by a new coronavirus. Later, WHO declared a pandemic. The pediatricians were ready for the worst. The novel infection was expected to promptly spread among the most vulnerable population, children. But the clinicians soon understood that the situation is unbelievable: adults develop severe disease and die, while the children remain almost excluded from the infection spreading. 9 months have passed in the “new reality”. The humankind was learning to respond to the new infection challenge by empirical search for the potential therapeutic and diagnostic solutions and conducting wide clinical studies in parallel. A few questions have been answered because of consolidated and/or isolated actions of researchers and clinicians at the national, regional, and international levels. However, most aspects of how the new coronavirus affects the humans, including children, is still unclear and our knowledge of these aspects cannot be transferred in the routine practice. This review presents latest understanding of the course of the novel coronavirus infection in children, its treatment and outcomes.

scholarly journals GAAREIP: Indian Innovation of Caps and Personal Protective Equipment

2020 ◽  
Vol 34 (1-2) ◽  
pp. 24-27
Author(s):  
Aakash Pandita ◽  
Girish Gupta
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Personal Protective Equipment ◽  
Significant Risk ◽  
Protective Equipment ◽  
The Novel ◽  
Care Workers ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The world has recently been hit by a pandemic caused by the novel Coronavirus infection. The infection is highly contagious and possesses a significant risk for health care workers caring for the infected patients. With more than 200 countries being affected and around 3,00,000 deaths across the globe, the essential supply of masks and personal protective equipment has been falling short of the ever increasing need. In such crisis there is a need for innovating and designing endogenous masks and equipment to avoid compromise in care of the effected patients and for safeguarding the health of health care workers.

scholarly journals Review on COVID-19: Rise of SARS-CoV-2 Pandemic Outbreak

2020 ◽  
Vol 3 (Special-1) ◽  
pp. 103-120 ◽  
Author(s):  
Vidhan Chand Bala ◽  
Punet Kumar
Keyword(s):  
World Health ◽  
Whole Genome ◽  
The Novel ◽  
The Family ◽  
The World ◽  
Coronavirus Infection ◽  
Genome Level ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Bat Coronavirus

Initially recognized of COVID-19 within the world in 2019, the World Health Organization situational report from May 22nd, 2020, globally, there is a complete of 5,204,508 confirmed cases, with 212 countries being affected by the novel coronavirus. 2019 novel coronavirus (SARS-CoV-2) is that the seventh member of the family of coronaviruses is enveloped viruses with a positive sense, single-stranded RNA genome. The SARS-CoV-2 may be a �-CoV of group 2B there is 70% comparability in genetic sequence to SARS-CoV. The source of the new coronavirus infection has been resolved as bats. With whole-genome sequences of SARS-CoV-2 is 96% comparatively at the whole-genome level to a bat coronavirus. Mechanisms of transmission are concluded to incorporate contact, droplet, and possibly airborne under certain circumstances supported ancient experiences associated with SARS-CoV outbreaks. Although antiretroviral therapy is being widely used everywhere the globe for such patents, effects at finding a SARS-CoV vaccine haven�t succeeded so far.

Epidemic risks during endoscopic examinations in the conditions of a specialized COVID-19 hospital in the pandemic of the novel coronavirus infection

2021 ◽  
pp. 12-25
Author(s):  
Sergey Anatolievich Babanov ◽  
Mikhail Lvovich Shteiner ◽  
Yuriy Iskhakovich Biktagirov ◽  
Aleksandr Viktorovich Zhestkov ◽  
Leonid Aleksandrovich Strizhakov ◽  
...  
Keyword(s):  
High Risk ◽  
Respiratory System ◽  
Scientific Community ◽  
Respiratory Diseases ◽  
The Novel ◽  
Daily Work ◽  
The World ◽  
Epidemiological Risk ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The pandemic of the novel coronavirus infection has posed additional challenges for endoscopy services. Endoscopy departments face a high risk of spreading airborne respiratory diseases in their daily work. This is especially true for endoscopic departments and offices that perform bronchoscopic examinations. The world scientific community recognizes the highest epidemiological risk of personnel infection during any interventional manipulations and operations related to the respiratory system, including bronchoscopic interventions.

scholarly journals condition of the oral cavity in patients who have had a viral infection COVID-19

2021 ◽  
Vol 4 (4) ◽  
pp. 381-383
Author(s):  
Avzal Nigmatullaevich Akbarov ◽  
Davron Nigman Ugli Xabilov
Keyword(s):  
Literature Review ◽  
Oral Cavity ◽  
Scientific Paper ◽  
Healthcare Systems ◽  
The Novel ◽  
The World ◽  
Respiratory Pathology ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Prompt Diagnosis

Coronavirus COVID-19 is the cause of severe respiratory pathology and is a dangerous disease, proceeding in various clinical forms with varying degrees severity. This scientific paper presents a literature review of the latest collected data on the course of the novel coronavirus infection COVID-19 and its manifestations in the oral cavity during illness and after convalescence. The transmission routes of the disease and the main symptoms are also described. All healthcare systems in the world have been tasked with prompt diagnosis of coronavirus infection, specialized medical care and rehabilitation. In COVID 19 (SARS-CoV-2), changes in OOM are not the primary cause, but are manifested as a result of drug treatment and disease progression, despite the fact that the oral cavity is one of the sources of entry gate for infection.

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