scholarly journals IAPSO: tales from the ocean frontier

2019 ◽  
Vol 10 (1) ◽  
pp. 137-150
Author(s):  
Denise Smythe-Wright ◽  
W. John Gould ◽  
Trevor J. McDougall ◽  
Stefania Sparnocchia ◽  
Philip L. Woodworth

Abstract. Our 21st century perspective on the oceans is due to the realization that knowledge of them and specifically their role in earth's climate are central to determining the future health of our planet. This present knowledge of the oceans builds on the farsighted work of people who, over the past century, worked to address seemingly intractable problems. The International Association for the Physical Sciences of the Oceans (IAPSO) has, over that long time span, promoted and supported the international approach that is now commonplace and has championed the provision of cross-cutting activities, the value of which we now fully recognize. This paper describes the key events in IAPSO's history and the roles played by the scientists involved.

2015 ◽  
Vol 58 (4) ◽  
pp. 357-375 ◽  
Author(s):  
Anne MacDonald

Over the past century Nāgārjuna’s Mūlamadhyamakakārikā (MMK) has been translated, in part and in its entirety, into an array of languages. Although a number of English translations have appeared, a philologically reliable yet readable English rendering of the MMK has remained a desideratum. A new translation by Mark Siderits and Shōryū Katsura now supersedes Jay Garfield’s previously popular MMK translation, which, made in reliance on only the Tibetan version of the MMK, is often problematic (The Fundamental Wisdom of the Middle Way, Oxford, 1995). Siderits’ and Katsura’s attempt to improve upon previous translations of the MMK was recently acknowledged by the Khyentse Foundation, which at the 17th Congress of the International Association of Buddhist Studies awarded them its 2014 “Prize for Outstanding Translation.”


PMLA ◽  
1965 ◽  
Vol 80 (5) ◽  
pp. 549-553 ◽  
Author(s):  
James M. Kuist

In a volume of miscellaneous manuscripts at the British Museum, placed at random and inconspicuously among larger folio leaves, is a set of notes headed “Sterne.” The notes were written by Joseph Hunter, the nineteenth-century antiquary and literary historian, and they came to the British Museum with Hunter's other papers shortly after his death in 1861. In view of the abundant information about Sterne's private life which the notes contain, it is surprising that this item has remained unindexed and that it is not mentioned in the catalogue description of the volume. In the absence of such references, very likely only an occasional reader who has happened upon them has seen these notes, and, since the major biographies of Laurence Sterne make no use of distinct details which Hunter provides, it is quite possible that none of Sterne's biographers have encountered Hunter's information during the past century. At present, our familiarity with the early years of Sterne's marriage and his residence at Sutton-on-the-Forest is rather limited, based as it is upon isolated public records, some letters, fugitive anecdotes, and the unflattering and sometimes vicious account written by John Croft. No impartial memoirs with any claim to authenticity or wealth of details have until now seemed available. Thus, the intimate account of Sterne which Hunter has given presents to modern scholars an unexpected and promising opportunity to gain new insight into the life and, perhaps, into the work of one of England's most unusual writers. A transcript of Hunter's notes appears below, followed by a brief evaluation of them according to our present knowledge of Laurence Sterne.


2019 ◽  
Vol 1 (2) ◽  

In the early 1900’s, in a small geographical region in northeastern Europe, a mysterious early-onset human malady was brought to the attention of physicians. In this disease, children appeared normal at birth and met usual developmental milestones up to the age of about 4-5 months. At that time, infants began to lose muscle tone and could no longer control their head movements. The disease was progressive, and by age 2, characterized by enlargement of the head, spastic responses to stimulation, and a general listlessness. By age 3, blindness was apparent and there was extension and posturing of limbs due to uncontrolled muscle contractions. Death usually occurred between ages 3-4. In large family’s common at that time, there could be 2-3 afflicted children out of a total of 8-9 siblings. There is no metric to measure pain and suffering of CD children, but we can measure progress made over the past century in solving the mystery. At the present time, there are great expectations that a human cure is possible since a mouse model of CD was recently shown to be completely cured by an unusual genetic engineering outcome. In this short review are chronicled key findings made over the past 100 + years that have led to identification of the genetic and cellular etiology of CD, and the reasons for such encouragement.


Communication ◽  
2012 ◽  
Author(s):  
Marcel Danesi

Semiotics is the discipline studying the meanings, uses, and functions of signs and sign systems—a “sign” being defined as anything (a word, gesture, facial expression, and so on) that stands for something other than itself, to someone, in some capacity. Some designate this discipline as a science, others as an analytical tool or a critical method. One of its modern-day founders, the American philosopher Charles Sanders Peirce (b. 1839–d. 1914), called it a “doctrine,” in the sense of a set of principles. It has also been called “semiology” by Ferdinand de Saussure (b. 1857–d. 1913), another modern-day founder. The terms “significs,” coined by Victoria Lady Welby (b. 1837–d. 1912), and “sematology” are also sometimes used. The term “semiotics” was adopted by the International Association for Semiotics Studies in 1969, becoming, ever since, the main one to designate the discipline. Debate is ongoing today about whether semiotics is a science and if it should encompass the study of nonhuman as well as human sign systems. This has led to the rise to prominence of “biosemiotics,” which aims to do exactly that. Several theoretical debates have also characterized semiotics proper for more than a century. The most important one has been whether sign construction is, in its origin, an arbitrary process, producing sign forms with no sensory, experiential, or affective connection to their referents, or if it is a “motivated” process, or generating sign forms that do. This basic debate is discussed in several core texts and in many of the theoretical works listed here. In a general annotated bibliography such as this one, selections must be made, given the extensive amount of writing that has marked the field over the past century. Also, decisions have to be made to classify certain works under particular rubrics, rather than others, because of the built-in thematic overlap of a large portion of semiotic writing. So, some listings included here under one category may be found classified under some other category elsewhere. Also, only English-language works have been listed here. This in no way implies that works in other languages are less important. On the contrary, many non-English works have been critical to the establishment and development of semiotics as a discipline. They are not included here unless they have English translations.


2002 ◽  
Vol 41 (4II) ◽  
pp. 683-698 ◽  
Author(s):  
M. Azeem Khan ◽  
Muhammad Iqbal ◽  
Iftikhar Ahmad ◽  
Mazoor H Soomro

At the inception of Pakistan in 1947, there was practically no plant protection service in the country and economic soundness of plant protection measures was not even realized for a long time. The use of chemicals as preventive measures to reduce losses by insects and diseases was almost non-existent during 1960s. However, the “grow more” pressure rendered the traditional methods insufficient, to control the ever increasing pest problem from 1970s onwards. Consumption of pesticides in Pakistan has increased from 665 metric tonnes (MT) in 1980 (when subsidy was withdrawn) to 69897 MT in 2002. This colossal increase in pesticide consumption has not led necessarily to an increase in the yield of crops, as demonstrated by Poswal and Williamson (1998) and Ahmad and Poswal (2000). This indiscriminate use of pesticides has destroyed the bio-control agents in the agro-ecosystems and the populations of natural enemies of the insects and pests have declined up to 90 percent during the last decade (of the past century) especially, in cotton growing areas of the country [Hasnain (1999)].


Servis plus ◽  
10.12737/7587 ◽  
2015 ◽  
Vol 9 (1) ◽  
pp. 86-97
Author(s):  
Валерий Чудинов ◽  
Valeriy Chudinov

The article covers a new scientific branch — the science of geoglyphics, which studies space-eye view (1,000 and over km from the surface of the earth) of ancient inscriptions, images, symbols and traces of ancient settlements. The author provides a brief description of the history ofgeoglyph studies, geoglyph types, interpretations of a geoglyph, and makes seven conclusions concerning the signification ofgeoglyphs for research into the history of different ethnic groups. The author defines a geoglyph as at least a 4-metre all-angle image or inscription on the surface of the Earth. Throughout the 20th century it was the Nazca Lines in Peru were the only scientifically acclaimed geogplyphs. However, there seems to be noplace on the planet that could not boast a geoglyph of its own. Despite the fact that for a long time Russian researchers have abstained from studying geoglyphs, at present Russian science has produced interesting reports, for example byAleksei Loktev. However, pessimistic views are also voiced, for example, Oleg Utkin claims that the topic receives undeservedly little attention. Men of art also resort to creating geoglyphs of nonexistent objects such as, for example, the fictitious land ofAtlaropa (also referred to as Panropa). Private collections of the geoglyphs of the past century are being created as well.


2020 ◽  
Vol 4 (4) ◽  
pp. 365-381
Author(s):  
Ny Anjara Fifi Ravelomanantsoa ◽  
Sarah Guth ◽  
Angelo Andrianiaina ◽  
Santino Andry ◽  
Anecia Gentles ◽  
...  

Seven zoonoses — human infections of animal origin — have emerged from the Coronaviridae family in the past century, including three viruses responsible for significant human mortality (SARS-CoV, MERS-CoV, and SARS-CoV-2) in the past twenty years alone. These three viruses, in addition to two older CoV zoonoses (HCoV-229E and HCoV-NL63) are believed to be originally derived from wild bat reservoir species. We review the molecular biology of the bat-derived Alpha- and Betacoronavirus genera, highlighting features that contribute to their potential for cross-species emergence, including the use of well-conserved mammalian host cell machinery for cell entry and a unique capacity for adaptation to novel host environments after host switching. The adaptive capacity of coronaviruses largely results from their large genomes, which reduce the risk of deleterious mutational errors and facilitate range-expanding recombination events by offering heightened redundancy in essential genetic material. Large CoV genomes are made possible by the unique proofreading capacity encoded for their RNA-dependent polymerase. We find that bat-borne SARS-related coronaviruses in the subgenus Sarbecovirus, the source clade for SARS-CoV and SARS-CoV-2, present a particularly poignant pandemic threat, due to the extraordinary viral genetic diversity represented among several sympatric species of their horseshoe bat hosts. To date, Sarbecovirus surveillance has been almost entirely restricted to China. More vigorous field research efforts tracking the circulation of Sarbecoviruses specifically and Betacoronaviruses more generally is needed across a broader global range if we are to avoid future repeats of the COVID-19 pandemic.


VASA ◽  
2018 ◽  
Vol 47 (3) ◽  
pp. 165-176 ◽  
Author(s):  
Katrin Gebauer ◽  
Holger Reinecke

Abstract. Low-density lipoprotein cholesterol (LDL-C) has been proven to be a causal factor of atherosclerosis and, along with other triggers like inflammation, the most frequent reason for peripheral arterial disease. Moreover, a linear correlation between LDL-C concentration and cardiovascular outcome in high-risk patients could be established during the past century. After the development of statins, numerous randomized trials have shown the superiority for LDL-C reduction and hence the decrease in cardiovascular outcomes including mortality. Over the past decades it became evident that more intense LDL-C lowering, by either the use of highly potent statin supplements or by additional cholesterol absorption inhibitor application, accounted for an even more profound cardiovascular risk reduction. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a serin protease with effect on the LDL receptor cycle leading to its degradation and therefore preventing continuing LDL-C clearance from the blood, is the target of a newly developed monoclonal antibody facilitating astounding LDL-C reduction far below to what has been set as target level by recent ESC/EAS guidelines in management of dyslipidaemias. Large randomized outcome trials including subjects with PAD so far have been able to prove significant and even more intense cardiovascular risk reduction via further LDL-C debasement on top of high-intensity statin medication. Another approach for LDL-C reduction is a silencing interfering RNA muting the translation of PCSK9 intracellularly. Moreover, PCSK9 concentrations are elevated in cells involved in plaque composition, so the potency of intracellular PCSK9 inhibition and therefore prevention or reversal of plaques may provide this mechanism of action on PCSK9 with additional beneficial effects on cells involved in plaque formation. Thus, simultaneous application of statins and PCSK9 inhibitors promise to reduce cardiovascular event burden by both LDL-C reduction and pleiotropic effects of both agents.


1901 ◽  
Vol 51 (1309supp) ◽  
pp. 20976-20977
Author(s):  
W. M. Flinders Petrje
Keyword(s):  

Author(s):  
Matthew Bagot

One of the central questions in international relations today is how we should conceive of state sovereignty. The notion of sovereignty—’supreme authority within a territory’, as Daniel Philpott defines it—emerged after the Treaty of Westphalia in 1648 as a result of which the late medieval crisis of pluralism was settled. But recent changes in the international order, such as technological advances that have spurred globalization and the emerging norm of the Responsibility to Protect, have cast the notion of sovereignty into an unclear light. The purpose of this paper is to contribute to the current debate regarding sovereignty by exploring two schools of thought on the matter: first, three Catholic scholars from the past century—Luigi Sturzo, Jacques Maritain, and John Courtney Murray, S.J.—taken as representative of Catholic tradition; second, a number of contemporary political theorists of cosmopolitan democracy. The paper argues that there is a confluence between the Catholic thinkers and the cosmopolitan democrats regarding their understanding of state sovereignty and that, taken together, the two schools have much to contribute not only to our current understanding of sovereignty, but also to the future of global governance.


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