scholarly journals OVERCROWDED PRISONS IN PAKISTAN: UNDERSTANDING THE CRITICAL ROLE OF PROBATION, PAROLE OFFICERS AND COURTS

2021 ◽  
Vol 03 (01) ◽  
pp. 40-47
Author(s):  
Mukhtyar Nabi ◽  
◽  
Saddam Hussain ◽  
Muhammad Kamran ◽  
◽  
...  
Keyword(s):  
Present Article ◽  
Behavioral Problems ◽  
High Frequency ◽  
Critical Role ◽  
Prison System ◽  
Probation Officers ◽  
Parole Officers ◽  
The World

Prison is a place for rehabilitation of offenders in every country of the world. The present study has tried to explore the present-day situation of the prison system of Pakistan and discuss its overcrowding condition in all four provinces. There are total 120 prisons in the country which hold authorized space for not more than 57,712 prisoners, but the number of inmates is 77,275, which is far away from the authorized space. This congested prison system not only creates hurdles in rehabilitation of prisoners but makes them more criminal by mixing of low and high frequency offenders. It also leads to various health and behavioral problems. Rehabilitation is only possible if there is balance in authorized and available prisoners in the prisons. The present article has come up with some viable suggestion for concerned authorities that can better perform their duty in eradication of this problem. The authors discussed the role of parole and probation officers in the elimination of these numbers in prison. The majority of the prisoners in our prisons are under-trail, thus the role of the judiciary has also been explored in balancing the incarceration ratio in prisons. Keywords: Prison System, Overcrowded Prisons, Parole and Probation, Judiciary, Courts, Pakistan

scholarly journals May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells

2018 ◽  
Vol 39 (2) ◽  
pp. 367-370 ◽  
Author(s):  
Cesar V Borlongan ◽  
Hung Nguyen ◽  
Trenton Lippert ◽  
Eleonora Russo ◽  
Julian Tuazon ◽  
...  
Keyword(s):  
United States ◽  
Stem Cells ◽  
Therapeutic Option ◽  
Critical Role ◽  
The United States ◽  
Brain Disorders ◽  
Mitochondrial Dysfunctions ◽  
Limited Therapeutic Option ◽  
The World

Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.

God, Woman, and Morality: The Democratic Family in the New Political Science of Alexis de Tocqueville

1995 ◽  
Vol 57 (1) ◽  
pp. 7-30
Author(s):  
William Mathie
Keyword(s):  
Political Science ◽  
Present Article ◽  
Alexis De Tocqueville ◽  
American Democracy ◽  
American Women ◽  
The Family ◽  
The World ◽  
Role Of Women ◽  
New Political Science

Tocqueville says that the superiority of American women is the chief cause of the power and prosperity of American democracy. That superiority is the result of an education that treats women as capable of freedom, but the use of that freedom is to maintain the bonds that restrict women to the household. The present article examines the role of the family and women in the new political science Tocqueville thought necessary for the defence of democratic liberty. It is argued that as the primary influence of democracy upon the family for Tocqueville has been to eliminate the authority of fathers who were the “arbiters of mores” and thereby the defenders of liberty in aristocracy, so democratic liberty depends for him above all upon the new role of women as the makers of mores. Through the agency of women, otherwise fragile religion constitutes an effective limit to the authority of the majority, but what makes it possible for religion to operate through women is their exclusion from the world of commerce, and what maintains this exclusion is the strict conjugal morality that women themselves defend in America. How far the role of women as guardians of democratic liberty might be justified is shown to depend for Tocqueville upon arguments for it that are other than those commonly accepted by American men.

scholarly journals Public Health Literacy for Lawyers

2003 ◽  
Vol 31 (4) ◽  
pp. 701-713 ◽  
Author(s):  
Wendy E. Parmet ◽  
Anthony Robbins
Keyword(s):  
Public Health ◽  
Health Professionals ◽  
Critical Role ◽  
The Public ◽  
Health Measures ◽  
Public Health Professionals ◽  
The World ◽  
Key Issues ◽  
Public Health Literacy

Public health professionals recognize the critical role the law plays in determining the success of public health measures. Even before September 11, 2001, public health experience with tobacco use, HIV, industrial pollution and other potent threats to the health of the public demonstrated that laws can assist or thwart public health efforts. The new focus on infectious threats and bioterrorism, starting with the anthrax attacks through the mail and continuing with SARS, has highlighted the important role of law.For lawyers to serve as effective partners in public health, they should have a basic familiarity with public health: how public health professionals see the world and the key issues they tackle. A practical grasp of public health can be acquired, and often is acquired, “on the job.”

scholarly journals Urban nature as a source of resilience during social distancing amidst the coronavirus pandemic

2020 ◽  
Author(s):  
Karl Samuelsson ◽  
Stephan Barthel ◽  
Johan Colding ◽  
Gloria Macassa ◽  
Matteo Giusti
Keyword(s):  
Public Space ◽  
Critical Role ◽  
Well Being ◽  
Good Health ◽  
Urban Nature ◽  
Urban Populations ◽  
Social Distancing ◽  
The Public ◽  
The World

The 2020 coronavirus pandemic caused countries across the world to implement measures of social distancing to curb spreading of COVID-19. The large and sudden disruptions to everyday life that result from this are likely to impact well-being, particularly among urban populations that live in dense settings with limited public space. In this paper, we argue that during these extraordinary circumstances, urban nature offers resilience for maintaining well-being in urban populations, while enabling social distancing. We discuss more generally the critical role of urban nature in times of crisis. Cities around the world need to take the step into the 21st century by accepting crises as a new reality and finding ways to function during these disturbances. Thus, maintaining or increasing space for nature in cities and keeping it accessible to the public should be part of the sustainability agenda, aiming simultaneously to strive towards SDG 3 (good health and well-being), and SDG 11 (sustainable and resilient cities).

scholarly journals Suicidal behaviour: genes, environmental stress and temperamental traits

Suicidologi ◽  
2015 ◽  
Vol 16 (2) ◽  
Author(s):  
Laura Mandelli ◽  
Vladimir Carli ◽  
Alessandro Serretti ◽  
Marco Sarchiapone
Keyword(s):  
Risk Factors ◽  
Environmental Stress ◽  
Personality Traits ◽  
Present Article ◽  
Suicidal Behaviour ◽  
Life Stress ◽  
Critical Role ◽  
Early Adversity ◽  
Multiple Risk Factors

Multiple risk factors have been involved in the risk for suicide and multiple trajectories have been hypothesized leading to suicidal behaviour. Consistent evidence suggests the involvement of heritable factors, as well as a critical role of life stress and early adversity. In the present article we will review the evidence for the involvement of genetic, environmental as well as personality traits in the risk for suicide, together with recent evidence supporting an interaction between these different factors.

scholarly journals Insights into the mysterious genetic variation profile oftprKinTreponema pallidumunder the development of natural human syphilis infection

2019 ◽  
Author(s):  
Dan Liu ◽  
Man-Li Tong ◽  
Yong Lin ◽  
Li-Li Liu ◽  
Li-Rong Lin ◽  
...  
Keyword(s):  
Amino Acid ◽  
Immune Evasion ◽  
High Frequency ◽  
Critical Role ◽  
Treponema Pallidum ◽  
Secondary Syphilis ◽  
Human Infection ◽  
Amino Acid Sequences ◽  
Potential Vaccine

AbstractAlthough the variations of thetprKgene inTreponema pallidumwere considered to play a critical role in the pathogenesis of syphilis, how actual variable characteristics oftprKin the course of natural human infection enabling the pathogen’s survive has thus far remained unclear. Here, we performed NGS to investigatetprKofT. pallidumdirectly from primary and secondary syphilis samples. Compared with diversity intprKof the strains from primary syphilis samples, there were more mixture variants found within seven V regions of thetprKgene among the strains from secondary syphilis samples, and the frequencies of predominant sequences within V regions oftprKwere generally decreased (less than 80%) with the proportion of minor variants in 10-60% increasing. Noteworthy, the variations within V regions oftprKalways obeyed a strict 3 bp changing pattern. AndtprKin the strains from the two-stage samples kept some stable amino acid sequences within V regions. Particularly, the amino acid sequences IASDGGAIKH and IASEDGSAGNLKH in V1 not only presented a high proportion of inter-population sharing, but also presented a relatively high frequency (above 80%) in the populations. Besides,tprKalways demonstrated remarkable variability in V6 at both the intra- and inter-strain levels regardless of the course. These findings unveiled that the different profile oftprK in T. pallidumdirectly from primary and secondary syphilis samples, indicating that throughout the development of syphilisT. pallidumconstantly varies its domaintprKgene to obtain the best adaptation to the host. While this changing was always subjected a strict gene conversion mechanism to keep an abnormal TprK. The highly stable peptides found in V1 would probably be promising potential vaccine components. And the highly heterogenetic regions (e.g. V6) could provide insight into the mysterious role oftprKin immune evasion.Author summaryAlthough the variations of thetprKgene inTreponema pallidumwere considered to play a critical role in the pathogenesis of syphilis, how actual variable characteristics oftprKin the course of natural human infection enabling the pathogen’s survive has thus far remained unclear. Here, we performed next-generation sequencing, a more sensitive and reliable approach, to investigatetprKofTreponema pallidumdirectly from primary and secondary syphilis patients, revealing that the profile oftprKinT. pallidumfrom the two-stage samples was different. Within the strains from secondary syphilis patients, more mixture variants within seven V regions oftprKwere found, the frequencies of their predominant sequences were generally decreased with the proportion of minor variants in 10-60% was increased. And the variations within V regions oftprKalways obeyed a strict 3 bp changing pattern. Noteworthy, the amino acid sequences IASDGGAIKH and IASEDGSAGNLKH in V1 presented a high proportion of inter-population sharing and presented a relatively high frequency in the populations. And V6 region always demonstrated remarkable variability at intra- and inter-patient levels regardless of the course. These findings provide insights into the mysterious role of TprK in immune evasion and for further exploring the potential vaccine components.

scholarly journals The Othering of Islam in a European Context

2008 ◽  
Vol 29 (2) ◽  
pp. 295-308 ◽  
Author(s):  
Karin Creutz-Kämppi
Keyword(s):  
Present Article ◽  
Historical Perspective ◽  
Media Representations ◽  
The Other ◽  
European Context ◽  
The World

Abstract Media representations of Islam mostly appear in the Finnish media in connection with events in other parts of the world. In this context, Islam is often treated as something distant and ascribed the role of the Other. These representations function as definers for collective categorizations, having an impact on which categories for self-identifications are relevant in specific cases. The aim of the present article is to discuss othering discourses on Islam in Swedish-language dailies in Finland on the basis of the debate following the cartoons of the Prophet Muhammad. These discourses build upon a broader tradition of othering and have a great deal in common with medieval representations, thus the othering of Islam in a historical perspective is also briefly discussed.

scholarly journals JOHANA NJUMBI (1886–1991): THE PIONEER AFRICAN LEADER IN MUTIRA MISSION

2016 ◽  
Vol 1 (1) ◽  
pp. 74-95 ◽  
Author(s):  
Julius Gathogo
Keyword(s):  
20Th Century ◽  
Social Life ◽  
Critical Role ◽  
Mandatory Retirement ◽  
Retirement Age ◽  
Extensive Literature ◽  
Maternal Role ◽  
Modern Education ◽  
The World

The article sets out to retrieve the critical role of the pioneer African clergyman, Johana Njumbi (1886–1991), in the Mutira mission of Kirinyaga, Kenya. Despite the death of the first wife in 1921, and the second one in 1952, Njumbi surged on to provide leadership in the new socioreligious dispensation following the introduction of Christianity in the first half of the 20th century. His stewardship is seen in his emphasis on ‘modern’ education, farming and medical services. As Mutira mission marked one hundred years of missionary Christianity (1912–2012), in August 2012, it is imperative to assess the pedigree and the religious-social life times of the key character who contributed immensely in mid-wifing Christianity and modern education in an area hitherto unknown in the map of the world. In so doing, Njumbi catapulted the desolate hills and valleys of Mutira mission into greater heights of human progress. As the area produced its second Bishop, Joseph Karimi Kibucwa, in December 2012, after Daniel Munene Ngoru proceeded to his retirement upon reaching the mandatory retirement age of 65, one cannot fail to see the fruits of the pioneer clergy who persuaded the reluctant locals to ‘accept the white man’s religion and education as our own’ under difficult circumstances. In other words, did Njumbi’s leadership leave a lasting legacy in Mutira mission? Does the maternal role of Canon Njumbi’s wife, Agness Wambui (1914–1952), have any relevance for African motherhood today? The materials in this article are gathered mainly through oral interviews, reading of extensive literature and archival sources.

scholarly journals Primary cilia respond to intermittent low-magnitude, high-frequency vibration and mediate vibration-induced effects in osteoblasts

2020 ◽  
Vol 318 (1) ◽  
pp. C73-C82 ◽  
Author(s):  
Yan-Hui Li ◽  
Dong Zhu ◽  
Zongbing Cao ◽  
Yanwei Liu ◽  
Jian Sun ◽  
...  
Keyword(s):  
Western Blot ◽  
Blot Analysis ◽  
High Frequency ◽  
Western Blot Analysis ◽  
Primary Cilia ◽  
Critical Role ◽  
Rt Pcr ◽  
High Frequency Vibration ◽  
Low Magnitude

Our objective was to investigate the role of primary cilia in low-magnitude, high-frequency vibration (LMHFV) treatment of MC3T3-E1 osteoblasts (OBs). We used chloral hydrate (CH), which has a well-characterized function in chemically removing primary cilia, to elucidate the role of primary cilia in LMHFV-induced OB osteogenic responses through cell viability assay, Western blot analysis, real-time quantitative RT-PCR, and histochemical staining methods. We observed a significant, 30% decrease in the number of MC3T3-E1 OBs with primary cilia (reduced from 64.3 ± 5%) and an approximately 50% reduction in length of primary cilia (reduced from 3 ± 0.8 μm) after LMHFV stimulation. LMHFV stimulation upregulated protein expression of the bone matrix markers collagen 1 (COL-1), osteopontin (OPN), and osteoclacin(OCN) in MC3T3-E1 OBs, indicating that LMHFV induces osteogenesis. High-concentration or long-duration CH exposure resulted in inhibition of MC3T3-E1 OB survival. In addition, Western blot analysis and RT-PCR revealed that CH treatment prevented LMHFV-induced osteogenesis. Furthermore, decreased alkaline phosphate activity, reduced OB differentiation, mineralization, and maturation were observed in CH-pretreated and LMHFV-treated OBs. We showed that LMHFV induces morphological changes in primary cilia that may fine-tune their mechanosensitivity. In addition, we demonstrated the significant inhibition by CH of LMHFV-induced OB mineralization, maturation, and differentiation, which might reveal the critical role of primary cilia in the process.

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