Subchronic oral toxicity of Rabella powder in experimental rats

2021 ◽  
Vol 148 (12) ◽  
pp. 78-85
Author(s):  
Pham Thi Van Anh ◽  
Tran Thai Ha ◽  
Ta Minh Nguyet ◽  
Dinh Thi Thu Hang
Keyword(s):  
Current Trend ◽  
World Health ◽  
Oral Toxicity ◽  
Subchronic Toxicity ◽  
The Past ◽  
Prevalence Of Obesity ◽  
Treatment Of Obesity ◽  
Health Organization ◽  
Oral Doses ◽  
A Current

It has recently become obvious that the prevalence of obesity has been rapidly increasing in Vietnam, as well as other countries, over the past two decades. There has been a current trend for researchers to discover new natural ingredients which are safe and effective in the treatment of obesity. RABELLA powder was a herbal-derived product which contained Amorphophalus konjac (K. Koch starch). This plant was used as an oral medication for controlling body weight in the past as well as in the present. So far, the safety of this product, has not been reported yet in Vietnam. Thus, this study was designed to assess the subchronic toxicity of RABELLA powder in Wistar rats. The method used in this study followed the guidance of the World Health Organization and Organization for Economic Co-operation and Development; 2 oral doses of 1.2 g/kg b.w/day and 3.6 g/kg b.w/day was administered to rats for 12 consecutive weeks. The results show that RABELLA powder caused no significant change in the general condition, hematological indexes, functions and microscopic images of livers and kidneys. We conclude that RABELLA powder did not cause subchronic toxicity in experimental rats. Moreover, this also revealed partly the safety of RABELLA powder in clinical practice.

scholarly journals Time trends in socio-economic, urban-rural and regional disparities in prevalence of obesity among non-pregnant women in Lesotho: evidence from Lesotho demographic and health surveys (2004–2014)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Betregiorgis Zegeye ◽  
Gebretsadik Shibre ◽  
Gashaw Garedew Woldeamanuel
Keyword(s):  
Pregnant Women ◽  
Health Surveys ◽  
Educational Inequality ◽  
Statistical Significance ◽  
World Health ◽  
Demographic And Health Surveys ◽  
Obesity Prevalence ◽  
Urban Rural ◽  
Prevalence Of Obesity ◽  
Health Organization

Abstract Background The growing rates of obesity in developing countries are alarming. There is a paucity of evidence about disparities of obesity in Lesotho. This study examined socioeconomic and area-based inequalities in obesity among non-pregnant women in Lesotho. Methods Data were extracted from the 2004, 2009 and 2014 Lesotho Demographic and Health Surveys (LDHS) and analyzed through the recently updated Health Equity Assessment Toolkit (HEAT) of the World Health Organization. Obesity prevalence was disaggregated by four equity stratifiers, namely education, wealth, residence and sub-national region. For each equity stratifier, simple and complex as well as relative and absolute summary measures were calculated. A 95% confidence interval was used to measure statistical significance of findings. Results We noticed substantial wealth-driven (D = -21.10, 95% CI; − 25.94, − 16.26), subnational region (PAR = -11.82, 95%CI; − 16.09, − 7.55) and urban-rural (− 9.82, 95% CI; − 13.65, − 5.99) inequalities in obesity prevalence without the inequalities improved over time in all the studied years. However, we did not identify educational inequality in obesity. Conclusions Wealth-driven and geographical inequalities was identified in Lesotho in all the studied time periods while education related inequalities did not appear during the same time period. All population groups in the country need to be reached with interventions to reduce the burden of obesity in the country.

scholarly journals Morphological Characteristics, Classifications and Difficulties in the Use of Diagnostic Criteria for Serrated Lesions of the Large Intestine

2021 ◽  
Author(s):  
Cesar de Souza Bastos Junior ◽  
Vera Lucia Nunes Pannain ◽  
Adriana Caroli-Bottino
Keyword(s):  
Diagnostic Criteria ◽  
Morphological Characteristics ◽  
World Health ◽  
Diagnostic Tools ◽  
Serrated Adenoma ◽  
The Past ◽  
The World ◽  
Serrated Lesions ◽  
Health Organization

Abstract Introduction Colorectal carcinoma (CRC) is the most common gastrointestinal neoplasm in the world, accounting for 15% of cancer-related deaths. This condition is related to different molecular pathways, among them the recently described serrated pathway, whose characteristic entities, serrated lesions, have undergone important changes in their names and diagnostic criteria in the past thirty years. The multiplicity of denominations and criteria over the last years may be responsible for the low interobserver concordance (IOC) described in the literature. Objectives The present study aims to describe the evolution in classification of serrated lesions, based on the last three publications of the World Health Organization (WHO) and the reproducibility of these criteria by pathologists, based on the evaluation of the IOC. Methods A search was conducted in the PubMed, ResearchGate and Portal Capes databases, with the following terms: sessile serrated lesion; serrated lesions; serrated adenoma; interobserver concordance; and reproducibility. Articles published since 1990 were researched. Results and Discussion The classification of serrated lesions in the past thirty years showed different denominations and diagnostic criteria. The reproducibility and IOC of these criteria in the literature, based on the kappa coefficient, varied in most studies, from very poor to moderate. Conclusions Interobserver concordance and the reproducibility of microscopic criteria may represent a limitation for the diagnosis and appropriate management of these lesions. It is necessary to investigate diagnostic tools to improve the performance of the pathologist's evaluation, for better concordance, and, consequently, adequate diagnosis and treatment.

scholarly journals Tobacco Control in Low- and Middle-Income Countries: Changing the Present to Help the Future

2018 ◽  
Vol 13 (4) ◽  
pp. 187-188 ◽  
Author(s):  
Bethany Hipple Walters ◽  
Ionela Petrea ◽  
Harry Lando
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Second Hand Smoke ◽  
Vulnerable Children ◽  
Middle Income ◽  
Middle Income Countries ◽  
The Past ◽  
Second Hand Smoke Exposure ◽  
Health Organization ◽  
Low And Middle Income

While the global smoking rate has dropped in the past 30 years (from 41.2% of men in 1980 to 31.1% in 2012 and from 10.6% of women in 1980 to 6.2% in 2012), the number of tobacco smokers has increased due to population growth (Ng et al., 2014). This tobacco use and second-hand smoke exposure continue to harm people worldwide. Those harmed are often vulnerable: children, those living in low- and middle-income countries (LMICs), those with existing diseases, etc. As noted by the World Health Organization (WHO), nearly 80% of those who smoke live in a LMIC (World Health Organization, 2017). Furthermore, it is often those who are more socio-economically disadvantaged or less educated in LMICs that are exposed to second-hand smoke at home and work (Nazar, Lee, Arora, & Millett, 2015).

Impact of a poignant pandemic COVID-19 on Indian Economy

2020 ◽  
Vol 11 (SPL1) ◽  
Author(s):  
Krati Sethi ◽  
Manas Roy
Keyword(s):  
Public Health Emergency ◽  
World Health ◽  
Special Treatment ◽  
Supply Side ◽  
Growth Path ◽  
Indian Economy ◽  
The Past ◽  
Policy Measures ◽  
Health Organization ◽  
Consumption Demand

Coronavirus disease (COVID-19) is a contagious disease caused due to a “Severe Acute Respiratory Syndrome Coronavirus -2 virus” (SARS-COV-2). People who fall ill will experience mild to moderate fever and will retrieve without any special treatment. This pandemic was first seen at Wuhan, China in December 2019. After seen it’s dreadfulness it was declared as a “public health emergency of international concern” (World Health Organization, WHO). As on 1 May 2020 more than 35000 cases have been reported in India resulting in more than 1147 deaths in India till date. It has also led severe socio-economic global disruption. Presently significant slowdown is experienced by Indian economy over the past few quarters.To rectify sluggish consumption demand and investment a numeral of incentive measures has been taken to retrieve the economy towards prosperity. The last quarter of the current fiscal exhibits robust prospect of improvement. However, the new COVID-19 epidemic has contrived the recovery exceptionally arduous in the near to middle terms. The pandemic has thrown new threats for the Indian economy from demand as well as from the supply side. This study is descriptive. The objective of the current study is to find out the impacts of the outbreak of COVID-19 on different sectors of our country. In conclusion, this study suggests policy measures to safeguard the Indian economy from the outbreak of it and bring it back on the growth path.

scholarly journals Mental health law in Saudi Arabia

2018 ◽  
Vol 15 (1) ◽  
pp. 17-19
Author(s):  
Jessica Carlisle
Keyword(s):  
Mental Health ◽  
Saudi Arabia ◽  
Psychiatric Patients ◽  
International Standards ◽  
World Health ◽  
Health Law ◽  
Kingdom Of Saudi Arabia ◽  
Mental Health Law ◽  
The Past ◽  
Health Organization

During the past 30 years the Kingdom of Saudi Arabia has developed an extensive hospital-based mental health system culminating in the passing of a mental health law in 2014. This legislation embodies many of the international standards promoted by the World Health Organization. However, the mechanisms for protecting the human rights of psychiatric patients are neither sufficiently independent nor adequately robust.

scholarly journals Trends in tuberculosis incidence rates in the Region of Sousse (Tunisia) from 1992 to 2016

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
J Sahli ◽  
M Mellouli ◽  
M Limam ◽  
M El Ghardallou ◽  
A Mtiraoui ◽  
...  
Keyword(s):  
Current Trend ◽  
National Level ◽  
Incidence Rates ◽  
World Health ◽  
Epidemiological Surveillance ◽  
Tuberculosis Control ◽  
Tuberculosis Incidence ◽  
Significant Downward Trend ◽  
Development Goals ◽  
Health Organization

Abstract Introduction In 1993, the World Health Organization declared that tuberculosis is a public health emergency of global concern. All efforts were made in accordance with the Millennium Development Goals (MDGs) to reduce the burden of Tuberculosis. The MDG framework built into national priorities and development strategies has, in fact, strengthened epidemiological surveillance and the use of reliable data to make decisions based on objective data. These data are essential for planning, managing the activities of the National Tuberculosis program, monitoring and ongoing evaluation of its performance. In this context, we conducted this study to trace the trend of Tuberculosis incidence rate recorded in the Sousse Region between 1992 and 2016. Methods This is a longitudinal study of the registered data of tuberculosis cases in Sousse between 1992 and 2016. For the trend analysis the software JOINPOINT version 4.5.0.1 was used. This software offers the closest possible regression model of the different points and gives an annual percentage change (APC) with a 95% confidence interval. Results The highest TB incidence rates was recorded in 1993 (85.66 cases per 100 000 inhabitants). Between 1992 and 1997, there was a significant downward trend of TB incidence (APC = -23.2; 95% CI [-28.8, 1]). Between 1997 and 2004 the trend was stable. Between 2004 and 2016, there was a significant upward trend (APC = 8.3; 95% CI: [4.3, 12.4]). Conclusions At the national level, between 1992 and 2002, tuberculosis experienced a fall in incidence rates, as a result of an improvement in the socio-economic level and the organization of tuberculosis control. Since 2004, the trend has been rising. Increased tuberculosis control is advocated to end tuberculosis by 2030 in line with sustainable development goals. Key messages After a significant decrease, the tuberculosis incidence has increased significantly since 2004. The tuberculosis prevention efforts should be intensified to reverse the current trend.

scholarly journals Challenges Facing the Chinese Health Care System

2020 ◽  
pp. 101053952096846
Author(s):  
Kaixuan Hu
Keyword(s):  
Health Care ◽  
Health Care System ◽  
Disease Surveillance ◽  
World Health ◽  
Outbreak Response ◽  
The Past ◽  
Disease Surveillance System ◽  
Rural And Urban ◽  
Health Organization ◽  
Care System

The purposes of this article are to explore the challenges the Chinese health care system will be facing in the next decade. The recent outbreak of coronavirus disease (COVID-19) having infected more than 90 000 persons in China (Source: World Health Organization, WHO Coronavirus Disease Dashboard) again reveals the weaknesses of the fragmental health care system. Over the past 3 decades, increasing out-of-pocket spending on health care, increasing mortality rate of chronic disease, growing disparities between rural and urban populations, the defectiveness of disease surveillance system, and disease outbreak response system have been pressing Chinese authorities for action. As this country has experienced an unprecedented economic growth along with an unparalleled development of health care system in the past 3 decades, the challenges ahead are unavoidably numerous and complex.

scholarly journals Expanding Waistlines: A "Nutrition Transition" in China

Elements ◽  
2010 ◽  
Vol 6 (1) ◽  
Author(s):  
Kitsy Smith
Keyword(s):  
Nutrition Transition ◽  
Future Generations ◽  
World Health ◽  
Economic Productivity ◽  
Obesity Epidemic ◽  
The Past ◽  
The World ◽  
Health Organization ◽  
Medical Advances

As China's coffers have swelled over the past three decades, its citizens' waistlines have also expanded. Western goods and lifestyles habits are consistently being imported into the Asian giant, including the obesity epidemic. Chinese children are particularly susceptible and future generations face tremendous health risks despite medical advances. States and international bodies such as the World Health Organization are alarmed at the damage obesity is already producing. The price tag to treat the health problems associated with obesity and the rsulting loss in economic productivity is staggering. While this essay uses China as a case study to examine the causes of obesity and its consequences, social and economic health, the grim reality is that this pattern is occurring worldwide as countries develop and their people adopt Western "nutritional" norms.

Quality of Life: Policy Concept and Reality

2014 ◽  
Vol 15 (2) ◽  
pp. 163-182
Author(s):  
TAKU YAMAMOTO
Keyword(s):  
Quality Of Life ◽  
Current Trend ◽  
Subjective Quality ◽  
World Health ◽  
Subjective Quality Of Life ◽  
Self Assessment ◽  
World Health Organization Quality ◽  
Using Data ◽  
Health Organization

AbstractThis study examines the process by which the concept of quality of life has been increasing in importance as the key to ASEAN's socio-cultural integration. This study also focuses on the current trend that emphasizes subjective quality of life and clarifies that ASEAN has been moving toward including this perspective. Then, it analyzes the subjective quality of life of people in ASEAN in terms of self-assessment and the multidimensional World Health Organization Quality of Life metric by using data from the ASEAN Barometer 2009.

scholarly journals Dengue and Recent Mosquito-borne Viral Fever Outbreak in Bangladesh: Concern, Causes and Control

2019 ◽  
pp. 44-48 ◽  
Keyword(s):  
Control Measures ◽  
World Health ◽  
Health Concern ◽  
The Past ◽  
Directorate General ◽  
Elevated Rate ◽  
Health Organization ◽  
And Control ◽  
Control Division ◽  
Great Public Health

Bangladesh is struggling with dreadful outbreaks of mosquito-borne diseases for the past few years. Disease Control Division of Directorate General (DG) of Health Service considered the capital of Bangladesh as the breeding ground for mosquitos. Recent incidence of Dengue and Chikungunya outbreaks have surpassed all past records of outbreak. Thus, the country is witnessing an elevated rate of viral fever incidence alarmingly. Though symptoms of mosquito-borne viral infection are very typical, the recent incidence of fatalities is growing great public health concern. World Health Organization (WHO) recommends practical control measures to minimize the breeding within the community of Bangladesh. The actions of Kolkata City Corporation to control Dengue are also suggestive for Bangladesh. There is no medication to treat Dengue, and Chikungunya infection, but initial recognition and apposite medical care can reduce the death threat.

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