scholarly journals Hypoglycemic Effect of Lycopersicon esculentum (Tomato) on Alloxan-Induced Diabetic Rats

2021 ◽  
Vol 9 (2) ◽  
pp. 15-18
Author(s):  
Abubakar Aisami ◽  
Jalil Idi James ◽  
Fatima Umar Maigari ◽  
M. K. Atiku
Keyword(s):  
Lycopersicon Esculentum ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Albino Rats ◽  
Sugar Levels

Diabetes mellitus has been a key degenerative disease affecting the world’s population. Lycopersicon esculentum (Tomato), a fruit consumed by many and known to have certain phytochemicals was used to determine its hypoglycemic effect on alloxan induced diabetic rats. The tomato was dried, pulverized and dissolved in distilled water and administered orally to albino rats in various concentrations according to their body weight. 30 albino rats were divided into 6 groups of 5 rats each. Groups I and II served as normal and diabetic control respectively, while groups III to VI were induced with diabetes and treated with different concentrations of the prepared tomato. After 14 days of treatment with various concentrations of tomato, there was a marked decrease in blood sugar levels at all the study concentrations. The result of the lipid profile a significant increase (p<0.05) in total cholesterol (150.67±7.02 mg/dL), triglyceride (159.33±5.03 mg/dL), LDL-Cholesterol (77.53±1.83 mg/dL) and a decrease in HCL-Cholesterol (51.67±1.00 mg/dL) levels in untreated diabetic rats when compared to the normal control. Upon treatment with 200 mg/kg of tomato, there was a significant decrease (p< 0.05) in the levels of Triglyceride, total cholesterol and LDL-cholesterol and an increase in the HDL-cholesterol. These results suggest that tomato may have the ability to reduce blood sugar level and the risk of cardiovascular disease.

scholarly journals Hypoglycaemic and Hypolipidemic Effects of Treculia africana Aqueous Leaves Extract in Alloxan Induced Diabetic Rats

2018 ◽  
pp. 1-9
Author(s):  
Idris A. Kankara ◽  
Gayus A. Paulina ◽  
M. Aliyu
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Treculia Africana

This study investigated the hypoglycaemic and hypolipidaemic effects of Treculia africana plant used in Nigeria as medicinal plant. Diabetes mellitus was induced by a single dose intraperitoneal injection of alloxan 150 mg/kg body weight. Twenty five (25) male albino rats were divided into five groups, five (5) rats per group; normal control, diabetic control and diabetic groups treated with aqueous leaves extract of 200,400 and 800 mg/Kg body weight respectively for 21 days orally. The effects of the extract on some biochemical parameters were evaluated; fasting blood glucose level was assayed using glucose oxidase method, total cholesterol and HDL –cholesterol were assayed using enzymatic method while LDL- cholesterol was determined by Friedewald equation. The results showed that, extract significantly (p<0.05) decrease the elevated fasting blood glucose levels, total cholesterol, triglyceride and LDL- cholesterol when compared with the diabetic control rats. The extract also caused significant (p<0.05) increased in HDL –cholesterol and body weight when compared with diabetic control rats. Aqueous leave extract of Treculia africana possess hypoglycemic effect and the most effective dose was 800 mg/Kg body weight in amelioration of hyperglycaemia and most all toxicity effects of alloxan on lipid profile.

scholarly journals Antidiabetic Activity of Aerial Parts and Seeds of Purslane (Portulaca oleracea) on Diabetic Rats

2020 ◽  
pp. 13-23
Author(s):  
E. G. El- Dreny
Keyword(s):  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Basal Diet ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Biological Experiment ◽  
Aerial Parts ◽  
Liver And Kidney

This study has been proposed to study the effect of aerial parts and seeds of purslane on diabetic rats. Chemical composition, phenolic compounds and fatty acids of purslane and seeds powder were determined. A biological experiment was performed using 30 male albino rats. The rats were divided into six groups (five in group) and the duration of experiment was 8 weeks. Normal control (G1) non- diabetic rats fed on the basal diet, diabetic control (G2) diabetic rats fed on the basal diet only, the other groups of diabetic rats fed on basal diet supplemented with purslane (5 and 10%) and  seeds (5 and 10%). The results of biological experiment indicated that adding of purslane and seeds to basal diet for diabetic rats, led to improvement in liver and kidney functions and an increase in body weight and HDL cholesterol and decrease blood glucose, TC, TG, LDL cholesterol, v-LDL cholesterol comparing to those of diabetic rats fed on basal diet only diabetic control. Purslane (5 and 10%) and seeds (5 and 10%) were added to burger as a replacement of fat. The results of sensory evaluation indicated that all sensory properties of the burger prepared with purslane and seeds were acceptable. Through the results of this study, we recommend the possibility of using purslane and seeds to prevent and reduce the symptoms caused by diabetes.

scholarly journals Effects of Ipomoea aquatica Forsk. in cyclophosphamide induced dyslipidaemia in albino rats

2017 ◽  
Vol 6 (11) ◽  
pp. 2743
Author(s):  
Rajesh Das ◽  
Khuraijam Sucheta Devi ◽  
Sayeri Dutta ◽  
Ananya Das ◽  
Prasenjit Das ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Aqueous Extract ◽  
Group Treatment ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Normal Group ◽  
Albino Rats ◽  
Ipomoea Aquatica ◽  
Group I ◽  
Toxic Group

Background: Cyclophosphamide (CP) is commonly used as anticancer and immuno suppressant agent. It induces hyperlipidemia and myocardium damage. Ipomoea aquatic Forsk. is traditionally used for cardiovascular disease, paralysis and general debility. The present study was done to evaluate the protective effect of the plant against CP induced dyslipidaemia in albino rats.Methods: Twenty albino rats were divided into 4 groups of 5 animals each. Group I (normal group) received normal saline intraperitoneally. Groups II to IV received CP (200mg/kg body weight, intraperitoneally) single dose on day 1 of experimental period. Groups I and II (toxic group) animals were given 2% gum acacia per orally daily for 10 days. Groups III and IV received aqueous extract of stem and leaves of Ipomoea aquatica 200mg/kg and 400mg/kg per orally respectively daily for 10 days. On 11th day, blood samples were collected for estimation of triglycerides, total cholesterol, LDL-cholesterol and HDL-cholesterol and heart tissues were sent for histopathology examination (HPE).Results: CP administration significantly (P<0.05) increased the levels of triglyceride, total cholesterol, LDL-cholesterol and decreased the level of HDL-cholesterol in toxic group compared to normal group. Treatment with aqueous extract of Ipomoea aquatica significantly (P<0.05) reversed the status of lipid profile compared to toxic group. HPE of myocardium showed reversal of the toxic effects of CP in the extract treated groups.Conclusions: Ipomoea aquatica showed protective effects against CP induced dyslipidaemia in albino rats.

scholarly journals PENGARUH AROMATERAPI MINYAK ATSIRI JAHE TERHADAP KADAR TRIGLISERIDA DAN KOLESTEROL DARAH TIKUS YANG DIBERI PAKAN TINGGI LEMAK

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Aji Agung Cahyaji
Keyword(s):  
Essential Oil ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
High Fat Diet ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Albino Rats ◽  
Standard Diet ◽  
High Fat

The study aims to determine the effect of ginger (Zingiber officinale) essential oil via inhalation on blood triglyceride, total cholesterol, High Density Lipoprotein (HDL) cholesterol, and Low Density Lipoprotein (LDL) cholesterol level of rats that fed high fat diet. Eighteen albino rats (Rattus norvegicus) were devided into three treatments groups. The treatments were K1 (standard diet) as negative control, K2 (high fat diet) as positive control, and K3 (high fat diet + ginger essential oil inhalation). Blood samples were collected after 5 weeks of treatment period. The result showed the level of triglyceride, cholesterol, and HDL cholesterol at treatment K3 tend to be lower than treatment K2. LDL cholesterol level at treatment K3 show higher result than treatment K2. From the result of this study cocluded that inhalation of ginger essential oil can lowering triglyceride, total cholesterol, and LDL cholesterol level and raise HDL cholesterol level. Keywords: triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, ginger essential oil

scholarly journals Turmeric Powder Gavage Improves Lipid Profile of Albino Rats

2020 ◽  
pp. 42-46
Author(s):  
A. V. Iwueke ◽  
W. C. Madu ◽  
E. C. Chukwu
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Curcuma Longa ◽  
Hdl Cholesterol ◽  
The Body ◽  
Albino Rats ◽  
Once Daily ◽  
Body Weights ◽  
Daily Oral Administration

Dyslipidemia is one of the key risk factors for cardiovascular diseases, which is a leading cause of global morbidity and mortality. This study was designed to investigate the effect of powdered Curcuma longa (turmeric) tubers on lipid profile of albino rats. Twenty-four (24) male albino rats were randomly divided into four groups (A-D), receiving once daily administration of distilled water, 50, 100 and 200 mg/kg of the powder respectively. The body weights of the animals were measured weekly, while lipid profile was determined after three weeks. The result showed that daily oral administration of graded doses of the C. longa powder for three weeks resulted in a non-significant increase in the body weights of the animals. Daily oral turmeric powder (200 mg/kg) treatment significantly (p ≤ 0.05) lowered the serum total cholesterol and triglyceride concentrations, while those that received 100 mg/kg significantly increased HDL-Cholesterol and reduced LDL-Cholesterol. Turmeric powder lowered total cholesterol, triglyceride and increasing HDL cholesterol in albino rats at the indicated doses and duration.

scholarly journals STUDIES ON GLYCOGEN NEPHROSIS IN ALLOXAN-TREATED DIABETIC RATS

1947 ◽  
Vol 85 (4) ◽  
pp. 373-379 ◽  
Author(s):  
G. W. Curtis ◽  
S. L. Robbins ◽  
I. Glickman
Keyword(s):  
Blood Sugar ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Maximum Height ◽  
A Value ◽  
Reversible Lesion ◽  
Glycogen Deposition ◽  
Sugar Levels ◽  
Terminal Blood ◽  
Convoluted Tubules

Two hundred and seven albino rats were injected subcutaneously with alloxan in doses varying from 140 to 200 mg. per cent per kilo of body weight. Fifty-nine animals which developed hyperglycemia (blood sugar levels above 150 mg. per cent) were observed for periods from 5 days to 32 weeks. Postmortem examination of the kidneys of these diabetic animals revealed glycogen deposition in the loops of Henle and convoluted tubules in 26 rats or 44 per cent. Glycogen could not be demonstrated in the glomeruli. Within the time limits of this experiment (32 weeks) no intercapillary glomerulosclerosis was observed. The following facts were revealed regarding glycogen nephrosis in alloxan diabetes: (a) Its appearance in the kidneys of the diabetic rats depended solely upon the terminal blood sugar levels of these animals. A value of 350 mg. per cent was the critical level, above which glycogen nephrosis was almost invariably demonstrable. With terminal levels below 300 mg. per cent no glycogen nephrosis was found. (b) No relationship existed between the postmortem finding of glycogen nephrosis and the initial blood sugar level, or the maximum height of the hyperglycemia attained by individual rats. (c) The results suggest that glycogen nephrosis is a reversible lesion.

scholarly journals Antidiabetic Activity of Extracts of Pithecellobium dulce Benth Leaves in Alloxan Induced Diabetic Rats

2016 ◽  
Vol 8 (05) ◽  
Author(s):  
V. S. Mul ◽  
N. Naikwade ◽  
C. Magdum ◽  
V. Jagtap
Keyword(s):  
Uric Acid ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Glycogen Level

The objective of the present study was to study effect of Pithecellobium dulce Benth (P. dulce) leaves in alloxan induced diabetic rats. The P. dulce leaves were extracted by maceration and soxhelation method by using water and ethanol as solvent. Acute toxicity study was performed according to OECD 425 guidelines for both aqueous and ethanolic extracts of P. dulce leaves. The dose of 200 mg/kg and 400 mg/kg was selected for further studies. Animals were rendered diabetic by administration of alloxan (130 mg/kg, i.p.). The albino rats were divided in to seven groups with five animals in each group. Diabetic animals were treated with aqueous and ethanolic extract for 20 days. Then blood glucose, triglyceride, total cholesterol, urea, uric acid, creatinine, aspartate aminotransferase (AST), alanine transaminase (ALT) and glycogen level in liver, muscle and kidney were estimated according to standard procedures. The result shows significant decrease in blood glucose, triglyceride, total cholesterol, urea, uric acid, creatinine, AST and ALT level when compared to diabetic group. The liver and muscle glycogen level was increased significantly in extract treated groups when compared to diabetic control group. Both extract of P. dulce posses antidiabetic and hypolipidemic potential.

scholarly journals PROPHYLACTIC LIPID LOWERING EFFECTS OF AQUEOUS EXTRACT OF EMILIA PREATEMISSA ON CARBON TETRACHLORIDE (CCL4)-INDUCED HYPERLIPIDEMIC ALBINO RATS

2021 ◽  
pp. 13-16
Author(s):  
YEMISI RUFINA ALLI SMITH ◽  
BUKOLA TOLA ALUKO ◽  
SAMUEL IDOWU FAYOMI ◽  
OLAJUMOKE OMOLARA OJO
Keyword(s):  
Carbon Tetrachloride ◽  
Total Cholesterol ◽  
Aqueous Extract ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipid Lowering ◽  
Control Group ◽  
Albino Rats ◽  
Hmgcoa Reductase

Objective: Hyperlipidemia has been described as one of the greatest risk factors contributing to the prevalence and severity of cardiovascular diseases which has been identified as a primary cause of death. This study evaluates the lipid-lowering effects of aqueous extract of Emilia praetermissa (EP) leaves. Methods: The investigation was carried out on rats induced with Carbon tetrachloride (CCl4 1 ml/kg body weight), pretreated with the aqueous extracts of Emilia praetermissa and then compared with a standard hypolipidemic drug, Simvastatin. The effects of Emilia praetermissa on the lipid profile were assessed by measuring the levels of total cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol. The effect on HMGCoA Reductase and Lecithine Cholesterol Acyltransferase (LCAT), which are important enzymes in lipid metabolism were also evaluated in the plasma, liver and heart of albino rats. Results: Administration of 50, 100 and 200 mg/kg doses of aqueous extract of Emilia praetermissa leaves led to a significant reduction (P<0.05) in total cholesterol, LDL cholesterol, triglyceride levels and a significant increase (P<0.05) in HDL cholesterol in the tissues in a manner close to that of Normal and Standard control group. Emilia praetermissa aqueous extract led to a significant increase (P<0.05) in the activity of LCAT and inhibition of HMGCoA reductase. Conclusion: These results suggest that Emilia praetermissa leaves could play a cardioprotective role and probably serve as a new potential natural product for the management of hyperlipidema. Further investigations are warranted to elucidate the mechanism of its lipid-lowering action.

scholarly journals EFFECT OF PITHECELLOBIUM DULCE BENTH LEAVES IN DEXAMETHASONE INDUCED DIABETIC RATS

2016 ◽  
Vol 8 (9) ◽  
pp. 317 ◽  
Author(s):  
Mule V. S. ◽  
Naikwade N. S. ◽  
Magdum C. S. ◽  
Jagtap V. A.
Keyword(s):  
Blood Glucose ◽  
Total Cholesterol ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Glycogen Level ◽  
Standard Drug ◽  
Diabetic Control Group

<p><strong>Objective: </strong>The objective of the present study was to study the effect of <em>Pithecellobium dulce </em>Benth (<em>P. dulce</em>) leaves in dexamethasone-induced diabetic rats.</p><p><strong>Methods: </strong>The authenticated <em>P. dulce</em> leaves were collected from a local area of Sangli, Maharashtra. The leaves of the plant were extracted with water and ethanol by maceration and soxhelation respectively. Acute toxicity studies of the both extracts were performed using rat and according to OECD 425 guidelines. The dose of 200 mg/kg and 400 mg/kg was selected for further studies. The albino rats were divided into seven groups with five animals in each group. The diabetes was induced by dexamethasone (10 mg/kg, s. c.) and treated with extract and standard drug for 10 d. Then blood glucose, triglyceride, total cholesterol and glycogen level in liver, muscle and kidney were estimated according to standard procedures.</p><p><strong>Results: </strong>The study revealed that <em>P. dulce</em> at 200 mg/kg and 400 mg/kg showed significant (p ˂ 0.05) antidiabetic activity. All the extract treated groups showed a significant reduction in blood glucose level on 11<sup>th</sup> day when compared to diabetic control group. The significant increase in blood glucose, triglyceride, and total cholesterol level was observed in the diabetic control group when compared to normal control group. The liver and muscle glycogen level was decreased significantly (p ˂ 0.05) in the diabetic control group.<strong></strong></p><strong>Conclusion: </strong>It can be concluded that <em>P. dulce</em>aqueous and ethanolic extract at two different doses (200 mg/kg and 400 mg/kg) possesses antidiabetic and hypolipidemic activity.<p> </p>

scholarly journals Aktivitas antidislipidemia Tepung tempe dan susu kedelai pada profil lipid tikus diabetes yang diinduksi streptozotocin

2017 ◽  
Vol 4 (3) ◽  
pp. 147 ◽  
Author(s):  
Kartika Nugraheni ◽  
Siti Harnina Bintari
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Sprague Dawley ◽  
Fermented Soybean ◽  
Sprague Dawley Rats ◽  
The Difference ◽  
Antidyslipidemic Activity

<p><strong>ABSTRACT</strong></p><p><strong>Background :</strong> dyslipidemia increases risk of cardiovascular disease on diabetes patients. Soybean contain many bioactive compounds which can help control lipid profile.</p><p><strong>Objectives :</strong> analyze the difference between fermented soybean (tempe flour) and unfermented soybean (soymilk) on lipid profile in diabetic rats.</p><p><strong>Methods : </strong>thirty male sprague dawley rats divided into 3 groups (1) diabetic control (2) tempe flour 1,8 gr (3) soymilk 1,35 gr. Tempe flour and soymilk were given for 28 days. Profile lipid measured including total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol. The data then were analyzed using Anova with confidence level of 95%.</p><p><strong>Results :</strong> the decrease values of total cholesteril, triglycerides and LDL cholesterol were better in tempe flour group (p&lt;0,05). In addition, tempe flour group also showed better increase in the value of HDL cholesterl (p&lt;0,05)</p><strong>Conclusion :</strong>fermented soybean (tempe flour) showed better antidyslipidemic activity than unfermented ones<p> </p>

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