SOME ASPECTS OF CLINICAL AND LABORATORY PARAMETERS IN NEWBORNS FROM MOTHERS WITH CORONAVIRUS INFECTION SARS-COV-2 (COVID-19), INFECTED AT DIFFERENT TIMES OF PERINATAL PERIOD

2021 ◽  
Vol 5 (1) ◽  
pp. 1202-1209
Author(s):  
I. Loginova ◽  
◽  
A. Ustinovich ◽  
E. Alferovich ◽  
I. Payuk ◽  
...  
Keyword(s):  
Postpartum Period ◽  
Neonatal Period ◽  
Clinical Laboratory ◽  
Perinatal Period ◽  
Time Of Infection ◽  
Laboratory Investigations ◽  
Coronavirus Infection ◽  
Postnatal Adaptation ◽  
Biochemical Research ◽  
Mother To Child

The problem of coronavirus infection has been the world’s concern since 2019. At the same time, the issues of infection of newborn children remain unclear, the issue of vertical transmission of the virus from mother to child is being discussed. The aim of our study was to study the features of the period of postnatal adaptation of newborns born to mothers with coronavirus infection SARS-CoV-2 (COVID-19), taking into account the time of infection occurrence. We analyzed the features of the neonatal course in children from the mothers with confirmed Covid-19 infection (PCR RNA of SARS-Cov 2) revealed in the mothers either during pregnancy or in the postpartum period. When examining children, we used clinical, laboratory, and biochemical research methods. It was found that children whose mothers contracted coronavirus infection COVID-19 immediately before childbirth had an aggravated course of the neonatal period compared with children from mothers who had recovered in the middle of pregnancy, and the manifestations of infection and post-hypoxic syndrome were more pronounced in the former. Laboratory investigations proved that newborns from the mothers who fell ill shortly before childbirth had acute viral inflammation.

scholarly journals New COVID-19 coronavirus infection in the practice of a neonatologist and pediatrician

2020 ◽  
Vol 65 (3) ◽  
pp. 11-17
Author(s):  
A. L. Zaplatnikov ◽  
I. M. Osmanov ◽  
V. V. Gorev ◽  
A. V. Dmitriev ◽  
A. K. Mironova ◽  
...  
Keyword(s):  
Neonatal Period ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Gastrointestinal Symptoms ◽  
Severe Pneumonia ◽  
Epidemiological Data ◽  
Medical Professional ◽  
Older Children ◽  
Strict Adherence ◽  
Coronavirus Infection

The article analyses the data published from January 2020 to April 25, 2020 in the print media or available on the official websites of peer-reviewed medical sources (pre print), international and national medical professional communities, and state regulatory authorities dedicated to the epidemiological and clinical laboratory features of the new coronavirus infection in newborns, infants and older children. The authors have concluded that currently there are no convincing data on vertical transmission of infection. At the same time, they have found that there is a risk of horizontal infection of a newborn child; therefore, there is the need for strict adherence to the recommended algorithms for monitoring children in the neonatal period born by the women with positive or presumably positive COVID-19 (Coronavirus disease 2019) status. The authors note that due to the limited quantity of observation cases, all existing recommendations are temporary and may be revised. The newborns from mothers with COVID-19 demonstrate the variability of clinical picture from asymptomatic course to severe respiratory failure. In the post-neonatal period children have asymptomatic or mild course of a new coronavirus infection. The authors note that some children with an asymptomatic course of the disease have pneumonia detectable during X-ray examination. Children with the manifest forms of COVID-19 do not have specific clinical symptoms; both children and adults have fever, cough and other catarrhal symptoms; tachypia, tachycardia and gastrointestinal symptoms are much less common. It has been found that children with COVID-19, unlike adults, are unlikely to develop severe pneumonia, as well as conditions requiring intensive care and mechanical ventilation. Changes in laboratory parameters in children also do not have a consistent pattern and they are less pronounced than in adults. The epidemiological data indicate that children are one of the main sources of the ongoing spread of infection in the human population. The authors present the first-ever data on the cases of 45 infants born from the mothers with positive COVID-19 status in Moscow.

scholarly journals Surgical management outcome of cerebral schistosomiasis: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Moayad Moawia ZainElabdin Ahmed ◽  
Haytham Hussein Mohammed Osman ◽  
Alaa Hatim Ameer Mohamed ◽  
Alaaeldin Ginawi
Keyword(s):  
Surgical Resection ◽  
Clinical Laboratory ◽  
Parasitic Infection ◽  
Differential Diagnoses ◽  
Limb Weakness ◽  
General Test ◽  
Bilateral Lower Limb ◽  
Laboratory Investigations ◽  
The Right ◽  
Antiparasitic Agents

Abstract Background Schistosomiasis is a parasitic infection that commonly affects the gastrointestinal and genitourinary tracts. Cerebral schistosomiasis is rare, and few operative cases have been reported in the literature. Diagnosis is usually challenging due to the similarity of the lesion to many other brain conditions. Treatment usually requires surgical resection combined with the use of antiparasitic agents, which often results in good outcomes and excellent prognosis. Case presentation A 24-year-old, previously healthy Afro-asiatic man presented to our neurosurgical outpatient clinic complaining of headache and an attack of convulsions. On examination, he had bilateral lower limb weakness more on the right side. Laboratory investigations including stool and urine general test results were unremarkable. Magnetic resonance imaging of the brain was performed and showed an intra-axial left parietal mass; a granulomatous lesion was suggested in the differential diagnoses. The patient underwent craniotomy and total resection of the lesion. Histopathology confirmed the presence of active cerebral Schistosoma mansoni infection. Orally administered praziquantel was initiated at a dose of 20 mg/kg twice a day for a total of 3 days along with oral administration of corticosteroids for 2 weeks. The patient improved postoperatively without residual weakness and with no further convulsions. Conclusion Cerebral schistosomiasis is a rare but important consideration in the list of differential diagnoses of cerebral space-occupying lesions. This is of particular importance in in endemic areas like Sudan. In order to reach a diagnosis, careful social and occupational history need to be obtained and correlated with the clinical, laboratory, and radiological findings. Surgical resection along with the use of proper antiparasitic agents usually provides the best clinical outcomes.

The novel coronavirus infection (COVID-19) concurrent with pseudomembranous colitis in the early postpartum period: a clinical case

2021 ◽  
Vol 9_2021 ◽  
pp. 232-236
Author(s):  
Shklyaev A.E. Shklyaev A ◽  
Bessonov A.G. Bessonov A ◽  
Chushyalova D.A. Chushyalova D ◽  
Mikhailova M.D. Mikhailova M ◽  
Meleshkina M.V. Meleshkina M ◽  
...  
Keyword(s):  
Postpartum Period ◽  
Pseudomembranous Colitis ◽  
Clinical Case ◽  
The Novel ◽  
Early Postpartum Period ◽  
Early Postpartum ◽  
Coronavirus Infection ◽  
Novel Coronavirus

scholarly journals Clinical Characteristics and Outcomes of Diabetic COVID-19 patients in Kuwait

2020 ◽  
Author(s):  
Abdullah Alshukry ◽  
Mohammad Bu Abbas ◽  
Yaseen Ali ◽  
Barrak Alahmad ◽  
Abdullah A. Al-Shammari ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Fasting Blood Glucose ◽  
List Type ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Patients With Diabetes ◽  
Laboratory Investigations ◽  
Insight Into ◽  
Variable Clinical Presentation

AbstractBackgroundCOVID-19 has a highly variable clinical presentation, ranging from asymptomatic to severe respiratory symptoms and death. Diabetes seems to be one of the main comorbidities contributing to a worse COVID-19 outcome.ObjectiveIn here we analyze the clinical characteristics and outcomes of diabetic COVID-19 patients.MethodsIn this single-center, retrospective study of 417 consecutive COVID-19 patients, we analyze and compare disease severity, outcome, associated complications, and clinical laboratory findings between diabetic and non-diabetic COVID-19 patients.ResultsCOVID-19 patients with diabetes had more severe outcomes and higher mortality than non-diabetic COVID-19 patients. Diabetic COVID-19 patients had significantly higher prevalence of comorbidities, such as hypertension. Laboratory investigations also highlighted notably higher levels of C-reactive protein in diabetic COVID019 patients and lower estimated glomerular filtration rate. They also showed a higher incidence of complications.ConclusionDiabetes could be a major contributor to worsening outcomes in COVID-19 patients. Understanding the pathophysiology underlining these findings could provide insight into better management and improved outcome of such cases.Highlights of the StudyA significantly higher proportion of Diabetic COVID-19 patients required admission to the ICU.Higher fasting blood glucose was associated with higher risk of COVID-19 associated mortality.Diabetic COVID-19 patients had significantly higher incidence of complications including sepsis, ARDS, cardiac failure and renal failure.

Severe Psychopathology During Pregnancy and the Postpartum Period

2014 ◽  
Author(s):  
Emma Roberston Blackmore ◽  
Jessica Heron ◽  
Ian Jones
Keyword(s):  
Bipolar Disorder ◽  
Mental Illness ◽  
Postpartum Period ◽  
Perinatal Period ◽  
Puerperal Psychosis ◽  
Infant Outcomes ◽  
Pregnancy And Childbirth ◽  
Severe Psychopathology ◽  
Maternal And Infant Outcomes ◽  
Key Questions

Pregnancy and childbirth can represent a challenging time for women with severe mental illness. Psychotic episodes in the perinatal period can lead to multiple adverse maternal and infant outcomes. This chapter addresses a number of key questions in relation to episodes of schizophrenia and bipolar disorder during the perinatal period. The identification and management of postpartum or puerperal psychosis is detailed, along with prognosis and risk to further pregnancies. The authors present data on epidemiology, nosology, and etiology for severe perinatal episodes. In addition, the authors discuss clinical management, and in particular, ways to identify and manage women at risk.

Studies of Transformer Repair Workers Exposed to PCBs: II. Results of Clinical Laboratory Investigations

1988 ◽  
Vol 14 (1) ◽  
pp. 47-62 ◽  
Author(s):  
Edward A. Emmett ◽  
Marco Maroni ◽  
Joan Jefferys ◽  
Joanne Schmith ◽  
Barry K. Levin ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Laboratory Investigations

scholarly journals Clinical, laboratory and instrumental indicators in patients who have undergone COVID-19

2021 ◽  
Vol 5 (3) ◽  
pp. 403-415
Author(s):  
Muso Urinov ◽  
Nigora Alikulova ◽  
Dilfuza Zukhritdinova ◽  
Mekhriddin Usmonov ◽  
Rakhimjon Urinov
Keyword(s):  
Clinical Laboratory ◽  
Reference Interval ◽  
The Elderly ◽  
Neurological Complications ◽  
Middle Aged ◽  
Coagulation Activity ◽  
Female Patients ◽  
Aged People ◽  
Male Patients ◽  
Coronavirus Infection

280 patients with COVID-19 were examined (average age 53.9±8.1 years; gender index 1.37:1.0 (162 men and 118 women). It was revealed that young people (especially women) were more common with a mild course of the disease (64.2%), middle – aged people-with a moderate-severe variant of COVID-19 (54.8%), In the group of patients with a severe course of coronavirus infection, female patients prevailed among the elderly, and among middle –aged men – 47.8% and 48.4%, respectively. The comorbid background before the disease CAVID-19 and the neurological complications that appeared on the background of CAVID-19 in the percentage ratio prevailed in males. There were no significant differences in the frequency of complications from the severity of the COVID-19 disease. It was revealed that at the time of hospitalization, all the studied markers of coagulation activity were changed and statistically significantly differed from the reference interval, which indicated the activation of the procoagulation potential. In the group of female patients, these indicators were more pronounced. CT examination revealed that the percentage of damage to both lungs was significantly higher in female patients compared to male patients.

scholarly journals Osobennosti adaptatsii novorozhdennykh u materey s ozhireniem

2008 ◽  
Vol 5 (2) ◽  
pp. 23-26
Author(s):  
L Yu Zernova ◽  
T V Kovalenko ◽  
N N Popova ◽  
N S Strelkov
Keyword(s):  
Distress Syndrome ◽  
Adjustment Disorder ◽  
Perinatal Period ◽  
Postnatal Period ◽  
Reproductive Disorders ◽  
High Incidence ◽  
Neonatal Adaptation ◽  
The Subject ◽  
Postnatal Adaptation ◽  
Available Information

According to various authors, obesity among pregnant recorded at a frequency of 15.5 to 26.9%. There is strong evidence that obesity contributes to complications of pregnancy, childbirth and the postpartum period, provoking the development of gestosis, placental insufficiency, abnormalities of labor, bleeding, et al., Which suggests the possibility of adjustment disorder in the neonatal period in infants of obese mothers. It should be recognized, however, that the available information on the subject are scarce and fragmentary. The purpose of this study was to investigate the features of postnatal adaptation of newborns of mothers with obesity. According to the study found that obesity in women is associated with a high incidence of reproductive disorders, gestational complications and pathological course of labor, resulting in abnormalities in the neonatal adaptation in the postnatal period. Disadaptation syndrome is manifested by the development of jaundice sustained over, edema, transient changes of the cardiovascular system, hypoglycemia. Violations in health are detected in the majority of infants (83.3%) born to mothers with obesity. The most significant pathologies are infections specific to the perinatal period (40.5%), respiratory distress syndrome (3.6%), diabetic fetopathy (4.8%), congenital malformations (2.4%).

scholarly journals Differential diagnosis of bilateral lungs opacities in the hospital for admission of community-acquired pneumonia – not only COVID-19

2020 ◽  
Vol 24 (2) ◽  
pp. 78-95
Author(s):  
A. S. Vinokurov ◽  
O. I. Belenkaya ◽  
E. A. Zolotova ◽  
S. V. Michurina ◽  
O. O. Vinokurova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Community Acquired Pneumonia ◽  
Lung Damage ◽  
Ground Glass ◽  
Small Areas ◽  
Radiological Data ◽  
Coronavirus Infection ◽  
To Receive

Due to the current epidemiological situation caused by the spread of the new SARS-CoV-2 coronavirus, in March 2020 several Moscow hospitals were completely or partially redesigned to receive patients with community- acquired pneumonia.Purpose. The aim of the survey is to analyze clinical, laboratory and radiological data in patients with coronavirus infection at the early stages of its spread in Russia, and to clarify diseases for differential diagnosis mainly based on CT evidence.Materials and methods. We studied data from 21 patients with verified coronavirus infection admitted to the hospital for community-acquired pneumonia. Clinical symptoms, laboratory and physical indicators, as well as typical lung changes on the CT were evaluated.Results. Major clinical symptoms in coronavirus patients are fever (100%), cough (90.5%), shortness of breath (76.1%). Laboratory indicators showed increases in CRP (85.7%), leukocytosis (66.6%), and LDG (84.6%). According to CT, 95.2% of lung changes involved both sides, and 66.7% occurred in all lung fields. The sign of “ground glass” was observed in a 100% of the cases, its combination with the “paving stone” – in 61,9%, “ground glass” coupled with small areas of consolidations were detected in 33,3% of the cases. Changes such as nodules, cavities and massive areas of consolidation were not identified.Conclusion. On the basis of our own data we confirmed the main trends of diagnostics and clinical features, which were identified by authors from Asia and Europe, who faced this infection earlier, and also considered important CT characteristics useful for differential diagnosis of coronavirus lung damage and other lung diseases.

Hepatitis E Virus

2018 ◽  
Author(s):  
Lisa J. Krain ◽  
Kenrad E. Nelson
Keyword(s):  
Pregnant Women ◽  
Hepatitis E Virus ◽  
Standard Treatment ◽  
Neonatal Period ◽  
Hepatitis E ◽  
Child Transmission ◽  
The Past ◽  
Maternal Illness ◽  
Increased Risk ◽  
Mother To Child

Hepatitis E virus (HEV) poses serious risks to pregnant women and their developing fetuses, including increased risk of pregnancy loss, stillbirth, preterm delivery, and early infant death. Supportive care is currently the standard treatment for pregnant women with HEV infection, but in some cases, ribavirin treatment or early delivery may be indicated. Infants born with acute HEV infection face increased risk of complications and death. Intensive monitoring and support may be required in the neonatal period, particularly for preterm infants. Infants who survive the early neonatal period are likely to recover fully and clear the virus. Immunoassays and molecular methods for diagnosis of HEV have improved markedly over the past decade. New HEV vaccines may provide an opportunity to prevent both maternal illness and mother-to-child transmission (vertical transmission) (MTCT).

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