Hypoglycemic Action of Seed Kernel of Caesalpinia bonducella Fleming In Normal and Alloxan- Induced Diabetic Albino Rats

10.5580/19d1 ◽  
2009 ◽  
Vol 6 (2) ◽  
Keyword(s):  
Albino Rats ◽  
Seed Kernel ◽  
Caesalpinia Bonducella ◽  
Hypoglycemic Action

scholarly journals The hypolipidemic activity of ethanolic extract of seed kernel of Caesalpinia bonducella fleming on serum lipids and atherogenesis in albino rats fed with high fat diet

2018 ◽  
Vol 7 (2) ◽  
pp. 266
Author(s):  
Gayatri Sarma ◽  
Swarnamoni Das
Keyword(s):  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Hypolipidemic Activity ◽  
Albino Rats ◽  
Seed Kernel ◽  
Test Drug ◽  
High Fat ◽  
Caesalpinia Bonducella

Background: An increase in the incidence and prevalence of hyperlipidemia in India has led to an increased demand for drugs with a lipid lowering potential. Thus, the present study was undertaken to evaluate the hypolipidemic activity of ethanolic extract of seed kernel of Caesalpinia bonducella Fleming (EESKCB) in albino rats fed with high fat diet.Methods: The extract was daily administered to healthy adult albino rats of either sex, fed with high fat diet for a period of 60 days. At the end of 60 days, i.e. on the 61st day, serum cholesterol, serum triglyceride, serum low density lipoprotein cholesterol, serum high density lipoprotein cholesterol, atherogenic index, the body weights of the rats and the serum levels of malondialdehyde (MDA) and catalase were estimated. Phytochemical analysis of the plant extract was also carried out. For statistical analysis, the methods employed were One-way ANOVA, Dunnett’s multiple comparison test and Student’s ‘t’ test (Paired). Values of p < 0.05 were considered significant.Results: The test drug brought about significant (p<0.05) decrease in the raised levels of all the lipid parameters except the High density lipoprotein cholesterol. There was also a significant (p<0.05) increase in the serum levels of catalase and a significant (p<0.05) reduction in the serum levels of MDA in the test drug treated group. The test drug also significantly (p<0.05) inhibited the rise in body weights of the rats.Conclusions: From this study, it can be said that the seed kernel of Caesalpinia bonducella Fleming has significant hypolipidemic activity. 

scholarly journals Effect of ethanolic seed extract of Caesalpinia bonducella pregnant female albino rats

2013 ◽  
Vol 2 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Lilaram ◽  
R Nazeer Ahmed
Keyword(s):  
Seed Extract ◽  
Pregnant Female ◽  
Albino Rats ◽  
Caesalpinia Bonducella

Safely effective hypoglycemic action of stevia and turmeric extracts on diabetic Albino rats

2020 ◽  
Author(s):  
Abdalla El‐Hadary ◽  
Mahmoud Sitohy
Keyword(s):  
Albino Rats ◽  
Hypoglycemic Action

scholarly journals Ethanolic Extract of Caesalpinia bonducella f. Seed Ameliorates Diabetes Phenotype of Streptozotocin- Nicotinamide-Induced Type 2 Diabetes Rat

2018 ◽  
Vol 11 (2) ◽  
pp. 1127-1133
Author(s):  
I. Gede Widhiantara ◽  
Pakajiraporn Arunngam ◽  
Ferbian Milas Siswanto
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Seed Extract ◽  
Postprandial Blood Glucose ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Caesalpinia Bonducella

Caesalpinia bonducella F. (Leguminosae) is widely used medicinal plant which contains flavonoid, tannin, saponin, and a potent antioxidant activity. However, the antihyperglycemic effect of the seed of C. bonducella is remained to be evaluated. This study used 24 male Wistar albino rats that were induced for type 2 diabetes with streptozotocin (STZ) and nicotinamide (NA). The rats were divided into three groups: the distilled water-treated group (NC group), glibenclamide-treated group (10 mg/kg/d, oral; PC group), and C. bonducella seed extract-treated group (500 mg/kg/d, oral; T group). Blood glucose and plasma insulin measurements were done after 14 days of treatment. The results showed that the postprandial blood glucose (PPBG) level of both PC and T groups were decreased significantly (p < 0.01 for both), whereas in NC group, the PPBG level was rising (p < 0.01). Glibenclamide was found to be more effective to decrease the PPBG level than C. bonducella seed extract (p < 0.01). The post-test fasting insulin level of T group was higher than other groups (p < 0.05). In summary, our results suggest that ethanolic extract of C. bonducella seed possesses antidiabetic activity against experimentally-induced type 2 diabetes.

scholarly journals Hypoglycemic and Hypolipidemic effects of Watermelon (Citrullus vulgaris) Seed Kernels on Male Albino Rats

2017 ◽  
Vol 5 (3) ◽  
pp. 368-373 ◽  
Author(s):  
Reetapa Biswas ◽  
Alok Chattopadhyay ◽  
Santa Datta De
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
Atherogenic Index ◽  
Control Group ◽  
Albino Rats ◽  
Seed Kernel ◽  
Low Density ◽  
Stock Diet ◽  
Modified Diet

The current investigation was planned to assess the hypoglycemic and hypolipidemic efficiency of watermelon seeds on male albino rats. Eight male albino rats weighing between 105-150g were randomly selected for the present experiment and were placed into two equal groups (n=4) designated as control and treated group. The control group received normal stock diet (20% protein, 5 % fat, 60 % carbohydrate). The treated group received a modified diet (90g Stock diet excluding groundnut oil + 9g watermelon seed kernel + 1g sugar). Percentages of protein, fat and carbohydrate in the modified diet were kept same as that of the stock diet. All animals were given water ad libitum. Rats were weighed at weekly intervals. After 28 days rats were anesthetized using chloroform anesthesia and blood samples were collected via cardiac puncture and serum was obtained for evaluation of some biochemical parameters. Result showed that serum glucose, triglyceride (TG) and very low density lipoprotein (VLDL) of the treated group were decreased significantly (p < 0.01, p < 0.05 and p < 0.05 respectively) compared to that of the control group. Liver glycogen, serum total cholesterol, low density lipoprotein (LDL) and AI (Atherogenic Index) were decreased (non-significant) whereas high density lipoprotein (HDL) increased (non-significant) in the treated group.

scholarly journals Myocardial potency of Caesalpinia bonducella Linn. on doxorubicin induced myocardial infarction in albino rats

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Agnel Arul John Nayagam ◽  
Shobana Gunasekaran ◽  
Sivasubramanian Rangarajan ◽  
Suganya Muthaiah
Keyword(s):  
Myocardial Infarction ◽  
Troponin T ◽  
Albino Rats ◽  
Cardiac Markers ◽  
Standard Drug ◽  
Group I ◽  
Creatine Kinase Mb ◽  
Caesalpinia Bonducella ◽  
Membrane Bound ◽  
Membrane Bound Enzymes

Abstract Objective Caesalpinia bonducella L. is well known and extremely valuable herb in ayurvedic system of medicine. The present study is aimed to design the evaluation of aqueous extract of Caesalpinia bonducella L. on doxorubicin induced myocardial infarction in wistar strains of albino rats of both sex. Materials and methods The experimental animals are divided in to 5 groups of 6 animals each. Group I (Normal Control), Group II (Negative Control, 2.5 mg/kgbw of Doxorubicin i.p.), Group III (2.5 mg/kgbw of Doxorubicin i.p.) + AECB (150 mg/kgbw), Group IV (2.5 mg/kgbw of Doxorubicin i.p.) + AECB (300 mg/kgbw), Group V (2.5 mg/kgbw of Doxorubicin i.p.) + standard drug (Propranolol 5 mg/kgbw). Doxorubicin induced myocardial infarction was confirmed by disturbances in levels of cardiac markers (Lactate Dehydrogenase, Troponin-T, Creatine Kinase-MB Isoenzyme, Creatine Phosphokinase), nucleic acid contents (DNA and RNA), Challenged levels of Membrane bound enzymes such as Na+/K + ATPase, Ca2 + ATPase and Mg2 + ATPase, Decreased tissue protein and altered lipid profile markers. Results Doxorubicin induced rats significantly showed increase in the activities of LDH, CK-MB, CPK, Troponin-T, nucleic acids, membrane bound enzymes, lipid profiles and decrease in the serum HDL. Treatment with AECB simultaneously at two different doses such as 150 mg/kg bw, 300 mg/kg bw prevented the leakage of myocardium markers and altered the levels of Protein, DNA, RNA and membrane bound enzymes. The AECB prevented the altered variations in Cholesterol, Triacylglycerols, Phospholipids and Free Fatty Acids. This extract also brought back the levels of Lipoproteins like HDL, LDL and VLDL which were varied in disease control animals. Conclusion The present study concludes that AECB is effective in controlling the cardiac markers and lipid levels which could be due to its ability to maintain the membrane stability and repair the myocardial damage.

scholarly journals GAS CHROMATOGRAPHY - MASS SPECTROMETRY ANALYSIS, INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY INVESTIGATION, AND ANTIMICROBIAL SCREENING OF CAESALPINIA BONDUCELLA (L.) ROXB SEED KERNEL

2019 ◽  
pp. 315-319
Author(s):  
ALI ALRABIE ◽  
OLA BASAʼA R ◽  
MAZAHAR FAROOQUI
Keyword(s):  
Mass Spectrometry ◽  
Heavy Metals ◽  
Inductively Coupled Plasma ◽  
Methanol Extract ◽  
Gas Chromatography Mass Spectrometry ◽  
Seed Kernel ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Caesalpinia Bonducella ◽  
Plasma Mass Spectrometry

Objective: The objective of this study was to determine heavy metals using inductively coupled plasma mass spectrometry (ICP-MS) and phytochemical constituents of methanol extract of Caesalpinia bonducella seed kernel using gas chromatography - mass spectrometry (GC-MS). Methods: In GC-MS investigation, 95% methanol extract of C. bonducella seed kernel was performed on JEOL GC MATE ΙΙ, column HP 5 MS, and Quadruple, double-focusing mass analyzer. Determination of heavy metals from C. bonducella powder was performed using Thermo scientific I CAP Q instrument, for plant powder digestion Anton Paar Microwave model: Multiwave 300 was used. Antimicrobial activity was evaluated using microdilutions broth method. Results: GC-MS analysis of methanol extract of C. bonducella seed kernel has shown 11 different phytoconstituents. ICP-MS analysis has shown the concentration of ten heavy metals in C. bonducella seed kernel as follows: Cr 1.5 ppm, Fe 72.72 ppm, Co 0.33 ppm, Ni 0.03 ppm, Cu 10.73 ppm, Zn 18.44 ppm, As 0.03 ppm, Cd 0.02 ppm, and Pb 0.58 ppm. Conclusion: Result showed that the plant is safe to use from toxic heavy metals such as As, Cd, and Pb. It is suitable to check frequently the heavy metal content in the plant used in traditional medicines before given to patients.

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