scholarly journals Crestal Bone Regeneration in Defective Bone Implants

2014 ◽  
Vol 3 (2) ◽  
pp. 95-97
Author(s):  
Mohammed Jasim Aljuboori
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Alveolar Bone ◽  
Medical Condition ◽  
Collagen Membrane ◽  
Bone Implants ◽  
Implant Surface ◽  
Primary Wound Closure ◽  
Narrow Ridge ◽  
Defective Bone

ABSTRACT Implant placement in narrow alveolar bone ridges end with buccal bone dehiscence and implant thread exposure. In this conditions, bone graft need to be placed in a addition to the collagen membrane to cover the dehiscence with primary wound closure. This paper presents an implant case with a medical history of diabetic type II and smoker patient. Implant placed in narrow ridge and three coronal threads of the fixture exposed when the implant torque into the final position. After 3 months healing period, the implant site exposed with complete bone formation and coverage of the threads. From this case, one might conclude that: first the type of the implant surface may enhance bone formation, second the periosteum may contribute in the bone regeneration. Third the medical condition of the patient may has no local influence on the implant site. How to cite this article Aljuboori MJ, Saini R. Crestal Bone Regeneration in Defective Bone Implants. Int J Experiment Dent Sci 2014;3(2):95-97.

The Effects of Collagen Membrane Coated with PLGA on Bone Regeneration in Rat Calvarial Defects

2007 ◽  
Vol 342-343 ◽  
pp. 357-360
Author(s):  
Kun Young Song ◽  
Yoo Jung Um ◽  
Ui Won Jung ◽  
Yong Keun Lee ◽  
Seong Ho Choi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Collagen Membrane ◽  
Histomorphometric Analysis ◽  
Local Bone ◽  
Calvarial Defects ◽  
Formation Behavior ◽  
Surgical Implantation ◽  
Collagen Membranes ◽  
Rat Calvarial Defect

The purpose of this study was to evaluate the effects of collagen membrane coated with PLGA on bone regeneration in rat calvarial defect. Five groups of 10 animals each received either collagen membrane coated with 0.5%, 1%, 3% concentration of PLGA, collagen membrane only or surgical control. Each group of animals was healed into 2 healing periods of 2(5 animals) and 8(5 animals)weeks and histologic and histomorphometric analysis were done. The results of the following study revealed that surgical implantation of collagen membranes coated with PLGA enhanced local bone formation at both 2 and 8 weeks independent of different PLGA concentrations. In conclusion, collagen membrane coated with PLGA shows a significant bone formation behavior irrespective of their concentration.

scholarly journals Guided Bone Regeneration- A Comprehensive Review

2021 ◽  
Author(s):  
Vineetha Venugopalan ◽  
Anegundi Raghavendra Vamsi ◽  
Santhosh Shenoy ◽  
Karishma Ashok ◽  
Biju Thomas
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Primary Stability ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Bony Defect ◽  
Graft Material ◽  
Bone Augmentation ◽  
Wide Range ◽  
Space Maintenance

Successful implant treatment requires prosthetically driven placement of an implant, primary stability at placement, and careful living bone management. The resorptive changes of alveolar bone are an inevitable process following tooth loss, periodontal disease or trauma which causes bone defects. This results in various aesthetic and functional complications such as soft tissue recession, infection and inflammation. Various methods have been tried and advocated for augmenting these bone deficiencies. Guided Bone Regeneration (GBR) is a successful modality for bone augmentation with a wide range of indications and helps restore the alveolar ridge dimensions. It utilises the principle of Guided Tissue Regeneration (GTR) for space maintenance within a bony defect. Different types of barrier membranes are being utilised along with various bone grafts in GBR. Thorough knowledge regarding the biology of bone is required before the initiation of any bone augmentation procedure. A combination of Collagen Membrane (CM) and graft material was found successful for GBR. Hence, this review focuses on presentation of best available evidence for various aspects of GBR.

scholarly journals The Role of Epigenetic Functionalization of Implants and Biomaterials in Osseointegration and Bone Regeneration—A Review

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5879
Author(s):  
Farah Asa’ad ◽  
Goda Pelanyte ◽  
Jincy Philip ◽  
Christer Dahlin ◽  
Lena Larsson
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Inflammatory Diseases ◽  
Standards Of Care ◽  
Epigenetic Mechanisms ◽  
Implant Surface ◽  
The Past ◽  
Need To Evaluate ◽  
Specific Search

The contribution of epigenetic mechanisms as a potential treatment model has been observed in cancer and autoimmune/inflammatory diseases. This review aims to put forward the epigenetic mechanisms as a promising strategy in implant surface functionalization and modification of biomaterials, to promote better osseointegration and bone regeneration, and could be applicable for alveolar bone regeneration and osseointegration in the future. Materials and Methods: Electronic and manual searches of the literature in PubMed, MEDLINE, and EMBASE were conducted, using a specific search strategy limited to publications in the last 5 years to identify preclinical studies in order to address the following focused questions: (i) Which, if any, are the epigenetic mechanisms used to functionalize implant surfaces to achieve better osseointegration? (ii) Which, if any, are the epigenetic mechanisms used to functionalize biomaterials to achieve better bone regeneration? Results: Findings from several studies have emphasized the role of miRNAs in functionalizing implants surfaces and biomaterials to promote osseointegration and bone regeneration, respectively. However, there are scarce data on the role of DNA methylation and histone modifications for these specific applications, despite being commonly applied in cancer research. Conclusions: Studies over the past few years have demonstrated that biomaterials are immunomodulatory rather than inert materials. In this context, epigenetics can act as next generation of advanced treatment tools for future regenerative techniques. Yet, there is a need to evaluate the efficacy/cost effectiveness of these techniques in comparison to current standards of care.

scholarly journals Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model

2022 ◽  
Vol 23 (1) ◽  
pp. 558
Author(s):  
Chih-Hsiang Fang ◽  
Chung-Kai Sun ◽  
Yi-Wen Lin ◽  
Min-Chih Hung ◽  
Hung-Ying Lin ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Critical Size ◽  
Lower Percentage ◽  
Type I ◽  
Defect Model ◽  
Good Biocompatibility ◽  
Alveolar Bone Defect

In this study, we fabricated gelatin/nano-hydroxyapatite/metformin scaffold (GHMS) and compared its effectiveness in bone regeneration with extraction-only, Sinbone, and Bio-Oss Collagen® groups in a critical size rat alveolar bone defect model. GHMS was synthesized by co-precipitating calcium hydroxide and orthophosphoric acid within gelatin solution, incorporating metformin, and cross-linked by microbial transglutaminase. The morphology, characterization, and biocompatibility of scaffold were examined. The in vitro effects of GHMS on osteogenic gene and protein expressions were evaluated. In vivo bone formation was assessed in a critical size rat alveolar bone defect model with micro-computed tomography and histological examination by comparing GHMS with extraction-only, Sinbone, and Bio-Oss Collagen®. The synthesized GHMS had a highly interconnected porous structure with a mean pore size of 81.85 ± 13.8 µm. GHMS exhibited good biocompatibility; promoted ALPL, RUNX2, SP7, BGLAP, SPARC and Col1a1 gene expressions; and upregulated the synthesis of osteogenic proteins, including osteonectin, osteocalcin, and collagen type I. In critical size rat alveolar bone defects, GHMS showed superior bone regeneration compared to extraction-only, Sinbone, and Bio-Oss Collagen® groups as manifested by greater alveolar ridge preservation, while more bone formation with a lower percentage of connective tissue and residual scaffold at the defect sites grafted with GHMS in histological staining. The GHMS presented in this study may be used as a potential bone substitute to regenerate alveolar bone. The good biocompatibility, relatively fast degradation, interconnected pores allowing vascularization, and higher bioactivity properties of the components of the GHMS (gelatin, nHA, and metformin) may contribute to direct osteogenesis.

Inorganic Polyphosphate: a Possible Stimulant of Bone Formation

2007 ◽  
Vol 86 (9) ◽  
pp. 893-897 ◽  
Author(s):  
Y. Hacchou ◽  
T. Uematsu ◽  
O. Ueda ◽  
Y. Usui ◽  
S. Uematsu ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Alveolar Bone ◽  
Bone Mineralization ◽  
Osteoblastic Differentiation ◽  
Inorganic Polyphosphate ◽  
Pit Formation

Inorganic polyphosphates [Poly(P)] are often distributed in osteoblasts. We undertook the present study to verify the hypothesis that Poly(P) stimulates osteoblasts and facilitates bone formation. The osteoblast-like cell line MC 3T3-E1 was cultured with Poly(P), and gene expression and potential mineralization were evaluated by reverse-transcription polymerase chain-reaction. Alkaline phosphatase activity, von Kossa staining, and resorption pit formation analyses were also determined. The potential role of Poly(P) in bone formation was assessed in a rat alveolar bone regeneration model. Poly(P) induced osteopontin, osteocalcin, collagen 1α, and osteoprotegerin expression and increased alkaline phosphatase activity in MC 3T3-E1 cells. Dentin slice pit formation decreased with mouse osteoblast and bone marrow macrophage co-cultivation in the presence of Poly(P). Promotion of alveolar bone regeneration was observed locally in Poly(P)-treated rats. These findings suggest that Poly(P) plays a role in osteoblastic differentiation, activation, and bone mineralization. Thus, local poly(P) delivery may have a therapeutic benefit in periodontal disease.

A Synthetic Biodegradable Polymer Membrane for Guided Bone Regeneration in Bone Defect

2021 ◽  
Vol 17 (3) ◽  
pp. 456-465
Author(s):  
Kangjie Ma ◽  
Dongmei Mei ◽  
Xiaodong Lin ◽  
Li Zhang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Bone Regeneration ◽  
Polylactic Acid ◽  
Bone Defect ◽  
Biodegradable Polymer ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Gbr Membrane ◽  
Alveolar Bone Defect

Guided bone regeneration (GBR) technique is most commonly used to treat alveolar bone defect. Polylactic acid (PLA) attracts much attention to utilize as a GBR membrane because it has relatively high mechanical strength and biodegradability. However, randomized controlled trials of PLA as a GBR membrane in animals were rare. The aim of this work is to observe the efficacy of polylactic acid membrane in guiding bone regeneration in Beagle canine alveolar bone defect restoration and to compare efficacy with the collagen membrane, providing an experimental basis for further clinical use of the polylactic acid membrane. The tests of physical and chemical properties showed that the PLA membrane has well mechanical strength to maintenance the space for the new bone, and has proper aperture for the attachment of osteoblasts. Through X-ray and histopathological examination of the different time points, the bone grafting material covered with PLA membrane can form similar mature bone compared to collagen membrane ones. Meanwhile, biodegradable speed of the PLA membrane was slower. Thus, this study showed that polylactic acid membrane as synthetic biodegradable polymer was reliably effective in guiding bone regeneration of alveolar bone defects, showed the favorable osteogenic capability and forecasts well applications in bone augmentation.

scholarly journals Osteogenic Potential of Bovine Bone Graft in Combination with Laser Photobiomodulation: An Ex Vivo Demonstrative Study in Wistar Rats by Cross-Linked Studies Based on Synchrotron Microtomography and Histology

2020 ◽  
Vol 21 (3) ◽  
pp. 778 ◽  
Author(s):  
Ruxandra Elena Luca ◽  
Alessandra Giuliani ◽  
Adrian Mănescu ◽  
Rodica Heredea ◽  
Bogdan Hoinoiu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Ex Vivo ◽  
Bone Defects ◽  
Osteogenic Potential ◽  
Collagen Membrane ◽  
Main Concern ◽  
Bovine Bone ◽  
Local Conditions ◽  
Analysis Protocol

Background: Alveolar bone defects are usually the main concern when planning implant treatments for the appropriate oral rehabilitation of patients. To improve local conditions and achieve implant treatments, there are several methods used for increasing bone volume, among which one of the most successful, versatile, and effective is considered to be guided bone regeneration. The aim of this demonstrative study was to propose an innovative analysis protocol for the evaluation of the effect of photobiomodulation on the bone regeneration process, using rat calvarial defects of 5 mm in diameter, filled with xenograft, covered with collagen membrane, and then exposed to laser radiation. Methods: The animals were sacrificed at different points in time (i.e., after 14, 21, and 30 days). Samples of identical dimensions were harvested in order to compare the results obtained after different periods of healing. The analysis was performed by cross-linking the information obtained using histology and high-resolution synchrotron-based tomography on the same samples. A comparison was made with both the negative control (NC) group (with a bone defect which was left for spontaneous healing), and the positive control (PC) group (in which the bone defects were filled with xenografts and collagen membrane without receiving laser treatment). Results: We demonstrated that using photobiomodulation provides a better healing effect than when receiving only the support of the biomaterial. This effect has been evident for short times treatments, i.e., during the first 14 days after surgery. Conclusion: The proposed analysis protocol was effective in detecting the presence of higher quantities of bone volumes under remodeling after photobiomodulation with respect to the exclusive bone regeneration guided by the xenograft.

scholarly journals Functionalized Scaffold and Barrier Membrane with Anti-BMP-2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Seiko Min ◽  
Taewan Kim ◽  
Oksu Kim ◽  
Carames Goncalo ◽  
Tadahiko Utsunomiya ◽  
...  
Keyword(s):  
Bone Formation ◽  
Alveolar Bone ◽  
Test Group ◽  
Canine Model ◽  
Bone Morphogenetic Protein 2 ◽  
Control Group ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Barrier Membrane ◽  
Bone Width

Introduction. The aim of this study was to investigate the ability of anti-bone morphogenetic protein 2 monoclonal antibody (anti-BMP-2 mAb) to functionalize scaffolds to mediate bone regeneration in a canine model. Materials and Methods. The mandibular right premolar 4 (PM4) was extracted in eight beagle dogs and grafted with anti-BMP-2 mAb+anorganic bovine bone mineral with 10% collagen (ABBM-C) and porcine bilayer native collagen membrane (CM). The ABBM-C and CM were functionalized with either anti-BMP-2 mAb (test group) or an isotype matched control mAb (control group). Animals were euthanized at 12 weeks for radiographic, histologic, and histomorphometric analyses. Outcomes were compared between groups. Results. 3D imaging using cone beam computed tomography (CBCT) revealed that sites treated with ABBM-C and CM functionalized with anti-BMP-2 mAb exhibited significantly more remaining bone width near the alveolar crest, as well as buccal bone height, compared with control groups. Histologic and histomorphometric analyses demonstrated that in anti-BMP-2 mAb-treated sites, total tissue volume was significantly higher in the coronal part of the alveolar bone crest compared with control sites. In anti-BMP-2 mAb-treated sites, bone formation was observed under the barrier membrane. Conclusion. Functionalization of the ABBM-C scaffold and CM appeared to have led to bone formation within healing alveolar bone sockets.

Sign in / Sign up

Export Citation Format

Share Document