Cases of Q fever detected in residents of the novosibirsk region hospitalized with suspection of infections transmitted by ticks

2021 ◽  
Vol 66 (4) ◽  
pp. 229-236
Author(s):  
E. I. Bondarenko ◽  
E. S. Filimonova ◽  
E. I. Krasnova ◽  
E. V. Krinitsina ◽  
S. E. Tkachev
Keyword(s):  
Causative Agent ◽  
Q Fever ◽  
Clinical Manifestations ◽  
Test Methods ◽  
Pcr Analysis ◽  
Laboratory Diagnostics ◽  
Novosibirsk Region ◽  
Complex Approach ◽  
Wide Range ◽  
The Republic

Coxiella burnetii is the causative agent of Q fever (coxiellosis), which, in addition to acute manifestations, often occurs in a latent form, is prone to chronic course and, in the absence of antibiotic therapy, has a high risk of disability or death. As a result of the presence of a wide range of clinical manifestations specific to other infectious diseases, the use of laboratory test methods (LTM) is required to make a diagnosis. The presence of Q fever anthropurgic foci in the Novosibirsk region was described in the 90s of the last century, but due attention to its laboratory diagnostics is not paid in this region. The aim of the study was to identify genetic and serological markers of the causative agent, C. burnetii, in patients of the Novosibirsk region who were admitted for treatment with fever with suspected tick-borne infections (TBIs). DNA marker of the causative agent of Q fever was detected in blood samples by real time PCR in 9 out of 325 patients. In three patients, the presence of C. burnetii DNA was confirmed by sequencing of the IS1111 and htpB gene fragments. In ELISA tests, antibodies against the causative agent of coxiellosis were detected in the blood sera of 4 patients with positive results of PCR analysis. Contact with tick was registered in 7 out of 9 patients who had C. burnetii DNA and lacked markers of other TBIs. Six people were infected in the Novosibirsk region, two suffered from tick’s bite in Altai, and one case was from the Republic of Kyrgyzstan. Thus, a complex approach using both PCR analysis and ELISA provided the identification of markers of the Q fever causative agent in patients admitted with suspected TBIs, thereby differentiating it from other infections. Contact with ticks in most cases suggests that infection with C. burnetii had a transmissible pathway.

New association Сladophoro fractae–Stuckenietum chakassiensis of the class Ruppietea maritimae from Siberia

2017 ◽  
pp. 55-60
Author(s):  
L. M. Kipriyanova
Keyword(s):  
Salinity Range ◽  
Ruppia Maritima ◽  
East Siberia ◽  
The South ◽  
Diagnostic Species ◽  
Novosibirsk Region ◽  
Wide Range ◽  
Saline Waters ◽  
New Association ◽  
The Republic

New ass. Cladophoro fractae–Stuckenietum chakas­siensis Kipriyanova ass. nov. hoc loco, referred to the alliance Сladophoro fractae–Stuckenion chakassiensis Kipriyanova all. nov. hoc loco, to the order Ruppietalia maritimae J. Tx. ex Den Hartog et Segal 1964 and to the class Ruppietea maritimae J. Tx. ex Den Hartog et Segal 1964 was described in Siberia. Nomenclature type (holotypus) — relevé 3 (author′s number 5.3) in Table. Dominating diagnostic species is Stuckenia chakassiensis (Kaschina) Klinkova (Flora Nizhnego Povolzhiya, 2006). (Synonyms are Potamogetonpectinatus L. subsp. chakassiensis Kaschina in Krasnob. et Safonova, 1986, Novoe o Fl. Sibiri: 245. — P. chakassiensis (Kaschina) Volob. 1991, Sibir. Biol. Zhurn. 5: 75. — P. chakassiensis var. tenuior Volob. 1993, Sibir. Biol. Zhurn. 3: 57. — P. intramongolicus Ma, 1983, Acta Bot. Bor.-Occid. Sin. 3(1): 8, nom. inval. — P. acifolius Ma, 1983, Acta Bot. Bor.-Occid. Sin. 3(1): 8, nom. inval. — Stuckeniaintramongolica (Ma) Tzvel. 1999, Bot. Zhurn. 84(7): 111, nom. illeg.). The species richness (data of fifteen relevés) is 1–4 per relevé, which is explained by relatively high salinity values. A total of 8 species were registered in association communities. Communities with total cover 20–95 %, occupy quite large (from 20 to more than 100 m2) areas in the studied lakes. The main ­layer — submerged plants — is made by shoots of Stuckenia chakassiensis. There are other species with a wide range of halotolerance (Cladophora species), as well as brackish and saline water species (Ruppia maritima, Chara aspera, C. canescens, C. altaica) and Althenia orientalis, Ruppia drepanensis, R. cirrhosa, Lamprotamnium papulosum, which are much rarer in Western Siberia. Other layers are not expressed, except for the emergent plants represented by reed on the border of belts of submergent and emergent vegetation. Communities of associations were observed only in the brackish (oligohaline, mesohaline, polyhaline) waters of the various classes and groups: mainly sodium-chloride in the south of West Siberia, and sodium-bicarbonate in East Siberia. Not too often they were found in sodium-sulfate and magnesium-bicarbonate waters. Salinity range of association in Transbaikalia was 1.11–9.57 g/dm3. Maximum salinity for Stuckenia chakassiensis communities in the Novosibirsk region was 10.32 g/dm3, in the lakes of Khakassia — 28.8 g/dm3. The pH values varied from 6.55 to 10.50. Special publications (Kipriyanova et al., 2016, 2017) are devoted to a description of the hydrochemical preferences of the S. chakassiensis and some other species of the genus Stuckenia in the lakes of Transbaikalia. According to the obtained data in the brackish waters of the lakes of East Siberia, S. chakassiensis forms thickets with rather high productivity (up to 517.4±89.51 g/m2 abs. dry weight) (Kipriyanova et al., 2017). The association′s area of distribution appears to coincide with the range of the species, which is a southern part of Siberia (Kurgan Region, Novosibirsk Region, Altai Territory, the Republic of Khakassia, the Republic of Buryatia, Trans-Baikal Territory), northern Kazakhstan, northern China, Mongolia, and rarely — the South Eastern Europe: Volgograd Region (Chernyshkovsky district, in the estuaries and lakes of the Tsimlyansky sand massif near the hamlets Tormosin and Morskoy ) (Flora of the Lower Volga region, 2006; Krasnaya..., 2006) and in the Caucasus ­(Tzvelev, 1990). The association quite logically fits into the class Ruppietea and the order Ruppietalia. In addition to the actual cenoses of different Ruppia species, the communities of other aquatic halotolerant plants, such as the association of emergent plant Eleocharitetum parvulae (Christiansen 1934) Gillner 1960, the bryophyte cenoses Rielletum helicophyllae Cirujano et al. 1993, Rielletum notarisii Cirujano et al. 1993 may be included into this class (Rivas-Martínez et al., 2002; and others). Some researchers place into this class the communities of halotolerant charophytes of the Charion canescentis Krausch 1964 alliance, and the ass. Ranunculetum baudotii Br.-Bl. in Br.-Bl. et al. 1952 (Berg et al., 2014). The input of the ass. Cladophoro fractae–Stuckenietum chakassiensis to the Ruppietea class corresponds to principles and methods of the Braun-Blanquet approach (Braun-Blanquet, 1964), since the diagnostic species of the new association is accompanied with different species abundance in the brackish and saline waters: Ruppia maritima, Chara canescens, C. altaica, as well as species with a wide range of halotolerance — Cladophora fracta and others. The character diagnostic species of Сladophoro fractae–Stuckenion chakassiensis alliance are the species specific for continental brackish and saline waters of forest-steppe and steppe zones of Asia such as Stuckenia chakassiensis, S. macrocarpa, Chara altaica.

Comorbidity of tic hyperkineses with impulsive disorders

2020 ◽  
Vol 18 (5) ◽  
pp. 88-92
Author(s):  
S. E. MUNASIPOVA ◽  
◽  
Z. A. ZALYALOVA ◽  
D. M. KHASANOVA ◽  
◽  
...  
Keyword(s):  
Movement Disorders ◽  
Clinical Manifestations ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Hyperactivity Disorder ◽  
Diagnostic Center ◽  
Wide Range ◽  
The Republic ◽  
Obsessive Compulsive Disorders

Tourette’s syndrome, the most common cause of tics, manifests itself in a wide range of motor and behavioral disorders and is found in men about three times more often than in women. The purpose — to establish the comorbidity of neuropsychiatric disorders in patients with tic hyperkinesis. Material and methods. The study included 111 patients with tic hyperkinesis of various ages and sex, who were outpatiently observed at the Clinical and Diagnostic Center for Movement Disorders and Botulinum Therapy of the Republic of Tatarstan from 2011 to 2014. Results and conclusions. In the group of patients we studied, tics were more common in males (in 71.6% of cases), and patients with Tourette’s syndrome were numerically predominant, taking into account the visits to the Clinical and Diagnostic Center for Movement Disorders and Botulinum Therapy of the Republic of Tatarstan. Clinical manifestations of obsessive-compulsive disorders were found not only in patients with Tourette’s syndrome, but they are characteristic of 53.2% of patients with tic hyperkinesis of various severity and phenomenology. Also, regardless of the structural and phenomenological characteristics of tic hyperkinesis, they were almost always associated with attention deficit hyperactivity disorder with a predominance of hyperactivity.

scholarly journals Syphilis in pregnancy

2021 ◽  
Vol 50 (1) ◽  
pp. 57-66
Author(s):  
Milan Bjekić
Keyword(s):  
Pregnant Women ◽  
Congenital Syphilis ◽  
Clinical Manifestations ◽  
Screening Tests ◽  
Laboratory Diagnostics ◽  
Serological Screening ◽  
The Republic ◽  
The Moment ◽  
Diagnostics And Therapy ◽  
In Pregnancy

Early syphilis has been increasing in the Republic of Serbia since 2010 and its infectivity for sexual partners lasts for a year from the moment of infection. The exception is pregnant women who, if left untreated, can transmit the infection to the fetus within four years of infection. Syphilis in pregnancy can cause miscarriage, stillbirth, low birth weight or congenital syphilis. The aim of this paper is to present the clinical manifestations, laboratory diagnostics and therapy of syphilis in pregnancy, as well as to sensitize medical workers to this disease and the introduction of mandatory serological screening tests for syphilis in all pregnant women.

scholarly journals Response of Day Care Centers for Children and Youth with Disabilities in Republic of Srpska to Work Challenges During Covid-19 Pandemic

2021 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Andrea Radonjić Rakanović ◽  
Ćuk Mira
Keyword(s):  
Day Care ◽  
Social Protection ◽  
Test Methods ◽  
Local Communities ◽  
Children And Youth ◽  
Service Users ◽  
Youth With Disabilities ◽  
Day Care Centers ◽  
Wide Range ◽  
The Republic

In accordance with the Law of Social Protection of the Republic of Srpska Day care Centers are institutions of social protections that enable daily care of children in local communities and providing a wide range of services: food and care providing, storage, health care, upbringing and education, psychosocial rehabilitation, work occupation and integration. The proclamation of a pandemic COVID-19, Day care centers had to change the way of working and to provide support to children in their own homes. How the day centers worked and which activities they undertook in the new conditions is the subject of this research. The research was conducted on the entire territory of Republic of Srpska in the period from May to June 2020. The population consisted of all 18 Day care Centers for children and youth with disabilities. A total of 15 Day care Centers participated in the research. Methods of analysis and synthesis and test methods were used in the research, as well as Content analysis method. The technique that was used during the research was specially created survey. Day care Centers for children and youth with disabilities during the corona virus pandemic did not have a operational work plan. Most Day care Centers operated without instructions and guidelines. There was no systemic solution related to the organization of work in changed conditions. Communication with service users mostly took place in the online space, with all the limitations due to the modest technical conditions in Day care Centers, as well as the limited technical capacities of the users. Communication with service users maintained through home visits. During the pandemic, users needed help in a significant number of cases. Day care Centers were engaged in other activities related to the needs of users and the population of local communities during the pandemic. In some cases, they changed or supplemented their activities and developed new project.

scholarly journals Malaria in pregnancy in Hodiedah, Republic of Yemen

2002 ◽  
Vol 8 (2-3) ◽  
pp. 245-253
Author(s):  
A. M. Assabri ◽  
A. A. Muharram
Keyword(s):  
Plasmodium Falciparum ◽  
Pregnant Woman ◽  
Pregnant Women ◽  
Causative Agent ◽  
Clinical Manifestations ◽  
Malaria In Pregnancy ◽  
Laboratory Investigations ◽  
The Republic ◽  
In Pregnancy ◽  
Structured Questionnaire

In the Republic of Yemen, Plasmodium falciparum is the predominant causative agent of malaria and is associated with adverse consequences for pregnant women and their babies. The prevalence and clinical manifestations of malaria among 500 pregnant [260] and non-pregnant [240] women were compared. Clinical examinations, laboratory investigations and a structured questionnaire were used to collect data. The prevalence of malaria was higher among pregnant women [55%] than non-pregnant women [20%]. Anaemia was significantly more prevalent among pregnant woman than non-pregnant women and also more prevalent in pregnant women with malaria than non-pregnant women with malaria.

The Problem of Identifying and Modeling the Relationship between Monetary Factor and Inflation in the Russian Economy

2008 ◽  
pp. 61-76
Author(s):  
A. Porshakov ◽  
A. Ponomarenko
Keyword(s):  
Money Supply ◽  
Money Demand ◽  
Russian Economy ◽  
Long Run ◽  
Complex Approach ◽  
Wide Range ◽  
Long Time ◽  
The Relationship ◽  
Supply Side Factors

The role of monetary factor in generating inflationary processes in Russia has stimulated various debates in social and scientific circles for a relatively long time. The authors show that identification of the specificity of relationship between money and inflation requires a complex approach based on statistical modeling and involving a wide range of indicators relevant for the price changes in the economy. As a result a model of inflation for Russia implying the decomposition of inflation dynamics into demand-side and supply-side factors is suggested. The main conclusion drawn is that during the recent years the volume of inflationary pressures in the Russian economy has been determined by the deviation of money supply from money demand, rather than by money supply alone. At the same time, monetary factor has a long-run spread over time impact on inflation.

Search for mutations of the interferon-induced transmembrane protein 5 (IFITM5) gene in patients with osteogenesis imperfecta

2019 ◽  
pp. 21-29
Author(s):  
А.Р. Зарипова ◽  
Л.Р. Нургалиева ◽  
А.В. Тюрин ◽  
И.Р. Минниахметов ◽  
Р.И. Хусаинова
Keyword(s):  
Osteogenesis Imperfecta ◽  
De Novo ◽  
Transmembrane Protein ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Heterozygous Mutation ◽  
Type I ◽  
New Genes ◽  
Wide Range ◽  
Type V

Проведено исследование гена интерферон индуцированного трансмембранного белка 5 (IFITM5) у 99 пациентов с несовершенным остеогенезом (НО) из 86 неродственных семей. НО - клинически и генетически гетерогенное наследственное заболевание соединительной ткани, основное клиническое проявление которого - множественные переломы, начиная с неонатального периода жизни, зачастую приводящие к инвалидизации с детского возраста. К основным клиническим признакам НО относятся голубые склеры, потеря слуха, аномалия дентина, повышенная ломкость костей, нарушения роста и осанки с развитием характерных инвалидизирующих деформаций костей и сопутствующих проблем, включающих дыхательные, неврологические, сердечные, почечные нарушения. НО встречается как у мужчин, так и у женщин. До сих пор не определена степень генетической гетерогенности заболевания. На сегодняшний день известно 20 генов, вовлеченных в патогенез НО, и исследователи разных стран продолжают искать новые гены. В последнее десятилетие стало известно, что аутосомно-рецессивные, аутосомно-доминантные и Х-сцепленные мутации в широком спектре генов, кодирующих белки, которые участвуют в синтезе коллагена I типа, его процессинге, секреции и посттрансляционной модификации, а также в белках, которые регулируют дифференцировку и активность костеобразующих клеток, вызывают НО. Мутации в гене IFITM5, также называемом BRIL (bone-restricted IFITM-like protein), участвующем в формировании остеобластов, приводят к развитию НО типа V. До 5% пациентов имеют НО типа V, который характеризуется образованием гиперпластического каллуса после переломов, кальцификацией межкостной мембраны предплечья и сетчатым рисунком ламелирования, наблюдаемого при гистологическом исследовании кости. В 2012 г. гетерозиготная мутация (c.-14C> T) в 5’-нетранслируемой области (UTR) гена IFITM5 была идентифицирована как основная причина НО V типа. В представленной работе проведен анализ гена IFITM5 и идентифицирована мутация c.-14C>T, возникшая de novo, у одного пациента с НО, которому впоследствии был установлен V тип заболевания. Также выявлены три известных полиморфных варианта: rs57285449; c.80G>C (p.Gly27Ala) и rs2293745; c.187-45C>T и rs755971385 c.279G>A (p.Thr93=) и один ранее не описанный вариант: c.128G>A (p.Ser43Asn) AGC>AAC (S/D), которые не являются патогенными. В статье уделяется внимание особенностям клинических проявлений НО V типа и рекомендуется определение мутации c.-14C>T в гене IFITM5 при подозрении на данную форму заболевания. A study was made of interferon-induced transmembrane protein 5 gene (IFITM5) in 99 patients with osteogenesis imperfecta (OI) from 86 unrelated families and a search for pathogenic gene variants involved in the formation of the disease phenotype. OI is a clinically and genetically heterogeneous hereditary disease of the connective tissue, the main clinical manifestation of which is multiple fractures, starting from the natal period of life, often leading to disability from childhood. The main clinical signs of OI include blue sclera, hearing loss, anomaly of dentin, increased fragility of bones, impaired growth and posture, with the development of characteristic disabling bone deformities and associated problems, including respiratory, neurological, cardiac, and renal disorders. OI occurs in both men and women. The degree of genetic heterogeneity of the disease has not yet been determined. To date, 20 genes are known to be involved in the pathogenesis of OI, and researchers from different countries continue to search for new genes. In the last decade, it has become known that autosomal recessive, autosomal dominant and X-linked mutations in a wide range of genes encoding proteins that are involved in the synthesis of type I collagen, its processing, secretion and post-translational modification, as well as in proteins that regulate the differentiation and activity of bone-forming cells cause OI. Mutations in the IFITM5 gene, also called BRIL (bone-restricted IFITM-like protein), involved in the formation of osteoblasts, lead to the development of OI type V. Up to 5% of patients have OI type V, which is characterized by the formation of a hyperplastic callus after fractures, calcification of the interosseous membrane of the forearm, and a mesh lamellar pattern observed during histological examination of the bone. In 2012, a heterozygous mutation (c.-14C> T) in the 5’-untranslated region (UTR) of the IFITM5 gene was identified as the main cause of OI type V. In the present work, the IFITM5 gene was analyzed and the de novo c.-14C> T mutation was identified in one patient with OI who was subsequently diagnosed with type V of the disease. Three known polymorphic variants were also identified: rs57285449; c.80G> C (p.Gly27Ala) and rs2293745; c.187-45C> T and rs755971385 c.279G> A (p.Thr93 =) and one previously undescribed variant: c.128G> A (p.Ser43Asn) AGC> AAC (S / D), which were not pathogenic. The article focuses on the features of the clinical manifestations of OI type V, and it is recommended to determine the c.-14C> T mutation in the IFITM5 gene if this form of the disease is suspected.

The vegetation of the small rivers of Novosibirsk Region (a syntaxonomic essay)

2019 ◽  
pp. 3-27 ◽  
Author(s):  
L. M. Kipriyanova ◽  
M. A. Kleshchev
Keyword(s):  
Anthropogenic Impact ◽  
West Siberia ◽  
Steppe Zone ◽  
Small Rivers ◽  
Forest Steppe ◽  
Aquatic Communities ◽  
Emergent Plants ◽  
Novosibirsk Region ◽  
General Chemical ◽  
Wide Range

Information on the aquatic and semiaquatic vegetation of the major watercourses of West Siberia is relatively scarce, while this of small rivers is practically absent. There are 430 rivers whose length exceeds 10 km within the Novosibirsk Region. The aim of our work was to study the phytocenotic diversity of their aquatic and semiaquatic vegetation. 130 geobotanical relevés were performed by the authors in July–August 2003–2005. The object was aquatic communities formed by true aquatic (submergent and floating-leaved) plants and semiaquatic ones with emergent plants and these of water′s edge. In total 10 watercourses were studied (Table 1): 2–3 in each of five geomorphologic regions within the forest-steppe zone (Table 2). The upper, middle and lower courses (Fig. 1, Table 1) with the length of 2–2.5 km were studied in each case to ensure the 4–5 repetition of main elements (stream pools and ridges) that would give a reliable information on their flora and vegetation. The sample plots were selected above the settlements, whenever possible in sites with no to intensive anthropogenic impact. The data were collected according to J. Braun-Blanquet (1964) approach. The relevés were done on the sample plot of 100 m2 placed in the most homogeneous part of the community or, in case of its smaller area, within the natural boundaries. The following scale was used for abundance estimation: r — the species is extremely rare; + — rare, small cover; 1 — the number of individuals is large, the cover is small or individuals are sparse, but the cover is large; 2 —cover of 5–25 %; 3 — 26–50 %; 4 — 51–75 %; 5 — more than 75 %. The date on water depth, transparency (on a white Secchi disk with a diameter of 30 cm), temperature and the flow rate were obtained. The soil mechanical composition and color, the degree and nature of anthropogenic impact on vegetation and river banks were quantified. Water samples for general chemical analysis were taken in the middle course of each river. Computer programs TURBOVEG and MEGATAB (Hennekens, 1996) were used for database. The syntaxonomic affiliation of phytocenoses was determined using modern literature (Bobrov, Chemeris, 2006; Vegetace..., 2011; Chepinoga, 2015; Landucci et al. 2015; Mucina et al., 2016, etc.). 36 associations and 3 communities belonging to 12 alliances, 9 orders, and 5 classes have been identified (Tables 3–14, Fig. 2–9). Such great syntaxonomic diversity is determined by the significant ecotopic variety, the variability of substrates, the wide range of water flow rates and the different water trophicity. For comparison, 26 associations, 13 variants, 2 communities were identified in the study of 50 rivers of Lithuania (Sinkyavichene, 1992); altogether 84 associations are known for the Upper Volga region as a whole (Bob­rov, Chemeris, 2006), while 45 ones were recorded previously in 130 watercourses of this region (Bobrov, 1999). Information on small river macroalgae cenoses in the study area is partially reflected in the paper published earlier (Bobrov et al., 2005).

Modern prevention and active longevity programs on the basis of disruptive domestic technologies: positive experience and prospects for application

2020 ◽  
pp. 66-73
Author(s):  
A. Simonova ◽  
S. Chudakov ◽  
R. Gorenkov ◽  
V. Egorov ◽  
A. Gostry ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Early Detection ◽  
Laboratory Diagnostics ◽  
Positive Experience ◽  
Practical Application ◽  
Wide Range ◽  
Integrated Program ◽  
Long Term Experience ◽  
Early Detection And Prevention

The article summarizes the long-term experience of practical application of domestic breakthrough technologies of preventive personalized medicine for laboratory diagnostics of a wide range of socially significant non-infectious diseases. Conceptual approaches to the formation of an integrated program for early detection and prevention of civilization diseases based on these technologies are given. A vision of the prospects for the development of this area in domestic and foreign medicine has been formed.

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