Evaluation of Anti-Ulcer activity of Tephrosia purpurea Linn Pers Leaf Extract in Wistar Rats

2021 ◽  
pp. 174-178
Author(s):  
D. Benito Johnson ◽  
Sivasakthi R. ◽  
Nazzneen M.V ◽  
Venkatanarayanan R.
Keyword(s):  
Histidine Decarboxylase ◽  
Decisive Role ◽  
Antiulcer Activity ◽  
Phytochemical Analysis ◽  
Histamine Secretion ◽  
Once Daily ◽  
Tephrosia Purpurea ◽  
Pylorus Ligation ◽  
Rig Veda ◽  
Pyloric Ligation

India is known for its traditional medicinal system – Ayurveda, Siddha and Unani. There are several references in our ancient literature about the miraculous curing properties of the plant-based drugs. “Rig Veda and Atharva veda” seems to be the earliest record of use of plant in the medicine. A stomach ulcer involves an erosion in a person’s gastrointestinal tract. ‘Peptic’ is derived from Greek word “Peptikos” who’s meaning is related to digestion. Peptic ulcer occurs in the part of the gastrointestinal track which is exposed to gastric acid and pepsin (i.e) the stomach and duodenum. The extract of Tephrosia purpurea flowers against viruses and is very good antibacterial against Gram +ve and Gram -ve strain. The Plant extract was prepared and the phytochemical analysis was performed. The extract was administered with animals. The drug were administered orally once daily for 2 days and 45 min prior to pyloric ligation. The animals are sacrificed after four hours of pylorus ligation. The result indicates that, Flavonoids and Tannins have shown to be present in the TPAL treated groups. Since flavanoids antagonize aggressive factor which play a decisive role in the pathogenesis of gastric lesion and also enhance defence factor to protect the gastric mucosa from injury. Flavanoids diminish histamine secretion from mast cell by inhibition of histidine decarboxylase and stimulate PG biosynthesis. So the antiulcer activity of TPAL may be attributed to its flavonoid content. The study concluded that TPAL has an anti ulcer activity which may be due to protection and the strengthening of the mucosal defensive factor like mucus, bicarbonate, prostaglandin.

scholarly journals Cytoprotective Effect of Morinda tinctoria Roxb. against Surgical and Chemical Factor Induced Gastric and Duodenal Ulcers in Rats

Ulcers ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
D. Sivaraman ◽  
P. Muralidharan
Keyword(s):  
Gastric Juice ◽  
Ion Concentration ◽  
Antiulcer Activity ◽  
Duodenal Ulcers ◽  
Pylorus Ligation ◽  
Gastric Cytoprotection ◽  
Ulcer Model ◽  
Dose Levels ◽  
Pyloric Ligation ◽  
Morinda Tinctoria

The present paper relates to the pharmacological validation of the antiulcer efficacy of ethanol leaf extract of Morinda tinctoria Roxb. (EEMT) against aspirin pyloric ligation-induced gastric ulcer model and cysteamine-induced duodenal ulcer in Wistar rats. Oral administration of EEMT at a dose of 200 and 400 mg/kg significantly prevented the occurrence of aspirin pyloric ligation and cysteamine-induced gastric and duodenal ulceration. The volume and acidity of gastric juice in pyloric ligated rats were significantly () reduced by EEMT. There was a significant decrease in the number of ulcers, and its severity in both the models proved the ulcer protective activity of EEMT. Administration of extract at both dose levels has shown a significant increase in potassium and sodium ion concentration in the gastric juice of pylorus ligation group. On the basis of these observations, we concluded that EEMT possessing antiulcer activity may be due to the modulation of defensive factors by improvement in gastric cytoprotection.

ANTIULCER AND ANTI-INFLAMMATORY ACTIVITIES OF HYDROALCOHOLIC EXTRACTS OF STEM BARK AND LEAF OF ANOGEISSUS PENDULA EDGEW

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (01) ◽  
pp. 41-46
Author(s):  
Deeksha Singh ◽  
◽  
Amit Nayak ◽  
Rakesh Yadav ◽  
Uttam Singh Baghel ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Stem Bark ◽  
Inflammatory Activity ◽  
Antiulcer Activity ◽  
Paw Edema ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Anti Inflammatory ◽  
Anogeissus Pendula

Anogeissus pendula Edgew has been reported to be used in gastric disorder even though no attempt has been made to evaluate the same. The present study was designed to evaluate the hydroalcoholic extracts of stem bark and leaves for in vivo acute antiulcer and anti-inflammatory activities. Antiulcer activity was studied by pylorus ligation induced ulcers while anti-inflammatory activities was studied by carrageenan induced paw edema. The extract of stem bark at 200 and 400 mg/kg b. w., significantly (P<0.05) reduced ulcer index whereas extracts of both stem bark and leaves significantly (P<0.001) reduced paw diameter at the fifth hour. The hydroalcholic extract of stem bark of A. pendula possesses more significant antiulcer and anti-inflammatory activity than the hydroalcholic extract of leaves may be due to the presence of higher amount of phenolic compounds.

scholarly journals Evaluation of anti ulcer activity of ethanolic root extract of Beta vulgaris in rats

2017 ◽  
Vol 6 (2) ◽  
pp. 359 ◽  
Author(s):  
K. Samyuktha ◽  
Krishna Mohan Chinnala ◽  
G. Prathiba ◽  
D. Rajendhar ◽  
P. Smana Reddy
Keyword(s):  
Beta Vulgaris ◽  
Maximum Dose ◽  
Antiulcer Activity ◽  
Root Extract ◽  
Alcoholic Extract ◽  
Free Acidity ◽  
Phytochemical Screening ◽  
Ulcer Index ◽  
Medicinal Uses ◽  
Pylorus Ligation

Background: Beta vulgaris (chenopodiacea) is a plant reported for its variety of ethnic medicinal uses. Hence we have planned to screen anti ulcer activity of root of the plant with the alcoholic extract. Root powders successively extracted with alcohol and were subjected for phytochemical screening to identify different phytoconstituents.Methods: Anti ulcer activity was evaluated in various animal models like pylorus ligation and ethanol induced ulcer models in rats.Results: Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, carbohydrates, saponins, polyphenols. No mortality was observed with root extract up to maximum dose level of 4g/kg. Further alcoholic extract of 200 and 400mg/ kg / p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pylorus ligation and ethanol induced ulcer models in rats.Conclusions: The present study revealed that the root extract of Beta vulgaris has antiulcer activity.

Comparing Nutritional Quality, Antioxidant, and Antiulcer Activity of Two Amaranthaceae Plants: Achyranthes aspera and Amaranthus spinosus

2020 ◽  
Vol 19 (4) ◽  
pp. 493-500
Author(s):  
Adebimpe Esther Ofusori ◽  
Roshila Moodley ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Antioxidant Activity ◽  
Inductively Coupled Plasma ◽  
Radical Scavenging ◽  
Emission Spectrometry ◽  
Antiulcer Activity ◽  
Phytochemical Analysis ◽  
Pheophytin A ◽  
Antioxidant Power ◽  
Achyranthes Aspera ◽  
Amaranthus Spinosus

Achyranthes aspera and Amaranthus spinosus are species of medicinal plants from the Amaranthaceae family, used to treat wounds, asthma, malaria, gonorrhea, burns, and diabetes. In this study, the nutritional value and phytochemical constituents in A. aspera and A. spinosus were determined using inductively coupled plasma-optical emission spectrometry and column chromatography, respectively. The antiulcer activity was determined using the α-chymotrypsin assay while the antioxidant activity was evaluated using the 2, 2-diphenyl-1-picrylhydrazyl radical scavenging assay, ferric reducing antioxidant power, and phosphomolybdate assay. The results showed leaves of A. spinosus to contribute between 43.4% and 97.8% toward the recommended dietary allowance for iron; therefore, it is recommended for consumption by patients suffering from chronic anemia. Arsenic, cadmium, and lead were not detected in the leaves of the two species giving credence to their use as nutraceuticals in South Africa while the concentration of cobalt, nickel, and selenium were below the detection limit of the instrument. The phytochemical analysis resulted in the isolation of oleanolic acid, lutein, pheophytin a, and chondrillasterol glucoside. The antioxidant activity was high for lutein, ethyl acetate extract from A. aspera, chondrillasterol glucoside, and the methanol extract from A. spinosus, relative to the control. The antiulcer activity using the α-chymotrypsin inhibition assay showed lutein to have maximum chymotrypsin inhibitory activity. Findings from this study show lutein, pheophytin a, chondrillasterol, and its derivatives to serve as potential taxonomic markers for species in the Amaranthaceae family.

scholarly journals Evaluation of anti-ulcer activity of 4-hydrooxy benzalydehide against NSAIDs induced ulcers in rats

2021 ◽  
Vol 9 (5) ◽  
pp. 1412
Author(s):  
Rupali V. Jadhav ◽  
V. K. Redasani ◽  
Shankar B. Kalbhare ◽  
Karishma Yadav ◽  
Aryan Langeh ◽  
...  
Keyword(s):  
Low Dose ◽  
Positive Control ◽  
Gastric Volume ◽  
Control Group ◽  
High Dose ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
The Impact ◽  
Intermediate Dose

Background: The aim of this study was to evaluate antiulcer activity of 4-hydroxybenzaldehyde against NSAIDs induced ulcer in rats based differences in its morphology, distance with other external landmarks and also to sigmoid and transverse sinuses.Methods: The antiulcer activity of 4-HBD was evaluated using pylorus ligation-aspirin induced ulcer method. Animals of this models were treated with 4-HBD (50mg/kg, 100mg/kg and 150mg/kg).Results: It has been observed that 4-HBD at low dose (50mg/kg), intermediate dose (100mg/kg) and high dose (150mg/kg) showed significant increase in pH, significant decrease in gastric volume, significant decrease in ulcer index and significant decrease in total acidity.Conclusions: The impact of 4-HBD therapy with intermediate (100mg/kg, p.o.) dose was observed to be similar with the positive control group.  

Phytochemical Analysis of Couropita guianesis Aubl of Leaves

2021 ◽  
pp. 4161-4164
Author(s):  
Shweta R. Patil ◽  
Savita S. Satpute ◽  
Shitalkumar S. Patil
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Anticancer Activity ◽  
Antiulcer Activity ◽  
Phytochemical Analysis ◽  
Pharmacological Effects ◽  
Active Compounds ◽  
Anthelminthic Activity ◽  
Couroupita Guianensis ◽  
Phenolic Substances

Couroupita guianensis Aubl is also called as “Cannon ball tree”. The tree has enormous medicinal values since most of the parts like leaves; flower, fruits and stem are used as medicine to cure various diseases. During the last few decades it has been observed that there are numerous reports on anti-inflammatory activity, antiulcer activity, anticancer activity, antioxidant activity, anthelminthic activity of this plant. It is enriched with a number of compounds such as oils, ketosteroids, glycosides, courouptine, indirubin, isatin and phenolic substances. Phytochemical analysis of the extract showed the presence of major classes of phytochemicals alkaloids, phenolic compounds such as flavonoids, tannins and saponins. Studies reveal that C. guianensis. Aubl. Is a source of medicinally active compounds and have various pharmacological effects.

Pharmacological Evaluation of Saccharum Officinarum Linn. as Anti-ulcer Agent

2018 ◽  
Vol 4 (1-2) ◽  
Author(s):  
Preksha Dwivedi ◽  
Vikas Mishra ◽  
Vipul Agarwal ◽  
Talha Jawaid
Keyword(s):  
Gastric Ulcer ◽  
Gastric Content ◽  
Index Volume ◽  
Saccharum Officinarum ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Significant Protection ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Plant Stem

The purpose of the study was to elucidate the antiulcer activity of stem of Saccharum Officinarum (Poaceae) in albino rats against aspirin induced gastric ulcer, ethanol induced gastric ulcer and pylorus ligation induced gastric ulcer models. Groups of rats were fasted overnight, received ranitidine (20 mg/kg) as a standard and plant stem juice extract at dose of 0.75 mL/100 gm and 1.5 mL/100 gm as a treatment against aspirin induced gastric ulcer, ethanol induced gastric ulcer and pylorus ligation induced gastric ulcer. The treatment produced significant protection of ulcer induced by aspirin, ethanol and pylorus ligation induced ulcer. The extract also reduced ulcer index, volume of gastric content, free and total acidity, suggesting that extract possesses significant anti-ulcer activity.

scholarly journals ANTIOXIDANT AND ANTIULCER ACTIVITY OF ABRUS PRECATORIUS LEAF EXTRACT AGAINST ACETIC ACID-INDUCED GASTRIC ULCER IN RATS

2019 ◽  
pp. 218-220
Author(s):  
LALITA NAGDA ◽  
CHANDRA PRAKASH JOSHI ◽  
JYOTI MENARIA
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Leaf Extract ◽  
Defense Mechanism ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Plant Leaves ◽  
Once Daily ◽  
Abrus Precatorius

Objective: The present study deals with the study of antiulcer activity of Abrus precatorius leaf extract in acetic acid-induced gastric ulcers was studied in rats. Methods: In the present study, A. precatorius leaf extract was carried out in antiulcer activity against acetic acid-induced gastric ulcer in rats. A. precatorius at doses of 150 mg/kg and 300 mg/kg were administered orally once daily for 10 days. Results: It was found that extract significantly reduced ulcer index. The plant leaves made gastric anti-secretory effect by decreasing gastric volume and acidity. Then, gastric mucin was increased, which showed gastric cytoprotective effect. The plant showed the prevention effect of increased lipid peroxidation during ulceration by acetic acid. Activities of the antioxidant enzymes were enhanced during ulceration by this plant leaves. Conclusion: Leaves of A. precatorius Linn. could decrease acetic acid-induced gastric ulcers in rats and this antiulcerogenic activity was mediated through antioxidant defense mechanism.

scholarly journals Antiulcer Activity of Methanolic Extract of Roots of Beta vulgaris, Chenopodiaceae

2018 ◽  
Vol 10 (6) ◽  
Author(s):  
Manoj Jagannath Jagtap ◽  
Amol Bhalchandra Deore
Keyword(s):  
Beta Vulgaris ◽  
Restraint Stress ◽  
Methanolic Extract ◽  
Gastric Lesion ◽  
Abnormal Behavior ◽  
Antiulcer Activity ◽  
Phytochemical Screening ◽  
Cold Restraint Stress ◽  
Pyloric Ligation ◽  
Cold Restraint

Beta vulgaris (chenopodiacea) is a medicinal plant reported for its variety of ethnic medicinal uses. Beta vulgaris showed antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti-inflammatory activities. Hence we have planned to screen antiulcer activity of root of the plant with the methanolic extract. Root powders successively extracted with methyl alcohol and were subjected for phytochemical screening to identify different phytoconstituents. The methanolic extracts of roots of Beta vulgaris were investigated for ulcer protective activity against pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcers. Preliminary phytochemical screening revealed the presence of flavonoids, saponins, sterols, and alkaloids. The extract was tested for their lethal effect up to the dose level of 2000 mg/kg. None of them have produced abnormal behavior or mortality in rats. Further methanolic extract of 200 and 400 mg/kg/p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcer models in rats. The present study revealed that the root extract of Beta vulgaris has antiulcer activity.

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