A CLINICAL CASE OF COVID-19 IN A NEWBORN

2021 ◽  
pp. 129-132
Author(s):  
E. N. Alferovich ◽  
◽  
I. A. Loginova ◽  
A. A. Ustinovich ◽  
E. A. Sarzhevskaya ◽  
...  
Keyword(s):  
Immune System ◽  
Breast Milk ◽  
Clinical Case ◽  
Clinical Symptoms ◽  
Infected Mother ◽  
Laboratory Confirmation ◽  
The World ◽  
Coronavirus Infection ◽  
One Year ◽  
System Today

The problem of coronavirus infection has captured the whole world. In one year, the views on the disease itself and its treatment have radically changed. Doctors all over the world cannot give definite answers to a number of questions regarding this virus and its impact on newborn babies. Low susceptibility to coronavirus in young children may be due to some peculiarities of the immune system. Today it is considered to be the main ways of transmission of the virus are airborne and contact. However, the airborne route of infection in newborns is unlikely, because from birth the child is isolated from the sick mother. The issue of the vertical transmission of the virus from an infected mother to a child is discussed. There is no evidence of transmission of coronavirus through breast milk. The diagnosis of coronavirus infection in children is established with a positive epidemiological history and with 2 clinical symptoms with laboratory confirmation. The article presents a single clinical case of coronavirus infection in a newborn. The possible ways of infection of the newborn, the clinical picture, the possibility of joint stay of the mother and the child, breastfeeding, and treatment of the newborn are discussed.

scholarly journals Associative influence of new coronavirus infection SARS-CoV-2 during pregnancy on formation of neurological disorders in newborns: clinical case

2021 ◽  
Vol 38 (5) ◽  
pp. 165-172
Author(s):  
T. P. Shevlyukova ◽  
Zh. K. Zhusupova ◽  
E. N. Solovyeva
Keyword(s):  
Pregnant Women ◽  
Neurological Disorders ◽  
Clinical Case ◽  
Viral Infections ◽  
Acute Inflammatory Response ◽  
Infected Mother ◽  
Neuroimmune Interactions ◽  
The World ◽  
Coronavirus Infection ◽  
Respiratory Viral Infections

The Severe Acute Respiratory Syndrome caused by Coronavirus-2 (SARS-CoV-2) has a destructive impact on the population all over the world. In this scenario, the extent, to which the disease will affect more vulnerable individuals, such as pregnant women, is a major concern. Since pregnancy can be a risk factor for respiratory viral infections, there are significant differences regarding the severity of COVID-19 between pregnant and non-pregnant women. In these circumstances, there arises a serious problem associated with the possibility of harm to the health and neuropsychiatric development of the posterity of infected mothers. The acute inflammatory response observed during the disease can lead to several types of nervous system disorders in the newborn. In the light of neuroimmune interactions on the mother-fetus hematoplacental relationship, a clinical case is described that reflects the consequences for the nervous and psychoneurological development of the newborn from SARS-CoV-2 infected mother.

scholarly journals New onset of generalized myasthenia gravis developed after a new coronavirus infection (COVID-19)

2021 ◽  
Vol 13 (4) ◽  
pp. 127-132
Author(s):  
T. M. Alekseeva ◽  
P. Sh. Isabekova ◽  
M. P. Topuzova ◽  
N. V. Skripchenko
Keyword(s):  
Immune System ◽  
Autoimmune Diseases ◽  
Myasthenia Gravis ◽  
Viral Infection ◽  
Clinical Case ◽  
Neurological Complications ◽  
Medical Society ◽  
Immune Mediated ◽  
Coronavirus Infection ◽  
New Onset

Development of various immune-mediated neurological complications after a viral infection is of particular interest to medical society during a pandemic of COVID-19. It was found that SARS-CoV-2 has the ability to cause hyperstimulation of the immune system, thereby initiating developing of autoimmune diseases. The article describes a clinical case of new onset of generalized myasthenia gravis with thymoma in a patient after previous COVID-19. 

scholarly journals Experience in managing a patient with a complicated course of SARS-COV-2 infection: early pulmonary rehabilitation and prevention of pulmonary fibrosis (clinical case)

2020 ◽  
Vol 43 (3) ◽  
pp. 365-372
Keyword(s):  
Lung Function ◽  
Large Scale ◽  
Clinical Case ◽  
Clinical Symptoms ◽  
Oral Anticoagulants ◽  
Diagnosis And Treatment ◽  
Complicated Course ◽  
Coronavirus Infection ◽  
Polymerase Chain ◽  
Virus Strains

Over the past two decades the world community has been shocked by the three largest coronavirus pandemics, each of which, despite the similarity of clinical symptoms in many aspects, has its own differences. This fact significantly complicates the diagnosis and treatment of new virus strains, which leads to a forced delay in early diagnosis and treatment of the disease, as well as the impossibility of suppressing the epidemic at the initial stages of its development. The article presents the clinical case of a complicated course of a new coronavirus infection – COVID-19 from the practice of a pulmonologist. There is data on the tactics of managing the patient until the visit to the pulmonologist. Minor changes are observed only in the auscultatory picture among physical data. Certain changes in laboratory and instrumental parameters are noted during the treatment of the patient. An important role in the diagnosis of the disease was played by the methods of enzyme immunoassay and polymerase chain reaction, as well as spiral computed tomography (SCT) of the chest, which made it possible to detect lesions, diagnose excessive consolidation (formation of pneumofibrosis) and its regression in dynamics against the background of active treatment. Spirometry made it possible to assess lung function over time. In the treatment were used drugs with anticoagulant and anti-fibrotic activity (new oral anticoagulants – apixaban (Eliquis®), a polyenzyme drug – Wobenzym® and enzyme – bovgialuronidase azoxymer (Longidaza®)), together with a set of antioxidant vitamins and minerals, and there was an improvement in lung function. The scientific community is carrying out a large-scale work to find new approaches in the treatment of coronavirus infection (COVID-19), however, the majority of the developed diagnostic and treatment methods are currently under study, while an ordinary doctor needs to prescribe a suitable therapy for a patient here and now.

CT imaging research progress in 2019 novel coronavirus pneumonia

2021 ◽  
Vol 17 ◽  
Author(s):  
Zhi Yong Shen ◽  
Xun Cheng Yan ◽  
Xiao Dong You ◽  
Xue Wen Zhang
Keyword(s):  
Clinical Symptoms ◽  
Disease Recurrence ◽  
Ct Imaging ◽  
Research Progress ◽  
Imaging Examination ◽  
The World ◽  
Imaging Research ◽  
Asymptomatic Infections ◽  
One Year ◽  
Novel Coronavirus

: The highly contagious novel coronavirus disease 2019 (COVID-19) broke out at the end of 2019 and has lasted for nearly one year, and the pandemic is still rampant around the world. The diagnosis of COVID-19 is on the basis of the combination of epidemiological history, clinical symptoms, and laboratory and imaging examinations. Among them, imaging examination is of importance in the diagnosis of patients with suspected clinical cases, the investigation of asymptomatic infections and family clustering, the judgment of patient recovery, rediagnosis after disease recurrence, and prognosis prediction. This article reviews the research progress of CT imaging examination in the COVID-19 pandemic.

scholarly journals Rapid Induction and Maintenance of Remission in Refractory Ulcerative Colitis with Ustekinumab

Diseases ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 55
Author(s):  
An-Yu Chen ◽  
Helieh S. Oz
Keyword(s):  
Ulcerative Colitis ◽  
Chronic Ulcerative Colitis ◽  
Clinical Case ◽  
Intestinal Inflammation ◽  
Clinical Symptoms ◽  
Standard Of Care ◽  
Rapid Induction ◽  
Current Therapies ◽  
Maintenance Of Remission ◽  
One Year

Ulcerative colitis is a chronic debilitating disease characterized by relapsing in intestinal inflammation and ulcers with no available cure. This is a clinical case report of a 52-year-old female patient with 30 years history of left-sided chronic ulcerative colitis controlled with standard of care (mesalamine and azathioprine) which subsequently relapsed and developed into active refractory ulcerative colitis. The patient became unresponsive to her medications including different forms of mesalamines and did not respond favorably to any of the other current therapies. Numerous attempts to stabilize her condition with immunosuppressants, steroids, probiotics, antibiotics, mesalamines, and various biologic agents failed to improve her clinical symptoms, and the patient was being considered for colectomy. As the last resort, modified therapy was prescribed with ustekinumab, a non-selective, anti-IL12/23 p40 monoclonal antibody. This medication has not been yet approved for use in ulcerative colitis patients. In this clinical case we report the efficacy of ustekinumab to rapidly induce and maintain remission of the severe chronic ulcerative colitis in the patient. To the best of our knowledge, this is the first report of utilizing ustakinamub therapy for rapid induction in an active refractory ulcerative colitis patient resulting in complete remission for over one year.

scholarly journals Features of tuberculosis diagnosis in the COVID-19

2021 ◽  
Vol 13 (1) ◽  
pp. 117-123
Author(s):  
O. L. Ekaterincheva ◽  
A. M. Malkova ◽  
V. E. Karev ◽  
I. V. Kudryavtsev ◽  
Yu. S. Zinchenko ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Incidence Rate ◽  
Clinical Case ◽  
Clinical Course ◽  
Diagnosis And Treatment ◽  
Published Data ◽  
The World ◽  
History Of ◽  
Tuberculosis Diagnosis ◽  
Coronavirus Infection

2020 began with the most significant pandemic COVID-19 in the history of this century. The epidemiology indicators are growing every day. The spread of COVID-19 may affect an increase in the incidence of tuberculosis, despite a decrease in the incidence rate that is associated with objective difficulties in detecting tuberculosis against the background of COVID-19 and severe complications after the new coronavirus infection. Tuberculosis is one of the infectious diseases, and the problem of its spread continues to be relevant throughout the World. The effect of the SARS-CoV-2 virus can cause certain difficulties in the diagnosis and treatment of tuberculosis infection. The possibility of concomitant these infectious diseases can affect the clinical course of tuberculosis, an influence on mortality of the disease, but at the same time, there is a decrease in the number of cases that is not objective. The authors analyzed the currently published data on detecting tuberculosis in the conditions of the COVID-19 problem and presented difficulties in the diagnosis of COVID-19 and TB concomitant diseases with a description in the clinical case.

scholarly journals Clinical features of patients with COVID19, hospitalized in a multi-somatic hospital

2021 ◽  
Author(s):  
O. A. Markelova ◽  
N. N. Vezikova ◽  
S. N. Kondrichina ◽  
O. Y. Barysheva
Keyword(s):  
Observational Study ◽  
Clinical Features ◽  
Scientific Community ◽  
Clinical Symptoms ◽  
Viral Pneumonia ◽  
Hospital Treatment ◽  
Constant Increase ◽  
The World ◽  
Coronavirus Infection

The prevalence of COVID-19 infection and the mortality associated with the disease are steadily progressing [1, 2]. The difficulties in diagnosing and treating COVID-19 in the context of a constant increase in the number of cases cause an urgent need to study and describe this infection, which is important for the medical and scientific community around the world. We performed an observational study of patients with COVID 19 infection, which developed during hospital treatment of another acute or exacerbation of chronic somatic pathology. We analyzed the clinical symptoms, the severity of the course of the new coronavirus infection and viral pneumonia.

Measles (Morbilli) today: problems, statistics, and clinical manifestations in children and adults

2020 ◽  
Vol 15 (4) ◽  
pp. 54-61
Keyword(s):  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Preventive Measure ◽  
Inosine Pranobex ◽  
Treatment And Prevention ◽  
Disease Characteristics ◽  
The World ◽  
Acute Infectious Disease ◽  
Coronavirus Infection ◽  
New Treatment

Doctors are currently observing an increase in the incidence of measles in Moscow and other cities in Russia and all over the world. Such an increase is primarily caused by parent's refusal to accept vaccination for their children. We have reviewed the main issues related to this acute infectious disease, analyzed the epidemiological situation in different countries (including Russia), and presented the main preventive measure, which is vaccination. In addition to that, some authors reported various types of exanthema, including measles-like, in patients with coronavirus infection, which is widespread now. The aim of this article is to draw the attention of practitioners to the typical initial and main clinical symptoms of measles, stages of rash, specific disease characteristics in patients of different ages, and complications. We have provided a rationale for a new treatment regimen for measles that includes a recombinant α-interferon (Viferon) and an immunomodulator with antiviral action (inosine pranobex; Groprinosin) Key words: measles, children, incidence, clinical forms, complications, treatment and prevention, inosine pranobex (Groprinosin)

scholarly journals Common variable immunodeficiency disorder: a clinical case

2021 ◽  
Vol 23 (1) ◽  
pp. 185-190
Author(s):  
E. A. Sobko ◽  
I. V. Demko ◽  
I. A. Soloveva ◽  
A. Yu. Kraposhina ◽  
N. V. Gordeeva ◽  
...  
Keyword(s):  
Immune System ◽  
Primary Immunodeficiency ◽  
Common Variable Immunodeficiency ◽  
Clinical Case ◽  
Clinical Symptoms ◽  
Inherited Disorders ◽  
Age Cohorts ◽  
Immunodeficiency Disorder ◽  
Medical Network ◽  
Common Variable

Primary immunodeficiency is a rare congenital pathology associated with failure of immune system, manifested by disturbances of its functions. These defects lead to increased susceptibility of patients to various infectious agents, as well as the development of autoimmune, malignant and other diseases. Primary immunodeficiency is classified as a rare disease, which was previously associated with a poor prognosis with a high risk of mortality in childhood. To date, the emergence of highly effective treatment methods has changed the course and prognosis of these diseases. Clinicians of various specialties increasingly meet with this pathology in everyday practice, including adult age cohorts. In this regard, early diagnosis of primary immunodeficiency in adults becomes relevant, being associated with choosing optimal therapy, prevention of severe internal organ damage, determination of management strategy for the patient, as well as the need to identify inherited disorders and provide information to the patient’s family. Delayed verification of the diagnosis may cause disability of the patient and development of irreversible, often fatal complications. This article presents our own clinical case with a newly diagnosed clinical condition: Common variable immunodeficiency disorder (CVID), the most common form of primary immunodeficiency in adults. The symptoms of common variable immunodeficiency disorder appear in these patients in adulthood, but a high-quality collected history of the disease will allow you to trace symptoms in the patients even since early childhood. There is a common gap for several years between the onset of the disease and clinical diagnosis, since erroneous diagnosis is often made due to non-specific clinical symptoms that resemble other, more frequent diseases. The prognosis of patients with CVID depends on several factors: frequency of infections, structural disorders in the lungs, the occurrence of autoimmune diseases and the success of infection prevention. Thus, a variety of clinical forms of primary immunodeficiency, lack of awareness of doctors about this pathology, complexity of immunological examination in the general medical network lead to the fact that CVID is not diagnosed for long terms, and patients do not receive the necessary pathogenetic therapy. There is a need for drawing attention of doctors of various disciplines to the fact that the recurrent inflammatory processes of various localization, which are difficult to respond to adequate traditional therapy, may be caused by changes in the immune system, including congenital, genetically determined immunodeficiency.

scholarly journals COVID-19 Cytokine Storm Complications in Asthmatic Patients

2020 ◽  
Vol 13 (1) ◽  
pp. 625-626
Author(s):  
Entezar Mehrabi Nasab ◽  
Seyyed Shamsadin Athari
Keyword(s):  
Immune System ◽  
Mortality Rate ◽  
High Mortality ◽  
Respiratory System ◽  
Adverse Outcomes ◽  
Cytokine Storm ◽  
Asthmatic Patients ◽  
The World ◽  
Coronavirus Infection ◽  
Anti Inflammatory

The pandemic of coronavirus disease 2019 has inflicted millions of people in the world and caused severe complications in immunocompromised individuals. Some evidences suggest that severe COVID-19 complications are associated with the cytokine storm syndrome, contributing to the high mortality rate of the disease. Asthma is a complicated disease of the respiratory system. COVID-19 symptoms can be worse in asthmatic patients than others. Corticosteroids with anti-inflammatory functions which are used in asthmatic patients may have adverse outcomes in coronavirus infection and are not recommended for the treatment of COVID-19. Furthermore, asthmatic patients (using inhalation corticosteroids) have a suppressed immune system in the lung, which increases their susceptibility to COVID-19 infection.

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