scholarly journals Syphilis in pregnancy

2021 ◽  
Vol 50 (1) ◽  
pp. 57-66
Author(s):  
Milan Bjekić
Keyword(s):  
Pregnant Women ◽  
Congenital Syphilis ◽  
Clinical Manifestations ◽  
Screening Tests ◽  
Laboratory Diagnostics ◽  
Serological Screening ◽  
The Republic ◽  
The Moment ◽  
Diagnostics And Therapy ◽  
In Pregnancy

Early syphilis has been increasing in the Republic of Serbia since 2010 and its infectivity for sexual partners lasts for a year from the moment of infection. The exception is pregnant women who, if left untreated, can transmit the infection to the fetus within four years of infection. Syphilis in pregnancy can cause miscarriage, stillbirth, low birth weight or congenital syphilis. The aim of this paper is to present the clinical manifestations, laboratory diagnostics and therapy of syphilis in pregnancy, as well as to sensitize medical workers to this disease and the introduction of mandatory serological screening tests for syphilis in all pregnant women.

scholarly journals Malaria in pregnancy in Hodiedah, Republic of Yemen

2002 ◽  
Vol 8 (2-3) ◽  
pp. 245-253
Author(s):  
A. M. Assabri ◽  
A. A. Muharram
Keyword(s):  
Plasmodium Falciparum ◽  
Pregnant Woman ◽  
Pregnant Women ◽  
Causative Agent ◽  
Clinical Manifestations ◽  
Malaria In Pregnancy ◽  
Laboratory Investigations ◽  
The Republic ◽  
In Pregnancy ◽  
Structured Questionnaire

In the Republic of Yemen, Plasmodium falciparum is the predominant causative agent of malaria and is associated with adverse consequences for pregnant women and their babies. The prevalence and clinical manifestations of malaria among 500 pregnant [260] and non-pregnant [240] women were compared. Clinical examinations, laboratory investigations and a structured questionnaire were used to collect data. The prevalence of malaria was higher among pregnant women [55%] than non-pregnant women [20%]. Anaemia was significantly more prevalent among pregnant woman than non-pregnant women and also more prevalent in pregnant women with malaria than non-pregnant women with malaria.

scholarly journals Microbial pathogens in urogenital infection in pregnant women

2019 ◽  
pp. 13-20
Author(s):  
A. V. Karaulov ◽  
M. S. Afanasiev ◽  
Yu. V. Nesvizhsky ◽  
S. S. Afanasiev ◽  
E. A. Voropaeva ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Pregnant Women ◽  
Pregnancy Termination ◽  
Clinical Manifestations ◽  
Microbial Pathogens ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cervical Canal ◽  
Type I ◽  
Urogenital Infection ◽  
In Pregnancy

Introduction. Chronic and latent infections are often activated during pregnancy.Aim - to asses the pathogenetic role of microbial pathogens in urogenital tract infection (UTI) in pregnant women.Materials and methods. 89 pregnant women underwent general clinical examination, examination of smears from urethra, vagina, cervical canal; bacteriological analysis of vaginal contents; enzyme-linked immunosorbent assay, polymerase chain reaction and determination of specific antibodies for verification of herpes simplex virus (HSV) type I and II, cytomegalovirus (CMV), Epstein-Barr (EBV) and UTI pathogens in pregnant women in blood and mucosal scrapes.Results. Prevalence of Herpesviridae was revealed (90-100% -EBV, HSV type I and II, CMV); in 41% of cases - bacterial pathogens, in 57% of cases - Mycoplasma, Ureaplasma.Discussion. In preterm birth and pregnancy termination mycoplasma and ureaplasma were more often revealed, and in pregnancy termination - association of HSV type I and II in comparison with urgent birth; in the last equally often - HSV type I and association of HSV type I and II; in urgent birth (infection) more often - HSV type I, than association of HSV type I and II; in preterm birth more often - HSV type I, than the association of HSV types I and II, and less often than combination of HSV type I and association of HSV types I and II in pregnancy termination; in the last, the association of HSV types I and II is more common than HSV type I. Increase of TLRs genes expression levels depends on HSV type I less than from association of HSV types I and II, less than from combination of HSV type I and association of HSV types I and II (it determines the clinical manifestations of genital herpes).Conclusion. Microbial pathogens determine the character of pregnancy course, and HSV types I and II- are the triggers of the infectious process, prognosing its course.

Cases of Q fever detected in residents of the novosibirsk region hospitalized with suspection of infections transmitted by ticks

2021 ◽  
Vol 66 (4) ◽  
pp. 229-236
Author(s):  
E. I. Bondarenko ◽  
E. S. Filimonova ◽  
E. I. Krasnova ◽  
E. V. Krinitsina ◽  
S. E. Tkachev
Keyword(s):  
Causative Agent ◽  
Q Fever ◽  
Clinical Manifestations ◽  
Test Methods ◽  
Pcr Analysis ◽  
Laboratory Diagnostics ◽  
Novosibirsk Region ◽  
Complex Approach ◽  
Wide Range ◽  
The Republic

Coxiella burnetii is the causative agent of Q fever (coxiellosis), which, in addition to acute manifestations, often occurs in a latent form, is prone to chronic course and, in the absence of antibiotic therapy, has a high risk of disability or death. As a result of the presence of a wide range of clinical manifestations specific to other infectious diseases, the use of laboratory test methods (LTM) is required to make a diagnosis. The presence of Q fever anthropurgic foci in the Novosibirsk region was described in the 90s of the last century, but due attention to its laboratory diagnostics is not paid in this region. The aim of the study was to identify genetic and serological markers of the causative agent, C. burnetii, in patients of the Novosibirsk region who were admitted for treatment with fever with suspected tick-borne infections (TBIs). DNA marker of the causative agent of Q fever was detected in blood samples by real time PCR in 9 out of 325 patients. In three patients, the presence of C. burnetii DNA was confirmed by sequencing of the IS1111 and htpB gene fragments. In ELISA tests, antibodies against the causative agent of coxiellosis were detected in the blood sera of 4 patients with positive results of PCR analysis. Contact with tick was registered in 7 out of 9 patients who had C. burnetii DNA and lacked markers of other TBIs. Six people were infected in the Novosibirsk region, two suffered from tick’s bite in Altai, and one case was from the Republic of Kyrgyzstan. Thus, a complex approach using both PCR analysis and ELISA provided the identification of markers of the Q fever causative agent in patients admitted with suspected TBIs, thereby differentiating it from other infections. Contact with ticks in most cases suggests that infection with C. burnetii had a transmissible pathway.

scholarly journals Drug-induced cytolytic syndrome in pregnancy: clinical and biochemical diagnostic criteria

2016 ◽  
Vol 65 (6) ◽  
pp. 28-35
Author(s):  
Irina V Borisova
Keyword(s):  
Pregnant Women ◽  
Hormone Therapy ◽  
Clinical Manifestations ◽  
First Trimester ◽  
Gamma Glutamyl Transpeptidase ◽  
Drug Induced ◽  
Planning Stage ◽  
Protein Levels ◽  
First Trimester Of Pregnancy ◽  
In Pregnancy

The aim of the study was evaluation of clinical and laboratory manifestations of drug-induced cytolytic syndrome in pregnancy. In the research group included 62 pregnant women with drug-induced liver injury (DILI) in the first trimester of pregnancy. These pregnant women received hormone therapy at the planning stage and/or during pregnancy for the prevention and treatment of miscarriage and had clinical and biochemical manifestations of cytolytic syndrome. Pregnancy after IVF and ovulation induction was in 60.8% of cases. Hormone therapy for pregnant patients received long-term, 85% of pregnant women used estrogen and progestin drugs. DILI during pregnancy characterized by low-symptom or asymptomatic clinical manifestations. DILI manifested cytolytic biochemical syndrome, in which there is isolated increase of transaminase levels, in some cases accompanied by increased level of gamma glutamyl transpeptidase, liver glutamate dehydrogenase and decreased total protein levels, in the first place due to the albumin fraction.

scholarly journals A study of prevalence of asymptomatic bacteriuria in pregnant women from rural areas attending to Obstetric Department in Akash Hospital, Karnataka, India

2019 ◽  
Vol 8 (7) ◽  
pp. 2845
Author(s):  
Rohini N. S. ◽  
Ravishankar S. N. ◽  
Kala K. ◽  
Rakshith N. R.
Keyword(s):  
Pregnant Women ◽  
Urine Culture ◽  
Screening Method ◽  
Asymptomatic Bacteriuria ◽  
Significant Risk ◽  
Screening Tests ◽  
Rapid Screening ◽  
Screening Methods ◽  
Gram Staining ◽  
In Pregnancy

Background: Asymptomatic bacteriuria (ASB) in pregnancy is a significant risk factor for developing upper urinary tract infection and pyelonephritis which is associated with significant maternal and fetal risks. The aim of this study was to know the prevalence of asymptomatic bacteriuria in pregnancy, to identify the organisms and their antibiotic susceptibility patterns and to formulate a single or combined rapid screening method as an acceptable alternative to urine culture.Methods: A total of 375 pregnant women aged between 18 to 45 years were included in this study. Clean catch mid-stream urine samples were collected. Screening tests done were gram staining of uncentrifuged urine, pus cell count, nitrite test and leukocyte esterase test. Identification of pathogens and antibiotic sensitivity tests were performed as per standard urine culture and sensitivity methods.Results: Out of the 375 pregnant women, 31 (8.4%) had significant bacteriuria. High percentage of women with ASB were primigravidas (51.38%) and in 2nd trimester (43.86%). The most common organism isolated was E.coli (56.14%). In screening tests, gram staining of uncentrifuged urine had a sensitivity of 85.71%. Sensitivity of 71.42% was found in Nitrite and leucocyte esterase tests. However, the combination of these two tests, with either test positive, showed sensitivity and negative predictive value of 90.47% and 99.09% respectively.Conclusions: Early detection and treatment of ASB in pregnancy can prevent complications. ASB can be identified by simple and combined rapid screening methods and urine culture along with antibiogram. Therefore, screening and treatment of ASB may be incorporated as routine antenatal care for safe motherhood and healthy newborn.

scholarly journals Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Marco De Santis ◽  
Carmen De Luca ◽  
Ilenia Mappa ◽  
Terryann Spagnuolo ◽  
Angelo Licameli ◽  
...  
Keyword(s):  
Congenital Syphilis ◽  
Clinical Manifestations ◽  
Fetal Loss ◽  
Immunological Response ◽  
Maternal Infection ◽  
Serological Tests ◽  
Syphilis Infection ◽  
Serological Screening ◽  
Adequate Treatment ◽  
Adverse Pregnancy

Congenital syphilis is still a cause of perinatal morbidity and mortality. Untreated maternal infection leads to adverse pregnancy outcomes, including early fetal loss, stillbirth, prematurity, low birth weight, neonatal and infant death, and congenital disease among newborns. Clinical manifestations of congenital syphilis are influenced by gestational age, stage of maternal syphilis, maternal treatment, and immunological response of the fetus. It has been traditionally classified in early congenital syphilis and late congenital syphilis. Diagnosis of maternal infection is based on clinical findings, serological tests, and direct identification of treponemes in clinical specimens. Adequate treatment of maternal infection is effective for preventing maternal transmission to the fetus and for treating fetal infection. Prenatal diagnosis of congenital syphilis includes noninvasive and invasive diagnosis. Serological screening during pregnancy and during preconception period should be performed to reduce the incidence of congenital syphilis.

scholarly journals Congenital Syphilis in Neonate: A Single Center Study for 10 Years

2021 ◽  
Vol 25 (3) ◽  
pp. 204-210
Author(s):  
Narae Lee ◽  
Mun Hui Jeong ◽  
Seong Hee Jeong ◽  
Mi-Hye Bae ◽  
Young Mi Han ◽  
...  
Keyword(s):  
Congenital Syphilis ◽  
Clinical Manifestations ◽  
Single Center ◽  
Antibody Absorption ◽  
Appropriate Treatment ◽  
Single Center Study ◽  
The Republic ◽  
Bone Abnormalities ◽  
Center Study

Purpose: Syphilis infections are becoming more prevalent in the Republic of Korea, and inadequately treated syphilis can lead to congenital syphilis (CS) in newborns. This study aimed to analyze the clinical manifestations of syphilis in mothers and newborns and to make suggestions to improve disease prognosis. Methods: This single-center study was performed between August 2009 and August 2019 and included 29 newborns with CS. We retrospectively evaluated the clinical features, rapid plasma reagin (RPR) card test, fluorescent treponemal antibody absorption test (FTA-ABS), morbidity, and treatment regimen of all the syphilis-affected mothers and their newborns. Results: At the time of delivery, mean maternal age was 29.0±6.1 years old, and newborn gestational age was 38.0 weeks. In cases when syphilis was confirmed during the second and third trimesters of pregnancy, the newborn with CS had morbidity (p=0.004). The mean RPR titer was related to morbidity (p= 0.036). Positive results of FTA-ABS IgM (p<0.001) and pleocytosis in the cerebrospinal fluid (CSF) (p= 0.020) also increase morbidity. The most common symptoms were desquamation and skin rash, followed by hepatomegaly, neurodevelopmental disability, and bone abnormalities. The highest number of CS cases per 1,000 live births in this hospital was in 2014. Conclusion: CS is a preventable and treatable disease if physicians detect symptoms and provide appropriate treatment through RPR examinations during every trimester. General practitioners should be widely trained on various aspects including early detection, formal treatment, and regular follow-up. Additionally, medical services should be provided for the entire childbearing population regardless of the socioeconomic status.

scholarly journals Practical aspects of Lyme disease in children

2020 ◽  
pp. 33-38
Author(s):  
N.V. Banadyha ◽  
◽  
I.O. Rogalskyy ◽  
Keyword(s):  
Lyme Disease ◽  
Lyme Borreliosis ◽  
Conflict Of Interest ◽  
Patient Management ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Laboratory Diagnostics ◽  
Pediatric Practice ◽  
Key Words Lyme Disease ◽  
The Moment

Lyme disease is especially important in the spring–autumn period, despite the fact that its clinical manifestations may be throughout the year. Awareness of general practitioners with this problem is insufficient, it requires additional knowledge about diagnosis and treatment. In pediatric practice, the fact of a child being bitten by an Ixodes mite that carries the causative agent of Lyme borreliosis, in addition to babesiosis, anaplasmosis, often goes unnoticed. Therefore, parents seek medical help only when various problems arise, often the thought of Lyme disease does not even arise. Lyme disease has a wide polymorphism of clinical symptoms, is characterized by multisystem lesions, cyclical course — all this complicates the diagnostic search. The difficulty also lies in the fact that there are no domestic clinical recommendations. This publication presents approaches to the diagnosis, treatment, prevention of Lyme disease based on the experience of experts from different countries. Modern approaches to two-stage laboratory diagnostics, tactics of patient management from the moment of bite, treatment at different stages of Lyme borreliosis are analyzed. Attention is paid to the need for epidemiological research in Ukraine and the beginning of educational programs to prevent the disease. The differentiated approach to the treatment of Lyme disease in children due to age aspects, concomitant pathology, safety of long_term antibacterial therapy should be studied more. No conflict of interest was declared by the authors. Key words: Lyme disease, children, diagnosis, treatment, prevention.

scholarly journals The reality of 13 years of prenatal care to pregnant women with syphilis in Sergipe state (2007-2019)

2019 ◽  
Vol 31 (4) ◽  
pp. 123-130 ◽  
Author(s):  
Rute de Oliveira Farias ◽  
Izailza Matos Dantas Lopes ◽  
Letícia Goes Santos ◽  
Amanda Silveira de Carvalho Dantas
Keyword(s):  
Prenatal Care ◽  
Pregnant Women ◽  
Considerable Increase ◽  
Congenital Syphilis ◽  
Treponema Pallidum ◽  
Serological Screening ◽  
Cross Sectional ◽  
Infant Deaths ◽  
Clinical Phase ◽  
High Prevalence

Introduction: Syphilis is an infectious disease caused by Treponema pallidum, its two main routes of transmission are sexual and transplacental (vertical). The latter is of particular worrisome, since it can generate congenital syphilis and can be avoided by early maternal serological screening. Objective: To analyze the conditions of prenatal care for syphilitic pregnant women in Sergipe State between 2007 and 2019. Methods: A cross-sectional, retrospective, and descriptive study was carried out, with the collection of notified cases of gestational and congenital syphilis in the Brazilian Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação - SINAN). Results: There was a considerable increase in the number of reported cases of gestational syphilis in the last 13 years. About 36% of pregnant women were identified in the 3rd trimester of pregnancy, 68.1% were brown, 56.8% had studied for up to 8 years, and 50.1% were between 20 and 29 years old. The clinical phase latent to the diagnosis was responsible for 70.3% of the cases, followed by the primary (11%) and tertiary (7.3%) phases. Of the total number of pregnant women, 20.2% did not perform the non-treponemal test, and 97.2% were treated with penicillin. Regarding the numbers of congenital syphilis, although 75% of the mothers performed prenatal care, 37.8% received the diagnosis at the time of delivery/curettage, resulting in 72.9% of infant deaths from the disease. Moreover, there was a predominance of untreated partners (77.7%) in relation to those treated (10.8%). Conclusion: Although most of them performed prenatal care, there was a predominance of diagnoses performed only in the 3rd trimester of pregnancy, mainly at the time of delivery or curettage, not respecting the minimum therapeutic interval of 30 days before delivery. Thus, in Sergipe State, the most important factor in the high prevalence of vertical transmission of syphilis is the ineffectiveness of prenatal care provided to infected pregnant women, which remains.

scholarly journals Gambaran Kejadian Persalinan Disfungsional pada Pasien Anemia dalam Kehamilan di RSUP Dr. M. Djamil Periode 2010–2012

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Mega Redha Putri ◽  
Joserizal Serudji ◽  
Efrida Efrida
Keyword(s):  
Pregnant Women ◽  
Clinical Manifestations ◽  
Uterine Contractions ◽  
Mild Anemia ◽  
Labor Dystocia ◽  
Moderate Anemia ◽  
Anemia In Pregnancy ◽  
Severe Degree ◽  
Dysfunctional Labor ◽  
In Pregnancy

AbstrakPersalinan disfungsional (distosia akibat kelainan tenaga) merupakan masalah persalinan dunia dan merupakan salah satu indikasi dilakukannya intervensi selama persalinan dengan tingkat kekerapan kejadian sebesar 4-40%. Persalinan disfungsional dapat disebabkan oleh anemia dalam kehamilan. Kekuatan kontraksi uterus atau his ibu hamil dengan anemia kurang dari normal, lemah dan dalam durasi yang pendek sehingga tidak cukup kuat untuk melahirkan janin dan ibu hamil akan cepat lelah, akibatnya persalinan dapat mengalami perlambatan atau terhenti. Semakin berat anemia, semakin berat manifestasi klinis yang muncul. Tujuan penelitian ini adalah untuk mengetahui gambaran kejadian persalinan disfungsional pada pasien anemia dalam kehamilan berdasarkan derajat anemia di RSUP Dr. M. Djamil Padang. Ini merupakan penelitian deskriptif menggunakan data retrospektif bagian rekam medik RSUP. Dr. M. Djamil Padang periode 2010-2012. Data yang digunakan sebanyak 61 sampel. Hasil penelitian menunjukkan distribusi kejadian persalinan disfungsional paling tinggi pada anemia derajat ringan yaitu sebanyak 4 orang (8,7%), anemia derajat sedang sebanyak 1 orang (8,3%) dan anemia derajat berat 0%. Hasil penelitian menunjukkan bahwa derajat anemia dalam kehamilan tidak mempengaruhi angka kejadian persalinan disfungsional.Kata kunci: anemia dalam kehamilan, persalinan disfungsional, distosia, ibu hamil AbstractDysfunctional labor (dystocia due to abnormal labor) is a worldwide labor problem and one of the indications for intervention during labor with prevalence rate 4-40%. Dysfunctional labor can be caused by anemia in pregnancy. The strength of uterine contractions or his in pregnant women with anemia is less than normal, weak and short in duration so it is not strong enough to bear the fetus and the pregnant women will get tired, causing a slow or stopped. The more severe anemia, the more severe clinical manifestations appear. The objective of this study was to know the incidence of dysfunctional labor in patients with anemia on pregnancy based on the degree of anemia in Dr. M. Djamil Hospital Padang. This research was a descriptive study using retrospective data from medical record of Dr M. Djamil Hospital Padang on period 2010-2012. The samples used were 61 samples. The results showed the distribution of the high incidence of dysfunctional labor is mild anemia as many as 4 people (8.7%), on moderate anemia is 1 person (8.3%) and there is none on the severe degree (0%). The study shows that the degree of anemia in preganacy doesn’t affect the incidence of dysfunctional labor.Keywords: anemia in pregnancy, dysfunctional labor, dystocia, pregnant woman

Sign in / Sign up

Export Citation Format

Share Document