FORMULATION AND OPTIMIZATION OF CEFIXIME TRIHYDRATE DISPERSIBLE TABLETS BY DIRECT COMPRESSION TECHNIQUE
The optimized formulation of cefixime dispersible tablets were developed using super disintegrants sodium starch glycolate and crospovidone. D-optimal design is used to optimize the formulation of cefixime dispersible tablet to study the effective concentration of independent variables SSG, crospovidone and MCC on responses (dependent variables) i.e. dispersion time, % drug release and % friability. Twelve formulations were prepared and evaluation of pre-compression and post compression parameters of tablets was perfomed. Analysis of variance (ANOVA) probability (p) < 0.05 for responses was found to be significant. A response surface plot is also presented graphically to represent the effect of the independent variables on the dispersion time, % friability and % drug release. Finally, a checkpoint batch is prepared to prove the validity of evolved method. The stability studies of the optimized formulation F13 were carried as per ICH guidelines proved that the optimized formulation was stable even after 2 months.