scholarly journals Earth-like planetary magnetotails as non-linear oscillators

2020 ◽  
Author(s):  
Robert J. Burston
Keyword(s):  
Chaotic Behavior ◽  
Noise Component ◽  
General Terms ◽  
Wide Range ◽  
Non Linear ◽  
Observational Noise ◽  
Short Term Forecasting ◽  
Non Linear Oscillator ◽  
Magnetotail Dynamics ◽  
First Time

Abstract. A non-linear oscillator model of a simple system analogous to Earth-like magnetotail plasmoid formation and release dynamics is presented. In this context, Earth-like refers to any magnetosphere with an upstream bow-shock and an elongated downstream tail that undergoes tail plasmoid formation and release. It includes, for the first time in such a model, separate drivers for the Dungey and Vasyliunas Cycles and the capacity to include stochastic and deterministic driving in varying relative and absolute terms. The effects of measurement noise on the model output can also be simulated. This makes the model suitable to investigate the magnetotail dynamics of Mercury, Earth, Jupiter, Saturn and hypothetical exoplanets with similar magnetospheric configurations. The capacity to predict, in general terms, the behavior of a wide range of stellar-wind – magnetosphere interactions has become even more important in the light of the discovery of thousands of exoplanets in recent years. This model represents the first step towards being able to make such predictions for a wide variety of cases without resorting to detailed modelling of individual cases. It is demonstrated that the model can exhibit limit cycle (periodic) and chaotic (long-term unpredictable) behavior. The effects of a sufficiently strong dynamical noise component (stochastic driving) are shown to be inherently different from the effects of an equivalent level of simulated observational noise (simulated Gaussian instrument error). The possibilities of chaotic behavior and of dynamical noise dominating the underlying determinism imply that often only short-term forecasting of magnetotail plasmoid formation is possible.

On Categorization of Seismic Load As Primary or Secondary for Piping Systems With Hardening Capacity

2018 ◽  
Author(s):  
Pierre B. Labbé
Keyword(s):  
Natural Frequency ◽  
Response Spectrum ◽  
A Priori ◽  
Effective Stiffness ◽  
Linear Oscillator ◽  
Seismic Load ◽  
Wide Range ◽  
Non Linear ◽  
Piping Systems ◽  
Non Linear Oscillator

The concept of primary/secondary categorization is first reviewed and generalized for its application to a non-linear oscillator subjected to a seismic load. Categorizing the seismic load requires calculating the input level associated with the oscillator ultimate capacity and comparing it to the level associated with the plastic yield. To resolve this problem, it is assumed that the non-linear oscillator behaves like a linear equivalent oscillator, with an effective stiffness (or frequency) and an effective damping. However, as it is not a priori possible to predict the equivalent stiffness and damping, a wide range of possibilities is systematically considered. The input motion is represented by its conventional response spectrum. It turns out that key parameters for categorization are i) the “effective stiffness factor” (varying from 0 for perfect damage behaviour to 1 for elastic-perfectly plastic) and the slope of the response spectrum in the vicinity of the natural frequency of the oscillator. Effective damping and spectrum sensitivity to damping play a second order role. A formula is presented that enables the calculation of the primary part of a seismically induced stress as a function of both the oscillator and input spectrum features. The formula is also presented in the form of a diagram. This paper follows-up on a similar paper presented by the author at the PVP 2017 Conference [1]. The new development introduced here is that the oscillator exhibits hardening capacity, while no hardening was assumed in [1]. It appears that the conclusions are slightly modified but the trend is very similar to the non-hardening case. Regarding piping systems, it appears that even when experiencing large plastic strains under beyond design input motions, their observed effective frequency is very close to their natural frequency, decreasing only by a few percents (experimental data from USA, Japan and India are processed). These observations lead to the conclusion that the seismic load, or the seismically induced inertial seismic strains, should basically be regarded as secondary.

On Categorization of Seismic Load As Primary or Secondary

2017 ◽  
Author(s):  
Pierre B. Labbé
Keyword(s):  
Natural Frequency ◽  
Response Spectrum ◽  
A Priori ◽  
Effective Stiffness ◽  
Seismic Load ◽  
Perfectly Plastic ◽  
Wide Range ◽  
Non Linear ◽  
Piping Systems ◽  
Non Linear Oscillator

The concept of primary/secondary categorization is first recalled and generalized for its application to an elastic-plastic oscillator subjected to a seismic load. Categorizing the seismic load requires calculating the input level associated to the oscillator ultimate capacity and compare it to the level associated to the plastic yield. In order to resolve this non-linear dynamic problem, it is assumed that the non-linear oscillator behaves like a linear equivalent oscillator, with an effective stiffness (or frequency) and an effective damping. However, as it is not a priori possible to predict the equivalent stiffness and damping, a wide range of possibilities is systematically considered. The input motion is represented by its conventional response spectrum. It turns out that key parameters for categorization are i) the “effective stiffness factor” (varying from 0 for perfect damage behaviour to 1 for elastic-perfectly plastic) and the slope of the response spectrum in the vicinity of the natural frequency of the oscillator. Effective damping and spectrum sensitivity to damping play a second order role. A formula is presented that enables to calculate the primary part of a seismically induced stress as a function of both the oscillator and input spectrum features. The formula is also presented in the form of an abacus. The actual “effective stiffness factor” of different piping systems is derived from outputs of experimental research programs carried out in the past in USA and Japan and still ongoing in India. It appears that even when experiencing large plastic strains under beyond design input motions, the observed effective frequency of piping systems is very close to their natural frequency, decreasing only by a few percents. These observations enable to calculate an effective stiffness factor value around 0.9 and lead to the conclusion that the seismic load, or the seismically induced inertial seismic strains, should basically be regarded as secondary in the sense of the definition adopted here.

Solution chemistry effects on the solvation shell of metal ions

2020 ◽  
Author(s):  
Xiangwen Wang ◽  
Dimitrios Toroz ◽  
Seonmyeong Kim ◽  
Simon Clegg ◽  
Gun-Sik Park ◽  
...  
Keyword(s):  
Metal Ions ◽  
Pure Water ◽  
Solvation Shell ◽  
Solution Chemistry ◽  
Chemical Characteristics ◽  
Velocity Autocorrelation Function ◽  
Ionic Solvation ◽  
General Terms ◽  
Alkaline Earth Metal Ions ◽  
Wide Range

<div> <p>As natural aqueous solutions are far from being pure water, being rich in ions, the properties of solvated ions are of relevance for a wide range of systems, including biological and geochemical environments. We conducted ab initio and classical MD simulations of the alkaline earth metal ions Mg<sup>2+</sup> and Ca<sup>2+</sup> and of the alkali metal ions Li<sup>+</sup>, Na<sup>+</sup>, K<sup>+</sup> and Cs<sup>+</sup> in pure water and electrolyte solutions containing the counterions Cl<sup>–</sup> and SO<sub>4</sub><sup>2–</sup>. Through a detailed analysis of these simulations, this study reports on the effect of solution chemistry (composition and concentration of the solution) to the ion–water structural properties and interaction strength, and to the dynamics, hydrogen bond network, and low-frequency dynamics of the ionic solvation shell. Except for the ion–water radial distribution function, which is weakly dependent on the counter-ions and concentrations, we found that all other properties can be significantly influenced by the chemical characteristics of the solution. Calculation of the velocity autocorrelation function of magnesium ions, for example, shows that chlorine ions located in the second coordination shell of Mg<sup>2+</sup> weaken the Mg(H<sub>2</sub>O)<sub>6</sub><sup>2+</sup> hydration ‘cage’ of the cation. The result reported in this study suggest that ionic solvation shell can be significantly influenced by the interactions between other ions present in solution ions, especially those of opposite charge. In more general terms, the chemical characteristics of the solution, including the balance between ion-solvent and ion-ion interactions, could result in significant differences in behavior and function of the ionic solvation shell.</p> </div>

Safety assessment of biological raw materials in the system of medicines quality assurance

2020 ◽  
pp. 63-72
Author(s):  
Yu. Olefir ◽  
E. Sakanyan ◽  
I. Osipova ◽  
V. Dobrynin ◽  
M. Smirnova ◽  
...  
Keyword(s):  
Raw Materials ◽  
State Level ◽  
The State ◽  
Spongiform Encephalopathy ◽  
Safety Standards ◽  
Wide Range ◽  
The Russian Federation ◽  
Key Aspects ◽  
First Time ◽  
Medicines Quality

The entry of a wide range of biotechnological products into the pharmaceutical market calls for rein-forcement of the quality, efficacy and safety standards at the state level. The following general monographs have been elaborated for the first time to be included into the State Pharmacopoeia of the Russian Federation, XIV edition: "Viral safety" and "Reduction of the risk of transmitting animal spongiform encephalopathy via medicinal products". These general monographs were elaborated taking into account the requirements of foreign pharmacopoeias and the WHO recommendations. The present paper summarises the key aspects of the monographs.

Innovation in Byzantine Medicine

2020 ◽  
Author(s):  
Petros Bouras-Vallianatos
Keyword(s):  
Human Physiology ◽  
Medical Literature ◽  
Cultural Exchange ◽  
Significant Degree ◽  
Medieval Medicine ◽  
Medieval Latin ◽  
Main Thesis ◽  
Wide Range ◽  
Comprehensive Examination ◽  
First Time

Byzantine medicine is still a little-known and misrepresented field not only in the wider arena of debates on medieval medicine but also among Byzantinists. Byzantine medical literature is often viewed as ‘stagnant’ and mainly preserving ancient ideas; and our knowledge of it continues to be based to a great extent on the comments of earlier authorities, which are often repeated uncritically. This book presents the first comprehensive examination of the medical corpus of, arguably, the most important late Byzantine physician John Zacharias Aktouarios (c.1275–c.1330). The main thesis is that John’s medical works show an astonishing degree of openness to knowledge from outside Byzantium combined with a significant degree of originality, in particular, in the fields of uroscopy, pharmacology, and human physiology. The analysis of John’s edited (On Urines and On Psychic Pneuma) and unedited (Medical Epitome) works is supported for the first time by the consultation of a large number of manuscripts. The study is also informed by evidence from a wide range of medical sources, including previously unpublished ones, and texts from other genres, such as epistolography and merchants’ accounts. The contextualization of John’s works sheds new light on the development of Byzantine medical thought and practice, and enhances our understanding of the late Byzantine social and intellectual landscape. Finally, John’s medical observations are also examined in the light of examples from the medieval Latin and Islamic worlds, placing his medical theories in the wider Mediterranean milieu and highlighting the cultural exchange between Byzantium and its neighbours.

Rebels, Believers, Survivors

2020 ◽  
Author(s):  
Noel Malcolm
Keyword(s):  
Catholic Church ◽  
Religious Conversion ◽  
Late Nineteenth Century ◽  
Napoleonic Wars ◽  
Conversion To Islam ◽  
Wide Range ◽  
History Of ◽  
External Powers ◽  
First Time ◽  
Modern Myth

This book of essays covers a wide range of topics in the history of Albania and Kosovo. Many of the essays illuminate connections between the Albanian lands and external powers and interests, whether political, military, diplomatic or religious. Such topics include the Habsburg invasion of Kosovo in 1689, the manoeuvrings of Britain and France towards the Albanian lands during the Napoleonic Wars, the British interest in those lands in the late nineteenth century, and the Balkan War of 1912. On the religious side, essays examine ‘crypto-Christianity’ in Kosovo during the Ottoman period, the stories of conversion to Islam revealed by Inquisition records, the first theological treatise written in Albanian (1685), and the work of the ‘Apostolic Delegate’ who reformed the Catholic Church in early twentieth-century Albania. Some essays bring to life ordinary individuals hitherto unknown to history: women hauled before the Inquisition, for example, or the author of the first Albanian autobiography. The longest essay, on Ali Pasha, tells for the first time the full story of the role he played in the international politics of the Napoleonic Wars. Some of these studies have been printed before (several in hard-to-find publications, and one only in Albanian), but the greater part of this book appears here for the first time. This is not only a contribution to Albanian and Balkan history it also engages with many broader issues, including religious conversion, methods of enslavement within the Ottoman Empire, and the nature of modern myth-making about national identity.

Recycling and Reuse in the Roman Economy

2020 ◽  
Keyword(s):  
Building Materials ◽  
Computational Modelling ◽  
Late Antique ◽  
Roman Economy ◽  
Wide Range ◽  
The Status ◽  
Recent Developments ◽  
Methodological Approaches ◽  
First Time ◽  
Site Types

The recycling and reuse of materials and objects were extensive in the past, but have rarely been embedded into models of the economy; even more rarely has any attempt been made to assess the scale of these practices. Recent developments, including the use of large datasets, computational modelling, and high-resolution analytical chemistry, are increasingly offering the means to reconstruct recycling and reuse, and even to approach the thorny matter of quantification. Growing scholarly interest in the topic has also led to an increasing recognition of these practices from those employing more traditional methodological approaches, which are sometimes coupled with innovative archaeological theory. Thanks to these efforts, it has been possible for the first time in this volume to draw together archaeological case studies on the recycling and reuse of a wide range of materials, from papyri and textiles, to amphorae, metals and glass, building materials and statuary. Recycling and reuse occur at a range of site types, and often in contexts which cross-cut material categories, or move from one object category to another. The volume focuses principally on the Roman Imperial and late antique world, over a broad geographical span ranging from Britain to North Africa and the East Mediterranean. Last, but not least, the volume is unique in focusing upon these activities as a part of the status quo, and not just as a response to crisis.

scholarly journals A Virtual Telescope for the Open University Science Foundation Course

1998 ◽  
Vol 162 ◽  
pp. 100-105
Author(s):  
Andrew J. Norton ◽  
Mark H. Jones
Keyword(s):  
Social Science ◽  
Open University ◽  
Distance Teaching ◽  
The Arts ◽  
Wide Range ◽  
University Science ◽  
First Time ◽  
Degree Level ◽  
Selection Of

The Open University is the UK's foremost distance teaching university. For over twenty five years we have been presenting courses to students spanning a wide range of degree level and vocational subjects. Since we have no pre-requisites for entry, a major component of our course profile is a selection of foundation courses comprising one each in the Arts, Social Science, Mathematics, Technology and Science faculties. The Science Faculty's foundation course is currently undergoing a substantial revision. The new course, entitled “S103: Discovering Science”, will be presented to students for the first time in 1998.

scholarly journals Autophagy Deficiency by Atg4B Loss Leads to Metabolomic Alterations in Mice

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 481
Author(s):  
Gemma G. Martínez-García ◽  
Raúl F. Pérez ◽  
Álvaro F. Fernández ◽  
Sylvere Durand ◽  
Guido Kroemer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acids ◽  
Mammalian Cells ◽  
Tissue Homeostasis ◽  
In Vivo Studies ◽  
Protective Mechanism ◽  
Cardiac Damage ◽  
Wide Range ◽  
First Time

Autophagy is an essential protective mechanism that allows mammalian cells to cope with a variety of stressors and contributes to maintaining cellular and tissue homeostasis. Due to these crucial roles and also to the fact that autophagy malfunction has been described in a wide range of pathologies, an increasing number of in vivo studies involving animal models targeting autophagy genes have been developed. In mammals, total autophagy inactivation is lethal, and constitutive knockout models lacking effectors of this route are not viable, which has hindered so far the analysis of the consequences of a systemic autophagy decline. Here, we take advantage of atg4b−/− mice, an autophagy-deficient model with only partial disruption of the process, to assess the effects of systemic reduction of autophagy on the metabolome. We describe for the first time the metabolic footprint of systemic autophagy decline, showing that impaired autophagy results in highly tissue-dependent alterations that are more accentuated in the skeletal muscle and plasma. These changes, which include changes in the levels of amino-acids, lipids, or nucleosides, sometimes resemble those that are frequently described in conditions like aging, obesity, or cardiac damage. We also discuss different hypotheses on how impaired autophagy may affect the metabolism of several tissues in mammals.

scholarly journals Fructose Enhanced Reduction of Bacterial Growth on Nanorough Surfaces

2013 ◽  
Vol 1498 ◽  
pp. 73-78 ◽  
Author(s):  
N. Gozde Durmus ◽  
Erik N. Taylor ◽  
Kim M. Kummer ◽  
Thomas J. Webster
Keyword(s):  
Bacterial Growth ◽  
Biofilm Formation ◽  
Antibacterial Agents ◽  
Bacteria Growth ◽  
Planktonic Bacteria ◽  
Combined Use ◽  
Wide Range ◽  
Metabolic Stimulation ◽  
Antibacterial Surfaces ◽  
First Time

ABSTRACTBiofilms are a major source of medical device-associated infections, due to their persistent growth and antibiotic resistance. Recent studies have shown that engineering surface nanoroughness has great potential to create antibacterial surfaces. In addition, stimulation of bacterial metabolism increases the efficacy of antibacterial agents to eradicate biofilms. In this study, we combined the antibacterial effects of nanorough topographies with metabolic stimulation (i.e., fructose metabolites) to further decrease bacterial growth on polyvinyl chloride (PVC) surfaces, without using antibiotics. We showed for the first time that the presence of fructose on nanorough PVC surfaces decreased planktonic bacteria growth and biofilm formation after 24 hours. Most importantly, a 60% decrease was observed on nanorough PVC surfaces soaked in a 10 mM fructose solution compared to conventional PVC surfaces. In this manner, this study demonstrated that bacteria growth can be significantly decreased through the combined use of fructose and nanorough surfaces and thus should be further studied for a wide range of antibacterial applications.

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