scholarly journals FACTORS ASSOCIATED WITH HAEMATURIA IN CHILDREN IN AGE GROUP OF 1 TO 14 YEARS

2021 ◽  
Vol 32 (01) ◽  
pp. 32-36
Author(s):  
Farzana Latif ◽  
Rai Muhammad Hammad Arif ◽  
Arif Zaheer ◽  
Agha Shabbir Ali

BACKGROUND: Haematuria is the most common urinary finding that bring children to the attention of the paediatric nephrologists. It can be caused by glomerular & non-glomerular diseases. The main causes of Haematuria are urinary tract infections, trauma to abdomen, acute post streptococcal glomerulonephritis and congenital hydronephrosis. OBJECTIVE: The objective of this study was to identify the distribution of factors in children with haematuria in age group of 1 to 14 years METHODS: A total of 84 admitted patients of haematuria, who fulfill the inclusive criteria,were enrolled in this study after consent from their parents. Each patient was evaluated through history, examination and investigated. Urine sample of each patient was analyzed for a microscopic examination. Investigations / imaging were performed in clinical laboratory of LGH / PGMI, Lahore. The collected information was entered into SPSS version 20, and analyzed. RESULTS:  There were 47(44.05%) male and 37(55.95%) female patients in this study. The mean age of patients was 8.69 ± 3.63 years.We found 14 patients (16.66%) has urological anomalies,6 boys have posterior urethral valves.2 girls and one boy has vesicoureteral reflux.One boy and one girl has ureterovesical junction obstruction,one boy has hypospadias and 2 girls , ureteropelvic junction obstruction.History of recent bladder catheterization was seen in 5(5.59%), urinary tract infection 17(20.23%) and 14 patients has urological anomalies(16.66%). CONCLUSION: According to this study ,most common factors causing haematuria was urinary tract infection 17(20.23%) , acute poststreptococcal glomerulonephritis 16(19.04%) and congenital urological anomalies 14(16.66%).Renal stones were found in 10(11.90%).   

Author(s):  
Heather Lambert

Vesicoureteric reflux (VUR) describes the flow of urine from the bladder into the upper urinary tract when the ureterovesical junction fails to perform as a one-way valve. Most commonly, VUR is primary, though it can be secondary to bladder outflow obstruction and can occur in several multiorgan congenital disorders. There is good evidence of a genetic basis with a greatly increased risk of VUR in children with a family history of VUR. VUR is a congenital disorder, which largely shows improvement or complete resolution with age. Fetal VUR may be associated with parenchymal developmental defects (dysplasia). Postnatally non-infected, non-obstructed VUR does not appear to have a detrimental effect on the kidneys. However there is an association of VUR with urinary tract infection and acquired renal parenchymal defects (scarring). The parenchymal abnormalities detected on imaging, often termed reflux nephropathy, may be as a result of reflux-associated dysplasia or acquired renal scarring or both. It is difficult to distinguish between the two on routine imaging. Higher grades of VUR are associated with more severe reflux nephropathy. The precise role of VUR in pyelonephritis and scarring is not clear and it may be that VUR simply increases the risk of acute pyelonephritis. Whilst most VUR resolves during childhood, it is associated with an increased risk of urinary tract infection and burden of acute disease. Investigation strategies vary considerably, related to uncertainties about the natural history of the condition and the effectiveness of various interventions. The long-term prognosis is chiefly related to the morbidity of reflux nephropathy leading in some cases to impairment of glomerular filtration rate, hypertension, proteinuria, and pregnancy-related conditions including hypertension, pre-eclampsia, and recurrent urinary tract infection. Management is controversial and ranges from simple observation with or without provision of rapid access to diagnosis and treatment of urinary tract infections; to long-term prophylactic antibiotics or various antireflux surgical procedures.


2013 ◽  
Vol 38 (3) ◽  
pp. 79-83 ◽  
Author(s):  
S Ahmad

Antibiotic resistance of urinary tract pathogens has increased worldwide. The purpose of this study is to provide information regarding the causative agents of urinary tract infection in Kashmiri patients, identify the uropathogens responsible for the infection and study the antibiotic susceptibility patterns of the uropathogens. Clean voided mid-stream urine samples were collected from 2190 patients. The specimens were cultured and the isolates were identified using standard microbiological techniques. The antibiotic susceptibilities of the isolates were also determined. Of 2190 specimens, 591 (27%) showed significant growth upon culture. Approximately 84.1 % (497/591) of the 591 patients with UTI were females, most of which belonged to the 21-30 age group (206). The males accounted for 15.9% (94/591) UTI cases. Most of the male patients belonged to the 21-30 age group (34). The lowest incidence of urinary tract infections was seen among the 13-20 years age group. Throughout this study males accounted for only 16% of all UTI cases. Esherichia coli was the most predominant isolate, 53.8% followed by Klebsiella pneumoniae 22.4% and Pseudomonas aeruginosa 7.6%. All isolates were fully sensitive to ofloxacin, and more than 94% were sensitive to cefuroxime. Apart from group D Streptococcus , the overall response to ampicillin by all isolates was less than 15%. The prevalence of multi-resistant Pseudomonas aeruginosa in community-acquired urinary tract infections is increasing. All Pseudomonas aeruginosa isolates were fully susceptible to cefuroxime and ofloxacin. It is recommended that cefuroxime and ofloxacin or both are used in the blind treatment of urinary tract infection while awaiting the culture and sensitivity results. Concurrent with the necessary shift in the prescription pattern, attention should be paid to restriction of antibiotic abuse in the community to retard development of further drug resistance. DOI: http://dx.doi.org/10.3329/bmrcb.v38i3.14330 Bangladesh Med Res Counc Bull 2012; 38(3): 79-83 (December)


PEDIATRICS ◽  
1988 ◽  
Vol 82 (1) ◽  
pp. 91-95
Author(s):  
James A. Roberts ◽  
M. Bernice Kaack ◽  
Anne B. Morvant

High-grade reflux commonly lasts longer than moderate reflux, which disappears with maturtion of the ureterovesical junction. It is known that ureteral function is affected by urinary tract infection from studies in experimental animals, as well as through clinica1 findings in patients with upper tract infection. Whether infection might affect the ability of the ureter to prolong high-grade reflux was questioned. This observation might explain why high-grade reflux does not disappear as rapidly as moderate reflux in children with recurrent urinary tract infections. Vesicoureteral reflux was produced surgically in combination with bladder neck obstruction using infant monkeys. The reflux thus produced was high grade with ureteral dilation and caliectasis. In the group of animals in which the bladder neck obstruction was relieved surgically, the reflux rapidly disappeared. In the other group, a bladder infection was produced with Escherichia coli at the time of release of the bladder neck obstruction. The reflux lasted significantly longer, an average of 18 months. Therefore, it appears that treatment of urinary tract infection rather than vesicoureteral reflux is the most important therapy.


2018 ◽  
Vol 41 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Nure Ishrat Nazme ◽  
Abdullah Al Amin ◽  
Farhana Jalil ◽  
Jesmin Sultana ◽  
Nurun Nahar Fatema

Background: Urinary tract infection (UTI) is an important cause of morbidity and mortality in the paediatric age group. The spectrum of etiologic agents causing UTI and their antimicrobial resistance pattern has been continuously changing over the years. It varies among geographical locations, hospitals and also in different age groups.Objective: The aim of this study was to find out the causative agents of UTI and their antibiotic sensitivity pattern in paediatric patients in CMH, Dhaka.Methodology: This is an observational cross sectional study. A total of 180 children aged 0 months to 15 years attending pediatric outpatient department or admitted in Department of Paediatrics CMH, Dhaka with suspected UTI were subjected for urine routine and microscopic examination between June 2015 to May 2016. Those having pyuria (n=120) were then sent for urine culture and sensitivity to the laboratory of Armed Forces Institute of Pathology (AFIP). Patients having significant growth of organism were enrolled as cases of confirmed UTI. After enrollment, relevant information such as age, sex, sociodemographic profile was obtained and recorded in case record form.Result: In the present study, urine routine microscopy was done in all 180 cases of suspected UTI. Among all urine analysis 67% had significant pyuria (n=120). Of the 120 cases with pyuria, 58 cases were having culture positive accounting 48.3% of the total sample studied. Occurrence of urinary tract infections was highest in the age group below 5 year (62.5%). UTI was more prevalent in girls (63.3%) with male to female ratio 1:1.7. E. coli was the commonest isolate (62.1%) followed by Enterococcus (19.2%) and Klebsiella (10.2%). E. coli was found to be most sensitive to Ciprofloxacin, Nitrofurantoin, Amikacin, and Levofloxacin in descending order. There was a generally high level of resistance of isolates to Cotrimoxazole, Amoxycillin, Aminoglycosides, Azythromycin and the Cephalosporins like Cefuroxime, Ceftazidime, Cefixime and Ceftriaxone compared to Ciprofloxacin, Nitrofurantoin and Levofloxacin.Conclusion: Based on our findings, Ciprofloxacin, Levofloxacin and Nitrofurantoin are appropriate for initial empirical therapy for UTI among Bangladeshi children.Bangladesh J Child Health 2017; VOL 41 (2) :77-83


2021 ◽  
pp. 1-2
Author(s):  
Spriha Smriti ◽  
R.K Srivastava ◽  
N.P Sahu

Introduction- Urinary tract infections refers to both microbial colonization of urine and tissue invasion of any structure of urinary tract. ASYMPTOMATIC BACTERIURIA (ASB) is a condition in which urine culture reveals significant growth of pathogens that is greater than 1,00,000 bacteria/ml of urine but not showing symptoms of urinary tract infection. Asymptomatic bacteriuria may be of significance or to doubtful significance or of no significance depending on number of bacteria present in urine. ASB is more common in women. Material and Method- The present study was conducted on 200 pregnant women without any symptoms of urinary tract infection attending Obs & Gynae department of RIMS, Ranchi, Jharkhand. It was conducted between August 2013 to December 2014. Urine specimen should be cultured for isolation of the common agents of UTI. The urine should be mixed thoroughly before plating. The plates are inoculated using a calibrated loop designed to deliver a known volume either 0.01 or 0.001 ml. Choice of media to inoculate depends on patient served and microbiologist preference, usually MacConkey Agar and 5% Blood Agar were used. In recent years a selective media CLED (Cysteine lactose electrolyte deficient) agar is used. This media is selective for urinary pathogens cultured plates are incubated at 37⁰C for 24 hrs. Colony count is done>100000/ml of CFU was taken as significant bacteriuria. Kirby Baeur disc diffusion is used for sensitivity test. Result – Asymtomatic bacteriuria is seen in 7.5% cases. It is more common in age group 20- 30 yrs age group and in second trimester of pregnancy. Most common species isolated was E.coli followed by Klebsiella species.Discussion- The percentage of ASB in the present study (7.5%) correlates with the studies of Lavanya SV et al 2002 (8.4%) CA Turpin et al 2007 (7.3%) & R. Sujata et al 2012 (7.3%).In this study, culture positivity with significant bacteriuria was highest in age group 20-30 yrs (73.34%). In 2011 study done by Dr. Rajshekhar maximum incidence was seen in 20-30 yrs age (57.57%).


Author(s):  
Stella Chinenye Kama ◽  
Emmanuel Ifeanyi Obeagu ◽  
M. N. Alo ◽  
Kingsley Chinedum Ochei ◽  
Uchenna Modestus Ezugwu ◽  
...  

The investigation of urinary tract infection (UTI) among diabetic patients 15-51 years and above was assessed using 100 mid-stream urine specimen with the objective of isolating and identifying different types of bacteria and their respective frequencies among diabetic patients attending diabetic clinic at Alex Ekwueme Federal University Teaching Hospital, Abakaliki. A urine culture was performed combined with a full report of urine to establish the diagnosis. The result showed that the majority of bacteria in urinary tract infections were in 27-32 years of age group (71.4%) and lowest in 15-20 years age group (0%). The predominant bacteria isolates and their percentage occurrences include; Escherichia coli (39.13%), Klebsiella pneumonia (21.74%), Proteus (8.69%), Pseudomonas aeruginosa (8.69%), Streptococcus (8.69%), Staphylococcus aureus (6.52%), Enterococcus faecalis (4.25%). There was a high prevalence of the isolated organisms in female (47.7%) compared to males (36%). It follows that most predominant agent of UTI in diabetic patients in Abakaliki Metropolis is Escherichia coli followed by Klebsiella pneumonia.


2020 ◽  
Vol 12 (1) ◽  
pp. 19-24
Author(s):  
Willie Jack Blacio Vidal ◽  
Veronica Irene Siranaula Arias

BACKGROUND: Urinary tract infection is the colonization and microbial replication along the urinary tract, it is a frequent cause for seeking medical attention. Its clinical presentation is often nonspecific and represents a risk of permanent kidney damage, which is higher as younger is the patient. The aim of this study was to determine the prevalence of known risk factors for urinary tract infection in hospitalized patients under the age of 5 years and older than a month of age. METhODS: A descriptive cross-sectional study was carried out in 68 patients with diagnosis of urinary tract infection (confirmed by urine culture), hospitalized at the Pediatrics department of Hospital Hu-manitario Pablo Jaramillo from January 2014 to December 2015. We measured the prevalence of the known risk factors for urinary tract infection. Data was collected in a form with the information obtained from the medical records and analyzed in SPSS V 20. Possible associations between the variables was evaluated with the Chi square test. RESUlTS: 67.6% of the sample were women and 32.4% were men. The age group with the highest prevalence of UTI was the group under 12 months (80.9%), with a higher frequency in females in all age groups. Among the risk factors, the maternal background of urinary infection represented 13.3%. Ve-sico-ureteral reflux represented 7.2% and hydronephrosis 8.8%. Phimosis was predominant in children under 12 months (11.7% of the total sample). The prolonged use of the diaper corresponded to 36.7 %. 5.9% of the patients with UTI presented constipation. CONClUSiON: UTIs are a frequent infectious disease in children under 5, with different distribution ac-cording to age and sex. The age group more frequently affected was the group under 12 months of age, and it was higher on women. Prolonged used of diaper (higher than 8 hours) was the most frequent risk factor in this study, and we found statistical significant association between this two variables. KEyWORDS: URINARY TRACT INFECTIONS, RISK FACTORS, CHILD, HOSPITALIZED, HYDRONEPHROSIS, PHYMOSIS, DIAPERS.


2019 ◽  
Vol 6 (2) ◽  
pp. 765
Author(s):  
R. Ravikumar Naik ◽  
Venkatesha K. R.

Background: Urinary tract infection is diagnosed by the growth of many organisms of a single specimen in the urine with presence of many symptoms. bacteriuria is defined as growth with a colony of >105/ml of a single species in a midstream clean catch urine sample.Methods: A cross sectional study was undertaken in febrile children with urinary tract infection attending Department of Paediatrics, tertiary care hospital, Bangalore during the period January 2017 to December 2017.Results: Out of the 200 children studied, 93 children belonged to the age group of 6 year to 12 year and 57 children belong to 1 year to 6-year age group and 50 children belongs to 12 year to 18-year age group. 97 children showed significant pyuria in centrifuged urine sample of which 49 were males and 48 were females. Majority 45 children were belonging to age group of 6 year to 12 year. Out of 97 children showed significant pyuria in centrifuged urine sample of which 46 children 5-10 cells/HPF and 27 children showed > 10 cells/HPF and 24 cases showed < 5cells / HPF. Out of 200 children, in 29 cases urine culture showed E. coli growth and 51 cases showed no growth.Conclusions: Urinary tract infections are common in childhood. Nearly all UTIs are caused by bacteria that enter the opening of the urethra and move upward to the urinary bladder and sometimes the kidneys.


2018 ◽  
Vol 1 (3) ◽  
pp. 26-38
Author(s):  
Abdulghani Mohamed Alsamarai ◽  
Shler Ali Khorshed

Background: Urinary tract infection is common with health impact in women and characterised by failure to treatment and recurrent episodes. Aim: This study was conducted to determine the risk factors for the development of urinary tract infection in diabetic and pregnant women in comparison to student female. Materials and methods: A prospective cross-sectional study conducted during the period from 1st of June 2015 to the end of January 2016. The population included in the study are 563 women, of them 425 were outpatients, and 138 were inpatients. Their age range between 18 and 80 years, with a mean age of 33.59±15.29 years. Urine samples collected and cultured on blood agar and MacConkey agar by spread plate technique. Bacterial colonies with different morphology were selected, purified and identified according to their biochemical characteristics using conventional standard methods. Results: In diabetic women, there were no significant difference in mean age and BMI values between culture positive and culture negative groups. However, pus cell mean scale was significantly higher [P=0.000] in women with urinary tract infection [1.76±1.25] than in those with negative culture [0.69±1.00]. In pregnant women, BMI mean value was significantly [P=0.013] lower in pregnant women with UTI [26.14] as compared to those without infection [26.99]. Pus cell scale mean value was significantly [P=0.000] higher in pregnant women with UTI [1.55] than women with negative UTI [0.85]. While there was no significant difference in mean age between UTI positive and negative pregnant women. In female student, there was a significant difference between UTI infected and non-infected in mean age [P=0.041] and pus cell scale [P=0.000]. However, BMI was not significantly different between infected and non-infected female student. Other risk factors association are variables in the 3 groups when analysed using X2, while AUC and OR show different trends of association between risk factors and UTI. Conclusion: BMI, pus cell scale, child number, delivery method, operation history and hospital setting were significantly associated with culture positivity in the 3 studied groups as determined by AUC. While OR confirmed association with pus sale scale in the 3 groups.


Author(s):  
Rana M. Abdullah Al-Shwaikh ◽  
Abbas Falih Alornaaouti

       Current study obtained (75) isolate of Pseudomonas aeruginosa collected from different cases included : 28 isolates from otitis media, 23 isolates from burn infections, 10 isolates from wound infections, 8 isolates from urinary tract infections and 6 isolates from blood, during the period between 1/9/2014 to 1/11/2014        The result revealed that the tox A gene was present in 54 isolates (72%) of Pseudomonas aeruginosa. The gel electrophoresis showed that the molecular weight of tox A gene was 352 bp. The result shows 17 isolates (60.71%) from otitis media has tox A gene, 18 isolates (78.26%) from burn followed by 8 isolate (80%) from wound infection and 5 isolates (62.5%) from urinary tract infection , finally 6 isolates (100%) from blood have this gene.


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