scholarly journals Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

2018 ◽  
Author(s):  
Mushap Kuru ◽  
Abdulsamed Kükürt ◽  
Hasan Oral ◽  
Metin Öğün
Keyword(s):  
Oxidative Stress ◽  
Clinical Use

scholarly journals Citrulline, Biomarker of Enterocyte Functional Mass and Dietary Supplement. Metabolism, Transport, and Current Evidence for Clinical Use

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2794
Author(s):  
Stefano Maric ◽  
Tanja Restin ◽  
Julian Louis Muff ◽  
Simone Mafalda Camargo ◽  
Laura Chiara Guglielmetti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Current Evidence ◽  
Clinical Use ◽  
Intestinal Function ◽  
Protein Balance ◽  
Intestinal Integrity ◽  
Important Amino Acid ◽  
Citrullinated Proteins ◽  
Improve Muscle Strength ◽  
Rheumatoid Diseases

L-Citrulline is a non-essential but still important amino acid that is released from enterocytes. Because plasma levels are reduced in case of impaired intestinal function, it has become a biomarker to monitor intestinal integrity. Moreover, oxidative stress induces protein citrullination, and antibodies against anti-citrullinated proteins are useful to monitor rheumatoid diseases. Citrullinated histones, however, may even predict a worse outcome in cancer patients. Supplementation of citrulline is better tolerated compared to arginine and might be useful to slightly improve muscle strength or protein balance. The following article shall provide an overview of L-citrulline properties and functions, as well as the current evidence for its use as a biomarker or as a therapeutic supplement.

scholarly journals What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis?

2021 ◽  
Vol 21 (3) ◽  
pp. 80-89
Author(s):  
Adamcakova Jana ◽  
Mokra Daniela
Keyword(s):  
Oxidative Stress ◽  
Lung Injury ◽  
Silicon Dioxide ◽  
Pulmonary Disease ◽  
Therapeutic Potential ◽  
Therapeutic Effects ◽  
Clinical Use ◽  
Fundamental Factor ◽  
Long Term Experience

Abstract Lung silicosis is a serious pulmonary disease caused by an exposure of lung to inhaled silicon dioxide (SiO2) or silica. Although pathomechanisms of the disease have not been fully elucidated, oxidative stress has been recognized as a fundamental factor triggering a fibrotizing inflammation leading to irreversible changes in lung tissue. Based on this knowledge, therapeutic potential of various antioxidants has been intensively discussed. Among them, N-acetylcysteine with its multiple anti-inflammatory and antioxidant actions and a long-term experience with its clinical use in various diseases appears as a very promising choice. The purpose of this article is to review the therapeutic effects of N-acetylcysteine particularly in relation to a lung injury and to point out a potential of N-acetylcysteine in the treatment of lung silicosis.

scholarly journals Salivary Redox Biomarkers in the Course of Caries and Periodontal Disease

2020 ◽  
Vol 10 (18) ◽  
pp. 6240
Author(s):  
Anna Skutnik-Radziszewska ◽  
Anna Zalewska
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
Dental Plaque ◽  
Pathological Process ◽  
Clinical Use ◽  
Biological Variability ◽  
Oral Diseases ◽  
Stress Markers ◽  
Inorganic Substances ◽  
The Relationship

Caries are a pathological process of extracorporeal nature, characterized by demineralization of inorganic substances as well as proteolysis triggered by acids produced by bacteria present in dental plaque, as a result of metabolism of sugars of both external and internal origin. Periodontal disease, on the other hand, is a multifactorial degenerative disease associated with inflammation, involving a group of tissues that surround the dental cervix and root of the tooth. It is believed that one of the mechanisms in the etiopathogenesis of caries and periodontitis are disorders of local and/or general oxidative stress (OS) parameters. Numerous clinical studies have confirmed the relationship between oxidative stress markers and oral diseases. In most analyzed studies, technical and biological variability was so high that none of the markers so far has proven suitable for routine clinical use. The aim of systematic reviews of the literature is to present the existing studies on OS parameters, mainly concerning the activity of antioxidant enzymes in saliva of patients with caries and periodontitis.

scholarly journals MnDPDP: Contrast Agent for Imaging and Protection of Viable Tissue

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Per Jynge ◽  
Arne M. Skjold ◽  
Ursula Falkmer ◽  
Rolf G. G. Andersson ◽  
John G. Seland ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Contrast Agent ◽  
Molecular Level ◽  
Tissue Injury ◽  
Quantitative Imaging ◽  
Clinical Use ◽  
Channel Activity ◽  
Delayed Imaging ◽  
Liver And Pancreas ◽  
Clinical Potential

The semistable chelate manganese (Mn) dipyridoxyl diphosphate (MnDPDP, mangafodipir), previously used as an intravenous (i.v.) contrast agent (Teslascan™, GE Healthcare) for Mn-ion-enhanced MRI (MEMRI), should be reappraised for clinical use but now as a diagnostic drug with cytoprotective properties. Approved for imaging of the liver and pancreas, MnDPDP enhances contrast also in other targets such as the heart, kidney, glandular tissue, and potentially retina and brain. Transmetallation releases paramagnetic Mn2+ for cellular uptake in competition with calcium (Ca2+), and intracellular (IC) macromolecular Mn2+ adducts lower myocardial T1 to midway between native values and values obtained with gadolinium (Gd3+). What is essential is that T1 mapping and, to a lesser degree, T1 weighted imaging enable quantification of viability at a cellular or even molecular level. IC Mn2+ retention for hours provides delayed imaging as another advantage. Examples in humans include quantitative imaging of cardiomyocyte remodeling and of Ca2+ channel activity, capabilities beyond the scope of Gd3+ based or native MRI. In addition, MnDPDP and the metabolite Mn dipyridoxyl diethyl-diamine (MnPLED) act as catalytic antioxidants enabling prevention and treatment of oxidative stress caused by tissue injury and inflammation. Tested applications in humans include protection of normal cells during chemotherapy of cancer and, potentially, of ischemic tissues during reperfusion. Theragnostic use combining therapy with delayed imaging remains to be explored. This review updates MnDPDP and its clinical potential with emphasis on the working mode of an exquisite chelate in the diagnosis of heart disease and in the treatment of oxidative stress.

scholarly journals The Impact of Oxidative Stress in Male Infertility

2022 ◽  
Vol 8 ◽  
Author(s):  
Amanda Mannucci ◽  
Flavia Rita Argento ◽  
Eleonora Fini ◽  
Maria Elisabetta Coccia ◽  
Niccolò Taddei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Causative Factor ◽  
Ros Production ◽  
Clinical Use ◽  
Oxygen Species ◽  
Male Factor ◽  
Stress Assessment ◽  
The Impact

At present infertility is affecting about 15% of couples and male factor is responsible for almost 50% of infertility cases. Oxidative stress, due to enhanced Reactive Oxygen Species (ROS) production and/or decreased antioxidants, has been repeatedly suggested as a new emerging causative factor of this condition. However, the central roles exerted by ROS in sperm physiology cannot be neglected. On these bases, the present review is focused on illustrating both the role of ROS in male infertility and their main sources of production. Oxidative stress assessment, the clinical use of redox biomarkers and the treatment of oxidative stress-related male infertility are also discussed.

scholarly journals He-Wei granules inhibit chemotherapy-induced vomiting (CINV) in rats by reducing oxidative stress and regulating 5-HT, substance P, ghrelin and obestatin

RSC Advances ◽  
2017 ◽  
Vol 7 (69) ◽  
pp. 43866-43878
Author(s):  
Zehai Song ◽  
Hang Chang ◽  
Na Han ◽  
Zhihui Liu ◽  
Zhonglin Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Substance P ◽  
Side Effect ◽  
Common Side Effect ◽  
Clinical Use ◽  
Chemotherapy Drugs

As a common side effect of a variety of chemotherapy drugs, CINV severely limits the clinical use of chemotherapy drugs.

scholarly journals The Functions of PPARs in Aging and Longevity

PPAR Research ◽  
2007 ◽  
Vol 2007 ◽  
pp. 1-10 ◽  
Author(s):  
Adnan Erol
Keyword(s):  
Oxidative Stress ◽  
Aging Process ◽  
Peroxisome Proliferator ◽  
Clinical Use ◽  
Age Related ◽  
Therapeutic Uses ◽  
Ppar Agonists ◽  
Peroxisome Proliferator Activated Receptors ◽  
And Oxidative Stress

Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes. Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.

Ameliorating oxidative stress and inflammation by Hesperidin and vitamin E in doxorubicin induced cardiomyopathy

2018 ◽  
Vol 44 (2) ◽  
pp. 207-217
Author(s):  
Thoria Donia ◽  
Samar Eldaly ◽  
Ehab M.M. Ali
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Vitamin E ◽  
Reduced Glutathione ◽  
Human Cancer ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Clinical Use ◽  
Chemotherapeutic Drug ◽  
Cardiac Histopathology

Abstract Background Doxorubicin (DOX) is a common chemotherapeutic drug. However, it causes cardiomyopathy which reduces its clinical use in human cancer therapy. Objective The purpose of our study was to assess the cardioprotective effect of hesperidin (HSP) and vitamin E (VIT.E) against DOX-induced cardiomyopathy. Material and methods Seventy rats were allocated into seven groups: control, HSP (50 mg/kg, orally), VIT.E (100 mg/kg orally), DOX [4 mg/kg, intraperitoneally (i.p.)], DOX+HSP, DOX+VIT.E and DOX+HSP+VIT.E. Results Our findings showed that serum lactate dehydrogenase (LDH), creatine kinase (CK), myeloperoxidase (MPO), cardiac catalase and caspase activities as well as cardiac malondialdehyde (MDA) and serum nitric oxide (NO) concentrations were reduced DOX+HSP or DOX+VIT.E or DOX+VIT.E+HSP groups compared to DOX group. Whereas, cardiac reduced glutathione (GSH) level, serum arylesterase, and paraoxonase activities were higher in rats injected with DOX and administrated with HSP and VIT.E than that of rats injected with DOX only. Cardiac histopathology of DOX group showed some changes that were improved during administration with HSP and VIT.E. Conclusion HSP and VIT.E possess a protective effect against DOX-induced cardiomyopathy via inhibiting oxidative stress, inflammation, and apoptosis.

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

2020 ◽  
Vol 11 (10) ◽  
pp. 8547-8559
Author(s):  
Hongjing Zhao ◽  
Yu Wang ◽  
Mengyao Mu ◽  
Menghao Guo ◽  
Hongxian Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Human Health ◽  
Grass Carp ◽  
Aquatic Environment ◽  
Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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