scholarly journals STUDY OF THE IN VITRO LIPOPROTEIN PLASMASORPTION AND PHYSICOCHEMICAL PROPERTIES OF POLYMERIC SORBENTS WITH SUBSTITUTED AMINO GROUPS

2020 ◽  
Vol 17 (34) ◽  
pp. 188-199
Author(s):  
Elena Vladimirovna DORSKAIA ◽  
Sergei Mihaylovich PESTOV
Keyword(s):  
Lipid Profile ◽  
Propylene Glycol ◽  
Theoretical Calculations ◽  
Chemical Properties ◽  
Exchange Capacity ◽  
Dust Particles ◽  
Polymeric Sorbents ◽  
Liquid Phases ◽  
Total Exchange Capacity

Currently, the plasmasorption method is widely used in clinical practice to remove excessive amounts of metabolites that cause various pathologies. However, the plasmasorbents applied often can give a number of side effects for the patient, such as the blood clotting, the release of dust particles, and the sorption of useful components from the plasma. Besides that, they can be quite expensive. The aim of the work was to create available plasmasorbents with a good hemocompatibility for the lipoprotein adsorption from the plasma. A number of anion exchangers with groups of trimethylamine, monoethanolamine, and triethanolamine were synthesized. For the sorbents obtained, adsorption and physico-chemical properties were investigated. Bulk density, specific volume at swelling, the swelling coefficient in various solvents (water, ethanol, isopropanol, propylene glycol, acetone) were determined and the theoretical calculations of total exchange capacity and crosslinking mass and molar fractions were made. It was found that the best swelling is achieved in propylene glycol. For the sorbents LP27 and LP29, the capacities on triglyceride and lipoprotein fractions and the coefficient of distribution of lipid profile components between the solid and liquid phases were determined. It is shown that both sorbents have good sorption properties, the sample LP29 being quite promising for the lipid profile components extraction. The developed sorbents are assumed to be cheaper than currently used ones as they are synthesized on the basis of commercially available matrix. The results obtained are expected to be useful for further investigations aimed at the modern plasmasorption technology quality improvement.

Propylene Glycol Plasma Level

PEDIATRICS ◽  
1985 ◽  
Vol 76 (4) ◽  
pp. 654-654
Author(s):  
ALLEN M. GLASGOW ◽  
ROGER L. BOECKX ◽  
MARILEA K. MILLER ◽  
MHAIRI G. MACDONALD ◽  
GILBERT P. AUGUST ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Plasma Level ◽  
Propylene Glycol ◽  
Theoretical Calculations ◽  
Linear Regression Analysis ◽  
Chemical Properties ◽  
Typographical Error ◽  
Correct Formula ◽  
Derived Data ◽  
Osmolal Gap

In Reply.— We thank Dr Hall and his associates for pointing out the typographical error in our formula for estimating propylene glycol concentration from osmolal gap.1 The correct formula is, as presumed by Hall et al, propylene glycol (mg/dL) = 47.5 + (osmolal gap x 9.2). It is important to remember that both our formula and that developed by Fligner et al2 are determined from linear regression analysis of experimentally derived data and are not theoretical calculations based on chemical properties of propylene glycol.

scholarly journals The effect of filter-press cake on the physical and chemical properties of soils

1969 ◽  
Vol 37 (3) ◽  
pp. 213-223
Author(s):  
M. A. Lugo-López ◽  
E. Hernández-Medina ◽  
H. R. Cibes-Viadé ◽  
J. Vicente-Chandler
Keyword(s):  
Press Cake ◽  
Chemical Properties ◽  
Exchange Capacity ◽  
Filter Press ◽  
Soil Conditions ◽  
Available Phosphorus ◽  
Silty Clay ◽  
Undisturbed Soil ◽  
Total Exchange Capacity ◽  
Chemical Properties Of Soils

Data are presented here on soil conditions at the Arecibo and Corozal filter-press-cake experimental fields 18 months after establishing the treatment differentials. The experiments were located on a Bayamón silty clay and a Lares clay, respectively, both representative of the group of soils generally used for growing pineapples in the northern and interior districts of the Island. A previous report indicated that maximum yields of pineapple in the Arecibo region could be obtained with applications of 1,500 pounds to the acre of a 12-6-10 fertilizer, if applications of filter-press cake were made at the rate of 32 tons to the acre. At Corozal, however, both heavy applications of filter-press cake (32 tons) and of fertilizer (3,000 pounds) were necessary for obtaining maximum yields. Soil samples were taken from the top 6 inches at both locations and analyzed for pH, nitrogen, organic matter, total exchange capacity, exchangeable calcium, magnesium, and manganese, and available phosphorus and iron. In addition, undisturbed soil cores were taken at Corozal and data were gathered on the permeability, rapidity of drainage, maximum saturation, water retained at various tensions, porosity, and bulk density. Although no significant differences were obtained in most cases, some trends were observed, such as the retention of larger quantities of available moisture at low tensions in a state of ready availability for plants by soils to which filter-press cake was added than by those to which only fertilizer was applied. The C/N ratios were narrow in all cases, indicative of quick decomposition of the organic residues after application.

’Propylene glycolate’ used as a top coat seal to protect thick juice from degradation in ellipsoidal storage tanks

2013 ◽  
pp. 215-218
Author(s):  
Robert O. Hatch ◽  
Craig M. Giles ◽  
Jay S. Creiglow ◽  
David R. Smith
Keyword(s):  
Propylene Glycol ◽  
Barrier Layer ◽  
Chemical Properties ◽  
Polypropylene Glycol ◽  
Storage Tanks ◽  
First Results ◽  
Thick Juice

The use of sodium propylene glycol for thick juice storage was investigated at Spreckels Sugar Company, in Brawley, California (USA). Sodium-polypropylene glycol has a density of 1.07 and does not mix with thick juice. Therefore it is suitable as a barrier layer. Chemical properties of propylene glycol, and the deposition on the top of thick juice are described. First results of the last campaign are compared with data from previous years. A significantly lower tendency in the reduction of the quality of the thick juice was found.

Development and Ex-vivo Evaluation of Topiramate Mucoadhesive Nanoparticles for Intranasal Delivery

2020 ◽  
Vol 13 (6) ◽  
pp. 5250-5255
Author(s):  
Ashwin Kumar Tulasi ◽  
Anil Goud Kandhula ◽  
Ravi Krishna Velupula
Keyword(s):  
Particle Size ◽  
Nasal Mucosa ◽  
Intranasal Administration ◽  
Ex Vivo ◽  
Chemical Properties ◽  
Brain Targeting ◽  
Oral Tablet ◽  
Promising Alternative ◽  
Ex Vivo Permeation

Topiramate is a second-generation antiepileptic drug used in partial, generalized seizures as an oral tablet. Oral route of administration is most convenient but shows delayed absorption. Moreover, in emergency cases, parenteral administration is not possible as it requires medical assistance. Hence, the present study was aimed to develop topiramate mucoadhesive nanoparticles for intranasal administration using ionotropic gelation method. The developed nanoparticles were evaluated for physico-chemical properties like particle size, zeta potential, surface morphology, drug content, entrapment efficiency, in vitro drug release, mucoadhesive strength, and ex vivo permeation studies in excised porcine nasal mucosa. Optimized nanoparticle formulation (T9) was composed oil mucoadhesive agent (Chitosan 1% w/w), cross linking polymer (TPP) and topiramate 275mg, 100mg and 4% respectively. It showed particle size of 350nm, high encapsulation efficacy and strong mucoadhesive strength. In vitro drug diffusion of optimized formulation showed 95.12% release of drug after 180min. Ex-vivo permeation of drug across nasal mucosa was   88.05 % after 180min. Nasocilial toxicity studies showed optimized formulation did not damage the nasal mucosa. Thus, the intranasal administration of topiramate using chitosan can be a promising alternative for brain targeting and the treatment of epilepsy.

New Platinum (II) Ternary Complexes of Formamidine and Pyrophosphate: Synthesis, Characterization and DFT Calculations and In vitro Cytotoxicity

2020 ◽  
Vol 23 (7) ◽  
pp. 611-623
Author(s):  
Ahmed A. Soliman ◽  
Fawzy A. Attaby ◽  
Othman I. Alajrawy ◽  
Azza A.A. Abou-hussein ◽  
Wolfgang Linert
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Theoretical Calculations ◽  
Thermal Analyses ◽  
Cancer Cell Line ◽  
Cellular Growth ◽  
Planar Geometry ◽  
Square Planar ◽  
Vis Spectroscopy

Aim and Objective: Platinum (II) and platinum (IV) of pyrophosphate complexes have been prepared and characterized to discover their potential as antitumor drugs. This study was conducted to prepare and characterize new ternary platinum (II) complexes with formamidine and pyrophosphate as an antitumor candidate. Materials and Methods: The complexes have been characterized by mass, infrared, UV-Vis. spectroscopy, elemental analysis, magnetic susceptibility, thermal analyses, and theoretical calculations. They have been tested for their cytotoxicity, which was carried out using the fastcolorimetric assay for cellular growth and survival against MCF-7 (breast cancer cell line), HCT- 116 (colon carcinoma cell line), and HepG-2 (hepatocellular cancer cell line). Results: All complexes are diamagnetic, and the electronic spectral data displayed the bands due to square planar Pt(II) complexes. The optimized complexes structures (1-4) indicated a distorted square planar geometry where O-Pt-O and N-Pt-N bond angles were 82.04°-96.44°, respectively. Conclusion: The complexes showed noticeable cytotoxicity and are considered as promising antitumor candidates for further applications.

Flavonoids Extracted from Asteriscus graveolens Improve Glucose Metabo-lism and Lipid Profile in Diabetic Rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Fadwa El-ouady ◽  
Fatima Bachir ◽  
Mohamed Eddouks
Keyword(s):  
Glucose Tolerance ◽  
Lipid Profile ◽  
Histopathological Examination ◽  
Oral Treatment ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Traditional Use ◽  
Soxhlet Apparatus

Aim: This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of Asteriscus graveolens. Background: Asteriscus graveolens (Asteraceae) is a medicinal plant widely used by the Moroccan population to treat various diseases including diabetes. Objective: This work aimed to assess the capacity of flavonoids extracted from Asteriscus graveolens (FEE) to improve diabetes mellitus and dyslipidemia in normal and STZ-induced diabetic rats. Methods: Flavonoids were extracted from A. graveolens using the Soxhlet apparatus and using different organic solvents. Normal and streptozotocin-induced diabetic rats were treated orally by the extract of A. graveolens at a dose of 10 mg/kg. The oral treatment during 15 days was used to evaluate the effect of the flavonoids extracted from A. graveolens on blood glucose level and lipid profile in normal and diabetic rats. The oral glucose tolerance test as well as the analysis of histopathological examination of liver was performed. The antioxidant activity of FEE was also assessed by the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl (DPPH), in order to estimate the mechanisms of action involved by FEE to improve hyperglycemia and lipid profile in normal and diabetic rats. Results: FEE reduced serum glucose concentrations in both normal and diabetic rats and exhibited in the last group lowering total cholesterol and triglycerides effects as well as improvement of the HDL-cholesterol serum level. In addition, a remarkable influence on glucose tolerance was also noticed after FEE treatment. Moreover, FEE was able to improve histopathological status of liver and possess a potential antioxidant effect in vitro. Conclusion: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of FEE in rats supporting then its traditional use for the management of diabetes.

The effect of partial exchange of sulphonated macroporous styrene-divinylbenzene copolymers for different ions on their catalytic activity

1981 ◽  
Vol 46 (10) ◽  
pp. 2354-2363 ◽  
Author(s):  
Svatomír Kmošták ◽  
Karel Setínek
Keyword(s):  
Catalytic Activity ◽  
Transition Metal ◽  
Metal Ions ◽  
Gas Phase ◽  
Transition Metal Ions ◽  
Exchange Capacity ◽  
Total Exchange Capacity ◽  
Styrene Divinylbenzene ◽  
Na Ions ◽  
Type Of Transition

The catalytic activity of sulphonated macroporous styrene-divinylbenzene copolymers, the exchange capacity of which was neutralized from 30, 50 and 80% by Fe(III) ions and from 30% by Na ions and that of Wofatit Y-37 ion exchanger neutralized from 10% of its total exchange capacity by several transition metal ions and by sodium has been studied in isomerisation of cyclohexene and dehydration of 1-propanol in the gas phase at 130 °C. It was demonstrated that in both reactions transition metal ions exhibit additional effect to the expected neutralization of the polymer acid groups. In the case of cyclohexene isomerization, this effect depends on the degree of crosslinking of polymer mass of the catalyst. Such dependence has not been, however, observed in dehydration of 1-propanol. The type of transition metal ions did not exhibit any significant effect on the catalytic activity of the polymer catalysts studied.

scholarly journals Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 883
Author(s):  
Mebeaselassie Andargie ◽  
Maria Vinas ◽  
Anna Rathgeb ◽  
Evelyn Möller ◽  
Petr Karlovsky
Keyword(s):  
Biological Activities ◽  
Chemical Properties ◽  
Transformation Products ◽  
Extensive Literature ◽  
Controversial Issues ◽  
Sesame Seeds ◽  
Historical Texts ◽  
Health Promoting ◽  
Processed Products

Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans. Sesamol, sesaminol, its epimers, and episesamin are transformation products found in processed products. Synthetic routes to all lignans are known but only sesamol is synthesized industrially. Biosynthesis of furofuran lignans begins with the dimerization of coniferyl alcohol, followed by the formation of dioxoles, oxidation, and glycosylation. Most genes of the lignan pathway in sesame have been identified but the inheritance of lignan content is poorly understood. Health-promoting properties make lignans attractive components of functional food. Lignans enhance the efficiency of insecticides and possess antifeedant activity, but their biological function in plants remains hypothetical. In this work, extensive literature including historical texts is reviewed, controversial issues are critically examined, and errors perpetuated in literature are corrected. The following aspects are covered: chemical properties and transformations of lignans; analysis, purification, and total synthesis; occurrence in Seseamum indicum and related plants; biosynthesis and genetics; biological activities; health-promoting properties; and biological functions. Finally, the improvement of lignan content in sesame seeds by breeding and biotechnology and the potential of hairy roots for manufacturing lignans in vitro are outlined.

scholarly journals Nanovesicles Loaded with Origanum onites and Satureja thymbra Essential Oils and Their Activity against Food-Borne Pathogens and Spoilage Microorganisms

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2124
Author(s):  
Giulia Vanti ◽  
Ekaterina-Michaela Tomou ◽  
Dejan Stojković ◽  
Ana Ćirić ◽  
Anna Rita Bilia ◽  
...  
Keyword(s):  
Essential Oils ◽  
Propylene Glycol ◽  
Antimicrobial Properties ◽  
Spherical Shape ◽  
Food Borne Pathogens ◽  
Food Borne ◽  
Spoilage Microorganisms ◽  
Satureja Thymbra ◽  
Origanum Onites

Food poisoning is a common cause of illness and death in developing countries. Essential oils (EOs) could be effective and safe natural preservatives to prevent and control bacterial contamination of foods. However, their high sensitivity and strong flavor limit their application and biological effectiveness. The aim of this study was firstly the chemical analysis and the antimicrobial evaluation of the EOs of Origanum onites L. and Satureja thymbra L. obtained from Symi island (Greece), and, secondly, the formulation of propylene glycol-nanovesicles loaded with these EOs to improve their antimicrobial properties. The EOs were analyzed by GC-MS and their chemical contents are presented herein. Different nanovesicles were formulated with small average sizes, high homogeneity, and optimal ζ-potential. Microscopic observation confirmed their small and spherical shape. Antibacterial and antifungal activities of the formulated EOs were evaluated against food-borne pathogens and spoilage microorganisms compared to pure EOs. Propylene glycol-nanovesicles loaded with O. onites EO were found to be the most active formulation against all tested strains. Additionally, in vitro studies on the HaCaT cell line showed that nanovesicles encapsulated with EOs had no toxic effect. The present study revealed that both EOs can be used as alternative sanitizers and preservatives in the food industry, and that their formulation in nanovesicles can provide a suitable approach as food-grade delivery system.

Sign in / Sign up

Export Citation Format

Share Document