Statistical Analysis on Surgical Orthodontic Treatment in the Clinic of Orthodontics of Meikai University Hospital over a 10-year Period

Summary Objective The aim of this study was to investigate the effects of piezocision (surgical protocol with sutures) in orthodontic treatment using CAD/CAM (computer-aided design and computer-aided manufacturing) customized orthodontic appliances. Design The study is designed as a parallel group, randomized controlled trial (RCT). Setting University Hospital. Ethical approval The study was approved by the ethic committee of the University Hospital Liege, Belgium. Subjects and methods This RCT was conducted on 24 adult patients requiring orthodontic treatment to release mild overcrowding. Patients were all treated with a customized appliance and randomly assigned by means of sealed envelopes containing group codes to either a test group treated with piezocision or a control group without any further treatment. A blinded orthodontist validated appliance removal or further adjustments based on the model study. Outcome measures The overall treatment time and the time between archwire changes were recorded. Moreover, clinical and radiological features such as tooth resorption, gingival recessions, and the presence of scars were evaluated. Results A total of 24 patients (12 control and 12 test) completed the study. The overall treatment time was significantly shorter in the test group than the control group. Likewise, the time difference between all arch changes was significantly lower when piezocision was performed, except for the first arch at the mandible and the last arches at both maxillae. During the fine-tuning phase, no significant difference was found between the two groups. All periodontal and radiographic parameters remained stable from the start to the end of treatment in both the groups. However, minor scars were found in 66 per cent cases. Limitations This trial was a single-centre trial. Conclusions Piezocision seems to be an effective method to accelerate orthodontic treatment in cases of mild overcrowding. However, the effect was only observed during the alignment phase and a greater efficiency was found in the maxilla. The technique may be contraindicated in patients with a high smile line since the risk of slight scarring exists. Registration ClinicalTrails.gov (Identifier: NCT03406130)

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Antimicrobial Resistance Patterns in Respiratory Pathogens Isolated in an Italian University Hospital during a Period of Eight Years: A Statistical Analysis

Chemotherapy ◽

10.1159/000007273 ◽

2000 ◽

Vol 46 (3) ◽

pp. 166-172 ◽

Cited By ~ 1

Author(s):

C. Dos Santos ◽

A. Capelo ◽

M. Cimbro ◽

A. Ferrara

Keyword(s):

Statistical Analysis ◽

Antimicrobial Resistance ◽

University Hospital ◽

Respiratory Pathogens ◽

Resistance Patterns

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Orthodontic Treatment Planning: Do Orthodontists Treat to Cephalometric Norms?

The Journal of Contemporary Dental Practice ◽

10.5005/jcdp-4-4-12 ◽

2003 ◽

Vol 4 (4) ◽

pp. 12-27 ◽

Cited By ~ 5

Author(s):

Khalid M. Al-Balkhi

Keyword(s):

Statistical Analysis ◽

Treatment Planning ◽

Orthodontic Treatment ◽

Rank Test ◽

Mean Values ◽

Kappa Test ◽

Signed Rank ◽

Wilcoxon Signed Rank Test ◽

Signed Rank Test ◽

Paired T Test

Abstract Cephalometric norms are important to orthodontists in their diagnosis, treatment, and evaluation of orthodontic treatment outcomes. The purpose of the present study is to establish if orthodontists treat and finish their cases to the cephalometric means or norms. Pre- and post-cephalometric radiographs and dental casts of 35 orthodontically treated cases were analyzed. The Kappa test, Wilcoxon Signed-Rank test, Paired t- test, and Z-test were used for the statistical analysis of the data. The result revealed that orthodontists do not reach the cephalometric mean values post-treatment. However, sagittal maxillomandibular relationship and interlabial gap are the main areas of improvements. This leads to improvement of soft tissue esthetics by camouflaging the skeletal and dental relationship. Citation Al-Balkhi KM. Orthodontic Treatment Planning: Do Orthodontists Treat to Cephalometric Norms? J Contemp Dent Pract 2003 November;(4)4:012-027.

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Influence of Orthodontic Rapid Maxillary Expansion on Nocturnal Enuresis in Children

BioMed Research International ◽

10.1155/2015/201039 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Lidia Hyla-Klekot ◽

Marek Truszel ◽

Andrzej Paradysz ◽

Lidia Postek-Stefańska ◽

Marcin Życzkowski

Keyword(s):

Comparative Analysis ◽

Statistical Analysis ◽

Nocturnal Enuresis ◽

Orthodontic Treatment ◽

Treated Group ◽

Rapid Maxillary Expansion ◽

Maxillary Expansion ◽

Group A ◽

Upper Jaw ◽

Group B

Background. The etiology of nocturnal enuresis (NE) is multifactorial and has not been fully explained yet. New ways of treatment are constantly being investigated, including the rapid maxillary expansion (RME).Methods. A total of 41 patients diagnosed with NE were divided into two experimental groups: A and B. Group A included 16 children who have been treated with RME. Group B comprised 25 children who have not undertaken orthodontic treatment. Children from both groups have been monitored in monthly intervals, during a 12-month period, towards the intensification of NE. The comparative analysis of both groups has been conducted after 3 years of observation.Results. Statistical analysis has shown a 4.5 times increase of the probability of reduction of NE in the case of the treated group in comparison with the group of children who have not undergone orthodontic treatment. Unfortunately, the chance of obtaining total dryness diminished proportionally to the higher degree of intensification of enuresis at the beginning of the test.Conclusion. RME can constitute an alternative method of NE treatment in children, irrespective of the occurrence of upper jaw narrowing.

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High-risk Human Papillomavirus (16, 18) are not the most common genotypes associated with cervical pre-cancer lesions: a retrospective study at a University Hospital in the Eastern-Province of Saudi Arabia

10.1101/2020.03.17.20037465 ◽

2020 ◽

Author(s):

Haitham Kussaibi ◽

Reem Al Dossary ◽

Ayesha Badar ◽

Aroub Omar Muammar ◽

Raghad Ibrahim Aljohani

Keyword(s):

Saudi Arabia ◽

Human Papillomavirus ◽

Statistical Analysis ◽

High Risk ◽

Pap Smear ◽

University Hospital ◽

Pap Smears ◽

Cervical Lesions ◽

High Risk Hpv ◽

Intraepithelial Lesions

AbstractObjectiveHigh-risk HPV (human papillomavirus) is found to be responsible for 4.5% of all cancer, especially cervical cancer. The prevalence of high-risk HPV associated with cervical lesions is not well- known in Saudi Arabia. This study aims to highlight the genotypes of high-risk HPV associated with pre- malignant cervical lesions.MethodsOver 6 years (2013 - 2018), 5091 Pap (Papanicolaou) smears results and 170 high-risk HPV test results were collected from the Information System at King Fahd University Hospital. Statistical analysis was performed using the software SPSS (Statistical Package for Social Sciences).ResultsOut of 5091 Pap smears, only 1.89% (n=96) were abnormal; 0.18% (n=9) were malignant (7 Squamous cell carcinomas and 2 adenocarcinomas), while 1.7% (n=87) showed pre-cancerous lesions, 44 ASCUS (Atypical Squamous Cells of Undetermined Significance), 17 LSIL (Low-grade Squamous Intraepithelial Lesions), 12 HSIL (High-grade Squamous Intraepithelial Lesions), and 14 AGC (Atypical Glandular Cells). Out of 170 patients co-tested for high-risk HPV, only 13.5% (n=23/170) had positive results (5 cases were positive for HPV16, 1 case was positive for both HPV16 and 18, while the remaining 17 cases were positive for high-risk HPV other than 16 or 18), among them, 6.47% (n=11/170) had normal Pap smear, while 7.06% (n=12/170) patients had abnormal Pap smear; 4 ASCUS, 6 LSIL and 2 HSIL. Statistical analysis showed a significant correlation between HPV findings and the Pap smear results (P- value 0.000), however, no significant correlation was found with the patients’ age and/or nationality.DiscussionOur study showed a unique distribution of high-risk HPV genotypes which reflects different geographical infection patterns. Furthermore, the high association of high-risk HPV with normal Pap smears highlights the need, for all women at risk, to be co-investigated for high-risk HPV. These findings could help in customizing regional vaccine-combinations and screening programs.

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A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources Data for Statistical Analysis: Design and Implementation Study (Preprint)

10.2196/preprints.25645 ◽

2020 ◽

Author(s):

Julian Gruendner ◽

Christian Gulden ◽

Marvin Kampf ◽

Sebastian Mate ◽

Hans-Ulrich Prokosch ◽

...

Keyword(s):

Statistical Analysis ◽

Open Source ◽

Clinical Data ◽

Medical Information ◽

Statistical Analyses ◽

University Hospital ◽

Data Repositories ◽

Web Based ◽

Source Database ◽

Laboratory Test Results

BACKGROUND The harmonization and standardization of digital medical information for research purposes is a challenging and ongoing collaborative effort. Current research data repositories typically require extensive efforts in harmonizing and transforming original clinical data. The Fast Healthcare Interoperability Resources (FHIR) format was designed primarily to represent clinical processes; therefore, it closely resembles the clinical data model and is more widely available across modern electronic health records. However, no common standardized data format is directly suitable for statistical analyses, and data need to be preprocessed before statistical analysis. OBJECTIVE This study aimed to elucidate how FHIR data can be queried directly with a preprocessing service and be used for statistical analyses. METHODS We propose that the binary JavaScript Object Notation format of the PostgreSQL (PSQL) open source database is suitable for not only storing FHIR data, but also extending it with preprocessing and filtering services, which directly transform data stored in FHIR format into prepared data subsets for statistical analysis. We specified an interface for this preprocessor, implemented and deployed it at University Hospital Erlangen-Nürnberg, generated 3 sample data sets, and analyzed the available data. RESULTS We imported real-world patient data from 2016 to 2018 into a standard PSQL database, generating a dataset of approximately 35.5 million FHIR resources, including “Patient,” “Encounter,” “Condition” (diagnoses specified using International Classification of Diseases codes), “Procedure,” and “Observation” (laboratory test results). We then integrated the developed preprocessing service with the PSQL database and the locally installed web-based KETOS analysis platform. Advanced statistical analyses were feasible using the developed framework using 3 clinically relevant scenarios (data-driven establishment of hemoglobin reference intervals, assessment of anemia prevalence in patients with cancer, and investigation of the adverse effects of drugs). CONCLUSIONS This study shows how the standard open source database PSQL can be used to store FHIR data and be integrated with a specifically developed preprocessing and analysis framework. This enables dataset generation with advanced medical criteria and the integration of subsequent statistical analysis. The web-based preprocessing service can be deployed locally at the hospital level, protecting patients’ privacy while being integrated with existing open source data analysis tools currently being developed across Germany.

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Geospatial clustering of childhood IgA vasculitis and IgA vasculitis-associated nephritis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-218649 ◽

2020 ◽

pp. annrheumdis-2020-218649

Author(s):

Matej Sapina ◽

Marijan Frkovic ◽

Mario Sestan ◽

Sasa Srsen ◽

Aleksandar Ovuka ◽

...

Keyword(s):

Statistical Analysis ◽

Spatial Variability ◽

Spatial Autocorrelation ◽

Census Data ◽

Analytical Techniques ◽

Danube River ◽

University Hospital ◽

Iga Vasculitis ◽

Spatial Statistical Analysis ◽

Continental Part

ObjectivesResearch on spatial variability of the incidence of IgA vasculitis (IgAV) in children and its potential implications for elucidation of the multifactorial aetiology and pathogenesis is limited. We intended to observe spatial variability of the incidence of IgAV and IgA vasculitis-associated nephritis (IgAVN) using modern geostatistical methods, and hypothesised that their spatial distribution may be spatially clustered.MethodsPatients' data were retrospectively collected from 2009 to 2019 in five Croatian University Hospital Centres for paediatric rheumatology, and census data were used to calculate the incidence of IgAV. Using spatial empirical Bayesian smoothing, local Morans’ I and local indicator of spatial autocorrelation (LISA), we performed spatial statistical analysis.Results596 children diagnosed with IgAV were included in this study, of which 313 (52.52%) were male. The average annual incidence proportion was estimated to be 6.79 per 100 000 children, and the prevalence of IgAVN was 19.6%. Existence of spatial autocorrelation was observed in both IgAV and IgAVN; however, clustering distribution differed. While IgAV showed clustering in Mediterranean and west continental part around cities, IgAVN was clustered in the northern Mediterranean and eastern continental part, where a linear cluster following the Drava and Danube river was observed.ConclusionIgAV incidence in Croatia is similar to other European countries. Spatial statistical analysis showed a non-random distribution of IgAV and IgAVN. Although aetiological associations cannot be inferred, spatial analytical techniques may help in investigating and generating new hypotheses in non-communicable diseases considering possible environmental risk factors and identification of potential genetic or epigenetic diversity.

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A statistical analysis of 47 cases of extramammary Paget’s disease treated in the Department of Dermatology, Sapporo Medical University Hospital

Skin Cancer ◽

10.5227/skincancer.29.12 ◽

2014 ◽

Vol 29 (1) ◽

pp. 12-17

Author(s):

Noriko MIZUGAKI ◽

Yasue OSAI ◽

Junji KATO ◽

Tokimasa HIDA ◽

Yasuyuki SUMIKAWA ◽

...

Keyword(s):

Statistical Analysis ◽

Paget’S Disease ◽

Paget's Disease ◽

University Hospital ◽

Extramammary Paget’S Disease ◽

Medical University ◽

Extramammary Paget's Disease

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Three Palatal Arches Used to Correct Posterior Dental Crossbites

The Angle Orthodontist ◽

10.2319/111105-397 ◽

2006 ◽

Vol 76 (6) ◽

pp. 1047-1051 ◽

Cited By ~ 2

Author(s):

Fernando Lima Martinelli ◽

Priscilla Sobral Couto ◽

Antonio Carlos Oliveira Ruellas

Keyword(s):

Mechanical Properties ◽

Stainless Steel ◽

Statistical Analysis ◽

Orthodontic Treatment ◽

Elasticity Modulus ◽

Steel Wire ◽

Testing Machine ◽

Stainless Steel Wire ◽

Quad Helix ◽

One Way Anova

Abstract Objective: To assess the force, resilience, and elasticity modulus produced by the Coffin appliance, “W” arch, and quad-helix made with 0.032-inch and 0.036-inch stainless steel wire. Materials and Methods: Two groups of 15 arches were made as Coffin appliances, two groups of 15 arches were made as “W” arches, and two groups of 15 arches were made as quad-helices. One group of each appliance was formed in 0.032-inch and one group in 0.036-inch stainless steel wire. All arches (6 groups of 15 each) were submitted to compression trials in the mechanical testing machine EMIC DL-10000, simulating 5-, 8-, 10-, and 12-mm activation. The force and resilience means received a one-way ANOVA statistical analysis. Results: The results showed that the mechanical properties depended on the shape of the appliance, the diameter of the wire used, and the amount of activation. Conclusions: The three appliances assessed produce appropriate forces for orthodontic treatment as long as they are correctly planned during clinical application.

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