scholarly journals Interferon Therapy for Hypertrophic Scars and Keloids

2021 ◽  
Author(s):  
Amalorpava Mary Loordhuswamy ◽  
Santhini Elango
Keyword(s):  
Extracellular Matrix ◽  
Clinical Trials ◽  
Interferon Therapy ◽  
Collagen Synthesis ◽  
The Other ◽  
Intralesional Injection ◽  
Hypertrophic Scars ◽  
Co2 Lasers ◽  
Combinatorial Therapy ◽  
The Family

Interferons (IFNs) belong to the family of cytokines are widely used to treat keloids owing to their ability to increase collagenase activity thereby reducing the production of collagen and other extracellular matrix (ECM). Intralesional injection of IFN-α – 2b increases the collagenase level by inhibiting the secretion of metalloproteinases, an inhibitor of collagenase. Moreover, the anti-fibrotic activity of IFNs, interfere with fibroblast mediated collagen synthesis. On the other hand, combinatorial therapy has been preferred recently along with IFN due to its side effects observed in various clinical trials conducted only with IFN. Triamcinolone acetonide (TAC) and CO2 lasers along with IFNs are found to be the potential therapy for the treatment of scars and keloids. In this chapter, IFN mediated therapy for the treatment of scars and keloids, its benefits and limitations and the advantages of combinatorial therapy with the appropriate literature support are discussed.

Endoscopic and Electroporation Therapy of Paranasal Sinus Tumors

2000 ◽  
Vol 14 (3) ◽  
pp. 187-192 ◽  
Author(s):  
William R. Panje ◽  
Nader Sadeghi
Keyword(s):  
Clinical Trials ◽  
Treatment Options ◽  
Complete Response ◽  
The Other ◽  
Cell Membrane Permeability ◽  
Intralesional Injection ◽  
Experimental Setting ◽  
Sinonasal Cancer ◽  
Sinonasal Malignancies ◽  
Invasive Method

The purpose of this article is to introduce the concept of endoscopic and electroporation therapy for the treatment of sinonasal carcinomas. Electroporation therapy is a technique that combines intralesional injection of bleomycin combined with application of high-voltage square wave electrical impulse into the tumor. A transient increase in cell membrane permeability allows intracellular entry of bleomycin, with subsequent cytotoxicity. Two cases of sinonasal cancer were treated with this technique. One patient had complete response and is free of disease at 20 months. The other had partial response with control of the disease up to a year. Endoscopic electroporation therapy is potentially a minimally invasive method for the treatment of sinonasal malignancies in an experimental setting where other treatment options do not exist. Phase II/III national clinical trials have been initiated to study the efficacy of electroporation therapy.

scholarly journals Minimal-Invasive Technologies for Treatment of HTS and Keloids: Corticosteroids

2020 ◽  
pp. 243-250
Author(s):  
Juhee Lee ◽  
Jihee Kim
Keyword(s):  
Mechanism Of Action ◽  
Collagen Synthesis ◽  
Treatment Options ◽  
Healing Process ◽  
Minimal Invasive ◽  
Treatment Modalities ◽  
Wound Healing Process ◽  
Intralesional Injection ◽  
Hypertrophic Scars ◽  
Clinical Presentations

AbstractHypertrophic scars and keloids are common lesions caused by abnormal wound healing process. Especially in keloids, abnormal fibroblast activity and excessive synthesis of collagen is a histopathological hallmark in its pathogenesis. Due to heterogeneity of etiologies and clinical presentations, treatment of hypertrophic scars and keloids are often challenging. The response rate varies widely, depending on treatment modalities and the timing of therapeutic intervention. Corticosteroid is considered to be one of the best treatment options, yet paucity of information exists on its mechanism of action. It is mostly known to inhibit abnormal fibroblast proliferation leading to collagen synthesis and promote further degeneration of extracellular matrix. Intralesional injection of corticosteroid has been well advocated in the treatment of both hypertrophic scars and keloids. Locally delivered corticosteroid causes significant decrease in scar volume and ameliorates the symptoms of the scars such as pain and pruritus. However, the lesions are prone to localized adverse reactions upon repeated treatments. Therefore, appropriate use of steroids requires awareness of its mechanism of action in scar treatment.

Problems of Marriage and Self Surrender in The Novels of Shashi Deshpande

2019 ◽  
Vol 7 (11) ◽  
pp. 18
Author(s):  
Dr. Indu Goyal
Keyword(s):  
Middle Class ◽  
The Other ◽  
Important Thing ◽  
Female Protagonists ◽  
Central Concern ◽  
Modern Age ◽  
The Family ◽  
Traditional Marriage ◽  
Shashi Deshpande ◽  
Middle Class People

Marriage is an important thing in the life of a woman. The importance that our society attaches to marriage is reflected in our literature and it is the central concern of Shashi Deshpade’s novels. In our society where girl learns early that she is ‘Paraya Dhan’, and she is her parents’ responsibility till the day she is handed over to her rightful owners. What a girl makes of her life, how she shapes herself as an individual, what profession she takes up is not as important as whom she marries. Marriage is the ultimate goal of a woman’s life. This paper attempts to probe into the problems of marriage through the protagonists of her novels where one enjoys the freedom of marriage and the other accepts the traditional marriage. Shashi Deshpade highlights the problems of marriage faced by middle-class people in finding suitable grooms for their daughters. This problem is well-illustrated through the characters of her novels. Since the girl’s mind over her childhood is tuned that she is another’s property, she tries to attach a lot of importance to it. it is indeed a tragedy that even in the modern age, Indian females echo the same sentiment where it was marriage which mattered most of them but not to the men. It is a beginning of females sacrifices in life that marriage brings to her. Shashi Deshpande encourages her female protagonists to rise in rebellion against the males in the family matters, instead she wants to build a harmonious relationship between man and woman in a mood of compromise and reconciliation.  

On Commutation Properties of the Composition Relation of Convergent and Divergent Permutations (Part I)

2014 ◽  
Vol 58 (1) ◽  
pp. 13-22
Author(s):  
Roman Wituła ◽  
Edyta Hetmaniok ◽  
Damian Słota
Keyword(s):  
Finite Order ◽  
Convergent Series ◽  
The Other ◽  
Other Hand ◽  
The Family ◽  
Composition Relation ◽  
The Continuum

Abstract In the paper we present the selected properties of composition relation of the convergent and divergent permutations connected with commutation. We note that a permutation on ℕ is called the convergent permutation if for each convergent series ∑an of real terms, the p-rearranged series ∑ap(n) is also convergent. All the other permutations on ℕ are called the divergent permutations. We have proven, among others, that, for many permutations p on ℕ, the family of divergent permutations q on ℕ commuting with p possesses cardinality of the continuum. For example, the permutations p on ℕ having finite order possess this property. On the other hand, an example of a convergent permutation which commutes only with some convergent permutations is also presented.

Status of Family Fissidentaceae in Gujarat

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
D.G. Shah ◽  
D.N. Mehta ◽  
R.V. Gujar
Keyword(s):  
Distinct Species ◽  
The State ◽  
The Other ◽  
Land Plants ◽  
Reproductive Structures ◽  
The Family ◽  
The Status ◽  
Vegetative Characters ◽  
First Time ◽  
Different Parts

Bryophytes are the second largest group of land plants and are also known as the amphibians of the plant kingdom. 67 species of bryophytes have been reported from select locations across the state of Gujrat. The status of family fissidentaceae which is a large moss family is being presented in this paper. Globally the family consists of 10 genera but only one genus, Fissidens Hedw. has been collected from Gujarat. Fissidens is characterized by a unique leaf structure and shows the presence of three distinct lamina, the dorsal, the ventral and the vaginant lamina. A total of 8 species of Fissidens have been reported from the state based on vegetative characters as no sporophyte stages were collected earlier. Species reported from the neighboring states also showed the absence of sporophytes. The identification of different species was difficult due to substantial overlap in vegetative characters. Hence a detailed study on the diversity of members of Fissidentaceae in Gujarat was carried out between November 2013 and February 2015. In present study 8 distinct species of Fissidens have been collected from different parts of the state. Three species Fissidens splachnobryoides Broth., Fissidens zollingerii Mont. and Fissidens curvato-involutus Dixon. have been identified while the other five are still to be identified. Fissidens zollingerii Mont. and Fissidens xiphoides M. Fleisch., which have been reported as distinct species are actually synonyms according to TROPICOS database. The presence of sexual reproductive structures and sporophytes for several Fissidens species are also being reported for the first time from the state.

Women-Friendly Policies being adopted by Organizations: An Innovative aspect

2016 ◽  
Vol 3 (01) ◽  
Author(s):  
Shlesha Singh ◽  
Mrinalini Pandey
Keyword(s):  
Sexual Harassment ◽  
Glass Ceiling ◽  
Gender Stereotype ◽  
The Other ◽  
Family Responsibilities ◽  
Other Hand ◽  
The Family ◽  
Workplace Barriers ◽  
Women In The Workforce ◽  
And Gender

Organizations are these days realizing the importance of women in the workforce and to tap that talent, organizations are now-a-days putting extra efforts. Workplaces were designed keeping men in mind and which has been intercepting women from continuing the competitive jobs and career along with the family responsibilities. On the other hand, there are various workplace barriers which are adding to the other problems. Women face several barriers at the workplace like sexual harassment, glass ceiling and gender stereotype.

scholarly journals Shall we quarrel or deal? The argumentation processes of parents and adolescents during family conflicts

2013 ◽  
Vol 3 (3) ◽  
pp. 195-205
Author(s):  
Nieves Correa Rodríguez ◽  
Juan Rodríguez ◽  
Esperanza Ceballos ◽  
Miriam Álvarez
Keyword(s):  
Perspective Taking ◽  
The Other ◽  
Family Conflicts ◽  
Observational Methodology ◽  
The Family ◽  
Family Harmony ◽  
Conflict Frequency

The polarization of postures in conflicts among parents and adolescents involve a threat for family harmony. Skills for argumentation and perspective taking are required to enable the achievement of satisfactory agreements during the processes of negotiation. The purpose of this paper has been to analyze the skills of parents and adolescents to adopt other perspectives when discussing a conflict by means of observational methodology. The study was carried out with 29 families (constituted by father, mother and an adolescent son or daughter) who were recorded while they argued about a real conflict. Frequency and duration of five levels of perspective-taking were registered (Myself; Reasoned myself; the other like an obstacle; the other adding to me; and us) in the discourse of the family, and also in the different members of the triad, considering their interrelations. The results were showing a moderated level of perspective-taking in family discussions, predominating the levels Reasoned myself, focused on explaining own perspective, and The other like an obstacle, focused on reasons to contest the perspective of the other. In general parents showed more perspective-taking. Particularly the mothers exhibited more sensitivity with her adolescent son or daughter, providing higher levels of perspective-taking and argumentation.

scholarly journals Ingredients, Functionality, and Safety of the Japanese Traditional Sweet Drink Amazake

2021 ◽  
Vol 7 (6) ◽  
pp. 469
Author(s):  
Atsushi Kurahashi
Keyword(s):  
Clinical Trials ◽  
Blood Glucose ◽  
Bowel Movement ◽  
Skin Barrier ◽  
Fermented Food ◽  
The Other ◽  
Added Sugar ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Main Components

The sweet drink amazake is a fermented food made from Aspergillus oryzae and related koji molds in Japan. There are two types of drinks called amazake, one made from koji (koji amazake) and the other made from sake lees, a by-product of sake (sakekasu amazake). The sweetness of koji amazake is from glucose, derived from starch broken down by A. oryzae amylase. The other, sakekasu amazake, depends on added sugar. The main components are glucose and sucrose, but they also contain more than 300 other ingredients. Koji amazake contains oligosaccharides and ergothioneine, and sakekasu amazake has a resistant protein and α-ethyl glucoside, which are characteristic ingredients of each amazake. However, there are also common ingredients such as glycosylceramide. Functionality is known to include anti-fatigue, bowel movement, skin barrier, and other effects on human health. In particular, the bowel movement-improving effects have been well studied for both amazakes. These functions result from ingesting approximately 100 mL per day, but human clinical trials have clarified that this amount has no effect on blood glucose levels and weight gain. In the future, the identification of substances associated with each function is required.

Barricyclin D1—a dimeric ellagitannin with a macrocyclic structure—and accompanying tannins from Barringtonia racemosa

2021 ◽  
Author(s):  
Shinji Yoshikawa ◽  
Lih-Geeng Chen ◽  
Morio Yoshimura ◽  
Yoshiaki Amakura ◽  
Tsutomu Hatano ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Natural Resource ◽  
The Other ◽  
Hydrolysable Tannin ◽  
The Family ◽  
Macrocyclic Structure

Abstract Our examination of high molecular weight polyphenolic constituents in the leaves of Barringtonia racemosa of the family Lecythidaceae uncovered five previously undescribed ellagitannins. One, barringtin M1 (1), among them was a hydrolysable tannin monomer, while remaining four, barringtins D1 (2), D2 (3), D3 (4) and barricyclin D1 (5), were all dimers. Barricyclin D1 had a first macrocyclic structure formed from casuarictin (6) and tellimagrandin I (7), and the other ellagitannins had structures related to 5. Two additional known phenolics, valoneic acid dilactone (8) and schimawalin A (9), were also isolated from the leaves. These results suggested that the leaves of B. racemosa is a natural resource rich in hydrolysable tannin oligomers.

scholarly journals Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity

2016 ◽  
Vol 397 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Miriam Olombrada ◽  
Lucía García-Ortega ◽  
Javier Lacadena ◽  
Mercedes Oñaderra ◽  
José G. Gavilanes ◽  
...  
Keyword(s):  
Active Sites ◽  
Structural Changes ◽  
The Other ◽  
Spatial Proximity ◽  
Ribonucleolytic Activity ◽  
The Family ◽  
Lysine Residues ◽  
Hirsutella Thompsonii ◽  
Close Spatial Proximity ◽  
High Degree

Abstract Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active sites. However, ribotoxins are larger, with a well-defined N-terminal β-hairpin, and display longer and positively charged unstructured loops. These structural differences account for their cytotoxic properties. Unexpectedly, the discovery of hirsutellin A (HtA), a ribotoxin produced by the invertebrate pathogen Hirsutella thompsonii, showed how it was possible to accommodate these features into a shorter amino acid sequence. Examination of HtA N-terminal β-hairpin reveals differences in terms of length, charge, and spatial distribution. Consequently, four different HtA mutants were prepared and characterized. One of them was the result of deleting this hairpin [Δ(8-15)] while the other three affected single Lys residues in its close spatial proximity (K115E, K118E, and K123E). The results obtained support the general conclusion that HtA active site would show a high degree of plasticity, being able to accommodate electrostatic and structural changes not suitable for the other previously known larger ribotoxins, as the variants described here only presented small differences in terms of ribonucleolytic activity and cytotoxicity against cultured insect cells.

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