scholarly journals Therapeutic Effect of Micro-Ecologics Combined with Blue Light Irradiation on Neonatal Jaundice: Randomized Control Trial

2021 ◽  
Vol 15 (8) ◽  
pp. 2294-2296
Author(s):  
Gao KE ◽  
Syed Haider Abbas ◽  
Ali Faheem ◽  
Muhammad Zeeshan ◽  
Rizwan Masud ◽  
...  
Keyword(s):  
Blue Light ◽  
Bilirubin Level ◽  
Randomized Control Trial ◽  
Neonatal Jaundice ◽  
Post Treatment ◽  
Light Irradiation ◽  
Control Group ◽  
P Value ◽  
Randomized Control ◽  
Observational Group

Abnormal bilirubin metabolism results in abnormally raised serum bilirubin level thus presenting as yellowing of face, skin and mucosa to varying degrees. Purpose: To observe clinical effects on neonatal jaundice of micro-ecological preparation combined with blue light irradiation. Study Design: Randomized control trial. Methodology: Enrolled 100 neonatal jaundiced children (50 each group). Control group received blue light irradiation while observation group was given probiotics on the basis of blue light irradiation. Percutaneous bilirubin levels, clinical efficacy and the incidence of side effects were compared between pre and post-treatment groups. Statistical analysis: Data analyzed by SPSS 20.0v. Results: Post-treatment, levels of percutaneous bilirubin were significantly lower than pre-treatment. Observational group had significantly lower levels than the control group, having significant p-value (P<0.05). However, total effective rate of the observational group was significantly higher than control group with statistically significant p-value (P<0.05).The difference in incidence of ADR was significant (P<0.05). Conclusion: This study concluded that microecological preparation combined with blue light irradiation had a definite effect on the treatment of neonatal jaundice, not only effectively reduced the bilirubin level of children, but also reduced adverse reactions hence the safety was high. Therefore, it was worthy of application and promotion. Key Words: Neonatal Jaundice, Micro-ecological Preparations, Blue Light Exposure

scholarly journals Preoperative lidocaine infusion for the pain management in laparotomy procedures: a randomized control trial

2019 ◽  
Vol 26 (06) ◽  
Author(s):  
Hamid Raza ◽  
Ahmed Uddin Soomro ◽  
Maqsood Ahmed Siddiqui ◽  
Kamlaish ◽  
Muhammad Sheraz Raza Naqvi
Keyword(s):  
Pain Management ◽  
Visual Analog Scale ◽  
Randomized Control Trial ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Care Hospital ◽  
Analog Scale ◽  
Significant Difference ◽  
Randomized Control

Objectives: To evaluate the role of pre-operative lidocaine infusion for pain management in laparotomy procedures. Study Design: Prospective double blind randomized control trial. Period: 8 months duration from April 2017 to November 2017. Setting: Tertiary care hospital in Karachi, Pakistan. Method: N= 50 patients belonging to ASA Classification types I and II were selected to be part of this study. All the patients underwent major abdominal surgeries (laparotomy). The study group received lidocaine 2%, 1.5mg/kg IV bolus half an hour before induction, followed by an infusion of 1.5mg/kg/hour. The anesthesia was induced with fentanyl 3ug/kg, propofol 2mg/kg, followed by rocuronium 1mg/kg to intubate the patient. Maintenance was done with using 33% nitrous oxide in oxygen along with 0.8% of isoflurane. Fentanyl was administered as an infusion initiating prior to the procedure with a maximum dose of 1ug/kg/hour and ceasing the infusion half an hour prior to end of procedure. Visual analog scale was used to measure the pain intensity at an interval of twenty minutes during the first hour of the procedure, and at 2,4,8,12,24 and 48 hours after the end of the procedure. If the visual analog scale score was found to be more than 3, 1 to 3mg of Morphine was administered every ten minutes up to a dose of 0.1mg/kg intravenously. A proforma was used to collect data, data was analyzed using IBM SPSS version 21.0. Results: The study was conducted on n=50 patients, with a mean age of 38.35 years in the study group and 36.48 years in the control group. The intensity of pain was found to be significantly less in the case group as compared to the control group having a p value of <0.001 during the first 48 hours of the procedure. Decreased consumption of morphine was observed in patients in the study group, as compared to the control group with a statistically significant difference, having a p value of less than <0.05. In our study we did not observe any side effects related to toxicity levels of lidocaine or morphine. Conclusion: Our study confirms the results of previously done studies, and we found that in our patient population Perioperative lidocaine infusion decreased the post-operative pain experienced by the patient and decreased the need for consumption of analgesics. Thus we conclude that lidocaine infusion perioperatively is an effective pain management modality.

scholarly journals Combination therapy of dry cupping and Pece Kau'a (traditional therapy in Bima, West Nusa Tenggara Province in Indonesia) against blood pressure

2021 ◽  
Vol 7 (2) ◽  
pp. 56-62
Author(s):  
Rini Hendari ◽  
Dahlan D. Ahmad ◽  
Martiningsih Martiningsih ◽  
Julhana Julhana
Keyword(s):  
Blood Pressure ◽  
Combination Therapy ◽  
Randomized Control Trial ◽  
Health Centers ◽  
Control Group ◽  
P Value ◽  
Group Approach ◽  
Hypertensive Patients ◽  
Nursing Services ◽  
Randomized Control

This research aimed at investigating the influence of combination therapy of cupping and Pece Kau'a on hypertensive patients. The research design that was utilized was experimental design by a pretest-posttest control group approach. The population of this research was all patients who suffered from hypertension in Bima City, West Nusa Tenggara Province in Indonesia. The sample in this research was 60 respondents and this sampling utilized a randomized control trial. The results showed that combination therapy of dry cupping and Pece Kau'a on hypertensive patients could reduce the average of systolic and diastolic blood pressure with a p-value of 0.000. Therapy of dry cupping and Pece Kau’a is expected to be an alternative for medical action in nursing services both in hospitals and Public Health Centers. Besides, the combination therapy of dry cupping and Pece Kau’a could be developed more again.

scholarly journals Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial

Respiration ◽  
2021 ◽  
pp. 1-11
Author(s):  
Xiao Tang ◽  
Ying-Mei Feng ◽  
Ji-Xiang Ni ◽  
Jia-Ying Zhang ◽  
Li-Min Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Randomized Control Trial ◽  
Corticosteroid Treatment ◽  
Clinical Deterioration ◽  
Control Group ◽  
Number Of Patients ◽  
Early Use ◽  
Randomized Control ◽  
And Control ◽  
Single Blind

<b><i>Background:</i></b> There is still no clinical evidence available to support or to oppose corticosteroid treatment for coronavirus disease 2019 (COVID-19) pneumonia. <b><i>Objective:</i></b> To investigate the efficacy and safety of corticosteroid given to the hospitalized patients with COVID-19 pneumonia. <b><i>Methods:</i></b> This was a prospective, multicenter, single-blind, randomized control trial. Adult patients with COVID-19 pneumonia who were admitted to the general ward were randomly assigned to either receive methylprednisolone or not for 7 days. The primary end point was the incidence of clinical deterioration 14 days after randomization. <b><i>Results:</i></b> We terminated this trial early because the number of patients with COVID-19 pneumonia in all the centers decreased in late March. Finally, a total of 86 COVID-19 patients underwent randomization. There was no difference of the incidence of clinical deterioration between the methylprednisolone group and control group (4.8 vs. 4.8%, <i>p</i> = 1.000). The duration of throat viral RNA detectability in the methylprednisolone group was 11 days (interquartile range, 6–16 days), which was significantly longer than that in the control group (8 days [2–12 days], <i>p</i> = 0.030). There were no significant differences between the 2 groups in other secondary outcomes. Mass cytometry discovered CD3<sup>+</sup> T cells, CD8<sup>+</sup> T cells, and NK cells in the methylprednisolone group which were significantly lower than those in the control group after randomization (<i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> From this prematurely closed trial, we found that the short-term early use of corticosteroid could suppress the immune cells, which may prolong severe acute respiratory syndrome coronavirus 2 shedding in patients with COVID-19 pneumonia. <b><i>Trial Registration:</i></b> ClinicalTrials.gov, NCT04273321.

EFFECT OF ACCUPRESSURE PEN ON DISTANCE VARIABLE IN SCIATICA PATIENTS -A RANDOMIZED CONTROL TRIAL

2021 ◽  
pp. 28-31
Author(s):  
Urja S. Vaidya ◽  
Roshani S. Patel
Keyword(s):  
Randomized Control Trial ◽  
Stride Length ◽  
Step Length ◽  
Control Group ◽  
Exclusion Criteria ◽  
Parametric Test ◽  
Group A ◽  
Randomized Control ◽  
Experimental Group ◽  
Distance Variable

Background: Sciatica is a radiating pain which is treated with manual accupressure and after a time electro accupressure came into introduction. Aim And Objective: Aim: To nd out the effectiveness of accupressure pen to improve the distance variable To nd out the effect of Objective: accupressure pen on pain and distance variable in sciatica patient To compare the experimental group to the control group On the basis of Method: inclusion and exclusion criteria 30 participants were selected. They were treated with electro accupressure pen for 3 alternative days / week for 3 weeks, after that re-assessment was taken with NPRS, Slump and Distance variables. The data was analyzed using SPSS Version Results: 21.Parametric test was used .In Group A improvement was seen Accupressure Conclusions: pen is effective to reduce pain and improve step length and stride length in Sciatica Patients

scholarly journals Effects of Nutrition Education on Improving Knowledge and Practice of Complementary Feeding of Mothers with 6- to 23-Month-Old Children in Daycare Centers in Hawassa Town, Southern Ethiopia: An Institution-Based Randomized Control Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Selam Deksiyous Muluye ◽  
Tefera Belachew Lemma ◽  
Tona Zema Diddana
Keyword(s):  
Nutrition Education ◽  
Randomized Control Trial ◽  
Complementary Feeding ◽  
Dietary Diversity ◽  
Southern Ethiopia ◽  
Control Group ◽  
Feeding Practice ◽  
Daycare Centers ◽  
Randomized Control ◽  
Knowledge And Practice

Undernutrition and hidden hunger threaten the survival, growth, and development of children, young people, economies, and nations. Inappropriate complementary feeding practice due to poor maternal knowledge and awareness in combination with low income and infectious disease is the contributing factor for child undernutrition. Hence, this study was aimed at determining the effect of nutrition education on improving the knowledge and practice of complementary feeding of the mothers with 6- to 23-month old children in daycare centers of Hawassa Town, Southern Ethiopia. An institution-based randomized control trial design was employed. Daycare centers were randomly allocated for the intervention group and the control group. Among the total daycare centers in the town, five were assigned to receive nutrition education and the rest five for the control group (CG). The simple random sampling technique used to select individual participants from each daycare center. Two hundred (200) mother-child pairs (100 for each group) were recruited. Sociodemographic and economic variables were collected by the structured questionnaire. Knowledge of appropriate complementary feeding was assessed by seven knowledge questions. Appropriate complementary feeding practice was assessed by adapting Alive and Thrive Infant and Young Child Feeding (IYCF) practice guidelines. Nutrition education was given for four consecutive months by using Alive and Thrive IYCF guidelines. Data were analyzed by the SPSS software program version 20. The chi-squared test was used to test the significant differences in the proportion of good knowledge and good practice of complementary feeding and good dietary diversity between two groups. The independent t test was used to test the significant differences in mean dietary diversity between two groups. At 95% confidence interval, p<0.05 was considered statistically significant. The results revealed that the proportion of mothers with good knowledge of appropriate complementary feeding was increased from 59% at pretest to 96% at posttest and the appropriate complementary feeding practice was improved from 54% at pretest to 86% at posttest in IG. There was no change in the knowledge and practice of complementary feeding practice in CG after four months. The proportion of mothers with good complementary knowledge was 54% both at pretest and at posttest and good complementary feeding practice was 51% and 52% at pre- and posttest in CG, respectively. There was no significant difference (p>0.05) on complementary feeding knowledge and practice between two groups at pretest, while the difference was highly significant (p<0.05) at the posttest. In conclusion, providing nutrition education improved the appropriate complementary feeding knowledge and practice of mothers. In recommendation, government and other partners working on sustainable child nutrition reduction should focus on the nutrition education to improve the knowledge and appropriate complementary feeding practice including daycare centers.

scholarly journals Efektivitas Klinis Ofloksasin Topikal Dibanding Ciprofloksasin Oral Pada Terapi Otitis Media Supuratif Kronik Aktif

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
Deasy Mediawaty ◽  
Pujo Widodo ◽  
Dian Ayu Ruspita
Keyword(s):  
World Health Organization ◽  
Otitis Media ◽  
Randomized Control Trial ◽  
World Health ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Randomized Control ◽  
Health Organization ◽  
Per Oral

Latar belakang : Otitis media kronik atau sering disebut Otitis Media Supuratif Kronik (OMSK) adalah otitis media yang berlangsung > 12 minggu. Prevalensi OMSK di seluruh dunia sebanyak 65-330 juta dan 60% di antaranya menderita kurang pendengaran yang signifikan. Angka kejadian OMSK aktif mencapai 3,8% dari pasien THT-KL. Gejala OMSK aktif berupa banyaknya discaj, kurang pendengaran, nyeri, pusing berputar, telinga tidak nyaman. Tanda OMSK aktif berupa discaj di liang telinga, perforasi membran timpani, dan gangguan pendengaran. World Health Organization (WHO) mencanangkan strategi untuk mengatasi OMSK secara serius berkaitan dengan komplikasi yang dapat disebabkan. Pilihan terapi medikamentosa yang tepat diperlukan untuk mengatasi OMSK aktif. Ofloksasin topikal dan ciprofloksasin oral adalah antibiotik golongan fluorokuinolon yang banyak digunakan. Efektivitas diantaranya dibuktikan dengan perbaikan gejala dan tanda klinis. Tujuan : Membuktikan efektifitas ofloksasin topikal, ciprofloksasin oral dan efektifitas ofloksasin topikal dibanding ciprofloksasin oral terhadap perbaikan gejala dan tanda klinis. Metode :  Penelitian intervensi dengan rancangan pretest and posttest control group design, randomized control trial Klinik THT-KL BKIM Semarang pada bulan Juni-Agustus 2016. Penderita OMSK aktif dilakukan anamnesis lalu dilakukan pemeriksaan fisik dan pemeriksaan pendengaran dilanjutkan randomisasi. Penderita diberi ofloksasin topikal 10 tetes/12 jam atau ciprofloksasin tablet 500 mg/12 jam per oral. Hari ke 4, 10 dan 14 setelah terapi penderita kontrol. Analisis uji komparatif menggunakan uji parametrik dan non parametrik. Hasil : Jumlah subyek penelitian 108 orang ; ofloksasin topikal 54 orang (50%) dan ciprofloksasin oral 54 orang  (50 %). Gejala dan tanda klinis setelah terapi lebih rendah dibanding sebelum terapi pada kelompok ofloksasin topikal dan ciprofloksasin oral dengan nilai kemaknaan p < 0,05. Gejala klinis kelompok ofloksasin lebih baik dibanding ciproloksasin secara bermakna (p<0,05). Tanda klinis kedua kelompok terdapat perbedaan yang tidak bermakna (p>0,05). Simpulan : Ofloksasin topikal dan ciprofloksasin oral terbukti efektif memperbaiki gejala dan tanda klinis penderita OMSK aktif. Ofloksasin topikal efektif memperbaiki gejala klinis dibandingkan ciprofloksasin oral. Kata kunci : Otitis media supuratif kronik, ofloksasin, ciprofloksasin, gejala dan tanda klinis

scholarly journals Efficacy of Single Pre-Operative Dose of Glucocorticoid (125mg of Solumedrol Intravenous) in Terms of Seroma Formation in Patients Undergoing Mastectomy with Axillary Clearance For Breast Cancer: A Randomized Control Trial

2020 ◽  
pp. 1-5
Author(s):  
Aliya Ishaq ◽  
Abida Parveen ◽  
Aliya Ishaq ◽  
Mariya Ishaq ◽  
Muhammad Jamshaid Hussain Khan ◽  
...  
Keyword(s):  
Single Dose ◽  
Randomized Control Trial ◽  
Removal Rate ◽  
Fluid Collection ◽  
Study Groups ◽  
Seroma Formation ◽  
Control Group ◽  
Drain Removal ◽  
Randomized Control ◽  
And Control

Objective: The study aimed to determine the efficacy of single dose of glucocorticoid (125 mg of Solumedrol intravenous) in terms of seroma formation after mastectomy in patient with carcinoma of breast. Study Design: Randomized control trial. Place and Duration of Study: Study was conducted in the Department of General Surgery, Liaquat National Hospital Karachi, Pakistan from july 1 to dec 31, 2010. Patients and Methods: Patients were randomly divided in two groups (study and control) each group consisting of 30 patients. Randomization was done by opening of a sealed envelope which had a slip bearing the name of study medication (solumederol or saline as placebo) to be administered. The study group received a single dose of inj 125mg solumedrol IV half an hour prior to surgery by resident scrub in surgery. A similar procedure was applied to the control group and patients in controlled group were administered an equal volume of saline intravenously. After drain removal patients in both groups were observed for a duration of 2 weeks for sermoa formation. Detection of seroma formation was based on clinical grounds by absence of any fluid collection at mastectomy bed as detected by manual palpation. SPSS 10 was used for analysis. Results: Seroma formation was observed in 66.7% (40/60) women 2 weeks post drain removal. Rate of seroma formation was significantly low in study groups than control groups (33.3% vs. 100%; p=0.0001). Conclusion: Single dose of steroid is efficacious in reducing the post mastectomy seroma formation.

Effects of thoracic spine manipulation on pressure pain sensitivity of rhomboid muscle active trigger points: a randomized control trial

2021 ◽  
pp. 1-12
Author(s):  
Bibi Haleema ◽  
Huma Riaz
Keyword(s):  
Thoracic Spine ◽  
Randomized Control Trial ◽  
Rating Scale ◽  
Trigger Points ◽  
Control Group ◽  
Pressure Sensitivity ◽  
Myofascial Trigger Points ◽  
Pain Pressure Threshold ◽  
Significant Difference ◽  
Randomized Control

Abstract Objective: The objective of study was to determine the effects of thoracic spine manipulation on interscapular pain and pain pressure sensitivity, thoracic mobility and disability due to active myofascial trigger points in rhomboid muscle. Methods: A randomized control trial was conducted at Women Institute of Rehabilitation Sciences Abbottabad, from July to December 2019.Ethical permission was taken fromResearch ethical committee of Riphah international university Islamabad. Participants were selected through non-probability purposive sampling technique as per inclusion criteria. It consisted of 60 participants with forward head posture having active trigger points in rhomboid muscle, with age ranging from 18 to 30 years. The participants were randomly allocated through sealed envelope method into two groups that are experimental and control. Experimental group has received thoracic manipulation along with conventional physical therapy (CPT) whereas control group has only received CPT including manual pressure release and therapeutic exercise. Intervention was applied with 2 sessions / week with 3 weeks in total. Pre and Post assessment was done with outcome measurement tools comprised of Numeric pain rating scale (NPRS) for pain severity, Algometry for pain pressure threshold(PPT), Inclinometer for Range of movement(ROM) and Neck disability index (NDI) for associated disability. Data analysis was done using SPSS-20 version. Results: Between group analysis has shown significant improvement of pain & pain pressure sensitivity with p value <0.01 and <0.05 respectively. All outcome measures have shown significant difference in pre post treatment (p<.000) in both groups. Continuous...

B Lynch Suture and Intrauteribne Balloon Tamponade for Management of Severe Postpartum Hemorrhage: A Comparative Study

2021 ◽  
Vol 15 (9) ◽  
pp. 2948-2951
Author(s):  
Mehwish Syed ◽  
Afrah Aman ◽  
Saeeda Safi ◽  
Rabia Nawaz ◽  
Asia Habib ◽  
...  
Keyword(s):  
Success Rate ◽  
Gestational Age ◽  
Postpartum Hemorrhage ◽  
Randomized Control Trial ◽  
P Value ◽  
Bleeding Control ◽  
Balloon Tamponade ◽  
Group I ◽  
Randomized Control ◽  
Group Ii

Objective: The aim of this study is to compare the effectiveness of intrauterine balloon tamponade and B lynch suture for management of severe postpartum hemorrhage. Study Design: Randomized Control trial Place and Duration: The study was conducted at Gynae & Obs department of Qazi Hussain Ahmad Medical Complex, Nowshera KPK for six months duration from January to 2021 to June 2021. Methods: There were one hundred and twenty patients with ages 20-45 years were presented in this study. All women had severe postpartum hemorrhage were included in this study. Demographically detailed of enrolled cases age, body mass index, gestational age and parity were recorded after taking informed written consent. Patients were equally divided into 2-groups I and II. Group I had 60 patients and received Lynch suture while in group II 60 patients received intrauterine balloon tamponade. Post-operative success rate among both groups were assessed and compared in terms of bleeding control within 10-15 minutes. SPSS 24.0 version was used to analyze the complete data. Results: In group I mean age was 29.09±2.53 years with mean BMI 25.11±7.64 kg/m2 while in group II mean age was 29.02±3.62 years with mean BMI 24.87±6.32 kg/m2. Mean gestational age in group I was 37.87±3.29 weeks and in group II mean gestational age was 38.19±6.41 weeks. Mean parity in group I was 4.03±1.19 and in group II it was 4.01±0.87. Frequency of success rate in group I was significantly higher among 54 (90%) cases as compared to group II 39 (65%) with p value < 0.05. We found that patients of group I was significantly satisfied than that of patients who received intrauterine balloon tamponade. Conclusion: In this research we concluded that lynch suture for the management of severe postpartum hemorrhage among females had higher effectiveness in terms of bleeding control within 15 minutes and with higher satisfaction among patients as compared to those females who received intrauterine balloon tamponade. Keywords: Postpartum hemorrhage, Lynch Suture, intrauterine balloon tamponade, Success Rate

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