scholarly journals INCIDÊNCIA HIPOTIREOIDISMO CONGÊNITO EM CRIANÇAS NASCIDAS NOS HOSPITAIS PÚBLICOS DO OESTE PAULISTA

2021 ◽  
Vol 13 (1) ◽  
pp. 1-6
Author(s):  
Franciele Cardoso Leite ◽  
Patricia Martins Luizari Escoboza
Keyword(s):  
Early Diagnosis ◽  
Congenital Hypothyroidism ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Public Hospitals ◽  
Diagnosis And Treatment ◽  
Screening Tests ◽  
Cross Sectional ◽  
Prick Test

Congenital hypothyroidism is a cause of mental retardation and has nonspecific signs and symptoms. Early diagnosis and treatment are essential for the normal development of children affected by this disorder. The objective of this study was to evaluate the incidence of changes in the screening tests of public hospitals in Presidente Prudente, the average age of the newborn at the time of collection of tests and confirmation of the diagnosis. A retrospective cross-sectional study was carried out to assess the data of newborns who underwent the “heel prick test” by the unified health system in 2017. Of the 3,351 evaluated, 48 had elevated levels of Thyroid Stimulating Hormone (TSH), 13 had the diagnosis confirmed congenital hypothyroidism. It was 61.54% the children that returned between days 16 and 30 to confirm the result and 23.07% that returned after 61 days. Early diagnosis and treatment is essential, as they enable mitigating actions for the serious cognitive and behavioral disorders of affected patients.

scholarly journals INCIDÊNCIA HIPOTIREOIDISMO CONGÊNITO EM CRIANÇAS NASCIDAS NOS HOSPITAIS PÚBLICOS DO OESTE PAULISTA

2021 ◽  
Vol 13 (1) ◽  
pp. 01-06
Author(s):  
Franciele Cardoso Leite ◽  
Patricia Martins Luizari Escoboza
Keyword(s):  
Early Diagnosis ◽  
Congenital Hypothyroidism ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Public Hospitals ◽  
Diagnosis And Treatment ◽  
Screening Tests ◽  
Cross Sectional ◽  
Prick Test

Congenital hypothyroidism is a cause of mental retardation and has nonspecific signs and symptoms. Early diagnosis and treatment are essential for the normal development of children affected by this disorder. The objective of this study was to evaluate theincidence of changes in the screening tests of public hospitals in Presidente Prudente, the average age of the newborn at the time of collection of tests and confirmation of the diagnosis. A retrospective cross-sectional study was carried out to assess the data of newborns who underwent the “heel prick test” by the unified health system in 2017. Of the 3,351 evaluated, 48 had elevated levels of Thyroid Stimulating Hormone(TSH), 13 had the diagnosis confirmed congenital hypothyroidism. It was 61.54% the children that returned between days 16 and 30 to confirm the result and 23.07% that returned after 61 days. Early diagnosis and treatment is essential, as they enable mitigating actions for the serious cognitive and behavioral disorders of affected patients.

Prevalence and Predictive Factors of Transient and Permanent Congenital Hypothyroidism in Fars Province, Iran

2021 ◽  
Author(s):  
Ashkan Habib ◽  
Alireza Shojazadeh ◽  
Mohadeseh Molayemat ◽  
Asadollah Habib ◽  
Marjan Jeddi ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Congenital Hypothyroidism ◽  
Predictive Factors ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Fars Province ◽  
Venous Sampling ◽  
Cross Sectional ◽  
Outpatient Visits

Abstract Introduction: There is no data on the number as well as the prevalence of congenital hypothyroidism (CH) in the Fars province. Hence, we designed this study to analyze the latest data and the possible predictive factors on transient and permanent CH in this province.Method: This cross sectional study is based on the Fars province screening data from 2013 till 2016. A total of 294,214 newborns were screened with 938 confirmed cases of CH, which were included in this study. After recall and completion of the missing data, follow-up data for 642 CH cases with thyroid stimulating hormone (TSH) concentrations and levothyroxine doses for ten outpatient visits and final transient vs. permanent CH diagnosis were included.Results: The incidence rate was 1:313.66, and out of the 642 CH cases, 66.04% had permanent CH, while 33.96% had transient CH. TSH level trend during the outpatient visits were not statistically different between the two groups (P=0.312). A cutoff point of >2.25 levothyroxine µg/kg (sensitivity: 76.11%, specificity: 58.52%) at the third year and a TSH concentration of >43.35 mIU/L at the venous sampling (initial TSH) (sensitivity: 31.66%, specificity: 90.32%) were the predictive factors for permanent CH.Conclusion: Fars province has one of the highest incidence rate of CH in Iran. Levothyroxine dose at the 3rd year and the 1st venous TSH sample are the predictive factors for permanent CH in the Iranian population; however, TSH concentrations during follow ups are unreliable predictors.

scholarly journals Subclinical Hypothyroidism Prevalence in Pregnant Ladies in AL-Hilla city in Iraq

2018 ◽  
Vol 26 (8) ◽  
pp. 157-163
Author(s):  
Ban Amer Mousa ◽  
Sijal Fadhil Farhood Al Joborae
Keyword(s):  
Subclinical Hypothyroidism ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Adverse Outcomes ◽  
Screening Tests ◽  
Overt Hypothyroidism ◽  
Free T4 ◽  
Cross Sectional ◽  
Normal Value

Recent guidelines adapted unique pregnancy thyroid function screening tests because pregnancy subclinical hypothyroidism is associated with different adverse outcomes.  There are no data from Iraq about the prevalence of thyroid hypofunction in the 1st trimester of pregnancy. This study aims to find the prevalence of thyroid dysfunction in the 1st trimester.                                              Patients and Methods: In this descriptive cross-sectional study, thyroid stimulating hormone (TSH) was measured in 100 pregnant women from  May 2017-December 2017 in Babylon teaching hospital for maternity and pediatric and in private clinic. If TSH was more than 2.5 mIU/L in the first trimester, free T4 was measured to diagnose then differentiate between subclinical & overt hypothyroidism. If free T4 was in the normal value (0.7-1.8 ng/dl) the diagnosis was subclinical hypothyroidism and if below the normal value, overt hypothyroidism was diagnosed.

scholarly journals Awareness and knowledge about prostate cancer among male teachers in the Sunyani Municipality, Ghana

2021 ◽  
Vol 21 (2) ◽  
pp. 655-662
Author(s):  
Bernard Yeboah-Asiamah Asare ◽  
Mercy Mawufenya Ackumey
Keyword(s):  
Prostate Cancer ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Screening Tests ◽  
Male Teachers ◽  
Sources Of Information ◽  
Cancer Awareness ◽  
Cross Sectional ◽  
Keywords Prostate Cancer ◽  
Adequate Knowledge

Objective: The study was aimed at assessing the awareness and knowledge of prostate cancer (PC) among male teachers in the Sunyani municipality of Ghana. Methods: This was a cross-sectional study conducted using a structured questionnaire to collect data from 160 male teach- ers aged 45 years or more, randomly selected from public elementary and high schools in the Sunyani Municipality. Pearson’s Chi square and Fishers exact tests were used to examine the association between socio-demographic characteristics and knowledge of PC. Results: On average, respondents were aged 50±3.95 years. There was a universal awareness of PC. Most of the respond- ents could identify at least one signs and symptoms of PC (88.1%), risk factors of PC (78.8%), and indicated that PC could be treated through surgery (70.6 %), but only 37.5% of respondents knew about screening tests for PC. The study found 57.5% of them had adequate knowledge about PC. Socio-demographics characteristics were not associated with knowledge about PC. Main sources of information were the television (68%) and radio (57 %). Conclusion: The outcomes of the study suggest the need for general educational campaigns with emphasis on modalities for the screening of PC using the appropriate media channels for accessibility. Keywords: Prostate cancer; awareness; knowledge; male teachers; Ghana.

scholarly journals Chemical, biological, radiological, and nuclear preparedness of public hospitals in Riyadh

2020 ◽  
Author(s):  
Ahmed Ali Alahmari ◽  
Anas A Khan
Keyword(s):  
Radiation Detection ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Public Hospitals ◽  
Cross Sectional ◽  
Biological Warfare Agents ◽  
Government Hospitals ◽  
Hospital Preparedness ◽  
Warfare Agents ◽  
Local Agencies

Abstract ObjectivesChemical, biological, radiological, and nuclear (CBRN) incidents are those that involve chemical or biological warfare agents or toxic radiological or nuclear materials. These agents can cause disasters intentionally or accidentally. Hospitals play a crucial role in handling CBRN disasters. This study aimed to assess the CBRN preparedness of government hospitals in Riyadh.MethodsA descriptive cross-sectional study was conducted across government hospitals in Riyadh, all government hospitals in Riyadh with more than 100 inpatient beds and an emergency department met the inclusion criteria. Hospital preparedness was assessed using an adaptation of the CBRNE Plan Checklist. Results were described in frequencies across several domains such as foundational considerations, planning, training and awareness, procedures, and modules for preparing for a biological incident, a chemical incident, and a radiological or nuclear incident.ResultsOf the 11 eligible hospitals, 10 participated in the study. Further, CBRN considerations were included in the disaster plans of 7 hospitals. Drills had been conducted in collaboration with local agencies in only 2 hospitals. The staff had been trained to recognize the signs and symptoms of exposure to class (A) biological agents in less than half of the hospitals. A majority of the hospitals had antidotes and prophylactics to manage chemical incidents, but only half of them had radiation detection instruments. Personal protective equipment was available in all hospitals, but rapid access to stockpiles of medications was available in only half of them.ConclusionGovernment hospitals in Riyadh demonstrated insufficient CBRN preparedness. Therefore, their staffs should be trained to manage CBRN emergencies, and local drills should be conducted to improve their preparedness.

scholarly journals Variations of physiological parameters in newly detected hypothyroidism

2019 ◽  
Vol 7 (12) ◽  
pp. 4686
Author(s):  
Seethalakshmi K. ◽  
Biju Bahuleyan ◽  
Sunil K. Menon
Keyword(s):  
Blood Pressure ◽  
Early Diagnosis ◽  
Pulse Rate ◽  
Cross Sectional Study ◽  
Physiological Parameters ◽  
Diagnosis And Treatment ◽  
Respiratory Morbidity ◽  
Public Health Issue ◽  
Cross Sectional ◽  
History Of

Background: Emergence of hypothyroidism as a public health issue apart from a common clinical entity, has gained much attention nowadays. The non-specific features of hypothyroidism lead to incorrect diagnoses, inadequate treatment and complications in the future. The present study was designed to unravel the effects of hypothyroidism on physiological parameters and to highlight the importance of early diagnosis and treatment. This study was done to assess the effects of hypothyroidism on pulse rate, blood pressure and respiratory rate.Methods: This descriptive cross-sectional study was done in 60 hypothyroid patients of 18-45 years age, both males and females, who were either newly detected or on treatment for less than 6 months. Patients with history of other systemic diseases, pregnancy and hyperthyroidism were excluded. After obtaining written consent from the patients, clinical examination was done.Results: Student t-test and ANOVA were used for analysis. Physiological parameters like pulse rate, blood pressure and respiratory rate had variations in the patients and there were changes with age, gender and BMI even though they were not significant. These changes were attributed to increased arterial wall thickness and endothelial dysfunction in blood vessels.Conclusions: The patients showed changes in cardiovascular and respiratory profiles. The variations in systolic and diastolic blood pressures were significant with increase in age. Physiological parameters had variations with gender and BMI also. This proves the cardiovascular and respiratory morbidity in newly detected hypothyroidism, which emphasizes the importance of early diagnosis and treatment in them.

scholarly journals Congenital hypothyroidism screening by umbilical cord blood: thyroid stimulating hormone

2020 ◽  
Vol 7 (2) ◽  
pp. 397
Author(s):  
Gaddam Eluzai Zion ◽  
Raheemunnisa .
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Congenital Hypothyroidism ◽  
Cost Effective ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Specific Marker ◽  
Cross Sectional ◽  
Screening Programs ◽  
Tsh Levels

Background: Congenital hypothyroidism (CH) is one of the common preventable cause of intellectual disability. Most cases of CH result from thyroid dysgenesis. CH is often asymptomatic in early infancy, and any delay in treatment can affect the child in terms of delayed cognitive milestones. NSCH (newborn screening for congenital hypothyroidism) has been universally accepted and it is one of the most cost effective screening programs in the field of preventive medicine and public health.Methods: A cross sectional study was conducted in Sri Venkata Sai Medical College and Hospital from 28th August to 28th February 2019 (1.5 years), this study was done on 73 newborns (70 deliveries, three mothers gave birth to twins). All data was collected prospectively. Mothers with known thyroid disease or on thyroid medication were excluded from the study. Under sterile aseptic conditions blood sample is collected from the umbilical cord soon after delivery.Results: In the present study Cord blood TSH level of >20 mIU/L was present in 10% (7) of neonates. When the blood TSH levels were repeated (on day 3) among those with high cord blood TSH levels (>20), the blood TSH levels was also high (>20) in 6 (85.7%) neonates and low (<20) in 1 (14.2%). In Neonates with cord blood TSH >20, 6 neonates also had Low T4 (T4<7) levels (85.7%) and 1 neonate (14.2%) had T4 >7. In the present study 6 neonates (85.7%) had Congenital Hypothyroidism. The present study finds that Cord blood TSH as a diagnostic tool has Sensitivity of 100% and specificity of 98.5% in diagnosing congenital hypothyroidism.Conclusions: The current study concludes that Cord blood TSH is a sensitive and specific marker to predict the presence of congenital hypothyroidism in neonates.

Prevalence of Congenital Hypothyroidism and G6PD Deficiency in Newborns in a Tertiary Care Hospital of Central India

2021 ◽  
pp. 097321792098771
Author(s):  
Suprava Patel ◽  
Ritu Priya ◽  
Phalguni Padhi ◽  
Tripty Naik ◽  
Jessy Abraham ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Tertiary Care Hospital ◽  
Screening Program ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Enzyme Deficiency ◽  
Screening Tests ◽  
Care Hospital ◽  
Cross Sectional ◽  
Diagnostic Center

Objectives: The fundamental prerequisite of a screening program is the accessible epidemiological data regarding disease burden and awareness regarding the disorder. This is the foremost study in this state to estimate the burden of congenital hypothyroidism (CH) and glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency in infants born or attending a tertiary care hospital, pursuing skill development for the technical staffs, and creating awareness for parents. Study Design: A cross-sectional study for 21 months was conducted in the Department of Biochemistry in collaboration with the Department of Pediatrics and Department of Obstetrics and Gynecology. Methods: The screening was conducted on 1282 babies, 48 hours subsequent to birth and up to 8 weeks of age. The dried blood spot specimens collected were analyzed for thyroid stimulating hormone (TSH) level and G6PD enzyme activity by fluoroimmunoassay method. Prevalence was calculated by percentage. Results: The proficiency of the program for all live birth babies delivered in the institute was 94.6%. In consequence to improper sampling, 4.1% samples could not be analyzed. The screening tests reported elevated TSH levels in 1.6% of total population and G6PD enzyme deficiency in 2.6% of all babies enrolled. Confirmatory tests revealed that 4 (3.1/1000) babies were declared positive for CH and 8 (6.2/1000) were announced to be G6PD deficient. Conclusion: The new prevalence observed is one of the highest prevalence of CH published in India that urges mandatory and immediate need for development of newborn screening program in the state, and improvisation and upgradation of regional diagnostic center with facilities for primary- and secondary-level testing.

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