scholarly journals Oncologic outcomes of pelvic bone sarcomas surgical

2021 ◽  
Vol 5 (3) ◽  
pp. 252-259
Author(s):  
Djamila Sh. Polatova ◽  
Ulugbek F. Islamov ◽  
Rasulbek R. Davletov ◽  
Aleksandr V. Savkin ◽  
Muxiddin M. Sharipov
Keyword(s):  
Preoperative Planning ◽  
Survival Rates ◽  
Oncologic Outcomes ◽  
Pelvic Bone ◽  
Review Of The Literature ◽  
Malignant Tumours ◽  
Reconstructive Operations ◽  
Bone Sarcomas ◽  
Definition Of ◽  
Single Approach

Despite the development and implementation of new regimens and methods of adjuvant therapy, one of the complex problems of modern oncology is the treatment of malignant tumours of the pelvic bones, which is reflected in low survival rates and a high percentage of postoperative complications. The article provides a review of the literature on the problem of diagnosis, pathology, and preoperative planning of intraoperative navigation with the definition of the resection zone in pelvic bone sarcomas. Due to the complex anatomical structure of the pelvis, as well as the rare occurrence of pelvic bone sarcomas, a single approach to the treatment of this category of patients has not been developed. The authors conducted a deep analysis of the effectiveness of various types of reconstructive operations from 4 types of pelvic bone resections, depending on the location of the tumour.

scholarly journals Efficacy of perioperative chemotherapy for synovial sarcoma: a retrospective analysis of a Nationwide database in Japan

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gang Xu ◽  
Hisaki Aiba ◽  
Norio Yamamoto ◽  
Katsuhiro Hayashi ◽  
Akihiko Takeuchi ◽  
...  
Keyword(s):  
Overall Survival ◽  
Synovial Sarcoma ◽  
Survival Rates ◽  
Surgical Margin ◽  
Oncologic Outcomes ◽  
Wide Resection ◽  
Perioperative Chemotherapy ◽  
Relapse Free Survival ◽  
Free Survival ◽  
Distant Relapse

Abstract Background Synovial sarcoma is an aggressive but chemosensitive soft-tissue tumor. We retrospectively analyzed the efficacy of perioperative chemotherapy for synovial sarcoma with data from the nationwide database, Bone and Soft Tissue Tumor Registry in Japan. Methods This study included 316 patients diagnosed with synovial sarcoma between 2006 and 2012. Oncologic outcomes were analyzed using a Cox-hazard regression model. Moreover, the effects of perioperative chemotherapy on outcomes were evaluated using a matched-pair analysis. The oncologic outcomes of patients who did or did not receive chemotherapy were compared (cx + and cx-). Results Multivariate analysis revealed significant correlations of age (over 40, hazard ratio [HR] = 0.61, p = 0.043), margin status (marginal resection, HR = 0.18, p < 0.001 and intralesional resection, HR = 0.30, p = 0.013 versus wide resection) with overall survival; surgical margin type (marginal resection, HR = 0.14, p = 0.001 and intralesional resection, HR = 0.09, p = 0.035 versus wide resection) with local recurrence; and postoperative local recurrence (HR = 0.30, p = 0.027) and surgical margin (marginal resection, HR = 0.31, p = 0.023 versus wide resection) with distant relapse-free survival. Before propensity score matching, perioperative chemotherapy was mainly administered for young patients and patients with deeper tumor locations, larger tumors, more advanced-stage disease, and trunk location. The 3-year overall survival, local control, and distant relapse-free survival rates were 79.8%/89.3% (HR = 0.64, p = 0.114), 89.6%/93.0% (HR = 0.37, p = 0.171) and 71.4%/84.5% (HR = 0.60, p = 0.089) in the cx+/cx- groups, respectively. After propensity score matching, 152 patients were selected such that the patient demographics were nearly identical in both groups. The 3-year overall survival, local control, and distant relapse-free survival rates were 71.5%/86.0% (HR = 0.48, p = 0.055), 92.5%/93.3% (HR = 0.51, p = 0.436) and 68.4%/83.9% (HR = 0.47, p = 0.046) in the cx+/cx- groups, respectively. Conclusion This large-sample study indicated that the margin status and postoperative disease control were associated directly or indirectly with improved oncologic outcomes. However, the efficacy of perioperative chemotherapy for survival outcomes in synovial sarcoma patients was not proven in this Japanese database analysis.

scholarly journals An assessment of the use of patient reported outcome measurements (PROMs) in cancers of the pelvic abdominal cavity: identifying oncologic benefit and an evidence-practice gap in routine clinical practice

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Miss Charlotte L. Moss ◽  
Ajay Aggarwal ◽  
Asad Qureshi ◽  
Benjamin Taylor ◽  
Teresa Guerrero-Urbano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Abdominal Cavity ◽  
Patient Reported Outcome ◽  
Oncologic Outcomes ◽  
Review Of The Literature ◽  
Outcome Measurements ◽  
Patient Reported ◽  
Cancer Setting

Abstract Background Patient reported outcome measurements (PROMs) are emerging as an important component of patient management in the cancer setting, providing broad perspectives on patients’ quality of life and experience. The use of PROMs is, however, generally limited to the context of randomised control trials, as healthcare services are challenged to sustain high quality of care whilst facing increasing demand and financial shortfalls. We performed a systematic review of the literature to identify any oncological benefit of using PROMs and investigate the wider impact on patient experience, in cancers of the pelvic abdominal cavity specifically. Methods A systematic review of the literature was conducted using MEDLINE (Pubmed) and Ovid Gateway (Embase and Ovid) until April 2020. Studies investigating the oncological outcomes of PROMs were deemed suitable for inclusion. Results A total of 21 studies were included from 2167 screened articles. Various domains of quality of life (QoL) were identified as potential prognosticators for oncologic outcomes in cancers of the pelvic abdominal cavity, independent of other clinicopathological features of disease: 3 studies identified global QoL as a prognostic factor, 6 studies identified physical and role functioning, and 2 studies highlighted fatigue. In addition to improved outcomes, a number of included studies also reported that the use of PROMs enhanced both patient-clinician communication and patient satisfaction with care in the clinical setting. Conclusions This review highlights the necessity of routine collection of PROMs within the pelvic abdominal cancer setting to improve patient quality of life and outcomes.

scholarly journals Suprafascial Free Flaps: Classification and Comprehensive Review of the Literature

2021 ◽  
Vol 6 ◽  
pp. 247275122110205
Author(s):  
Sebastian Rios ◽  
María Isabel Falguera-Uceda ◽  
Alicia Dean ◽  
Susana Heredero
Keyword(s):  
Survival Rate ◽  
Preoperative Planning ◽  
Donor Site ◽  
Free Flaps ◽  
Donor Site Morbidity ◽  
Anterolateral Thigh Flap ◽  
Cochrane Library ◽  
Review Of The Literature ◽  
Comprehensive Review ◽  
Search Terms

Study Design: Suprafascial free flaps have become common place in reconstructive surgery units. Nomenclature related to these flaps has not been uniform throughout the scientific literature, especially in regard to planes of dissection. This study is designed as a comprehensive review of the literature. Objectives: Our study highlights which flaps are used most frequently, their main indications, their survival rate, and how they have evolved in the last few decades as innovations have been introduced. Methods: A review of the literature was performed using keywords and Medical Subject Headings search terms. PubMed, Embase, and Cochrane Library were searched using the appropriate search terms. Data collected from each study included flap type, dissection plane, preoperative planning, area of reconstruction, as well as complications, donor-site morbidity and survival rate. Results: Seven hundred and fifty-five studies were found based on the search criteria. After full-text screening for inclusion and exclusion criteria 34 studies were included. A total of 1332 patients were comprised in these studies. The most common types of flaps used were superficial circumflex iliac perforator flap (SCIP), anterolateral thigh flap (ALT), and radial forearm flap. The most common areas of reconstruction were head & neck and limbs. There was no significant difference in survival rates between flaps that were raised in different planes of dissection. Conclusions: Based on the author’s review of the literature, suprafascial flaps are reliable, they have low donor site morbidity, and there is a wide selection available for harvest. The use of new technologies for preoperative planning, such as CT-Angiography and UHF ultrasound, have contributed to have more predictable results. We propose a standardized classification for these flaps, in order to create a uniform nomenclature for future reference.

Primary Intrapulmonary Thymomas: Case Report and Review of the Literature

2009 ◽  
Vol 37 (4) ◽  
pp. 1252-1257 ◽  
Author(s):  
L Gong ◽  
Y-H Li ◽  
X-L He ◽  
Q Wang ◽  
L Yao ◽  
...  
Keyword(s):  
Epithelial Membrane Antigen ◽  
Immunohistochemical Analysis ◽  
Lung Tumour ◽  
Review Of The Literature ◽  
Malignant Tumours ◽  
Pathological Characteristics ◽  
Immunological Phenotype ◽  
Type A Thymoma

Primary intrapulmonary thymomas (PIT), which are intrapulmonary tumours without an associated mediastinal component, are very rare; only 29 cases of PIT have been described in the literature since 1951. This report presents a case of PIT in a 59-year old Chinese woman with a type A thymoma (including its pathogenesis, clinical pathological characteristics, immunological phenotype, treatment and prognosis), in the context of a review of the current literature. The origin of thymomas in this unusual location remains unknown. In this case, immunohistochemical analysis demonstrated that the epithelial component was strongly positive for cytokeratin and focally reactive for epithelial membrane antigen. It is concluded that PIT should be considered when the histopathological appearance of a lung tumour is not typical of other pulmonary neoplasms. Complete resection appears sufficient in non-malignant tumours, while in cases of partial resection or malignancy, adjuvant radiotherapy should be considered. Long-term regular clinical follow-up is also warranted, due to the risk of late local recurrence.

Migraine and Muscle-Contraction Headache: Psychiatric and Personality Issues—A Review

1985 ◽  
Vol 14 (2) ◽  
pp. 157-170
Author(s):  
Ranjan Roy
Keyword(s):  
Muscle Contraction ◽  
Psychiatric Disorders ◽  
Tension Headache ◽  
Review Of The Literature ◽  
Clinical Issues ◽  
The Past ◽  
Current Thinking ◽  
Definition Of

Presented is a selected review of the literature pertaining to migraine and tension headache of the past thirty or more years. Existence of “migraine” personality is explored. Association between psychiatric disorders and headache is examined. Problems of definition of these concepts are discussed and current thinking to resolve some of the clinical issues of these two types of headaches is presented.

Pelvic Bone Sarcomas: Controversies and Treatment Options

2010 ◽  
Vol 8 (6) ◽  
pp. 731-737 ◽  
Author(s):  
Carol D. Morris
Keyword(s):  
Radiation Therapy ◽  
Disease Management ◽  
Treatment Options ◽  
Current Treatment ◽  
Management Team ◽  
Pelvic Bone ◽  
Orthopedic Oncology ◽  
Bone Sarcomas ◽  
Sarcoma Treatment ◽  
Made In

Treatment of pelvic bone sarcomas remains one of the most challenging areas of orthopedic oncology for all members of the disease management team. Although considerable advances have been made in all aspects of sarcoma treatment, the prognosis for patients with primary sarcomas of the pelvis continues to be guarded, and therefore, much controversy exists regarding optimal surgical management, radiation therapy, and systemic therapy. This article summarizes the current treatment paradigms for the 3 most common bone sarcomas (osteosarcoma, Ewing's sarcoma, and chondrosarcoma), highlighting the unresolved issues in their management as they pertain to the pelvis.

scholarly journals BRAF V600E Mutations in Papillary Thyroid Carcinoma: Their Relation to Clinical Features and Oncologic Outcomes in A Single Cancer Centre Experience

2020 ◽  
Author(s):  
Mahmoud Al-Masri ◽  
Tawfiq Al-Shobaki ◽  
Hani Al-Najjar ◽  
Rafal Iskanderian ◽  
Enas Younis ◽  
...  
Keyword(s):  
Middle Eastern ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Clinicopathological Characteristics ◽  
Braf V600e ◽  
Oncologic Outcomes ◽  
Papillary Thyroid ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Disease Free

Abstract Introduction BRAF V600E is one of the most common mutations in Papillary Thyroid Cancer (PTC). Its clinical correlation has been extensively studied with contradictory results. The aim of this study is to evaluate the oncological impact of BRAF V600E mutation on a cohort of Middle Eastern PTC patients treated at a single institute.Methods Patients with histologically confirmed PTC that were treated surgically between 2006 to 2015 were included in the study. Formalin fixed paraffin embedded tumor blocks were sectioned and tested for BRAF V600E mutation. Short- and long-term oncological outcomes were collected. Results 128 patients (68% females) were included with a mean age of 38 years (±13.8). Median follow-up was 50 months. BRAF V600E mutation was found in 71% of patientsIThe BRAF negative tumors were significantly larger than the BRAF positive (3.47 cm versus 2.31 cm respectively, P = 0.009). All other clinicopathological characteristics were comparable between BRAF V600E mutation positive and negative groups. The two groups showed similar 5-year Disease-free (P= 0.37) and Overall survival rates (P = 0.94).Conclusion BRAF V600E mutation did not affect loco-reginal recurrence, distant metastasis, overall and disease-free survival. These results support the diversity of BRAF V600E significance among various ethnicities.

scholarly journals On the legal regime of virtual assets in Ukraine and the world

2020 ◽  
pp. 18-23
Author(s):  
Vladyslava MATVIIENKO ◽  
Artem KOTENKO
Keyword(s):  
The United States ◽  
State Regulation ◽  
Investment Climate ◽  
Legal Regime ◽  
Effective System ◽  
Digital Asset ◽  
The Republic ◽  
Definition Of ◽  
Favorable Conditions ◽  
Single Approach

The development of the digital economy leads to the emergence of a new concept of “digital asset”. It is very important to ensure state regulation of relations related to the use of digital currency and their involvement in civil and commercial legal relations today. Thus, Ukraine will get closer to the technological leaders of the economic sphere. In addition, the IT sector will create additional motivation for Ukrainian and foreign professionals based on the favorable conditions that are created. Issues related to solving the problem of anonymous unregulated cross-border transfers, corrupt settlements, money laundering are those that are currently being considered and require the adoption of a legal act. Existing approaches are analyzed to determine the digital asset among scientists. The analysis showed that there is currently no single approach to the definition of virtual assets and cryptocurrencies. The existing substitution of concepts in the definition and this topic needs to be refined by scientists – practitioners. The paper gives examples of states that have created regulations that allow to reveal the understanding of the components that should have the regulation of cryptocurrencies. In particular, the paper points to the models of legislation of such states as the Republic of Belarus, Great Britain and the United States. Special attention is paid to attempts to legalize cryptocurrencies in Ukraine. In addition, existing bills aimed at regulating legal relations regarding the circulation, storage, possession, use and conduct of cryptocurrency transactions are subject to analysis. The main factors of application of effective regulatory approaches to cryptocurrency transactions are determined. It is argued that the creation of a transparent and effective system of regulation of legal relations in the use of virtual assets should lead to a positive investment climate in Ukraine.

scholarly journals ECONOMIC SECURITY OF SMALL AGRICULTURAL ENTERPRISES

2019 ◽  
Vol 1 (15) ◽  
pp. 181-185
Author(s):  
M.V. Boiko
Keyword(s):  
Economic Security ◽  
Risk Level ◽  
Economic Science ◽  
Economic Stability ◽  
Economic Space ◽  
Agricultural Enterprises ◽  
Basic Approaches ◽  
Definition Of ◽  
Theoretical Foundations ◽  
Single Approach

The article “Economic Security of Small Agricultural Enterprises” aims at exploring the theoretical foundations of economic security for small agricultural enterprises. The basic approaches to definition of the category "economic security of the enterprise" are investigated. The theoretical bases of the definition of "economic security" are considered. The integration of Ukraine into the global economic space implies the modernization of the modern financial and economic system, which envisages the transition of market entities to a new level of relations and the leveling of traditional geographical boundaries. At the same time, the conditions of functioning of enterprises in a market environment become more stringent due to the expansion of the range of probable threats and dangers, which increase the risk level of conducting business activities, increasing uncertainty, and increasing competition. It is economic security that can provide the enterprise with effective functioning, economic stability, development and improvement of its competitiveness level. The main purpose of this work is to research and analyze the major achievements of economic science in the economic security of a small business and to present the author's vision of the essence of this concept. The set of research methods is the methodology of analysis and organization of major publications, legislation and laws, namely methods of generalization, comparison, chronologization, analysis and generalization. The author's vision of interpreting the concept of "economic security of enterprises" is a scientific novelty. The practical value of the study is to analyze the main publications on the definition of the essence of the concept of “economic security of the enterprise”, because today there is no single approach that would clearly interpret this concept.

scholarly journals A REVIEW ON THE CHARACTERISTICS OF A GOOD QUALITY LEADERSHIP STYLE

2019 ◽  
Vol 7 (5) ◽  
pp. 1152-1159
Author(s):  
Wael Ibrahim Alsarrani ◽  
Ahmad Jusoh
Keyword(s):  
Leadership Styles ◽  
Leadership Style ◽  
Theoretical Knowledge ◽  
Review Of The Literature ◽  
Daily Lives ◽  
Future Studies ◽  
The Past ◽  
Leadership Process ◽  
Definition Of

Purpose: Leadership is an interactive concept that influences our daily lives. A quality concept is an approach and philosophy that leaders use to incorporate the leadership process into the organization successfully. Both concepts have an incremental history, correlation, and discussion. However, the two concepts have not yet been theoretically and empirically integrated. This paper attempts to integrate and discuss leadership and quality to create a single quality leadership style based on the definition of quality gurus and the leadership styles which relate more towards the quality of leadership. Methodology: The study used a systematic literature review to review the past literature related to the field of leadership and quality management. This study provides the constructs from definitions proposed by experts in this field. Each leadership styles have many constructs that may or may not be related to quality. Results: The study proposed a conceptual framework which combined the definitions of quality gurus and the different leadership styles. The finding of this study has contributed to the expansion of theoretical knowledge in the field of quality leadership style. Implications: This paper indicated that the review of the literature regarding what quality gurus define as important relating to leadership. This paper provides the constructs from quality gurus definitions. Novelty: Each leadership styles have many constructs that may or may not be related to quality. Therefore, future studies need to consider what the constructs from those leadership styles are considered effective to quality.

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