scholarly journals Preliminary pharmaceutico-analytical study of Mukhadooshikaharalepa Churna

2021 ◽  
Vol 12 (3) ◽  
pp. 538-543
Author(s):  
Ambika S ◽  
Gazala Hussain

Introduction: Lepa is a bahirparimarjana chikitsa that helps in bringing samyata in sthanika dosha and dhatu. Many lepa are mentioned in Ayurveda pharmaceutics for the treatment of mukhadooshika. Among it, one is a combination of Lodhra, Kustumburu, Vacha, Vatapallava, and Narikelashuktya. Mukhadooshika is a type of kshudraroga, featuring the formation of pidaka on face. The symptoms of mukhadooshika resembles with acne vulgaris. Aim: An attempt is made to analyze the physico-chemical parameters of the mukhadooshikahara lepa churna. Materials and methods: The pharmaceutical preparation is easy and simple with easily available ingredients. The organoleptic characters like appearance, odour, taste and physico-chemical parameters like pH, total ash. Water Soluble ash, Alcohol soluble extractives, Water soluble extractives, loss on drying and HPTLC were carried out. Observations and results: The obtained results were discussed in the present paper. Discussion and conclusion: Mukhadooshikahara lepa churna is a simple preparation and can be prepared by easily available drugs. HPTLC fingerprinting at different wavelengths was carried out. At 254 nm, 366nm and 620nm 11, 8 and 10 peaks were found with different retention factor starting from 0.02 to 0.80, 0.03 to 0.096 and 0.07 to 0.80respectively. The analytical study findings can be taken as a preliminary standard for mukhadooshikahara lepa churna.

Author(s):  
Jigyasa Pathak ◽  
Aswathi M. P. ◽  
B. R. Patel ◽  
Harisha C. R. ◽  
Shukla Vinay J.

Background: Desmodium velutinum (Fabaceae) is one of the wild edible plants used traditionally to treat diarrhoea, haematuria, infertility and also externally used to treat scorpion bites. Though various parts of the plant have been used for therapeutic purpose, panchanga of the plant has not been studied for its Pharmacognostical and phytochemical characteristics in detail, following scientific parameters. Hence in the present study Desmodium velutinum whole plant has been studied for its pharmacognostical and phytochemical characters and compared with commonly used species Desmodium gangeticum. Methods: Whole plant of Desmodim velutinum was collected from Paikmal, Odisha and Desmodium gangeticum was collected from Junagarh, Gujarat in the month of November 2019 following good collection practices and shade dried. Pharmacognostical study and analytical study were performed following standard pharmacopoeial procedures. Results: Whole plant (Panchanga) of former is sweetish and latter is bitter. Powder microscopy of Desmodium gangeticum showed presence of rhomboidal crystals and lignified annular and spiral vessels. Desmodium velutinum showed presence of prismatic crystals and lignified pitted vessels. Physico-chemical analysis showed higher loss on drying in Desmodium gangeticum, and higher water soluble extractive values of Desmodium velutinum. Phytochemical estimation showed the presence of Proteins, tannins, and carbohydrates in both samples. HPTLC study showed similar Rf value 0.82 and 0.94 at 254 and 0.03 and 0.41 at 366nm. Conclusion: Basing upon the analytical and microscopic similarities Desmodium velutinum may be considered as substitute of Desmodium gangeticum


Author(s):  
Kranti Natthuji Khekale

Ayaskriti is an ayurvedic formulation containing iron. It is a specific metal processing technique developed in ancient times to make iron suitable for internal use. Objective: To prepare and physicochemically evaluate lauha Ayaskriti (shusruta) and lauha bhasma. Materials and methods: lauha Ayaskriti (shusruta) and lauha bhasma was prepared as per ayurvedic text and characterized by Organoleptic characters, physico-chemical parameters. Results: This study clearly revealed bhasma prepared as per Sushruta and Rastangini are passed as per ayurvedic bhasma pariksha. Conclusion: The study of XRF of lauha Ayaskriti and lauha bhasma value of fe is persent in the elemental form along with other form of oxide. Further studies are required to prove the medicinal efficacy of this medicine.  


Author(s):  
Mayuree A. Patel ◽  
Sanjeev R Acharya ◽  
Carol P. Macwan ◽  
Tejas B. Patel ◽  
B. N. Suhagia

Objective: The present study was aimed to identify the physicochemical data of shodhit guggul. Guggul is a gum-resin exudate from the plant Commiphora weightii (Arn.) Bhandari, belonging to Burseraceae family. In Ayurveda, guggul is always purified. This purification is known as Shodhan. Shodhan is a process by which guggul is made non-toxic, effective, suitable and fit for therapeutic purposes.Methods: The seven different shodhan dravya were used to prepare shodhit guggul. They were evaluated by performing physicochemical parameters including five different extractive value; total ash, acid insoluble, water soluble and sulphated ash value; pH, and loss on drying.Results: Analytical results of raw guggul showed total ash, acid insoluble ash, water soluble ash and sulphated ash value to 5.36±0.04%, 0.96±0.03%, 4.51±0.03 % and 8.40±0.04% respectively. These all values of each shodhit guggul were different. The extractive value of raw guggul was comparable with standard value while the extractive value of each shodhit guggul was totally different. The pH value of 1% w/v and 10% w/v aqueous solution of raw guggul was 6.44±0.18 though pH of each shodhit guggul was changed. The loss on drying of raw guggul was found to be 1.88±0.02%w/v, however, this value was different for each shodhit guggul.Conclusion: The present study revealed that the different shodhan process with specific shodhan dravya affects the physicochemical parameters. The analysis and comparison of the data showed the difference in the properties of seven shodhit guggul with respect to raw Guggul.


Author(s):  
Abhishek Abhishek ◽  
Ashok Kumar BN ◽  
Sujatha K. ◽  
Sunil Kumar

Introduction: Mrityunjaya Rasa is a herbo–mineral formulation mentioned under Jwara Chikitsa in Rasendra Sara Sangraha along with different Anupanas. It is having ingredients like Shudha Hingula, Shudha Gandhaka, Shudha Vatsanabha, Shudha Tankana, Pippali and Maricha which show significant result on various types of fever. Aim: To prepare Mrityunjaya Rasa as per guidelines given in classical text book Rasendra Sara Sangraha and to validate physico-chemical analysis of the sample. Methods: The preparation of Mrityunjaya Rasa was carried out at practical hall, Department of Rasashastra and Bhaishajya Kalpana, Shri Dharmasthala Manjunatheshwara College of Ayurveda, Kuthpady, Udupi, Karnataka. It was subjected to analysis on parameters like organoleptic characters, loss on drying, total ash, acid insoluble ash, water soluble ash, pH, alcohol soluble extractive value, and water soluble extractive value. Results: The results of Analytical study showed specific characteristics which are in accordance with the properties of Mrityunjaya Rasa. Conclusion: The study showed significant results, which proves quality of the drugs and efficacy.


2016 ◽  
Vol 7 (3) ◽  
Author(s):  
Kalawana OTMRKSB ◽  
Harisha C R ◽  
Patel K S ◽  
Kori V K ◽  
Rajagopala S

Ayurveda is one of the oldest medical systems having its own strong scientific concepts. Most herbal, Animal and mineral products are used to make Ayurvedic formulations and ancient Ayurvedic Aachaaryas have mentioned various methods to quality control and to standardization those formulations. And also it has been developed different techniques to evaluate the quality of medicines by modern science. So there is a current need of analyze Ayurvedic products also according to modern scientific pharmaceutical and pharmacognostical parameters for the global acceptance of Ayurveda. Hence the present study was carried out to pharmacognosticaly analyze the ingredients and finished product of Gandhakadi Yoga Vati and to analyze the Physico-chemical parameters of the same. Gandhakadi Yoga Vati is an Ayurvedic formulation used as an adjuvant in the management of Thalassemia Major. Pharmacognostical characteristics of Gandhakadi Yoga Vati  under the microscope showed that oil globules, stone cells & oleoresin contents, of Vidanga (Embelia robusta Burm.f.), fibers and oil globules of Agastya Pathra (S. grandiflora Linn.), warty trichome with base of Bhringaraja (E.alba L.) and crystaline depositions of Gandhaka. In the pharmaceutical study, it was observed that Loss on drying was 3.5 %w/w, pH was 6.5, Alcohol soluble extractive was 8.9 % w/w and water soluble extractive was 5.5 % w/w.  HPTLC study showed 06 peaks at 254 nm and 03 peaks at 366 nm wave lengths.


Author(s):  
R. D. H. Kulathunga ◽  
E. D. T. P. Gunarathna ◽  
N. D. N. Jayawardhana ◽  
R. H. S. K. De Silva ◽  
R. L. D. S. Ranasinghe ◽  
...  

Aim: The present study aimed to compare the Sharibadi decoction which was prepared in two different ways. Sharibadi decoction A: All the ingredients are available including a local variety of H. indicus and Indian variety of H. indicus. Sharibadi decoction B: All the ingredients are available except the local variety of H. indicus and double the amount of Indian variety of H. indicus. Methodology: Phytochemical (in terms of secondary metabolites and Thin Layer Fingerprint profiles) and Physico-chemical (in terms of ash values and extractable matter) analyses were carried out to compare the Sharibadi decoction A with the Sharibadi decoction B. Results: Comparison of phytochemicals and Thin Layer Fingerprint profile of Sharibadi decoction A with that of Sharibadi decoction B revealed the differences in phytochemical compound/s presence in both decoctions. However, Physico-chemical parameters of Sharibadi decoction A were almost similar to that of Sharibadi decoction B. Conclusion: Absence of local variety of H. indicus gives an impact on phytochemical constituents rather than Physico-chemical parameters of Sharibadi decoction. However, phytochemicals play a major role when a drug exhibits its therapeutic effect/s. Therefore, to get the best therapeutic effect of Sharibadi decoction, both local variety of H. indicus and Indian variety of H. indicus should be used with other ingredients.


2020 ◽  
Vol 12 (17) ◽  
pp. 7082 ◽  
Author(s):  
Xin Wu ◽  
Liheng Ren ◽  
Lin Luo ◽  
Jiachao Zhang ◽  
Lihua Zhang ◽  
...  

Bacterial and fungal communities play significant roles in waste biodegradation and nutrient reservation during composting. Biochar and zeolite were widely reported to directly or indirectly promote microbial growth. Therefore, the effects of zeolite and biochar on the abundance and structure of bacterial and fungal communities and their shaping factors during the composting of agricultural waste were studied. Four treatments were carried out as follows: Run A as the control without any addition, Run B with zeolite (5%), Run C with biochar (5%), and Run D with zeolite (5%) and biochar (5%), respectively. The bacterial and fungal community structures were detected by high-throughput sequencing. Redundancy analysis was used for determining the relationship between community structure and physico-chemical parameters. The results indicated that the addition of biochar and zeolite changed the physico-chemical parameters (e.g., pile temperature, pH, total organic matter, ammonium, nitrate, and water-soluble carbon) during the composting process. Zeolite and biochar significantly changed the structure and diversity of bacterial and fungal populations. Moreover, the bacterial community rather than the fungal community was sensitive to the biochar and zeolite addition during the composting process. Community phylogenetic characteristics showed that Nocardiopsaceae, Bacillaceae, Leuconostocaceae, Phyllobacteriaceae, and Xanthomonadaceae were the predominant bacterial species at the family-level. Chaetomiaceae and Trichocomaceae were the two most dominant fungal species. The pH, total organic matter, and nitrate were the most important factors affecting the bacterial and fungal population changes during the composting process.


Author(s):  
Manpreet Kaur ◽  
Hayat M Mukhtar

Objective: This study provides the detailed summary of pharmacognostical characters of rhizomes to give clear standards for the identification ofdrug.Methods: Important details such as macroscopy, microscopy (transverse section [TS] and powder microscopy) along with physico-chemicalparameters (such as loss on drying, ash values, and extractive values), and quantitative studies (i.e foreign matter, length and width of xylem vesselsand calcium oxalate crystals, and diameter of starch grains) were performed by standard procedure.Results: The findings of macroscopic studies revealed that the rhizomes were internally creamish to light brown and dark brown externally withlongitudinal wrinkles. TS and powder microscopy of rhizomes showed the presence of fragments of cork, cellulosic parenchyma; scalariform typexylem vessels, fragments of ligneous parenchyma, lignified astrosclereids, and small ovoid, and rounded starch grains. The mean length and meanwidth of xylem vessels and calcium oxalate crystals were found to be 406 μm (micrometer) and 60.2 μm and 63.36 μm and 48.96 μm. Whereas meandiameter of starch grains was 34.56 μ. Physicochemical standards quantified were foreign organic matter (0.2%), total ash (12.3%), acid insolubleash (6.3%), water soluble ash (3%), loss on drying (12.5%), alcohol-soluble extractive value (32.6%), and water soluble extractive value (27.6%).Conclusion: As various pharmacognostical and physico-chemical parameters have pivotal roles in authentication, identification and establishmentsof quality parameters of the plant. This study was conducted for this purpose.


Author(s):  
И. И. Малахова ◽  
В. Д. Красиков ◽  
Н. И. Горшков ◽  
А. Н. Беляев ◽  
С. М. Староверов

The method for analysis of transition metal ions (Zn(II), Cu(II), Со(II), Ni(II), Fe(III)) by high-performance planar (thin layer) chromatography with the use of sorbents modified by chelating fragments of iminodiacetic acid was developed. The correlation between retention factor (Rf) and physico-chemical parameters of the separated systems was studied. It was demonstrated that unlike the pH value, ionic strength of a solution does not exert significant influence on resolution and mobility of transition metal cations


2021 ◽  
pp. 49-51
Author(s):  
Галина Андреевна Донская ◽  
Виктор Михайлович Дрожжин

Сохранение биологически активных компонентов молока является одной из главных задач научных работников и производителей молочных продуктов. Однако для выработки безопасного в санитарно-гигиеническом отношении продукта молоко от момента получения до реализации претерпевает различные термомеханические воздействия. При этом возможны нарушение оболочки жировых шариков, изменения массовой доли и структуры белка, минеральных солей, ферментной активности. В большей степени это происходит при гомогенизации. В процессе бактофугирования физико-химические показатели молока изменяются незначительно. Бактофугирование позволяет при щадящих температурных режимах снизить бактериальную обсемененность молока на 92-98 %. При этом удаляются анаэробные споры маслянокислых бактерий, что особенно важно для производства сыров. В связи с этим бактофугирование рекомендуют применять при производстве творога и творожных изделий, твердых сыров, где предусмотрены невысокие температуры пастеризации. Цель данной работы - изучение влияния бактофугирования на антиоксидантную активность молока. В задачи исследований входило определение физико-химических показателей и суммарного содержания водорастворимых антиоксидантов в сыром и бакто-фугированном молоке, получаемом с предприятия отрасли. После бактофугирования молоко термизировали и отправляли на производство сыров. Физико-химические показатели определяли стандартизованными методами, антиоксидантную активность - амперометрическим методом. Установлено, что титруемая кислотность, окислительно-восстановительный потенциал, массовая доля белка, содержание сухих веществ снижаются в бактофугированном и термизированном молоке в пределах 1,7-4,8 %. Содержание водорастворимых антиоксидантов уменьшается на 21-30 %. Preservation of biologically active components of milk is one of key goals of scientists and industry. However, to achieve required food safety, milk undergoes a number of thermomechanic steps when produced from from raw milk to end product. Often times this process is accompanied by breaking up of fat globule, alteration of mass weight and structure of proteins, mineral salts, enzymatic activity. Most of those occur during homogenization process. Bactofugation process has a minor impact on physico-chemical parameters of milk. When conducted at light temperatures, bactofugation allows to decrease bacterial contamination by 92-98 %. Anaerobic Butyric acid bacteria spores are removed which is of particular importance in cheese production. Therefore, bactofugation is recommended in production of curd and curd products, hard cheeses, processes with low pasteurization temperatures. The aim of this work was to study bactofugation impact on antioxidant activity of milk. Investigation scope included determination of physico-chemical parameters and total amount of water-soluble antioxidants in raw milk and after bactofugation. Followed by bactofugation, milk was heat treated and further utilized for cheese production. Physico-chemical parameters were determined by standard methods, antioxidant activity - by amperometric method. It was established that titrated acidity, redox potential, protein mass weight, and dry matter declined in milk after bactofugation and heat treatment with the range of 1.7-4.8 %. Water-soluble antioxidant composition was reduced by 21-30 %.


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