scholarly journals Adjunct therapy of Jivantyadi Ghrita with Anti Tubercular drugs in Rajyakshama (Pulmonary Tuberculosis) – A Case Report

2020 ◽  
Vol 8 (04) ◽  
Author(s):  
Nandkishor Bhaurao Kale
Keyword(s):  
Side Effects ◽  
Pulmonary Tuberculosis ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Adjunct Therapy ◽  
Significant Clinical Improvement ◽  
Wbc Count ◽  
Anti Tubercular Therapy ◽  
Present Case Study

Rajyakshma is oldest disease known to mankind as its first reference found in oldest literature Rugveda. It is called as King of Diseases, which indicates its severity. Tuberculosis remains major public health problem not only in India but also in world. According to WHO one third of global population is suffering from tuberculosis. Anti-tubercular therapy is long lasting and has many side effects, so it is necessary to develop adjunct therapy which will minimize the hazards and help patient to improve the immune status. Aims and objective – To evaluate the toxicity reduction and early restoration by adjunct therapy of Jivantyadi Ghrit.  Methodology - In the present case study DOTs therapy in the dose of 3 tablets once per day was given as an adjunct with Jivantyadi Ghrit 10 ml BD per day was administered for a period of 6 months in the diagnosed case of pulmonary tuberculosis. Assessment was recorded. Results – WBC count and ESR rate reduced to normal, Haemoglobin level increased, SGPT and Sr. Bilurubin level remains normal. Also significant resolution of lung Koch’s lesions was noted radiologically. Conclusion - Jivantyadi Ghrit as an adjunct therapy with DOTs reduces the side effects (especially hepatic) of DOTs therapy and also shows significant clinical improvement in sign and symptoms of PTB.

scholarly journals Multiorgan failure with fatal outcome after stem cell tourism

2020 ◽  
Author(s):  
Željka Večerić-Haler ◽  
Špela Borštnar ◽  
Boštjan Luzar ◽  
Nika Kojc
Keyword(s):  
Stem Cell ◽  
Side Effects ◽  
Multiorgan Failure ◽  
Fatal Outcome ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Cell Therapies ◽  
Stem Cell Tourism ◽  
Stem Cell Treatment ◽  
The Right

Abstract Background: unproven stem cell treatments may involve serious health, personal and financial considerations. Due to worldwide spread, illegal stem cell therapies have become a major public health problem. We have already witnessed numerous reports in the mass media of severe and occasionally even fatal outcomes after such therapies. However, there are only few scientifically documented cases in which the causality between stem cell therapy and side effects cannot be refuted.Case presentation: here we present a case report of a 48-years old patient with serious side effects including disseminated skin ulcers, hepatitis and cardiomyopathy with eventual fatal outcome following unproven stem cell treatment.Conclusions: the case of the patient presented here draws attention to the worst possible outcome of stem cell tourism. To effectively combat this issue, professionals and patients should be empowered with the right knowledge on possible side effects.

scholarly journals PENGARUH TERAPI ACTIVE CYCLE OF BREATHING TECHNIQUE (ACBT) TERHADAP FREKUENSI PERNAFASAN (RESPIRATORY RATE) PADA PENDERITA TUBERKULOSIS PARU DI RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN

2021 ◽  
Vol 4 (2) ◽  
pp. 499-506
Author(s):  
Eka Nugraha Varida Naibaho ◽  
Sri Mega Herlina Kabeakan
Keyword(s):  
Pulmonary Tuberculosis ◽  
Quantitative Research ◽  
Public Health Problem ◽  
Respiratory Frequency ◽  
Wilcoxon Test ◽  
Major Public Health Problem ◽  
Breathing Patterns ◽  
Tuberculosis Patients ◽  
A Value ◽  
Post Test

Pulmonary tuberculosis is a major public health problem in the world and is the second leading cause of death from infectious diseases. The purpose of this study was to determine the effect of active cycle of breathing technique (ACBT) therapy on breathing frequency in patients with pulmonary tuberculosis. Quantitative research method, with a Quasi Experimental research design with a pre-test and one-group post-test approach. The study was carried out in the Orchid room of the Imelda Indonesian Workers General Hospital in Medan in July - August 2021. The study population was 45 patients with pulmonary tuberculosis and the sample technique of this study was Nonprobability Sampling. The number of samples was 41 pulmonary tuberculosis patients according to the researcher's criteria. The data analysis technique used is Wilcoxon test analysis. The results of the study There was an effect of breathing patterns before the administration of active cycle of breathing technique (ACBT) Therapy on the improvement of respiratory frequency in patients with pulmonary tuberculosis with a value of M ± SD = 17.1081 ± 2.94188. There is an effect of breathing pattern after administration of active cycle of breathing technique (ACBT) Therapy on the respiratory frequency of Pulmonary Tuberculosis Patients with a value of M ± SD = 27.0400 ± 2.82076. There is a difference in the effect of breathing patterns before and after administration of active cycle of breathing technique (ACBT) therapy on the Improvement of respiratory frequency in pulmonary tuberculosis patients with a significant value of 0.000 < 0.005.   Abstrak Tuberkulosis paru adalah masalah pokok kesehatan pada masyarakat didunia dan merupakan penyebab kematian ke dua dari penyakit infeksi. Tujuan penelitian untuk mengetahui pengaruh pemberian terapi active cycle of breathing technique (ACBT) terhadap frekuensi pernafasan pada penderita tuberkulosis paru. Metode penelitian kuantitatif, dengan desain penelitian Quasi Eksperiment dengan pendekatan pre test dan post test one group. Penelitian dilaksanakan di ruangan Anggrek Rumah Sakit Umum Imelda Pekerja Indonesia Medan pada bulan Juli - Agustus 2021. Populasi penelitian sebanyak 45 orang pasien Tuberkulosis Paru dan teknik sampel penelitin ini adalah Nonprobability Sampling. Jumlah sampel 41 orang pasien tuberkulosis paru sesuai dengan kriteria peneliti. Teknik analisa data yang digunakan adalah analisis uji Wilcoxon. Hasil penelitian ada pengaruh pola nafas sebelum pemberian terapi active cycle of breathing technique (ACBT) terhadap perbaikan frekuensi pernafasan pada penderita tuberkulosis paru dengan nilai M ± SD =17.1081 ± 2.94188. Ada pengaruh pola nafas sesudah pemberian terapi active cycle of breathing technique (ACBT) terhadap frekuensi pernafasan pasien tuberkulosis paru dengan nilai M ± SD = 27.0400 ± 2.82076. Ada perbedaan pengaruh pola nafas sebelum dan sesudah pemberian terapi active cycle of breathing technique (ACBT) terhadap perbaikan frekuensi pernafasan pasien tuberkulosis paru dengan nilai signifikan 0,000 < 0,005.

scholarly journals COMPARATIVE ASSESSMENT OF BIOCHEMICAL AND IMMUNOLOGICAL MARKERS IN TUBERCULOSIS

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Abhijit Ninghot ◽  
Kanchan Mohod ◽  
Mohd. Sameer Khan ◽  
Azmat Kamal Ansari ◽  
Satish Kumar
Keyword(s):  
Pulmonary Tuberculosis ◽  
Adenosine Deaminase ◽  
Sensitivity And Specificity ◽  
Sputum Sample ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Immunological Markers ◽  
Tuberculosis Antigen ◽  
Commercial Kits ◽  
Antigen Antibody

Introduction: Pulmonary tuberculosis is major public health problem in developing countries like India.Millions of people have died from tuberculosis. Many times it is difficult to get sputum sample from the patients. Some tests lack specificity, some other lack sensitivity. Hence, there is need of precise and faster diagnosis for patients attending hospitals. In this study, we compared the detection potential of biochemical and immunological markers(ADA, LDH and Mycobacterium tuberculosis H37Ra ES-31 & EST-6 antigens & antibodies based ELISAs) in pulmonary tuberculosis. Methods: 50 pulmonary tuberculosis cases confirmed by sputum examinationfor acid fast bacilli (AFB) and 50 age and sex matched control subjects were included in this study.ADA & LDH were estimated by using commercial kits. Tubercular antigens and antibodies were detected by ELISA method. Results: SerumADA detected pulmonary tuberculosis with sensitivityand specificityof 94%. Sensitivity and specificity of serum LDH in detecting pulmonary tuberculosis was found to be 94% and 36% respectively.Serumtubercular antigens detected pulmonary tuberculosis with sensitivity and specificity of 88%. Sensitivity and specificity of serum tubercular antibodies in detecting pulmonary tuberculosis was found to be 80% and 90% respectively. Conclusion: Adenosine deaminase has better detection potential over other markers in pulmonary tuberculosis. Keywords: Adenosine deaminase, Lactate dehydrogenase, Tuberculosis antigen-antibody

scholarly journals Examining the Role of Health Facilities in Supporting Iron Folic Acid Supplementation Adherence Among Women in Malawi (OR25-03-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Rukundo Benedict ◽  
Wenjuan Wang ◽  
Lindsay Mallick
Keyword(s):  
Folic Acid ◽  
Side Effects ◽  
Rural Areas ◽  
Urban Areas ◽  
Public Health Problem ◽  
Health Facilities ◽  
Health System Strengthening ◽  
Gps Data ◽  
Major Public Health Problem ◽  
Iron Folic Acid

Abstract Objectives Maternal anemia is a major public health problem in many low and middle income countries. In Malawi, consumption of iron folic acid supplements (IFA) has remained low and unchanged since 2004, even with the support of national policy and programs. To understand program implementation challenges, our study examined the relationship between the IFA-related health service environment (HSE) during antenatal care (ANC) and women's adherence to IFA supplementation guidelines. Methods Data from the 2015–16 Malawi Demographic and Health Survey (DHS) and the 2013–14 Malawi Service Provision Assessment (SPA), both of which collect GPS data of clusters or health facilities, were used. Each DHS cluster was linked to SPA facilities within a specified buffer distance (5 km for urban and 10 km for rural) using GPS data. IFA-related HSE was defined as availability of IFA, observed prescription of IFA, and observed counseling on IFA in health facilities within the buffer. The HSE variables were aggregated to the cluster-level and classified as low, medium, or high. Multilevel logistic regressions, stratified by urban and rural locale, were used to model associations between consumption of IFA and HSE variables controlling for individual-level factors. Results In Malawi 44% of women in urban and 32% in rural areas reported IFA consumption for at least 90 days during their most recent pregnancy. IFA supplements were available in the majority of health facilities (94%) providing ANC. Among clients, 85% received IFA or were given a prescription, 59% were counseled on how to use IFA, and 3% were counseled on side effects. In rural areas, regression models showed that high levels of IFA availability in facilities (OR = 2.07; 95% CI: 1.13–3.80) and IFA counseling (OR = 1.42; 95% CI: 1.12–1.78) were associated with IFA consumption. No associations with any HSE variables were observed in urban areas. Conclusions Despite widespread availability and prescription of IFA supplements from health facilities, receipt of counseling was low, particularly for side effects. Findings in rural areas reinforce the importance of health system strengthening to ensure IFA availability and counseling to support IFA consumption during pregnancy. Further research is warranted to investigate factors that affect IFA consumption in urban areas. Funding Sources United States Agency for International Development (USAID) through the DHS Program (7200AA18C00083).

scholarly journals Transcutaneous Delivery of Immunomodulating Pollen Extract-Galactomannan Conjugate by Solid-in-Oil Nanodispersions for Pollinosis Immunotherapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 563 ◽  
Author(s):  
Qingliang Kong ◽  
Kouki Higasijima ◽  
Rie Wakabayashi ◽  
Yoshiro Tahara ◽  
Momoko Kitaoka ◽  
...  
Keyword(s):  
Side Effects ◽  
Immunoglobulin E ◽  
Mouse Skin ◽  
Public Health Problem ◽  
Japanese Cedar ◽  
Pollen Extract ◽  
Major Public Health Problem ◽  
Type I ◽  
T Helper ◽  
Japanese Cedar Pollinosis

Japanese cedar pollinosis is a type I allergic disease and has already become a major public health problem in Japan. Conventional subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) cannot meet patients’ needs owing to the side effects caused by both the use of conventional whole antigen molecules in the pollen extract and the administration routes. To address these issues, a surface-modified antigen and transcutaneous administration route are introduced in this research. First, the pollen extract (PE) was conjugated to galactomannan (PE-GM) to mask immunoglobulin E (IgE)-binding epitopes in the PE to avoid side effects. Second, as a safer alternative to SCIT and SLIT, transcutaneous immunotherapy (TCIT) with a solid-in-oil (S/O) nanodispersion system carrying PE-GM was proposed. Hydrophilic PE-GM was efficiently delivered through mouse skin using S/O nanodispersions, reducing the antibody secretion and modifying the type 1 T helper (Th1)/ type 2 T helper (Th2) balance in the mouse model, thereby demonstrating the potential to alleviate Japanese cedar pollinosis.

scholarly journals Evaluation of Risk Factors for Hepatotoxicity in Patients Receiving Antitubercular Four Drugs Regimen in Initial Two Months

2015 ◽  
Vol 14 (1) ◽  
pp. 15-18
Author(s):  
Saifun Nahar Faiz ◽  
Nasreen Chowdhury ◽  
Md Aminul Haque Khan ◽  
Rukhsana Parvin
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Alcohol Intake ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
High Alcohol ◽  
Drug Induced ◽  
Study Results ◽  
Pre Treatment ◽  
High Alcohol Intake

Background: Tuberculosis (TB) is a major public health problem in Bangladesh since long before. Standard first line drugs are isoniazid, rifampicin, pyrazinamide and ethambutol. Of these, isoniazid, rifampicin and pyrazinamide have been observed to have hepatotoxic potentials. Drug Induced Hepatotoxicity (DIH) is an important and commonly encountered adverse effect with anti-TB treatment. A higher risk of hepatotoxicity has been reported in Bangladeshi patients than in their western counterparts. The reasons for the higher rate of hepatotoxicity in Bangladeshi patients are unclear. Objectives: To know the possible risk factors for the development of drug induced hepatotoxicity and to see their association with hepatoxicity in patients receiving antitubercular treatment as per National Tuberculosis Control Programme. Materials and Methods: In this cross sectional prospective study, 100 freshly diagnosed pulmonary tuberculosis patients attending the Medicine Outpatient Department, admitted in Chittagong Medical College Hospital, DOTS center in the hospital were selected for the study. Results: In this study we found twenty percent patients (20%) developed Antituberculosis Treatment (ATT) induced hepatotoxicity and most of them were in the age group of 50–65 years. Among the patients who developed hepatotoxicity (DIH) 27% patients were in BMI 18.5 group. The patients presenting with radiologically severe Pulmonary Tuberculosis (PTB) developed higher hepatotoxicity than patients with milder disease. The patients with history of high alcohol intake and with pre-treatment hypoalbuminemia were also found to have higher drug induced hepatotoxicity as compared to non-alcoholics and normal serum albumin level respectively. This study showed the evidence of ATT induced liver damage in twenty percent (20%) patients. Among them 05% cases developed overt drug induced hepatotoxicity (DIH) and remaining 15% cases had asymptomatic elevation of serum ALT, AST and bilirubin levels. The remaining 80% cases did not show any significant change in their serum bilirubin and/or enzyme levels as compared to pre-treatment levels. Conclusion: Advanced age, high alcohol intake, radiologically severe disease before treatment and pretreatment hypoalbuminemia are predisposing factors for the development of ATT induced hepatotoxicity.DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22873 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 15-18

scholarly journals Multiorgan failure with fatal outcome after stem cell tourism

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Željka Večerić-Haler ◽  
Špela Borštnar ◽  
Boštjan Luzar ◽  
Maja Jerše ◽  
Nika Kojc
Keyword(s):  
Stem Cell ◽  
Side Effects ◽  
Multiorgan Failure ◽  
Fatal Outcome ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Cell Therapies ◽  
Stem Cell Tourism ◽  
Stem Cell Treatment ◽  
The Right

Abstract Background Unproven stem cell treatments may involve serious health, personal, and financial considerations. Due to worldwide spread, illegal stem cell therapies have become a major public health problem. We have already witnessed numerous reports in the mass media of severe and occasionally even fatal outcomes after such therapies. However, there are only few scientifically documented cases in which the causality between stem cell therapy and side effects cannot be refuted. Case presentation Here we present a case report of a 48-year-old patient with serious side effects, including disseminated skin ulcers, hepatitis, and cardiomyopathy, with eventual fatal outcome following unproven stem cell treatment. Conclusions The case of the patient presented here draws attention to the worst possible outcome of stem cell tourism. To effectively combat this issue, professionals and patients should be empowered with the right knowledge on possible side effects.

scholarly journals AYURVEDIC MANAGEMENT OF BRONCHIAL ASTHMA – A CASE STUDY

2020 ◽  
Vol 8 (10) ◽  
pp. 4894-4901
Author(s):  
Momin Jasmin Begam ◽  
Kulkarni Prasad ◽  
Gogate Vishwas
Keyword(s):  
Side Effects ◽  
Environmental Factors ◽  
Bronchial Asthma ◽  
Clinical Picture ◽  
Signs And Symptoms ◽  
Breathing Difficulty ◽  
Systemic Side Effects ◽  
Genetic And Environmental Factors ◽  
Present Case Study

Bronchial asthma is a heterogenous disease with reciprocity between genetic and environmental factors. The different triggering factors increase the frequency and severity of breathing difficulty attacks. The use of modern medicines is restricted due to its various local as well systemic side effects. The clinical picture of bronchial asthma can be correlated with Tamakashwas as explained in Ayurveda. In the present case study, a 24 years old female patient having signs and symptoms of Tamakashwas has been discussed. The treatment was administered in accordance with Shodhana Chikitsa, Shamana Aushadhis and Sthanika Chikitsa. Nidana Parivarjana is strictly instructed in order to avoid the stimulation to internal pathology of the disease. The classical management helps in relieving the symptoms as well as lowers the recurrence of the breathing difficulty attacks. Regular counselling and practice of Parnayama contributes in boosting and refreshing her mind. The assessment was done by using the gradation scale which was adopted from de-veloping guidelines for clinical research methodology in Ayurveda. This Ayurvedic management helps in achieving the positive output with complete stoppage of use of inhaler over a period of 6 months.

scholarly journals The Ethyl Acetate Extraction Obtained from Podocarpus Nagikernel Meal with Anticancer Activity

2021 ◽  
Vol 14 (1) ◽  
pp. 363-366
Author(s):  
Yuchen Xiao ◽  
Jianping Yong ◽  
Yang Yang ◽  
Canzhong Lu
Keyword(s):  
Side Effects ◽  
Anticancer Activity ◽  
Anticancer Drugs ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Public Health Problem ◽  
New Drugs ◽  
Major Public Health Problem ◽  
Drug Candidates

Cancer is a major public health problem worldwide, and it is one of the top three major diseases in terms of mortality. Some small molecular synthesized drugs have been used clinically. However, much side-effects were also appeared during treatment of the cancer patients with the synthesized anticancer drugs in clinical. Some Chinese Traditional Plant Medicines have ever been used for treatment of cancer with the low side-effects. Thus, it is essential to find anticancer drugs or drug candidates from Chinese Traditional Plant Medicines. Podocarpus nagicontains different kinds of biological components together with a wide spectrum of biological activities, and it has ever been used in the folk of Yao Nationality for treatment different diseases. It is essential to study this folk plant medicine to discover new drugs or drug candidates. In this work, we obtained different polar extractions and evaluated their in vitro anticancer activity.

scholarly journals Identification of socio-demographic factors and the causes of poor adherances of urban DOTS in Biratnagar

1970 ◽  
Vol 7 (1) ◽  
pp. 13-18
Author(s):  
V Kattel ◽  
R Rizal ◽  
D Katwal ◽  
S Subedi ◽  
G Kattel ◽  
...  
Keyword(s):  
Public Health ◽  
Side Effects ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Poor Compliance ◽  
Major Public Health Problem ◽  
Sectional Study ◽  
Cross Sectional ◽  
Socio Demographic Factors ◽  
Severe Degree

Background : TB is a major public health problem. Though Investigation and chemotherapy is free of cost we are still facing poor compliance and severe degree of disease among the poorly treated ones. We have tried to explore into reasons behind it. Methodology : It was a retrospective cross- sectional study done at Biratnagar Sub-metro Politian City. Result : People accept DOTS. They visit as early as they are referred but are diagnosed lately. They have multiple reasons to quit the treatment before completion. Conclusion : We found that early diagnosis and proper counselling about the need of prolonged regime of treatment and its side effects are important factors in preventing transmission and poor compliance. Keywords: TB; DOTS; HIV; BPKIHS; cases; defaulters     DOI: 10.3126/saarctb.v7i1.3957SAARC J. TUBER. LUNG DIS. HIV/AIDS 2010 VII(1) 13-18

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