scholarly journals Association of Non-alcoholic Fatty Liver Disease with Body Fat Percentage in Normal-Weight Individuals

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Zeynab Hatamizargaran ◽  
Mohammadreza Sasani ◽  
Masoumeh Akhlaghi
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Fat ◽  
Fatty Liver Disease ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Study Results

Background: Recent data have suggested that nonalcoholic fatty liver disease (NAFLD) can occur in normal-weight subjects. This study examined the association of body fat percentage (BF%) with NAFLD and its risk factors in normal-weight individuals. Objectives: The present study aimed to explain the influence of body fat on the risk of NAFLD. Methods: A total of 59 subjects with body mass index (BMI) within the range of 18.5 - 24.9 kg/m2 were selected from referrals to two major university polyclinics in Shiraz, Iran, from April to June 2019. Fatty liver grade, anthropometric characteristics, body composition, and cardiometabolic risk factors were measured in this study. Results: Waist circumference (P = 0.012), fat mass (P < 0.001), triglycerides (TG) (P = 0.027), very-low-density lipoprotein (VLDL) (P = 0.007), and TG/high-density lipoprotein cholesterol (HDL-C) ratio (P = 0.003) increased; however, skeletal muscle mass decreased (P < 0.001) across the tertiles of BF%. The average of fatty liver grade was similar in the first and second tertiles; nevertheless, the fatty liver grade of participants in the third tertile was significantly higher (1.3 ± 0.9 vs. 0.4 ± 0.7; P = 0.005). In ordinal regression analysis, BF% (1.13; 95% CI: 1.04 - 1.22; P = 0.003), BMI (1.95; 95% CI: 1.02 - 3.74; P = 0.045), VLDL (1.77; 95% CI: 1.00 - 3.12; P = 0.049), and TG/HDL-C ratio (2.21; 95% CI: 1.26 - 3.86; P = 0.006) had positive associations with NAFLD; nonetheless, HDL-C (0.33; 95% CI: 0.16 - 0.67; P = 0.002) and dietary cholesterol (0.97; 95% CI: 0.95 - 0.997; P = 0.028) had inverse associations with NAFLD after the adjustments for age, gender, BMI, and physical activity. Conclusions: The results of this study suggested that within normal weight ranges, NAFLD occurs more frequently in individuals with higher BF%. In addition, BF% can be used as an important marker in NAFLD screening.

Effect modification of body mass index and body fat percentage on fatty liver disease in a Japanese population

2013 ◽  
Vol 29 (1) ◽  
pp. 128-136 ◽  
Author(s):  
Tomomi Saida ◽  
Wakaba Fukushima ◽  
Satoko Ohfuji ◽  
Kyoko Kondo ◽  
Ichiro Matsunaga ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Mass ◽  
Body Fat ◽  
Japanese Population ◽  
Fatty Liver Disease ◽  
Effect Modification ◽  
Body Fat Percentage ◽  
Fat Percentage

scholarly journals Risk factors of arterial hypertension in patients with nonalcoholic fatty liver disease.

2018 ◽  
Vol 96 (6) ◽  
pp. 537-543
Author(s):  
E. V. Sevostyanova ◽  
V. Ya. Polyakov ◽  
Yu. A. Nikolaev ◽  
I. M. Mitrofanov
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Density Lipoprotein ◽  
Modifiable Risk Factors ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Purpose of the study. To study frequency of occurrence and values ofparameters of the main risk factors for cardiovascular diseases in patients with hypertension in combination with non-alcoholic fatty liver disease. Material and methods. The analysis of 17,202 medical cards of patients (6,730 men, 10,472 women), which were examined and treated in the clinic of the Scientific Research Institute of Experimental and Clinical Medicine, Novosibirsk, was carried out. Of them - 3,087patients with arterial hypertension (AH), combined with non-alcoholic fatty liver disease (NAFLD) (main group); 13,384 patients with isolated arterial hypertension; 731 patients with NAFLD (comparison groups). According to the clinical and laboratory examination, the following risk factors were assessed: high blood pressure, obesity, elevated blood levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, uric acid, a low content of high-density lipoprotein cholesterol in the blood. Results. In patients with hypertension combined with NAFLD, in comparison with patients with isolated diseases, an increase in the values of the indices determining the main modifiable risk factors for cardiovascular diseases (hypertension, obesity, hyperglycemia, hypercholesterolemia, hyperuricemia) was revealed. Similar changes were detected in both men and women. Conclusion. An important role of risk factors for cardiovascular diseases, which together represent the clinical manifestations of the metabolic syndrome, has been identified in the development of comorbid pathology - AH and NAFLD. The data obtained indicate the need for differentiated, personified prevention and treatment of patients with this comorbid pathology with mandatory identification and correction of modifiable risk factors for cardiovascular diseases.

Abstract P395: Non-Alcoholic Fatty Liver Disease in a Lean Population is Associated with Hypertension Independent of Metabolic Risk Factors

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Adil Karim ◽  
Pragya Sinha ◽  
Ehimen Aneni ◽  
Ebenezer T Oni ◽  
Michael J Blaha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Density Lipoprotein ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Alcoholic Fatty Liver ◽  
Nonalcoholic Fatty Liver

Introduction: Hypertension is the most common causal risk factor for coronary artery disease. The increased prevalence of hypertension in those with nonalcoholic fatty liver disease (NAFLD) is well studied. Less well studied is the prevalence of hypertension in lean (BMI<25) individuals with NAFLD. This warrants attention since the burden of cardiovascular disease is increasingly shifting to the lean. Methods: The data for this study was obtained from a cohort of 6464 Brazilians (41.4+/-9 Y, 62% M) free of diabetes mellitus or cardiovascular disease. Of these, 39% (n=2508) were lean (BMI<25). Hypertension was defined as systolic BP (SBP) ≥ 140 mmHg or DBP ≥90 mmHg, self-identification as hypertensive or being on medication for hypertension. NAFLD was diagnosed using ultrasound in those with <20g/d alcohol intake. Results: The prevalence of hypertension in the lean population was nine percent. NAFLD was significantly associated with the presence of hypertension. The prevalence of hypertension was 16% and 8% in those with and without NAFLD respectively (p<0.001). In a multivariate analysis controlling for age, gender, triglyceride and high density lipoprotein cholesterol, the risk of hypertension in those with NAFLD was 1.54 times those without NAFLD(p<0.001). Conclusion: There is significantly increased prevalence of hypertension in lean, healthy individuals with NAFLD. This association is present even after adjusting for age, gender and metabolic risk factors. This relationship needs to be explored further since an increasing number of lean individuals have NAFLD on examination (Younossi et al., 2012).

scholarly journals Relationship between body fat percentage determined by bioelectrical impedance analysis and metabolic risk factors in Syrian male adolescents (18–19 years)

2017 ◽  
Vol 80 (1) ◽  
pp. 103-113
Author(s):  
Mahfouz Al-Bachir ◽  
Mohamad Adel Bakir
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Metabolic Risk Factors ◽  
Body Fat Percentage ◽  
Metabolic Risk ◽  
Fat Percentage ◽  
Male Adolescents ◽  
Obese Subjects

Abstract The association between increasing obesity and metabolic syndrome among adolescent and the adverse consequences in adulthood including type-2 diabetes and coronary heart disease is well documented. The main objectives of this study were to evaluate the major metabolic risk factors and some clinical important parameters in Syrian male adolescents (18-19 years old), and to assess the correlations between BF% determined by BIA-man prediction equation and metabolic risk factors in the same group. The correlations between body fat percentage (BF%) based on BIA-man predictive equations, blood pressure, fasting blood sugar (FBS), cholesterol (Chol), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), Hematocrit (Ht), and hemoglobin (Hb) in 1596 healthy Syrian adolescents aged 18-19 years and the mean values of these parameters were examined. Data showed that, DBP, Chol, TG, LDL and TG/HDL-C were significantly (p<0.05) higher in overweight and obese subjects in compression to normal weight cases. Whereas, SBP, FBS and Ht were significantly (p<0.05) higher in obese subjects in compression to normal weight. However, all measured variable related to metabolic syndrome risk factors increased with increasing the BF% determined by BIA-man. The present study suggests that % BF by BIA-man is a good predictor of metabolic risks factors for Syrian adolescents.

scholarly journals Non-alcoholic fatty liver disease (NAFLD) in non-obese individuals

2019 ◽  
Vol 11 (6) ◽  
pp. 478-483
Author(s):  
Meaghan Phipps ◽  
Julia Wattacheril
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Normal Weight ◽  
Future Research ◽  
Alcoholic Fatty Liver ◽  
Atherogenic Dyslipidaemia ◽  
Genetic Features ◽  
Alcoholic Fatty Liver Disease

Individuals with non-alcoholic fatty liver disease (NAFLD) who lack classical risk factors also have the ability to develop nonalcoholic steatohepatitis (NASH) and progression to more advanced liver disease. The pathophysiology and risk factors for the development of NAFLD in non-obese persons are not fully understood but seem to be closely related to insulin resistance, atherogenic dyslipidaemia and alterations in body composition, with some patients harbouring predisposing genetic polymorphisms. In normal-weight individuals, also called ‘lean’, there is limited potential for effective lifestyle change in disease management. Additionally, biological mechanisms underlying the development of NASH in non-obese individuals may reveal novel targets for intervention. In this review, the authors discuss the clinical, histological and genetic features and risk factors for non-obese NAFLD and highlight gaps in knowledge and areas for future research.

scholarly journals Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hwi Young Kim ◽  
Su Jung Baik ◽  
Hye Ah Lee ◽  
Byoung Kwon Lee ◽  
Hye Sun Lee ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Muscle Mass ◽  
Fatty Liver Disease ◽  
Normal Weight ◽  
Fat Percentage ◽  
Nonalcoholic Fatty Liver ◽  
Body Components

Abstract The relationship between changes in body components and the risk of nonalcoholic fatty liver disease (NAFLD) is not fully understood. We investigated the effects of body components and subsequent changes on incident NAFLD at follow-up ultrasound scanning in a longitudinal cohort. We included 9967 participants without NAFLD at baseline who underwent serial health examinations. Sex-specific, weight-adjusted skeletal muscle index (SMI_Wt) was used. Mean follow-up duration was 48.5 ± 33.5 months. NAFLD developed in 2395 participants (24.0%). Body composition was measured using bioelectrical impedance analysis. The following baseline body components were significantly associated with incident NAFLD: the lowest and middle SMI_Wt tertiles in the normal-weight group (adjusted hazard ratio [aHR] = 2.20 and 1.54, respectively), and fat percentage in the normal-weight (aHR = 1.12), overweight (aHR = 1.05), and obese groups (aHR = 1.03) (all P < 0.05). Among 5,033 participants who underwent ≥ 3 health examinations, SMI_Wt increase between the first and second examinations was an independent protective factor against incident NAFLD in non-obese groups (P < 0.05). Increased fat percentage was an independent risk factor for incident NAFLD in all weight categories (P < 0.05). High fat mass at baseline may be a better predictor of incident NAFLD than muscle mass. Reciprocal changes in fat and muscle mass during the first year of follow-up predicted incident NAFLD in non-obese groups.

scholarly journals Prevalence and risk factors of dyslipidemia among male industrial workers in India

2018 ◽  
Vol 5 (4) ◽  
pp. 1458 ◽  
Author(s):  
Pratibha Suresh Wankhade ◽  
Ratnaprabha Bhalchandra Pedhambkar ◽  
Rajani Satish Pagare ◽  
Bhalchandra Sonu Pedhambkar
Keyword(s):  
Risk Factors ◽  
Body Fat ◽  
Density Lipoprotein ◽  
Lifestyle Changes ◽  
Blood Collection ◽  
Body Fat Percentage ◽  
Industrial Workers ◽  
High Cholesterol ◽  
Fat Percentage ◽  
Screening Programs

Background: Lipid Abnormalities are major risk factors for coronary artery diseases. Prevalence of dyslipidemia is high in India shown by various studies due to lifestyle changes. This study was conducted to estimate the prevalence of dyslipidemia and its association with body fat percentage, body mass index, diabetes, tobacco use and hypertension.Methods: A cross-sectional study was conducted among 300 male employees from a packaging and binding industry in Maharashtra. Behavioural data, anthropometric measurements and blood collection were conducted by trained staff using standard instruments.Results: Majority of the participants were in the age group between 30-60 years. Overall prevalence of dyslipidemia was 50.7% among study subjects.15.3%, 27% 62%, 23% and 50.7% of participants had high serum cholesterol, high triglycerides, low high density lipoprotein (HDL), high low density lipoprotein (LDL) and high cholesterol/HDL ratio respectively. Logistic regression analysis showed abnormal cholesterol level was associated with high body fat percentage and hypertension. Abnormal triglyceride level was associated with high blood sugar and hypertension. High LDL level was associated only with hypertension. Abnormal HDL level and high cholesterol/HDL ratio was strongly associated with age (>40 years).Conclusions: The prevalence of dyslipidemia was high among male industrial workers in India. Screening programs should be conducted at work places for early detection of dyslipidemia. Information, education and communication (IEC) programs based on lifestyle modification like healthy diet habits, regular physical activity for weight control and tobacco cessation need to be implemented at work places.

Effects of 2 Methods of Combined Training on Cardiometabolic Risk Factors in Adolescents: A Randomized Controlled Trial

2020 ◽  
Vol 32 (4) ◽  
pp. 217-226
Author(s):  
Waynne F. Faria ◽  
Filipe R. Mendonça ◽  
Géssika C. Santos ◽  
Sarah G. Kennedy ◽  
Rui G.M. Elias ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Fat ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Control Groups ◽  
Combined Training ◽  
And Control

Purpose: To analyze the effects of 2 combined training methods on the cardiometabolic risk factors in adolescents. Methods: A total of 76 adolescents (16.1 [1.1] y, n = 44 female) were randomized into groups of moderate-intensity continuous training combined with resistance training (MICT + RT), high-intensity interval training combined with resistance training (HIIT + RT), or control. The training sessions were performed twice weekly for 12 weeks. The outcomes evaluated included body fat percentage, waist circumference, fasting blood glucose, fasting insulin, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, glycated hemoglobin, insulin resistance index, blood pressure, peak oxygen consumption (VO2peak), and cardiometabolic risk Z score. Results: The intervention groups presented a significant reduction in the cardiometabolic risk Z score after 12 weeks of the combined exercise program. In relation to the cardiometabolic risk Z score between groups, the HIIT + RT group presented a significant intervention effect when compared with the control group (Cohen d = 0.23; P < .05). Significant intervention effects were found when comparing the MICT + RT and control groups for body fat percentage, high-density lipoprotein, and VO2peak. Between the HIIT + RT and control groups, significant intervention effects were found for body fat percentage, blood pressure, and VO2peak. There were not significant differences between the HIIT + RT and MICT + RT groups. Conclusion: Twelve weeks of HIIT + RT and MICT + RT were effective in significantly reducing the cardiometabolic risk in these adolescents.

Abstract 354: Prevalence and Predictors of Non Alcoholic Fatty Liver Disease Among Normal Weight Non Diabetic Individuals

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Pragya Sinha ◽  
Ebenezer T Oni ◽  
Omar Jamal ◽  
Michael J Blaha ◽  
Arthur A Agatston ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Normal Weight ◽  
Metabolic Risk Factor ◽  
Metabolic Risk ◽  
Alcoholic Fatty Liver ◽  
Nonalcoholic Fatty Liver ◽  
Low Hdl

BACKGROUND Nonalcoholic fatty liver disease(NAFLD) is generally considered a close manifestation of obesity and metabolic abnormalities. In the past, autopsy studies have also demonstrated NAFLD in 15% of non-obese subjects. Increasingly, NAFLD is considered an early manifestation of CAD. However, there is limited data on the prevalence and predictors of NAFLD in normal weight (NW) individuals. METHODS We evaluated 6,385 healthy non diabetic Brazilian subjects (43±10 years, 79% males) without clinical coronary heart disease between November 2008 and July 2010. NAFLD was diagnosed by ultrasound. RESULTS Overall 39% (n=2494) individuals (41±9 years, 62% males) had normal weight (BMI<25 kg/m 2 & normal waist circumference). The prevalence of NAFLD in this group was 11% compared to 43% in the overweight (BMI 25-29.9) and 79% in the obese (BMI≥30), respectively (p<0.0001). As shown in the table below, increasing age, male gender and metabolic risk factors (MRF) remained significant predictors of NAFLD in NW individuals in univariate and multivariate analyses. As compared to those with no known MRF, the adjusted odds ratio for presence of NAFLD with increasing risk factors (1,2 and 3) were 1.56 (1.13-2.14), 3.93 (2.75-5.75) and 3.81 (1.92-7.59) respectively. CONCLUSION Approximately 1/10th of normal weight non-diabetic individuals had NAFLD in our cohort. High triglyceride and low HDL were independent predictors of NAFLD. Increasing metabolic risk factor burden can be considered for further testing to identify those at risk for NAFLD in this group.

scholarly journals Effects of aerobic exercise and resistance exercise on physical indexes and cardiovascular risk factors in obese and overweight school-age children: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257150
Author(s):  
Tianhao Chen ◽  
Jingxia Lin ◽  
Yuzhe Lin ◽  
Lin Xu ◽  
Dian Lu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Body Fat ◽  
Density Lipoprotein ◽  
School Age Children ◽  
Body Fat Percentage ◽  
School Age ◽  
Fat Percentage

Background Obesity is a serious social and public health problem in the world, especially in children and adolescents. For school-age children with obesity, this stage is in the transition from childhood to adolescence, and both physical, psychological, and external environments will be full of challenges. Studies have showed that school-age children are the largest proportion of people who continue to be obese in adulthood. Physical exercise is considered as an effective way to control weight. Therefore, we focus on this point to study which factors will be improved to reduce childhood obesity. Objective To assess the effects of aerobic and resistance exercise on physical indexes, such as body mass index (BMI) and body fat percentage, and cardiovascular risk factors such as VO2peak, triglycerides (TG) and low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), insulin and insulin resistance in school-age children who are overweight or obese. Method PubMed, SPORTDiscus, Medline, Cochrane-Library, Scopus, Ovid and Web of Science were searched to locate studies published between 2000 and 2021 in obese and overweight school-age children between 6–12 years old. The articles are all randomized controlled trials (RCTs) and in English. Data were synthesized using a random-effect or a fixed-effect model to analyze the effects of aerobic and resistance exercise on six elements in in school-age children with overweight or obese. The primary outcome measures were set for BMI. Results A total of 13 RCTs (504 participants) were identified. Analysis of the between-group showed that aerobic and resistance exercise were effective in improving BMI (MD = -0.66; p < 0.00001), body fat percentage (MD = -1.29; p = 0.02), TG (std.MD = -1.14; p = 0.005), LDL (std.MD = -1.38; p = 0.003), TC (std.MD = -0.77; p = 0.002), VO2peak (std.MD = 1.25; p = 0.001). However, aerobic and resistance exercise were not significant in improving HDL (std.MD = 0.13; p = 0.27). Conclusions Aerobic exercise and resistance exercise are associated with improvement in BMI, body fat percentage, VO2peak, TG, LDL, TC, while not in HDL in school-age children with obesity or overweight. Insulin and insulin resistance were not able to be analyzed in our review. However, there are only two articles related to resistance exercise in children with obesity and overweight at school age, which is far less than the number of 12 articles about aerobic exercise, so we cannot compare the effects of the two types of exercises.

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