scholarly journals The Incidence of Ovulation and Detection of Genes Associated with Ovulation and Twinning Rates in Livestock

2021 ◽  
Author(s):  
Ozden Cobanoglu
Keyword(s):  
Genetic Structure ◽  
Environmental Factors ◽  
Fine Mapping ◽  
Reproductive Traits ◽  
Genomic Region ◽  
Economic Importance ◽  
The Other ◽  
Causative Mutation ◽  
Livestock Species ◽  
Multiple Ovulation

Cattle is a monotocous species that generally produce only one offspring per conception. However, multiple ovulations are a naturally emerging reproductive phenomenon typically controlled by genetic structure and environmental factors. On the other hand, few genes or causative mutations might explain significant genetic variations between animals for the reproductive traits. Studies report different methods, including QTL analysis, fine mapping, GWAS, and MAS selection, to improve such traits due to their economic importance. The recent fine-mapping study, which narrows the genomic region, indeed, influencing multiple ovulation, gives positive signals that causative mutation controlling high ovulation rate may be identified shortly. In conclusion, identifying the major genes that considerably affect ovulation and twinning rates provides the opportunity to increase reproduction efficiency by improving genetic gain in livestock species.

scholarly journals Estrus Behaviour and Reproductive Traits of Pulawska Gilts Associated with Selected Gene Polymorphisms

2021 ◽  
Vol 21 (1) ◽  
pp. 159-172
Author(s):  
Marek Babicz ◽  
Marcin Pastwa ◽  
Magdalena Szyndler-Nędza ◽  
Anna Kozubska-Sobocińska ◽  
Barbara Danielak-Czech ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Gene Polymorphisms ◽  
Rflp Analysis ◽  
Reproductive Traits ◽  
The Other ◽  
Molecular Analyses ◽  
Native Breed ◽  
Hair Roots ◽  
Pcr Rflp ◽  
Pcr Conditions

Abstract Searching for the associations between the gene polymorphism and the reproductive traits is essential in defining the genetic native breed specificity, which distinguishes them from the other breeds. The aim of our study was to determine the associations between mutations in the PRL, PRLR, PTGS2, FUT1 genes and sexual and periparturient activity in native Pulawska gilts. The analysis included 72 animals which gave birth to the first litter. Evaluation of the productive value of gilts accounted for indicators of sexual and periparturient activity as well as reproductive traits. The biological material for molecular analyses was obtained from the hair roots of the gilts. The genotype was verified by PCR RFLP analysis. The primers and PCR conditions were determined on the basis of available literature data. Statistically significant differences (P≤0.05) were found at the PRL locus: gilts of AA genotypes (Ins/Ins) at the PRL locus were characterised by longest farrowing duration compared to gilts of AB genotype (P≤0.05). The analysis of PRLR gene showed that gilts of TT genotype revealed a tendency for later occurrence of estrus signs (first and second estrus) and for the markedly longest farrowings (P≤0.05). With regard to PTGS2 and FUT1 loci, no significant differences were found in the parameters of sexual and periparturient activity of the gilts. However, gilts of FUT1 GG genotype gave birth to and reared the largest first litters (P≤0.05). The results of the studies expand the knowledge about the genetic structure and productivity of Pulawska gilts.

Variation in reproductive traits of the river prawn, Macrobrachium nipponense (De Haan, 1849) (Caridea, Palaemonidae) among different sites in southern Taiwan

Crustaceana ◽  
2021 ◽  
Vol 94 (4) ◽  
pp. 431-446
Author(s):  
Kwee Siong Tew ◽  
Hsin-Ling Chen ◽  
Chiao-Chuan Han
Keyword(s):  
Environmental Factors ◽  
Dissolved Oxygen ◽  
Oxygen Concentration ◽  
Reproductive Traits ◽  
The Other ◽  
Dissolved Oxygen Concentration ◽  
Macrobrachium Nipponense ◽  
Oriental River Prawn ◽  
Southern Taiwan ◽  
Study Sites

Abstract Previous studies have revealed that reproductive traits of the Oriental river prawn Macrobrachium nipponense (De Haan, 1849) (Palaemonidae) can differ markedly across populations, though the environmental factors responsible for such variation are unknown. We therefore conducted monthly surveys of these prawns to determine their reproductive traits over two years at four study sites in southern Taiwan. The temperature, dissolved oxygen concentration, conductivity, and turbidity in Long Luan Lake significantly differed from the other sites, yet levels of reproductive trait parameters were intermediate among all. The aforementioned environmental factors were similar between the two Sihchong River sites and Mudan Reservoir, yet the river populations had the highest values in all reproductive traits. The river’s substratum was comprised of >60% of cobbles and boulders, whereas <5% of the substratum of the reservoir and lake consisted of such rocks. We therefore suggest that this difference in substrate composition may be linked to the significant differences in reproductive traits observed.

scholarly journals Compatibility of Bt biopesticides and adjuvants for Spodoptera frugiperda control

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Cicero Antônio Mariano dos Santos ◽  
Joacir do Nascimento ◽  
Kelly Cristina Gonçalves ◽  
Giovani Smaniotto ◽  
Leonardo de Freitas Zechin ◽  
...  
Keyword(s):  
Spodoptera Frugiperda ◽  
Economic Importance ◽  
The Other ◽  
Distilled Water ◽  
Bt Crops

AbstractSpodoptera frugiperda is a pest of economic importance for several crops with resistance reports to Bt crops and pesticides. Eco-friendly Bt biopesticides may be an alternative to chemical insecticides due to their selectivity and specificity. However, the efficacy of Bt biopesticides may be influenced by the association with other chemicals, such as adjuvants. This study evaluated the compatibility and toxicity of Bt biopesticides mixed with adjuvants for the control of S. frugiperda. The treatments included the association of Dipel SC and Dipel PM with adjuvants. Compatibility tests were used to evaluate the Bt mixture. Bt suspensions obtained from mixtures of Bt and adjuvants at 106 and 3 × 108 spores/mL−1 were used to evaluate S. frugiperda mortality and distilled water was used as the control. The addition of the adjuvant LI increased growth and sporulation, indicating compatibility with Bt biopesticides. The other adjuvants were toxic to reducing Bt growth and sporulation. Only the mixture of Bt with LI and Bt alone was effective to S. frugiperda. The addition of adjuvants to Bt biopesticide affect the Bt sporulation, growth and mortality.

scholarly journals Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kevin K. Esoh ◽  
Tobias O. Apinjoh ◽  
Steven G. Nyanjom ◽  
Ambroise Wonkam ◽  
Emile R. Chimusa ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Ethnic Groups ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Genomic Region ◽  
Sub Saharan Africa ◽  
Genome Wide Association Studies ◽  
Fine Scale ◽  
Sub Saharan

AbstractInferences from genetic association studies rely largely on the definition and description of the underlying populations that highlight their genetic similarities and differences. The clustering of human populations into subgroups (population structure) can significantly confound disease associations. This study investigated the fine-scale genetic structure within Cameroon that may underlie disparities observed with Cameroonian ethnicities in malaria genome-wide association studies in sub-Saharan Africa. Genotype data of 1073 individuals from three regions and three ethnic groups in Cameroon were analyzed using measures of genetic proximity to ascertain fine-scale genetic structure. Model-based clustering revealed distinct ancestral proportions among the Bantu, Semi-Bantu and Foulbe ethnic groups, while haplotype-based coancestry estimation revealed possible longstanding and ongoing sympatric differentiation among individuals of the Foulbe ethnic group, and their Bantu and Semi-Bantu counterparts. A genome scan found strong selection signatures in the HLA gene region, confirming longstanding knowledge of natural selection on this genomic region in African populations following immense disease pressure. Signatures of selection were also observed in the HBB gene cluster, a genomic region known to be under strong balancing selection in sub-Saharan Africa due to its co-evolution with malaria. This study further supports the role of evolution in shaping genomes of Cameroonian populations and reveals fine-scale hierarchical structure among and within Cameroonian ethnicities that may impact genetic association studies in the country.

Notes on two Locusts of minor economic Importance in the Sudan

1932 ◽  
Vol 23 (1) ◽  
pp. 49-64 ◽  
Author(s):  
H. B. Johnston
Keyword(s):  
Economic Importance ◽  
The Other ◽  
Other Hand ◽  
Mutual Independence ◽  
Gregarious Locusts ◽  
Distinguishing Character

The so-called short-horned locusts are frequently, for convenience sake, regarded as comprising two classes: the true locusts (Arabic: Girad) and the short-horned grasshoppers (Arabic : Gabura). It is difficult, however, to find definitions of these classes by means of which every species may be correctly assigned to its true place. The swarming habits of the true locust are often cited as connoting this class only, involving, as these habits do, the periodical appearance of excessive numbers of both hoppers and adults. Moreover the true locust is gregarious, in that the hoppers move in bands from one place to another, and the adults fly in vast swarms often over long distances. The fact that the grasshoppers are solitary in habit and manifest mutual independence of action is often taken as their chief distinguishing character. There is no doubt that these features do partly separate these two classes of insects from each other, but there are certain species which appear to occupy a position intermediate between the two. One normally solitary may, in certain circumstances, multiply rapidly and give rise to hoppers, which in certain respects act like those true locusts. Moreover the winged adults may undertake short massed flights resembling the migrations of swarms. On the other hand the fact, now fully established, that most true gregarious locusts have their solitary forms, which never associate, places even them in this respect with the grasshoppers.

scholarly journals Genetic or Psychogenic? A Case Study of “Folie à Quatre” Including Twins

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Tohru Ohnuma ◽  
Heii Arai
Keyword(s):  
Environmental Factors ◽  
Social Isolation ◽  
Schizophrenia Patient ◽  
Monozygotic Twins ◽  
The Other ◽  
Positive Symptoms ◽  
Short Period ◽  
The Common ◽  
Shared Psychotic Disorder

Shared psychotic disorder, characterized by shared delusion among two or more subjects (termed “Folie à deux,” “trois,” etc.), is often associated with strong religious beliefs or social isolation, factors creating strong psychological sympathy. Recently, we treated a rare familial case of “Folie à quatre” in central Tokyo without such influences. The proband was a schizophrenia patient and younger brother within monozygotic twins. Positive symptoms were “transmitted” to remaining family members, his elder brother, mother, and father father, in a relatively short period of three months. Although the pathophysiology of these positive symptoms (delusions and hallucinations) remains unclear, the transmission pattern suggests the primacy of social and environmental factors (and/or their interaction), while genetics appeared less influential in this “Folie à famille.” Although undiagnosed psychoses in the whole family cannot be excluded, they did not share the other negative schizophrenia symptoms of the proband. A strong familial connection appeared to be the most important factor for the common delusion and hallucination.

SNP-based pool genotyping and haplotype analysis accelerate fine-mapping of the wheat genomic region containing stripe rust resistance gene Yr26

2018 ◽  
Vol 131 (7) ◽  
pp. 1481-1496 ◽  
Author(s):  
Jianhui Wu ◽  
Qingdong Zeng ◽  
Qilin Wang ◽  
Shengjie Liu ◽  
Shizhou Yu ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Stripe Rust ◽  
Fine Mapping ◽  
Rust Resistance ◽  
Haplotype Analysis ◽  
Genomic Region ◽  
Rust Resistance Gene ◽  
Stripe Rust Resistance ◽  
Stripe Rust Resistance Gene ◽  
Pool Genotyping

EPCO-02. GERMLINE SINGLE NUCLEOTIDE POLYMORPHISM rs55705857 AT 8q24 INTERACTS WITH SOMATIC IDH1 MUTATION TO ENHANCE HUMAN GLIOMA FORMATION

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi1-vi1
Author(s):  
Kristen Drucker ◽  
Connor Yanchus ◽  
Thomas Kollmeyer ◽  
Asma Ali ◽  
Decker Paul ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Dna Interaction ◽  
Genomic Region ◽  
Idh1 Mutation ◽  
Normal Brain ◽  
Nucleotide Polymorphisms ◽  
Human Glioma ◽  
Single Nucleotide ◽  
Coding Regions ◽  
Chromatin Immunoprecipitation Sequencing

Abstract BACKGROUND Determination of the causation of germline single nucleotide polymorphisms (SNPs) located in non-coding regions of the genome is challenging. The genomic region of 8q24 has been identified as important in many kinds of cancer, linked to a topologically associated domain (TAD) encompassing MYC; this TAD contains a GWAS SNP (rs55705857) associated with IDH-mutant glioma. METHODS Germline genotyping data from 622 IDH-mutant glioma and 668 controls were used to fine map the rs55705857 locus by detailed haplotype analysis. Chromatin immunoprecipitation sequencing (ChIP-seq) of histone markers H3K4me1, H3K4me3, H3K27ac and H3K36me3 was performed on normal brain samples (n=8) and human glioma samples (n=11 IDH-wt and 52 IDH-mut). RNAseq from 9 normal and 83 brain tumors (n=26 IDH-wt and 55 IDH-mut) were used to assess differential gene expression. RESULTS Fine-mapping identified rs55705857 SNP as the most likely causative allele (OR=8.69; p&lt;0.001) within 8q24 for the development of IDH-mutant glioma. At rs55705857, both H3K27ac and H3K4me1 in IDH-mutant vs IDH-wt tumors were increased 3.05- and 1.58-fold, respectively (DiffBind; p=5.81×10-7 and p=2.31×10-3). ChromHMM analysis of the marks indicated that promoter and enhancer functions were significantly increased, and the activity broadened at rs55705857 in IDH-mut gliomas compared to IDH-wt tumors and normal brain samples. This enhancement correlated with significant increased MYC expression in IDH-mut gliomas (p=3.1×10-13), as well as alterations of Myc signaling targets. Publicly available ATACseq, ChIPseq and long-range DNA interaction data demonstrated that the rs55705857 locus is open and interacts with the MYC promoter. CONCLUSIONS Fine-mapping of the 8q24 locus provided strong evidence that rs55705857 is the causative 8q24 locus associated with IDH-mut glioma. Functional experiments suggest that IDH mutation facilitates rs55705857 interaction with MYC to alter downstream MYC targets.

A Comparative Study of Palmar Dermatoglyphics in Thakurs and Lodhis of Bakshi Ka Talab Lucknow, Uttar Pradesh

2018 ◽  
Vol 2 (01) ◽  
Author(s):  
Preeti Gupta ◽  
Udai Pratap Singh
Keyword(s):  
Environmental Factors ◽  
Comparative Study ◽  
Uttar Pradesh ◽  
White Paper ◽  
The Other ◽  
Main Line ◽  
Males And Females ◽  
Index Value ◽  
Two Populations ◽  
Dermatoglyphic Traits

Dermatoglyphic characters vary widely and are unaffected by age, gender and least by environment. Unlike configurations and their distinctiveness with every individual, it also shows bilateral, bisexual and population variations. Palm prints once created are unchangeable throughout life and are unaffected by environmental factors. This paper is based upon the palmar dermatoglyphic. The study reports on bisexual and bilateral palm prints among Lodhis and Thakurs of Rudahi village of Bakshi Ka Talab, Lucknow District. The palmar dermatoglyphic traits have been analyzed among the two populations which are Main line Formula, Endings of main lines D and A, Position of Axial triradius, Angle atd, Main line Index, Hypothenar, Thenar/ Ist Interdigital area, IInd Interdigital area, IIIrd Interdigital area, IVth Interdigital area, and Palmar Ridge Counts. The prints have been obtained by using the duplicating ink method on white paper. On the perusal of Principal Main line Formula among Lodhis and Thakurs, it has been noticed that the frequency is more in Lodhi males than females in formula 11.9.7. On the other hand, the frequency of Thakur males is more than Thakur females in formula 9.7.5. The Ending of Main Line D in position 11 as clearly indicated in Lodhis is higher in both the genders in comparison to Thakurs, while the position 9 indicates highest frequency in Thakur females. The Ending of main line A at position 5’ has higher frequency in Lodhi males. The Main line index value 16 is observed higher in Lodhis in comparison to Thakurs. Higher frequency has been observed in Lodhis than Thakurs in Axial triradius in modal type‘t’. The range of Angle atd is observed to have higher frequency in 36º- 40º among the Lodhis as compared to Thakurs. The palmar ridge counts mean, is found higher in Lodhi females and Thakur males. Thus this paper shows the similarity and dissimilarity among the males and females of Thakurs and Lodhis in Palmar dermatoglyphics.

scholarly journals Fine-Mapping of Sorghum Stay-Green QTL on Chromosome10 Revealed Genes Associated with Delayed Senescence

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 1026 ◽  
Author(s):  
K. N. S. Usha Kiranmayee ◽  
C. Tom Hash ◽  
S. Sivasubramani ◽  
P. Ramu ◽  
Bhanu Prakash Amindala ◽  
...  
Keyword(s):  
Drought Tolerance ◽  
Fine Mapping ◽  
Mapping Population ◽  
Single Gene ◽  
Genotyping By Sequencing ◽  
Introgression Line ◽  
Genomic Region ◽  
Stay Green ◽  
Delayed Senescence ◽  
Genomic Regions

This study was conducted to dissect the genetic basis and to explore the candidate genes underlying one of the important genomic regions on an SBI-10 long arm (L), governing the complex stay-green trait contributing to post-flowering drought-tolerance in sorghum. A fine-mapping population was developed from an introgression line cross—RSG04008-6 (stay-green) × J2614-11 (moderately senescent). The fine-mapping population with 1894 F2 was genotyped with eight SSRs and a set of 152 recombinants was identified, advanced to the F4 generation, field evaluated with three replications over 2 seasons, and genotyped with the GBS approach. A high-resolution linkage map was developed for SBI-10L using 260 genotyping by sequencing—Single Nucleotide Polymorphism (GBS–SNPs). Using the best linear unpredicted means (BLUPs) of the percent green leaf area (%GL) traits and the GBS-based SNPs, we identified seven quantitative trait loci (QTL) clusters and single gene, mostly involved in drought-tolerance, for each QTL cluster, viz., AP2/ERF transcription factor family (Sobic.010G202700), NBS-LRR protein (Sobic.010G205600), ankyrin-repeat protein (Sobic.010G205800), senescence-associated protein (Sobic.010G270300), WD40 (Sobic.010G205900), CPK1 adapter protein (Sobic.010G264400), LEA2 protein (Sobic.010G259200) and an expressed protein (Sobic.010G201100). The target genomic region was thus delimited from 15 Mb to 8 genes co-localized with QTL clusters, and validated using quantitative real-time (qRT)–PCR.

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