USE OF "INTRAFEN" IN MILD TO MODERATE COVID-19

Vestnik ◽  
2021 ◽  
pp. 256-268
Author(s):  
А.М. Шарапханова ◽  
Д.М. Оспанбекова ◽  
Н.А. Сагатбаева ◽  
А.Ш. Бектасова
Keyword(s):  
Body Temperature ◽  
General Condition ◽  
Clinical Laboratory ◽  
Clinical Situation ◽  
The Body ◽  
Moderate Severity ◽  
Infection Disease ◽  
Coronavirus Infection ◽  
Anti Inflammatory ◽  
Elevated Body Temperature

Повышение температуры тела человека-это своеобразная реакция на воздействие какого-либо агента и/или возбудителя, попавшего в организм человека. При каких-либо инфекционных заболеваниях в организме человека повышается температура тела человека. Также в настоящее время повышение температуры тела при распространенной коронавирусной инфекции является одним из симптомов заболевания. Цель: в нашей статье мы хотели бы рассмотреть клиническую ситуацию с больными COVID-19 и отметить, что был проведен ряд наблюдений и анализов для оценки эффективности и безопасности применения препарата «Интрафен» с целью снятия повышенной температуры, что дает положительный эффект лекарственного средства. Материалы и методы: рекомендовать пациентам с симптомами заболевания короновирусной инфекцией легкой и средней тяжести, С целью снижения повышенной температуры тела, противовоспалительного и улучшения общего состояния пациента, что мы достигнем положительного результата путем введения препарата интрафен в Вену. Результат: на основании анамнезных данных, полученных от больного, результатов клинических, лабораторных, инструментальных исследований выявлено эффективное действие препарата интрафен. Вывод: пациентам легкой и средней тяжести, перенесшим короновирусную инфекцию, можно увидеть, что введение препарата интрафен в Вену эффективно влияет на кратковременное снижение повышенной температуры тела, противовоспалительное действие, улучшение общего состояния больного. An increase in a person's body temperature is a self-contained response to the action of some agent and/or pathogen that has entered the body. With any infectious diseases in the human body, a person's body temperature increases. In addition, with the current coronavirus infection, an increase in body temperature is one of the symptoms of the disease. Purpose: in our article, we would like to consider the clinical situation of patients with COVID-19 and draw attention to the fact that a number of observations and analyses were carried out to assess the effectiveness and safety of using the drug "Intrafen" in order to relieve elevated fever. Materials and methods: in order to reduce elevated body temperature, anti-inflammatory and improve the general condition of the patient, to suggest that we will achieve a positive result by injecting the drug intrafen into the vein in patients with mild to moderate severity with symptoms of coronavirus infection disease. Result: based on Anamnesis data obtained from the patient, the results of Clinical, Laboratory, and instrumental studies, the effective effect of intrafen was determined. Conclusion: by injecting the drug intrafen into the vein in patients of mild and moderate severity who have had a Coronavirus infection, it can be seen that it has an effective effect on the short-term reduction of elevated body temperature, anti-inflammatory effect, improvement of the general condition of the patient.

Antipyretic Plants: An Updated Review

2020 ◽  
Vol 16 (1) ◽  
pp. 4-12
Author(s):  
Vandana Garg ◽  
Rohit Dutt
Keyword(s):  
Side Effects ◽  
Body Temperature ◽  
Medicinal Plants ◽  
Inflammatory Mediators ◽  
Review Paper ◽  
The Body ◽  
Hypothalamic Area ◽  
Antipyretic Activity ◽  
Disease States ◽  
Elevated Body Temperature

Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature. Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects. Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity. Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases. Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.

CLASSIFICATION OF HUMAN FACIAL AND AURAL TEMPERATURE USING NEURAL NETWORKS AND IR FEVER SCANNER: A RESPONSIBLE SECOND LOOK

2005 ◽  
Vol 05 (01) ◽  
pp. 165-190 ◽  
Author(s):  
E. Y. K. NG ◽  
COLIN CHONG ◽  
G. J. L. KAW
Keyword(s):  
Neural Network ◽  
Body Temperature ◽  
False Negative ◽  
The Body ◽  
Body Core Temperature ◽  
Thermal Imager ◽  
Facial Skin ◽  
Thermal Imagers ◽  
Cardinal Symptom ◽  
Elevated Body Temperature

Severe Acute Respiratory Syndrome (SARS) is a highly infectious disease caused by a coronavirus. Screening to detect potential SARS infected subject with elevated body temperature plays an important role in preventing the spread of SARS. The use of infrared (IR) thermal imaging cameras has thus been proposed as a non-invasive, speedy, cost-effective and fairly accurate means for mass blind screening of potential SARS infected persons. Infrared thermography provides a digital image showing temperature patterns. This has been previously utilized in the detection of inflammation and nerve dysfunctions. It is believed that IR cameras may potentially be used to detect subjects with fever, the cardinal symptom of SARS and avian influenza. The accuracy of the infrared system can, however, be affected by human, environmental, and equipment variables. It is also limited by the fact that the thermal imager measures the skin temperature and not the body core temperature. Thus, the use of IR thermal systems at various checkpoints for mass screening of febrile persons is scientifically unjustified such as what is the false negative rate and most importantly not to create false sense of security. This paper aims to study the effectiveness of infrared systems for its application in mass blind screening to detect subjects with elevated body temperature. For this application, it is critical for thermal imagers to be able to identify febrile from normal subjects accurately. Minimizing the number of false positive and false negative cases improves the efficiency of the screening stations. False negative results should be avoided at all costs, as letting a SARS infected person through the screening process may result in potentially catastrophic results. Hitherto, there is lack of empirical data in correlating facial skin with body temperature. The current work evaluates the correlations (and classification) between the facial skin temperatures to the aural temperature using the artificial neural network approach to confirm the suitability of the thermal imagers for human temperature screening. We show that the Train Back Propagation and Kohonen self-organizing map (SOM) can form an opinion about the type of network that is better to complement thermogram technology in fever diagnosis to drive a better parameters for reducing the size of the neural network classifier while maintaining good classification accuracy.

scholarly journals Global Economic Impacts of COVID 19 to Increase the Protection of Society By Using Thermal Imaging Cameras to Measure the Temperature of Human Body

2021 ◽  
Vol 92 ◽  
pp. 01031
Author(s):  
Ladislav Mariš ◽  
Veronika Adamová
Keyword(s):  
Body Temperature ◽  
Preventive Measures ◽  
Economic Impacts ◽  
Value Added ◽  
Preventive Measure ◽  
The Body ◽  
Manufacturing Companies ◽  
Temperature Measuring ◽  
Expected Benefits ◽  
Elevated Body Temperature

Research background: In 2020, a pandemic of COVID-19 has started. One of the symptoms is that a person has an elevated body temperature. One of the preventive measures against the spread of COVID-19 is the body temperature measuring. But this does not immediately mean, that person´s elevated body temperature indicates the presence of COVID-19. It also does not mean, that a person with COVID-19 must have fever. In generally, there is accepted a preventive measure to measure a body temperature, that can help to detect an infected person. The demands for body temperature measuring devices has increased. One of these devices is the thermal security cameras (TSC). Purpose of the article: The aim of this paper is to point out the increased use of the TSC during the global pandemic of COVID-19. At the same time, it is necessary to point out the real benefits of using these devices in relation to global trend and significant economic impacts on society. Methods: The analysis of available materials and data of the implementation of the TCS in relation to COVID-19 crisis. There are case studies elaborated on two manufacturing companies with different approaches to the implementation of preventive measures. Findings & Value added: Firstly, the increased demand for protecting and preventive measures have an impact on the extreme increase in prices for these technologies compared to the pre-pandemic period. Secondly, accepted protecting and safety measures, such as TSC, do not have the expected benefits in relation to COVID-19.

scholarly journals Mechanism of Pharmacological Action of Chromones in Radix Saposhnikoviae Based on Biological Significance of Secondary Metabolites

2020 ◽  
Author(s):  
Si-Si Cao ◽  
Lei Shi ◽  
Ying Shen ◽  
Jing-Ming Yang ◽  
Xiang-Cai Meng
Keyword(s):  
Body Temperature ◽  
Secondary Metabolites ◽  
Correlation Coefficient ◽  
Biological Significance ◽  
Pharmacological Action ◽  
Biological Action ◽  
The Body ◽  
Before And After ◽  
Anti Inflammatory ◽  
Scavenging Efficiency

Abstract According to origin of species, both animals and plants come from a common ancestor, so they all possess similar/same metabolic activities. Plants adapt to stress conditions by eliminating reactive oxygen species (ROS) partly with secondary metabolites, which are often the medicinal ingredients. With this, the mechanism of pharmacological action and biological action of secondary metabolites may be the same. Radix saposhnikoviae the root of Saposhnikovia divaricata, has antipyretic, analgesic and anti-inflammatory effects. It was analyzed that the correlation between fever, analgesia and inflammation and the activities of POD, CAT, the H2O2 contents in serum before and after intravenous administration for cimicifugin, an active component. For the antipyretic, the correlation coefficient between the body temperature and the H2O2 contents was 0.9689 in the model group and 0.5221 in the treatment group, indicating that fever was closely related to the H2O2. In the presence of electron donor, POD can eliminate ROS, the correlation coefficient between POD activities and H2O2 content before and after administration were 0.8085 and -0.5070, respectively, indicating that cimicifugin can eliminate ROS through POD. At 39.5 ℃, POD activity was about 1.47 times that of normal body temperature, and the scavenging efficiency of POD was 2.94 times that of CAT, which indicated that cimicifugin enhanced the elimination of H2O2 mainly through POD. For the analgesic and anti-inflammatory, the correlation coefficients of POD activity with analgesic and anti-inflammatory effects were 0.6685 and 0.4466, respectively, indicating that they were closely related to the H2O2. In this paper, we found the ROS is an important factor of fever, pain and inflammation, the pharmacological actions of Radix Saposhnikoviae also is elimination of ROS through the synergistic action of chromone and POD, the mechanism of pharmacological action of Chromones being the same as the biological action of secondary metabolites.

scholarly journals Сlostridium difficile Infection in a COVID-19 Patient

2021 ◽  
Vol 31 (3) ◽  
pp. 68-73
Author(s):  
A. A. Timofeeva ◽  
Yu. O. Shulpekova ◽  
V. M. Nechaev ◽  
M. R. Skhirtladze
Keyword(s):  
Body Temperature ◽  
Clinical Observation ◽  
Watery Diarrhoea ◽  
Systemic Glucocorticoid ◽  
Screening Algorithm ◽  
General Weakness ◽  
Key Points ◽  
Coronavirus Infection ◽  
Elevated Body Temperature ◽  
Neutrophilic Leucocytosis

Aim. The clinical observation highlights plausible compound origins of diarrhoea, fever and neutrophilic leucocytosis in COVID-19 and the rationale to exclude Clostridium difficile infection in such patients.Key points. A 57-yo female patient was admitted in May 2020 with the complaints of 39 °C fever, general weakness, polymyalgia, diarrhoea to 3–4 times a day (mushy stool, no morbid inclusions). Initial diarrhoea was non-severe and likely triggered by the coronavirus infection. A background antibiotic and putative-immunosuppressive therapy proceeded with watery diarrhoea to 7–8 times a day and C. difficile toxins A and B detected in stool. The C. difficile infection relapsed on day 10 of vancomycin withdrawal and associated with elevated body temperature, diarrhoea and neutrophil leucocytosis; signs of colitis determined in ultrasound and CT. Exacerbation was successfully treated in a repeated metronidazole-combined vancomycin course.Conclusion. Patients with COVID-19 are at risk of clostridial colitis due to massive antibiotic, systemic glucocorticoid and biologics-based therapy they receive. The opportunistic bacterial infection of C. difficile often proceeds undetected due to its potential mirroring of COVID-19 presentation. A screening algorithm in COVID-19 patients with diarrhoea should imply steps for C. difficile detection.

USE OF ENTEROSORPTION TO PREVENT ENDOTOXEMIA IN ACUTE INTESTINAL OBSTRUCTION

2020 ◽  
pp. 14-17
Author(s):  
A. N. Shevchenko ◽  
Andrei Alekseevich Merkulov ◽  
Sergei Valerevich Tkach ◽  
D. O. Myroshnychenko ◽  
Igor Vladimirovich Volchenko ◽  
...  
Keyword(s):  
Small Intestine ◽  
Intestinal Obstruction ◽  
General Condition ◽  
Clinical Laboratory ◽  
Secondary Infection ◽  
Combined Treatment ◽  
Acute Intestinal Obstruction ◽  
The Body ◽  
Post Surgery ◽  
Microbial Invasion

The relevance of studying the measures to prevent the development of endotoxemia in acute intestinal obstruction is stipulated with an increasing incidence of multiple organ failure in debilitated patients and infectious−toxic shock. The development of endotoxemia is often accompanied with a secondary infection. Toxic effects of bacteria in small intestine, the trigger of which is their translocation and transformation of the small intestine into a focus of microbial invasion, prolongs the postoperative period, which increases the length of stay in the surgical hospital. Much attention is paid to the pathogenesis of the development of small bowel contamination syndrome, which results in changes in intestinal biocenosis and increased intoxication of the body, which worsens the patient general condition. To examine the results of entersorption as a method of detoxification and control of infectious and toxic complications in the patients with an acute intestinal obstruction before surgery to optimize surgical tactics and prevent post−surgery complications, a study was conducted in 36 patients with different stages of the disease. The effectiveness of detoxification in the combined treatment of an acute intestinal obstruction has been confirmed, which is indicated by the reduced pain, regression of radiological signs of obstruction in the patients and early normalization of their main clinical, laboratory and instrumental parameters. The use of the method of enterosorption as part of a comprehensive approach in the period after surgery contributed to the early restoration of intestinal motility, reducing the number of complications, improving the general condition of patients. Thus, the method of enterosorption is one of the most effective of modern detoxification methods, which determines its relevance and further prospects to study this problem. Key words: acute intestinal obstruction, endotoxemia, enterosorption.

Peloidotherapy in Pediatric Practice in the Conditions of a Ballogray Resort

2020 ◽  
Vol 98 (4) ◽  
pp. 77-81
Author(s):  
V.A. Poberskaya ◽  
N.A. Lyan
Keyword(s):  
Clinical Laboratory ◽  
The Body ◽  
Physical Factors ◽  
Repeated Treatment ◽  
Pediatric Practice ◽  
Extensive Experience ◽  
Bronchopulmonary Diseases ◽  
Spa Treatment ◽  
Anti Inflammatory ◽  
The Individual

Introduction. Currently, sulfide silt mud of Lake Saka has been widely used in both adult and pediatric practice, which has a positive effect in the treatment of various diseases. The effectiveness of peloidotherapy in the rehabilitation treatment of children with a number of chronic and disabling diseases has been established. The purpose of the review is to summarize and analyze the accumulated experience of applying peloidotherapy in children with various diseases. In order to achieve a targeted effect, it is necessary to study previously carried out scientific studies on the in-depth study of the mechanism of therapeutic action of natural factors. Data on methodology of application of peloidotherapy based on highly mineralized silt sulphide mud of Black Sea resorts are presented. It is necessary to take into account the response of the child body to peloidotherapy, which depend on the individual capabilities of the body, in connection with which the parameters of mud treatment methods in pediatrics should be justified. Indications for peloidotherapy for diseases of the cardiovascular system have been developed. The purpose of application method of peloidotherapy in the complex of sanatorium treatment of children with chronic bronchitis, pneumonia and other bronchopulmonary diseases is recognized in order to provide reparative and regenerative, anti-inflammatory, trophostimulating, anti-inflammatory, resolving effect, to improve bronchial permeability, ventilation function.. The dynamics of endothelial dysfunction indices in children with rheumatoid arthritis under the influence of spa treatment using mud applications, the results of complex spa treatment of children with different forms of pyelonephritis in clinical-laboratory remission against the background of application of Saki silt mud were studied. In children with celiac disease the efficiency of therapeutic complex of physical factors influence on pathogenetic links of the disease is shown. Extensive experience has been gained in mud treatment of children with cerebral palsy. Conclusion. In peloidotherapy, individual approaches to comprehensive rehabilitation are applied depending on the clinical picture of the disease with repeated treatment courses.

BODY TEMPERATURE AS A NEW PREDICTOR OF MORTALITY IN HEAD TRAUMA PATIENTS

2019 ◽  
Vol 3 (1) ◽  
pp. 37
Author(s):  
Nor Hayatunnisa ◽  
Rismia Agustina ◽  
Oski Illiandri
Keyword(s):  
Body Temperature ◽  
Trauma Patient ◽  
Head Trauma ◽  
Psychosocial Functioning ◽  
Sampling Technique ◽  
The Body ◽  
P Value ◽  
Trauma Patients ◽  
Risk Of Mortality ◽  
Elevated Body Temperature

Head trauma is a neurological emergency that has fairly complex impacts such as physical, cognitive, psychosocial functioning, temporary care. Sixty-five percent of patients with head trauma experience elevated body temperature. Any increase in body temperature by 1 ℃ can have a 5% effect on brain blood flow which lead patients to mortality. Nurses are responsible for patients who experience increased body temperature, especially in providing professional nursing care. The purpose of this research is to know the correlation of body with mortality of head trauma patient at RSUD Ulin Banjarmasin. This research uses non probability sampling method with consecutive sampling technique. The study was conducted in December 2017-January 2018 using an observation sheet. The data analysis shows the p value of 0.003 <0.05 which indicates that H0 is rejected means there is a correlation between the body and the mortality of the head trauma patient at Ulin Banjarmasin Hospital. The higher the patient's body temperature the more likely it is to be at risk of mortality.

scholarly journals Clinical characteristics and the main symptoms of coronavirus disease SARS and MERS: A descriptive minireview

2021 ◽  
Vol 2 (2) ◽  
pp. 116-118
Author(s):  
Fatma Mustafa Muhammad ◽  
Chateen Izaddin Ali Pambuk
Keyword(s):  
Body Temperature ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Characteristics ◽  
The Body ◽  
Viral Diseases ◽  
Acute Lower Respiratory Infection ◽  
Lower Respiratory Infection ◽  
Difficulty Breathing ◽  
Elevated Body Temperature ◽  
Shed Light

Coronavirus is one of the viral diseases, and it expresses a severe and acute respiratory syndrome accompanied by a severe rise in body temperature, and acute lower respiratory infection, and there are several types of corona virus, including the virus that causes Middle East respiratory syndrome. for short (MERS), severe acute respiratory syndrome, and the new coronavirus 2019 (2019-nCoV). Symptoms of the disease can be distinguished: Pain in the joints of the body. general fatigue headache. Sore throat. Visibly elevated body temperature. Cough and difficulty breathing. Severe inflammation and damage to the alveoli. Swelling of lung tissue. Kidney failure if symptoms worsen. The aim of this descriptive minireview, generally, is to shed light on the main clinical characteristics and the main symptoms of Coronavirus disease SARS and MERS.

Invivo Activity of Polyherbal Gels Prepared Using Carbopol

2020 ◽  
Vol 10 (3) ◽  
pp. 63-66
Author(s):  
Parasakthi N ◽  
Deepika R ◽  
Sivanathan C ◽  
Abubackkar Sithiq PD ◽  
Venkateshan N
Keyword(s):  
Physiological Stress ◽  
Defense Responses ◽  
The Body ◽  
Peptic Ulcers ◽  
Onset Of Action ◽  
Standard Drug ◽  
Root Extracts ◽  
Carbopol 940 ◽  
Anti Inflammatory ◽  
Rich Countries

Pain and inflammation are the basic defense responses of the body that the result of the injury and any other damage to the body. During the years the concerns were raised towards the inflammation that is caused to the oxidative damage that is resulted in the physiological stress due to oxidation. There are a lot of drugs that are used to treat the condition effectively and the typical examples are NSAID’s and SAID’s which have a noted mechanism to show the anti-inflammatory activity. They have serious problems with the side effects like Gastrointestinal irritation, Gastric pain, Gastric perforations and peptic ulcers. Herbs have been used as better alternatives that are used to treat diseases. The significance of the medicinal plants had been emphasized significantly in tradition rich countries like India and all over the world. The research proof of those herbs for their activities and their traditional claims were proven. Poly Herbal Gels were prepared using the root extracts of the plant Corchorus olitorius. The gels were prepared using the Carbopol 940 and the prepared gels were investigated for their anti-inflammatory property and the gels showed a significantly better activity compared to the plant extract and the standard drug too. The addition of other drugs in to the gels added and advantage to the increase in the activity and faster onset of action as the gel was applied directly in the place of the inflammation.

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