ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF CUCUMIS DIPSACEUS EHRENB. (FRUIT) IN STREPTOZOTOCIN- INDUCED DIABETIC RATS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (12) ◽  
pp. 53-61
Author(s):  
Gagandeep Kaur ◽  
◽  
D. Srivastav ◽  
Suman Lata
Keyword(s):  
Blood Glucose ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Methanolic Extract ◽  
Total Cholesterol Level ◽  
Serum Insulin ◽  
Glycosylated Hemoglobin ◽  
Diabetic Rats ◽  
The Body ◽  
Antidiabetic Activity

The present study was designed to investigate the hypoglycemic and antidiabetic properties of Cucumis dipsaceus fruit which is widely used in the Indian traditional medicine for the treatment of diabetes.Aim of present study, to investigate the antidiabetic action of the methanolic extract of C. dipsaceus fruits in Streptozotocin induced-diabetic rats. The antidiabetic activity of methanolic extract of fruit C. dipsaceus was evaluated by using normal and streptozotocin induced-diabetic rats. The acute effect of methanolic extract was evaluated by administering 500 mg/kg p.o. to normoglycemic rats. In the chronic model, the methanolic extract was administered to normal and STZ-induced-diabetic rats at dose of 250 mg/kg and 500 mg/kg p.o. per day for 21 days. Blood glucose levels and body weights were observed at specific intervals and different biochemical parameters were also monitored. Methanolic extract (500mg/kg) produced a significant reduction in blood glucose level in STZ- induced diabetic rats. The statistical data indicated a significant increase in the body weight and serum insulin level and decrease in the glycosylated hemoglobin levels. Total cholesterol level decreased while an increase in HDL and LDL cholesterol level was observed when treated with the extract. Thus the methanolic fruit extract of C. dipsaceus exhibited significant anti-hyperglycemic activities and beneficial effects in reducing the elevated total cholesterol level of STZ-induced-diabetic rats.

Antidiabetic activity of aqueous bark extract of Cassia glauca in streptozotocin-induced diabetic rats

2010 ◽  
Vol 88 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Md. Salahuddin ◽  
Sunil S. Jalalpure ◽  
Navneet B. Gadge
Keyword(s):  
Blood Glucose ◽  
Aqueous Extract ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Liver Glycogen ◽  
Diabetic Rats ◽  
Glycosylated Haemoglobin ◽  
The Body ◽  
Antidiabetic Activity ◽  
Significant Activity

The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normoglycemic and STZ-induced diabetic rats included the effect of the aqueous extract on oral glucose tolerance, fasting blood glucose, body weight, serum lipids, liver glycogen, serum insulin, and glycosylated haemoglobin. Oral administration of the aqueous extract of C. glauca bark at a dose of 500 mg/kg significantly reduced the effect of external glucose load. In a chronic treatment model, aqueous extract and glibenclamide (0.25 mg/kg) were administered for 21 days. At the end of the treatment, there was a significant increase in liver glycogen, serum insulin, and HDL cholesterol for both treatments. A significant decrease in fasting blood glucose, glycosylated haemoglobin, total cholesterol, and serum triglycerides was also observed. The body weights of the animals were observed to be consistent throughout the study. The findings showed the significant antidiabetic potential of the extract in ameliorating the diabetic condition in the diabetic rats. No significant activity was found in the normoglycemic rats.

scholarly journals The Comparison of Total Cholesterol Level in DMPA and Combination Injection Contraception Users

2020 ◽  
Vol 6 (2) ◽  
pp. 117
Author(s):  
Rara Yumna Elfrida ◽  
Gadis Meinar Sari ◽  
Sri Ratna Dwiningsih ◽  
Pudji Lestari
Keyword(s):  
Side Effects ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Sampling Technique ◽  
The Body ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Hormonal Content

Introduction: Hormonal injection contraception is the most widely used method of contraception in Indonesia. In long-term use, one of the side effects of injection contraception is changes in lipid metabolism in the body caused by the accumulation of hormones in the body. Two types of injectional contraception are widely used in Indonesia, namely combined injection and DMPA injection; different hormonal content has various side effects on the lipid profile. This study aimed to compare the total cholesterol level between acceptors of DMPA injection and combined injection.Methods: This study used an observational analytic method with a cross-sectional approach. The sample size is 60 respondents, including 30 DMPA injection acceptors and 30 combination injection acceptors. The sampling method uses a purposive sampling technique The independent variable in this study was the total cholesterol level of the acceptor, and the dependent variable was the acceptor of DMPA injection and the combination injection acceptor. Analysis of research data used the Independent T-test with α=0.05.Results: The results of the bivariate analysis found significant differences in total cholesterol levels in the DMPA injection contraception acceptor and combination injection with p= 0.037. It was found that overall cholesterol levels of DMPA injection acceptors were higher.Conclusion: There is a difference in total cholesterol levels in the DMPA injection contraception acceptor with a combination injection contraception acceptor.

scholarly journals ANTIDIABETIC ACTIVITY OF KALANCHOE PINNATA IN ALLOXAN-INDUCED DIABETIC RATS

2019 ◽  
pp. 241-245
Author(s):  
LATHA OPHELIA GEORGE ◽  
RADHA HR ◽  
SOMASHEKARAIAH BV
Keyword(s):  
Body Weight ◽  
Uric Acid ◽  
Methanolic Extract ◽  
Public Health Problem ◽  
Diabetic Rats ◽  
The Body ◽  
Antidiabetic Activity ◽  
Percentage Increase ◽  
Group I ◽  
Kalanchoe Pinnata

Objective: The main purpose of the present study was to analyze the antidiabetic activity of methanolic extract of the leaf of Kalanchoe pinnata in alloxan-induced diabetic rats. Methods: Diabetes mellitus (DM) is a chronic metabolic and endocrine disease regarded as a serious global public health problem. Albino Wistar rats were divided into four groups. Group I (normal) received drinking water throughout the course till 20 days. Groups II-IV received alloxan (120 mg/kg b.w) i.p on the 1st day of the study period. Group III animals received glibenclamide (10 mg/kg p.o) and Group IV received K. pinnata (200 mg/kg b.w p.o) for 20 days. The body weight, blood glucose level, serum urea, blood urea nitrogen (BUN), creatinine, cholesterol, total protein (TP), uric acid, and tissue (liver) antioxidant parameters: Malondialdehyde (MDA) and glutathione (GSH) were measured. Results: K. pinnata treated rats showed the percentage increase in the body weight, decrease in the blood sugar level, creatinine, TP level, urea, uric acid, and BUN, MDA, and GSH when compared to alloxan-induced diabetic mellitus control rats. Thus, K. pinnata could be possibly employed to treat DM. Conclusion: This preliminary analysis tested the most promising profile. It seems that methanolic extract of the leaf of K. pinnata improved general, blood serum, and liver antidiabetic agent. However, further studies confirming its potential is certainly warranted.

scholarly journals Promoting non-communicable disease risks in rural area: a Community and Family Health Care - inter professional education (CFHC-IPE) activity

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Dea Aryas Nugrahani ◽  
Diannisa Ikarumi Enisar Sangun ◽  
Khansa Anindya ◽  
Niken Kuntolowati
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Health Status ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Professional Education ◽  
Total Cholesterol Level ◽  
Family Health ◽  
Health Examination ◽  
Random Blood Glucose

Health is an aspect that could be viewed from various age groups and factors. Risk factors found during Community and Family Health Care-Inter Professional Education visits in Pondok 2, Widodomartani, Ngemplak are the habits of people who still lacking in controlling excessive consumption of sugar, salt, and oily foods. These may lead to  many problems such as hypertension, diabetes mellitus and hypercholesterolemia. Based on the problem, our group held the community service activities focusing on health screening, particularly on the measurement of blood pressure, random blood glucose, and total cholesterol level.  This activity aims  to screen the community health condition and to raise health awareness and understanding. Therefore, people may start to take action improving their lifestyle in order to maintain their long term health status. This research is a retrospective study using secondary data obtained from health examination records at the time of community service. The health check-up was conducted on May 4, 2019. We utilize mannual mercury sphygmomanometer for blood pressure measurement and automatic skin prick test device for random blood glucose and total cholesterol level. During the health examination, we also counsel the subjects about healthy lifestyle. Sixteen people from the targeted community attended the activity. Half of the people had normal blood pressure;  1 person pre-hypertension; 4 persons stage I hypertension, and 3 persons stage II hypertension.  For random blood glucose measurement, only 1 resulted in high random blood glucose whilst others were within normal limit.  Total cholesterol level was examined to 9 people with history of hypercholesterolemia with the following results; 2 people had high level, 2 people had borderline-high level ,and the rest had normal level. Most of the people within the community had good health status. This kind of activity can be routinely conducted not only to screen community health status but also to promote health awareness.

scholarly journals An antioxidant activity of Cinnamonum tamala improves histopathological alterations and biochemical parameters in alloxan induced diabetic rats

2019 ◽  
Vol 10 (6) ◽  
pp. 50-56 ◽  
Author(s):  
Mamata Laxmikant Pochhi
Keyword(s):  
Serum Insulin ◽  
Glycosylated Hemoglobin ◽  
Antioxidant Properties ◽  
Insulin Level ◽  
Diabetic Control ◽  
Protective Role ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Standard Drug ◽  
Cinnamomum Tamala

Background: Diabetic mellitus is a multifactorial disorder associated with its devastating consequences has assumed epidemic proportion. Diabetes mellitus (DM) is a global health problem and the incidence of DM is increasing at alarming rate all over the world. Many Indian medicinal plants have been reported to possess potential antidiabetic activity and could play important role in the management of diabetes with less adverse effects. Aims and Objectives: The main objective of this study was to focus on the anti-diabetic activity of Cinnamomum tamala, with special reference to its curative and protective role in alloxan induced diabetic rats. Attempts were further made to study the antioxidant properties of C. tamala leaves. Materials and Methods: The diabetic rats were administered orally with the aqueous leaves extracts of Cinnamonum tamala (250 mg/kg) for 30 days. The results were compared with standard drug Tolbutamide. Result: The alloxan treated diabetic control rats showed a significant increase in the plasma glucose, glycosylated hemoglobin (HbA1C), glucose-6-phosphatase, aldolase, LDH, ALT, AST, ALP and GGT activity, freeradicals formation with a concomitant decrease in glycogen content in the liver and serum insulin level and phosphoglucoisomerase and hexokinase activity in tissues as compared to normal control rats. Oral administration of C. tamala extract for 30 days showed significant result as compared to Tolbutamide and diabetic control rats. Conclusion: On the basis of above findings it can be concluded that extracts of C. tamala to alloxan induced diabetic rats showed significant positive changes in the biochemical and histopathological parametersrelated to carbohydrate and protein metabolism.

Anti-Diabetic Potential of Murraya Koenigii (L.) and its Antioxidant Capacity in Nicotinamide-Streptozotocin Induced Diabetic Rats

Drug Research ◽  
2018 ◽  
Vol 68 (11) ◽  
pp. 631-636 ◽  
Author(s):  
Fauzul Husna ◽  
Franciscus Suyatna ◽  
Wawaimuli Arozal ◽  
Erni Poerwaningsih
Keyword(s):  
Blood Glucose ◽  
Antioxidant Properties ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
The Body ◽  
Antidiabetic Activity ◽  
Murraya Koenigii ◽  
Insulin Mimetic ◽  
Protein Levels ◽  
Glucose Levels

Abstract Aim and Objective The present study aims to investigate whether the antihyperglycemic effect of Murraya koenigii is mediated by antioxidant properties and insulin mimetic effect. Methods Thirty Spraque-Dawley rats were induced hyperglycemia by streptozotocin and nicotinamide (STZ-NA). The STZ-NA diabetic rats were treated with an ethanolic extract of Murraya koenigii 200 mg/kg b.w and 400 mg/kg b.w. One group was treated with glibenclamide (1 mg/kg b.w). After the administration of Murraya koenigii extract and glibenclamide for four weeks, the rats were sacrificed. Blood and organ samples were collected under a fasting condition. The body weight and blood glucose levels were measured. Hepatic enzymes were determined using a commercial kit, protein levels were estimated by Bradford’s method, and plasma insulin was assayed by an ELISA kit. Malondialdehyde (MDA) and reduced glutathione (GSH) levels were estimated by the TBA-Wills method and Ellman’s method, respectively. Results Ethanolic extract of Murraya koenigii showed a significant reduction in blood glucose level at both doses, 200 and 400 mg/kg b.w. In addition, Murraya koenigii exhibited a profound antioxidant effect with decreased MDA level and increased GSH level, particularly at the 200 mg/kg b.w. and significantly decreased the HOMA-IR index. Conclusions The present study reveals that Murraya koenigii possesses antidiabetic activity and antioxidant effects on STZ-NA induced diabetes mellitus.

scholarly journals Effect of 5-HTP and L-Dopa on lipid profile of Streptozotocin induced diabetic mice

2014 ◽  
Vol 15 (3) ◽  
pp. 149-155
Author(s):  
Ulka Yadav ◽  
Rajkumari Batham
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Protein ◽  
Body Weight Gain ◽  
Glycosylated Hemoglobin ◽  
Hdl Cholesterol ◽  
The Body ◽  
Diabetic Mice

The present study was designed to test whether the precursor of serotonin (i.e.5-HTP) and dopamine (i.e. L-DOPA) can influence Body weight and certain hematological constitutes (i.e. blood glucose, glycosylated hemoglobin and serum protein) in streptozotocin induced diabetic mice. In the study, animals were divided into 6 groups. After 10 days at the termination of experiment body weight and blood glucose taken. Blood was collected from left ventricle and deposited to pathology for haematological analysis (i.e. blood Glucose, glycosylated heamoglobin, serum protein, triglyceride total cholesterol, HDL-cholesterol, LDC-cholesterol, and VLDL-cholesterol). Statistical analysis were done with the help of student’s ‘t’ test followed by analysis of variance (ANOVA). The result of the present study suggest that peripheral administration of 5-HTP (a precursor of serotonin) and L-DOPA (a precursor of dopamine) influences the body weight gain and lipid profile (i.e. triglyceride, total cholesterol, HDL-cholesterol , LDL-Cholesterol, VLDC-cholesterol) in streptozotocin induce diabetic mice. The finding of the present study supports the concept that insulin alone does not fully control diabetes. Other chemical substance like neurotransmitter/hormones may involve in controlling the diabetes.

scholarly journals In vivo antidiabetic activity of qwueous extract of Artemisia argyi (Chinese mugwort) in alloxan-induced diabetic rats

2020 ◽  
Vol 19 (7) ◽  
pp. 1487-1493
Author(s):  
Xinliang Wu ◽  
Junxue Zhuang ◽  
Zixia Bai ◽  
Daliang Guo
Keyword(s):  
Diabetes Mellitus ◽  
Total Cholesterol ◽  
Histological Examination ◽  
Glycosylated Hemoglobin ◽  
Intraperitoneal Administration ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Hypolipidemic Effect ◽  
Artemisia Argyi ◽  
Soxhlet Apparatus

Purpose: To determine the antidiabetic, antioxidant and anti-hyperlipidemic effects of aqueous leaf extract of Artemisia argyi (Asteraceae) in alloxan (ALX)-induced diabetic rats. Experimental: Soxhlet apparatus was packed with grinded leaves of A. Argyi and subjected to extraction by double distillation using water as  running solvent for 4 – 5 h. Male albino Wistar rats weighing 150 ± 10 g were used in this study. Diabetes was induced in overnight-fasted rats via intraperitoneal administration of freshly prepared 10 % alloxan solution at a dose of 186.9 mg/kg. Serum glucose (Glc), high-density lipoprotein cholesterol (HDL-c), triglycerides (TGs) and total cholesterol (TC) were evaluated using Randox assay kits. Serum reduced glutathione (GSH) was assayed using a slight modification of a previously reproted procedure, while histological examination was carried out microscopically after hematoxylin and eosin staining. Results: Oral administration of aqueous extract of Artemisia argyi significantly reduced ALX-induced increases in glycosylated hemoglobin and blood glucose, but significantly increased total protein, hemoglobin, insulin, and C-peptide levels (p < 0.05). Administration of the extract also led to a significant upsurge in non-enzymic antioxidants i.e. ceruloplasmin, GSH, vitamin E and vitamin C. The extract produced a hypolipidemic effect by significantly reducing total cholesterol (TC) and serum TGs. The hypoglycemic and hypolipidemic effects of the extract were dose-dependent (p < 0.05). Histological examination of the pancreas revealed that the extract protected the integrity of beta cells in ALXinduced diabetic rats. Conclusion: These results indicate the beneficial effects of Artemisia argyi against diabetes mellitus. Thus, Artemisia argyi may be useful in the management of diabetes mellitus. Keywords: Artemisia argyi, Antidiabetic, Glutathione, Histopathology, Antioxidant

scholarly journals Efektivitas Nasi Beras, Merah (Oryza Nivara) Terhadap Kadar Kolesterol Total Penderita Diperkolesterolemia

Jurnal GIZIDO ◽  
2019 ◽  
Vol 11 (01) ◽  
pp. 1-7
Author(s):  
Nonce Nova Legi ◽  
Mirna Kawulusan ◽  
Marstevi Olivia Gedoan
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Brown Rice ◽  
The Body ◽  
Water Soluble ◽  
Soluble Fiber ◽  
Oryza Nivara ◽  
Cholesterol Levels ◽  
Before And After

Hypercholesterolemia is an increase in total cholesterol levels in the blood beyond the normal limits. Excess cholesterol levels in the blood will have an impact on degenerative diseases. Brown rice (oryza nivara) is a rice rich in vitamins, minerals and contain water soluble fiber that can help bind cholesterol, then throw it out of the body. Regular consumption of brown rice is very beneficial for health that can reduce levels of LDL. The aim of this research is to know the effectiveness of brown rice rice to total cholesterol level in hypercholesterolemia patient in Vilage Sea Pineleng District of Minahasa Regency. The type of this research is Quasi Eksperimen with One Group of Pretest and Posttest Design. The sample in this study is the entire population of hypercholesterolemia patients recorded in Posbindu Village Sea Pineleng District Minahasa regency that meets the inclusion criteria. Rice brown rice is given for 8 consecutive days every morning, day and night. Total cholesterol levels were measured before and after administration of brown rice. Data analysis using Paired t-test. The results showed that the total cholesterol level before the study was the highest of 360 mg / dl, the lowest was 216 mg / dl, and after the highest total cholesterol was 298 mg / dl, the lowest was 164 mg / dl. The result of statistical test shows that p = 0,019 (p <0,05), which means that there is difference of total cholesterol before and after giving of rice of red rice to hypercholesterolemia patient in Vilage Sea Pineleng Sub-district of Minahasa Regency.

Mature coconut water exhibits antidiabetic and antithrombotic potential via L-arginine-nitric oxide pathway in alloxan induced diabetic rats

2015 ◽  
Vol 26 (6) ◽  
Author(s):  
Prabhakaran Prabha Preetha ◽  
Vishalakshiamma Girija Devi ◽  
Thankappan Rajamohan
Keyword(s):  
Nitric Oxide ◽  
Body Weight ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin ◽  
Diabetic Rats ◽  
Coconut Water ◽  
Antidiabetic Activity ◽  
Sprague Dawley ◽  
Glucose Plasma ◽  
Nitric Oxide Pathway

AbstractThe aims of the present study were to assess whether the antidiabetic activity of mature coconut water (MCW) is mediated through L-arginine-nitric oxide pathway in diabetic rats, and to study the effects of MCW on blood coagulation.Diabetes was induced in male Sprague-Dawley rats by injecting them with alloxan (150 mg/kg body weight). MCW (4 mL/100 g body weight) and L-arginine (7.5 mg/100 g body weight) was given orally for 45 days. L-NAME was given at a dose of 0.5 mg/kg body weight. Concentrations of blood glucose, plasma insulin, glycosylated hemoglobin (HbA: Treatment with MCW and L-arginine reduced the concentration of blood glucose and HbAThe results clearly indicate that L-arginine is a major factor responsible for the antidiabetic and antithrombotic potential of coconut water, and is mediated through the L-arginine-nitric oxide pathway.

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