Role of Ilaj Bit Tadbeer (Regimenal Therapy) in Waja-ul-Mafasil (Osteoarthritis): A Review

2021 ◽  
Vol 11 (12) ◽  
pp. 48-52
Author(s):  
Sayyed Adnan Mohammad ◽  
Mujassam M
Keyword(s):  
Side Effects ◽  
Treatment Modalities ◽  
Joint Diseases ◽  
Important Place ◽  
Surgical Interventions ◽  
Unani Medicine ◽  
Key Words Osteoarthritis ◽  
High Prevalence ◽  
All Treatment

Osteoarthritis is the commonest of all joint diseases. It results due to breakdown and destruction of joint tissues. The clinical picture of osteoarthritis strongly resembles with Waja-ul-Mafasil which has been elaborated in detail by Unani physicians. Considering the high prevalence, side effects of modern pharmacological treatment and high cost of surgical interventions with equivocal effectiveness of all treatment modalities, there is need for safe, economic and effective treatment in Unani Medicine for osteoarthritis. Unani System of Medicine has Ilaj Bit Tadbeer (Regimenal Therapy) as one of the modes of treatment. The Regimenal Therapy works on the principle of modifying or modulating the six essential factors (Asbaab-e-sittah zarooriya) for maintenance of health and prevention from diseases. Nowadays Regimenal Therapy holds an important place in Unani Medicine particularly for musculoskeletal and nervous disorders. The focus of this paper is to discuss and summarize the role of Ilaj bit Tadbeer in the management of Waja-ul-Mafasil. Key words: Osteoarthritis, Waja-ul-Mafasil, Unani System of Medicine, Ilaj Bit Tadbeer, Regimenal Therapy.

Current and Emerging Therapies for Ocular Rosacea

2013 ◽  
Vol 06 (02) ◽  
pp. 86
Author(s):  
Edward J Wladis ◽  
Alejandro P Adam ◽  
◽  
Keyword(s):  
Side Effects ◽  
Therapeutic Strategies ◽  
Treatment Modalities ◽  
Surgical Interventions ◽  
Oral Medications ◽  
Incurable Disease ◽  
Emerging Therapies ◽  
Improved Outcomes ◽  
Ocular Rosacea ◽  
Intense Research

Ocular rosacea is an incurable disease that affects millions of Americans annually. While multiple therapeutic strategies have been devised to address this disorder (including topical and oral medications, laser and light-based treatments, and surgical interventions), our current interventions are largely nonspecific and often ineffective. Nonetheless, ocular rosacea remains a source of intense research, and newer treatments offer tremendous promise for improved outcomes. In this review, we discuss the current and emerging treatment modalities for ocular rosacea and analyze novel basic science findings that will hopefully lead to highly targeted medications to treat this potentially blinding illness with greater specificity and fewer side effects.

Role of Nutraceuticals in Cancer

2019 ◽  
pp. 388-406
Author(s):  
Kiran Dahiya ◽  
Rakesh Dhankhar
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Mechanism Of Action ◽  
Healthcare Professionals ◽  
Standard Treatment ◽  
Treatment Modalities ◽  
Active Components ◽  
Prevention And Treatment ◽  
Prevention Of Cancer

Nutraceuticals are increasingly becoming popular for prevention and treatment of cancer. Association of adverse effects with standard treatment modalities of cancer has led to consideration of safer approaches. Nutraceuticals may help in prevention of cancer as well as in treatment and avoidance of side effects associated with chemo-radiation. The active components of nutraceuticals are known as phytochemicals. Many mechanisms have been put forward for the actions of these phytochemicals but an exact mechanism for a well defined role of a particular phytochemical in a specific type of cancer is yet to be elucidated. Thus, nutraceutical industry has emerged as a research oriented sector. It is important for the healthcare professionals to understand the categories, research developments, mechanism of action and areas of concern in the field of nutraceuticals.

scholarly journals Radiotherapy and Management in Maxillofacial Prosthodontic : Part 1- Before Radiotherapy

2021 ◽  
Vol 8 ◽  
Author(s):  
Wijdane El Hawari
Keyword(s):  
Side Effects ◽  
Oral Cavity ◽  
Dental Care ◽  
Cancer Treatments ◽  
Surgical Interventions ◽  
Rational Planning ◽  
Maxillofacial Prosthesis ◽  
Anti Cancer ◽  
Anticancer Treatment

Anti-cancer treatments (surgery, radiotherapy and chemotherapy) lead to numerous sequelae and side effects, unpleasant or even disabling in the oral cavity. In the absence of appropriate dental care, the consequences can be highly detrimental.The side effects of radiotherapy, the loss of substances following often associated surgical interventions and the unfavorable context of these patients require rational planning and consultation approved by the various practionners.The management of patients before, during and after these anticancer treatments by the specialist in maxillofacial prosthesis is important, in fact the objectives outlined to be achieved in terms of the management of PMF are: restoration of orofacial functions, participation in the proper conduct of anticancer treatment, palliation of its complications and psychological support for these patients.The aim of this article is to review the various complications of radiotherapy, as well as the protocols and recommendations for the management of patients before radiotherapy and to highlight the role of the specialist in maxillofacial prosthodontics in this management.

Aneurysm Treatment

2021 ◽  
pp. 53-60
Author(s):  
Christopher Storey ◽  
Jonathon Lebovitz ◽  
Eric C. Peterson ◽  
Pascal M. Jabbour
Keyword(s):  
New Technologies ◽  
Treatment Modalities ◽  
Transfemoral Approach ◽  
Transradial Approach ◽  
Femoral Approach ◽  
Aneurysm Treatment ◽  
High Prevalence ◽  
Reduce Risk ◽  
All Treatment

The transradial approach offers safer access than the transfemoral approach based on the cardiac literature. The dual-antiplatelet requirements of many interventions and the high prevalence of patients on anticoagulation have made the transradial approach the access of choice for elective interventions. For ruptured cases, the benefit provides quicker extubation to reduce risk of pneumonia. All treatment modalities up to 6F triaxial systems can be used for embolization as one would from the femoral approach. All current neurointerventional therapies can be performed from a transradial approach. One needs to realize that, with new technologies, transradial neurointervention will become simpler, more efficient, and reliable.

Factor XI deficiency—resolving the enigma?

Hematology ◽  
2009 ◽  
Vol 2009 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Paula H. B. Bolton-Maggs
Keyword(s):  
Side Effects ◽  
Coagulation Factor ◽  
Bleeding Tendency ◽  
Factor Xi ◽  
Factor Xi Deficiency ◽  
Factor Deficiency ◽  
Coagulation Factor Deficiency ◽  
Coagulation Pathway ◽  
All Treatment

Abstract The management of factor XI deficiency is not straightforward for three reasons: firstly, the role of this factor in the coagulation pathway is not clearly understood; secondly, the bleeding tendency, although mild, is unpredictable and does not clearly relate to the factor XI level; and thirdly, all treatment products, although available, have some potentially serious side effects. These factors (or enigmas) contribute to the variable management of patients with this coagulation factor deficiency, but recent research is helping to clarify some of these areas.

Man am I Stoned, I think! The role of experience and side effects in the perception of drug effects

1972 ◽  
Author(s):  
Cornelis Bakker ◽  
Albert S. Carlin ◽  
Robert Heaton ◽  
Reese T. Jones ◽  
Theodore X. Barber
Keyword(s):  
Side Effects ◽  
Drug Effects

Peptide Receptor Radionuclide Therapy for Pancreatic Neuroendocrine Tumours

2019 ◽  
Vol 12 (2) ◽  
pp. 126-134 ◽  
Author(s):  
Shahad Alsadik ◽  
Siraj Yusuf ◽  
Adil AL-Nahhas
Keyword(s):  
Side Effects ◽  
Effective Treatment ◽  
Radionuclide Therapy ◽  
Neuroendocrine Tumours ◽  
Peptide Receptor Radionuclide Therapy ◽  
Progression Free Survival ◽  
Treatment Modalities ◽  
Effective Treatment Option ◽  
Peptide Receptor ◽  
Pancreatic Neuroendocrine Tumours

Background: The incidence of pancreatic Neuroendocrine Tumours (pNETs) has increased considerably in the last few decades. The characteristic features of this tumour and the development of new investigative and therapeutic methods had a great impact on its management. Objective: The aim of this review is to investigate the outcome of Peptide Receptor Radionuclide Therapy (PRRT) in the treatment of pancreatic neuroendocrine tumours. Methods: A comprehensive literature search strategy was used based on two databases (SCOPUS, and PubMed). We considered all studies published in English, evaluating the use of PRRT (177Luteciuim- DOTA-conjugated peptides and 90Yetrium- DOTA- conjugated peptides) in the treatment of pancreatic neuroendocrine tumours as a standalone entity or as a subgroup within the wider category of Gastroenteropancreatic Neuroendocrine Tumours (GEP NETs). Results: PRRT was found to be an effective treatment modality as a monotherapy or in combination with other therapies in the treatment of non-operable and metastatic pNETs where other options are limited. Complete response was reported to be between 2-6% while partial response was achieved in up to 60% of cases. Survival analysis was also impressive. Progression Free Survival (PFS) reached a mean of 34 months and Overall Survival (OS) of 53 months. PRRT also proved to improve patients’ Quality of Life (QoL). Acute and sub-acute side effects like nephrotoxicity and haematotoxicity are usually mild and reversible. Conclusion: PRRT is well tolerated and effective treatment option for non-operable and/or metastatic pNETs. Side effects are usually mild and reversible. Larger randomized controlled trails need to be done to compare PRRT with other treatment modalities and to provide more detailed guidelines regarding patient selections, the choice of PRRT, follow up and response assessment to maximum potential benefit.

Role of Erlotinib in Influencing the Quality of Life of Cancer Patients

2020 ◽  
Vol 07 ◽  
Author(s):  
Deepika Purohit ◽  
Parijat Pandey
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Kinase Inhibitors ◽  
Treatment Modalities ◽  
Pancreatic Cancers ◽  
Review Reports ◽  
Causes Of Deaths

Background:: Cancer is one of the significant causes of morbidity and mortality in patients globally. Lung cancer, among other cancers, remains to be one of the principal causes of deaths in both men and women. The most common type of lung cancer is the non-small-cell lung cancer (NSCLC). Apart from lung cancer, pancreatic cancer is also one of the common cancers currently. Objective:: The assessment of QoL in erlotinib-treated patients can also prove to be very useful in the establishment of this drug as the main treatment option for the patients with pancreatic and lung cancer. Methods:: Therapies that target EGFR-mediated signalling are the latest keystones for treating these two types of cancers. They comprise of two main treatment modalities: firstly, against the extracellular fields, that include monoclonal antibodies and secondly, mechanisms that create interferences in the signalling pathways, primarily the small molecule tyrosine kinase inhibitors. Results:: Quality of life (QoL) is one of the key advantages in erlotinib therapy over chemotherapy. Conclusion:: The present review reports the role of erlotinib in improving the quality of life of cancer patients especially in NSCLC and pancreatic cancers. The studies or trials establishing the relations between erlotinib and QoL are discussed in detail in this review.

scholarly journals The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 675
Author(s):  
Saartje Uyttebroek ◽  
Jolien Onsea ◽  
Willem-Jan Metsemakers ◽  
Lieven Dupont ◽  
David Devolder ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Biofilm Formation ◽  
Potential Role ◽  
Phage Therapy ◽  
Well Being ◽  
Treatment Alternative ◽  
Surgical Interventions ◽  
Social And Emotional ◽  
Promising Treatment

Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

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