Impact of immunological, hematological and biochemical markers on discordant partners of Hepatitis B infection in Enugu State, Eastern Nigeria

2021 ◽  
Vol 1 (2) ◽  
pp. 029-039
Author(s):  
Ezea Moses Chukwuemeka ◽  
Chukwuma Okechukwu George ◽  
Okere Philip ◽  
Onah Christian Ejike ◽  
Adonu Cyril ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Liver Enzymes ◽  
Hematological Parameters ◽  
Serological Markers ◽  
Hepatitis B Infection ◽  
Cross Sectional ◽  
Detection Rates ◽  
Mean Values ◽  
Panel Test ◽  
And Control

Globally, hepatitis B infection is a serious health problem as its morbities are difficult to handle with the commonly used antivirals. This study therefore aims to evaluate the serological, biochemical and hematological markers of Hepatitis B virus infection in a discordant partner in an attempt to aid proper diagnosis, management and control of the infection. This is a cross-sectional study consisting of 150 subjects recruited using a simple random sampling technique. HBsAg was screened using a rapid ELISA diagnostic strip and rescreened later for confirmation using Ichroma Fluorescence Immunoassay (FIA). HBV Serological markers were determined using HBV 5 panel test, hematological parameters were assessed using Mindray BC 10 automated counter, while liver enzymes were estimated using COBAS 111 analyzer. Statistical analysis was performed using Graph Pad Prism. This study demonstrated a varying percentage detection rates of HBV serological markers in both groups: Discordant and Concordant partners (HBsAg- 62%, HBsAb- 4.2%, HBeAg- 2.5%, HBeAb- 50%, HBcAb-60.8%), and Control partners(HBsAg-0%, HBsAb-23.3%, HBeAg-0%, HBeAb- 0%,and HBcAb- 6.7%). The liver enzymes showed significant mean values (P<0.001) for both ALT and AST positive partners when compared to their negative counterparts. Hematological parameters, only hemoglobulin showed a significant mean (P<0.001) on male subjects as against females, while white blood cell and platelets were not statistically significant. There is a need for hepatitis B panel test inclusion in the routine investigation for Hepatitis B viral infection which will contribute immensely in proper clinical management and control of the infection in conjunction with vaccination, while periodic assessment of liver enzymes will ensure proper management of chronic hepatitis B infections.

scholarly journals Risk perception and knowledge of hepatitis B infection among cleaners in a tertiary hospital in Nigeria: A cross-sectional study

2019 ◽  
Vol 7 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Olumide Abiodun ◽  
Olusola Shobowale ◽  
Charles Elikwu ◽  
Daniel Ogbaro ◽  
Adebola Omotosho ◽  
...  
Keyword(s):  
Risk Perception ◽  
Hepatitis B ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Hepatitis B Infection ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Prevalence of serological markers for hepatitis and potential associated factors in patients with diabetes mellitus

2018 ◽  
Vol 26 (0) ◽  
Author(s):  
Clarissa Cordeiro Alves Arrelias ◽  
Fernando Belissimo Rodrigues ◽  
Maria Teresa da Costa Gonçalves Torquato ◽  
Carla Regina de Souza Teixeira ◽  
Flávia Fernanda Luchetti Rodrigues ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Associated Factors ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Blood Collection ◽  
Serological Markers ◽  
Cross Sectional ◽  
Patients With Diabetes

ABSTRACT Objective: to estimate the prevalence of serological markers for hepatitis B and C in patients with diabetes mellitus and analyze potential associated factors. Method: a cross-sectional study with 255 patients with diabetes mellitus. Demographic, clinical, and risk behavior factors for hepatitis B and C were selected. The markers HBsAg, Anti-HBc IgG, Anti-HBc IgM, Anti-HBs, and Anti-HCV were investigated. A questionnaire and venous blood collection and inferential statistical analysis were used. Results: 16.8% of the patients had a total reactive Anti-HBc marker, 8.2% an isolated Anti-HBs, and 75% were non-reactive for all hepatitis B markers. No case of reactive HBsAg was found and 3.3% of the patients had a reactive anti-HCV marker. The prevalence of prior hepatitis B virus infection was directly associated with the time of diabetes mellitus and the prevalence of hepatitis C virus infection was not associated with the investigated variables. The prevalence of hepatitis B and C infection in patients with diabetes mellitus was higher when compared to the national, with values of 16.8% and 3.3%, respectively. Conclusion: the results suggest that patients with diabetes are a population of higher vulnerability to hepatitis B and C, leading to the adoption of preventive measures of their occurrence.

scholarly journals Prevalence of hepatitis B infection markers in Lebanese children: the need for an expanded programme on immunization

2001 ◽  
Vol 126 (2) ◽  
pp. 285-289 ◽  
Author(s):  
M. M. NABULSI ◽  
G. F. ARAJ ◽  
I. NUWAYHID ◽  
M. RAMADAN ◽  
M. ARISS
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Horizontal Transmission ◽  
Cross Sectional Study ◽  
Family Characteristics ◽  
Hepatitis B Infection ◽  
Childhood Immunization ◽  
Cross Sectional ◽  
South Lebanon ◽  
Infection Markers

This multi-centre, cross-sectional study was designed to reveal the present status of hepatitis B infection markers among Lebanese children, and provide recommendations regarding childhood immunization policies. A total of 841 children, aged between 6 months and 6·5 years, were enrolled from Lebanon's five districts. Their sera were tested for hepatitis B surface antigen and hepatitis B core IgG. The overall prevalence of hepatitis B virus infection markers was 0·8 % with increasing age-specific rates from 0 % at 6 months to 1·3 % at > 5 years. There was no statistically significant association between the presence of hepatitis B markers and family characteristics or risk factors for infection. The highest prevalence rates were among children from Beirut suburbs (2·9 %) and South Lebanon (1·6 %). The risk of horizontal transmission of hepatitis B to uninfected children increased substantially after the age of 2 years. An expanded programme on immunization that integrates hepatitis B vaccine during the first year of life is needed.

scholarly journals FREQUENCY OF HBeAg POSITIVITY IN PATIENTS WITH HEPATITIS B INFECTION IN TEACHING HOSPITALS OF PESHAWAR

1969 ◽  
Vol 3 (2) ◽  
pp. 368-372
Author(s):  
RIAZ GUL ◽  
GHAZALA YASMIN ◽  
MANZAR ANWAR
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Screening Program ◽  
Tertiary Care ◽  
Serum Marker ◽  
Young Age ◽  
Teaching Hospitals ◽  
Hepatitis B Infection ◽  
Cross Sectional

OBJECTIVES: To determine the frequency of acute and chronic hepatitis HBeAg positivity in patients ofdifferent ages and gender suffering from Hepatitis B Virus infection, and to rectify the key factorsresponsible for its transmission.METHODOLOGY: Cross sectional study conducted for duration of 3 months at tertiary care hospitals ofPeshawar on 220 patients suffering from hepatitis B infection that are screened for serum markers.nonprobability convenient sampling technique was used and structured questionnaire was used as datacollection tool. Patient’s record was checked for serum markers. Data collected was analyzed by SPSSversion 16.RESULTS: Out of total 220 cases with hepatitis B infection 145 were male while 75 were females.103(46.8%) were found to be positive with raised level of serum marker HBeAg, predominantly more inmale gender and young age patients with mean age of 22 years. The serum level of (HBeAg) was high inpatients having chronic hepatitis as compare to acute hepatitis. Patients with positive HBeAg weresignificantly associated with raised level ofALT.CONCLUSIONS: The frequency of HBe Ag+ve in patients suffering from hepatitis B infection is 46.8%with more predominant in young age patients associated with raised level ofALT.RECOMMENDATIONS: Health education of the community regarding preventive measures fromhepatitis B infection and early diagnosis through mass screening program is recommended.KEYWORDS: Serum marker HBeAg, acute hepatitis, chronic hepatitis, incubation period, ALT.

scholarly journals A cross-sectional study of post-vaccination anti-HBs titer and knowledge of hepatitis B infection amongst medical students in a metropolitan city

2016 ◽  
Vol 5 (1) ◽  
pp. 83 ◽  
Author(s):  
Ashmaki A. Acchammachary ◽  
Milind Ubale ◽  
Deepali D. Belurkar ◽  
Poorva P. Bhave ◽  
Aniruddha Arjun Malgaonkar ◽  
...  
Keyword(s):  
Informed Consent ◽  
Hepatitis B Virus ◽  
Medical Students ◽  
Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Hepatitis B Infection ◽  
Cross Sectional ◽  
B Virus ◽  
Post Test ◽  
Written Informed Consent

Background: Medical students are at risk of acquiring hepatitis B virus infection due to occupational contact with patients’ blood or other body fluids. This study was conducted to determine knowledge of hepatitis B virus infection and anti-HBS antibody titer amongst medical students.Methods: This cross-sectional observational study was conducted on medical students who satisfied the intake criteria and gave written informed consent to participate in the study. After Institutional Ethics Committee clearance, written informed consent was obtained and a structured, pre-validated questionnaire (pre-test) was administered to the participants. After an educational session, an identical questionnaire was administered (post-test). For determining anti-HBs titer (vaccinated participants) and HBsAg (non-vaccinated participants), blood was aseptically collected by cubital venepuncture. HBsAg and anti-HBs antibody levels were determined by immuno-chromatographic assay and enzyme-linked immunosorbent assay, respectively.Results: 140 healthy, HBsAg-negative medical students (79 males; 61 females) participated in the present study. There was increased median correct response in the post-test with increased minimum and first quartile. 91 (65%) who were vaccinated against Hepatitis B were enrolled for anti-HBs titer estimation. There was no significant gender difference in mean antibody titer. 19 (20.9%) had inadequate levels of anti-HBS antibodies. 50% seroconversion was seen after single dose of hepatitis B vaccine.Conclusions: It is essential to delve into the logistic aspects of evaluating all medical students for hepatitis B infection, procuring and offering free vaccination and assessing anti-HBS titer of vaccinated individuals.

scholarly journals Perception and Practices relating to Hepatitis B Infection among In-school Adolescents in Ogun State, Nigeria

2021 ◽  
Vol 4 (1) ◽  
pp. 14-22
Author(s):  
Titilayo Olaoye ◽  
Catherine Agbede ◽  
Fredrick Oshiname
Keyword(s):  
Hepatitis B ◽  
Cross Sectional Study ◽  
Hepatitis B Infection ◽  
Unsafe Sex ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Multiple Sexual Partners ◽  
Ogun State ◽  
Multi Stage

Objective: This study examined the perception and practices relating to Hepatitis B infection among In-school adolescents in Ogun State, Nigeria. Methods:  A cross-sectional study of 300 in-school adolescents selected by a multi-stage sampling method. Data were elicited using a pretested self-administered questionnaire which included questions relating to respondents' risky practices, and a 35-point Hepatitis B perception scale. Descriptive statistics, as well as Chi-square statistics, were generated using IBM SPSS Version 23, and the significance level was set at 0.05. Results: The mean age of the respondents was 14.31 ± 1.73years and slightly over half (51.7%) were females. Less than half (45%) of the adolescents perceived themselves to be susceptible to Hepatitis B infection, while 31% perceived Hepatitis B infection to be a serious disease. Almost half (49%) of the adolescents had unfavorable perceptions. The most common risky practices among the respondents were sharing skin-piercing instruments with their family members (79%) and friends (68.7%). There are significant associations between sex (gender) and risky practices such as the practices of unsafe sex (X2= 9.11; p=0.10); having multiple sexual partners (X2= 12.08; p =0.02); and sharing skin-piercing instruments (X2= 5.52; p=0.01) with more males reporting the above practices than females. Conclusion/Recommendation: To minimize the identified risky practices and unfavorable perception, educational intervention programs aimed at promoting Hepatitis B virus preventive behaviors and increasing the level of perception of vulnerability and seriousness of HBV infection among in-school adolescents should be conducted.

scholarly journals Exploring the Knowledge, Attitude and Practice Regarding Hepatitis B Infection Among Dental Students in Saudi Arabia: A Cross-Sectional Study

2019 ◽  
Vol 7 (5) ◽  
pp. 805-809 ◽  
Author(s):  
Shahabe Saquib ◽  
Weam Ibrahim ◽  
Ali Othman ◽  
Mohammed Assiri ◽  
Hamoud Al-Shahri ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Hepatitis B ◽  
Dental Students ◽  
High Risk Group ◽  
P Value ◽  
Hepatitis B Infection ◽  
Cross Sectional ◽  
Attitude And Practice ◽  
Significant Difference ◽  
Knowledge Attitude And Practice

BACKGROUND: Hepatitis B infection is a universal health problem. Worldwide, 5% of health-care-related injections continued unsafe. Dentist considers being at high-risk group for cross infection. Therefore, their knowledge and practice towards Hepatitis B virus (HBV) positive patients should be at an optimal level. AIM: The current study is aimed to evaluate and comparison of the knowledge, attitude and practice of Saudi dental students and interns towards HBV infection. METHODS: A self-explanatory questionnaire comprising of 16 questions was designed to assess and compare students’ knowledge, attitude and risk perception regarding hepatitis B infection among dental students across Saudi Arabia. RESULTS: The response rate was 91.6% the overall knowledge of the participants was poor. The attitude was fair, with the female show a significant difference in attitude and practice (P-value < 0.05). The overall practice was good, 78.1% was vaccinated against HBV, and 73.2% stated that they regularly use personal protection equipment. The higher levels show a good attitude and practice compared with the lower levels; the difference was significant (P value < 0.05). CONCLUSION: The overall knowledge was below average, continuous health education courses are mandatory.

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