Hepatoprotective activity of Etlingera elatior (Jack) R.M. Smith extract against ccl4 -induced hepatic toxicity in male wistar rats

Syzygium campanulatum and Syzygium aromaticum contains antioxidant components suchas flavonoids, phenolic, and terpenoids. May have hepatoprotective properties in reducing SGPT and SGOT activity. This research wants to determine the potency of hepatoprotective of ethanolic extract of Syzygium campanulatum (Korth) and Syzygium aromaticum leaf compared with curcuma tablets. This research uses 24 male Wistar rats divided into 6 groups: I, II, III (as a normal, induction, and compared control), group IV, V, VI were treated 105, 210, and 420 mg/kg BW respectively. The study was conducted for 9 days. After 7 days of treatment, treated groups were exposed by hepatotoxic dose of paracetamol (2000 mg/kg BW). The SGPT and SGOT activity of all groups was measured by enzimatic assay. The result can be concluded that Syzygium campanulatum extract was found to be active as hepatoprotective agent with 210 mg/kg BW dosage (SGPT 21.76 ± 3.98 U/L and SGOT 7.32±6.74U/L) as eff ective as with the curcuma tablets (SGPT 23.91 ± 4.41 U/L and SGOT 14.12±5.37 U/L) and the hepatoprotective activity of Syzygium campanulatum extract at a dosage 420 mg/kg BW better than curcuma tablets (SGPT 12.43 ± 6.51 U/L and SGOT 6.64 ± 5.88 U/L). While the hepatoprotec Syzygium campanulatum and Syzygium aromaticum contains antioxidant components such as flavonoids, phenolic, and terpenoids.May have hepatoprotective properties in reducing SGPT and SGOT activity. This research wants to determine the potency of hepatoprotective of ethanolic extract of Syzygium campanulatum (Korth) and Syzygium aromaticum leaf compared with curcuma tablets. This research uses 24 male Wistar rats divided into 6 groups: I, II, III (as a normal, induction, and compared control), group IV, V, VI were treated 105, 210, and 420 mg/kg BW respectively. The study was conducted for 9 days. After 7 days of treatment, treated groups were exposed by hepatotoxic dose of paracetamol (2000 mg/kg BW). The SGPT and SGOT activity of all groups was measured by enzimatic assay. The result can be concluded that Syzygium campanulatum extract was found to be active as hepatoprotective agent with 210 mg/kg BW dosage (SGPT 21.76 ± 3.98 U/L and SGOT 7.32±6.74U/L) as eff ective as with the curcuma tablets (SGPT 23.91 ± 4.41 U/L and SGOT 14.12±5.37 U/L) and the hepatoprotective activity of Syzygium campanulatum extract at a dosage 420 mg/kg BW better than curcuma tablets (SGPT 12.43 ± 6.51 U/L and SGOT 6.64 ± 5.88 U/L). While the hepatoprotective activity of Syzygium aromaticum extracts eff ective as with curcuma tablets at all dosage variation.

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Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats

Pharmacological Reports ◽

10.1016/j.pharep.2018.02.007 ◽

2018 ◽

Vol 70 (4) ◽

pp. 712-719 ◽

Cited By ~ 25

Author(s):

Saeed Mehrzadi ◽

Iman Fatemi ◽

Ali Reza Malayeri ◽

Ali Khodadadi ◽

Fatemeh Mohammadi ◽

...

Keyword(s):

Ellagic Acid ◽

Wistar Rats ◽

Sodium Arsenite ◽

Hepatic Toxicity ◽

Male Wistar Rats

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Hepatoprotective activity of Livshis, a polyherbal formulation in CCl4-induced hepatotoxic male Wistar rats: A toxicity screening approach

Genomic Medicine Biomarkers and Health Sciences ◽

10.1016/j.gmbhs.2012.03.001 ◽

2011 ◽

Vol 3 (3-4) ◽

pp. 103-110 ◽

Cited By ~ 1

Author(s):

Tushar Kanti Bera ◽

Kausik Chatterjee ◽

Debasis De ◽

Kazi Monjur Ali ◽

Kishalay Jana ◽

...

Keyword(s):

Wistar Rats ◽

Hepatoprotective Activity ◽

Toxicity Screening ◽

Polyherbal Formulation ◽

Screening Approach ◽

Male Wistar Rats

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Aktivitas Hepatoprotektif Ekstrak Metanol Buah Lakum (Cayratia trifolia (L.) Domin) Terhadap Diameter Vena Sentralis, Lebar Sinusoid dan Berat Hepar Tikus Putih (Rattus novergicus L.) yang Diinduksi Parasetamol

Jurnal Protobiont ◽

10.26418/protobiont.v7i3.29088 ◽

2018 ◽

Vol 7 (3) ◽

Author(s):

Rizki Perdana Putri Diah Wulandari Rousdy, Ari Hepi Yanti

Keyword(s):

Wistar Rats ◽

Methanolic Extract ◽

Antioxidant Properties ◽

Liver Weight ◽

Hepatoprotective Activity ◽

Central Vein ◽

Standard Drug ◽

Cayratia Trifolia ◽

Male Wistar Rats ◽

Vein Diameter

Secondary metabolites of lakum (Cayratia trifolia (L.) Domin) fruit have been evaluated in previous researches. The fruit contains flavonoids, terpenoids and phenols which have antioxidant properties. The aim of this research was to determine the hepatoprotective activity of methanolic extract of lakum fruit in Wistar rats’ liver induced by high doses of paracetamol. Ripe lakum fruits were macerated with methanol as the solvent. Thirty-five male Wistar rats (Rattus novergicus L.) were used in this research and devided into 7 groups (normal, negative, positive, solvent, 115 mg kg-1, 230 mg kg-1, and 345 mg kg-1 of lakum fruit methanolic extract). Results showed that the effect of 230 mg kg-1 of lakum fruit methanolic extract (central vein diameter: 40,20 ± 6,97 µm; sinusoid wide: 5,60 ± 0,94 µm; and liver weight: 6,33 ± 0,98 g) were similar to the effect of silymarin (central vein diameter: 42,99 ± 6,60 µm; sinusoid wide: 4,49 ± 0,44 µm; and liver weight: 6,58 ± 0,88 g) as the standard drug.

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Hepatoprotective Effect of Corn Silk Infusion in Male Wistar Rats

Eksakta Jurnal Ilmu-Ilmu MIPA ◽

10.20885/eksakta.vol1.iss1.art8 ◽

2020 ◽

Vol 20 (1) ◽

pp. 51-55

Author(s):

Arba Pramundita Ramadani ◽

Hady Anshory Tamhid ◽

Tika Luthfi Sadrina ◽

Jasno Jasno ◽

Mabrurotul Mustafidah

Keyword(s):

Wistar Rats ◽

Hepatoprotective Activity ◽

Hepatic Disease ◽

Hepatoprotective Effect ◽

Flavonoid Compound ◽

Corn Silk ◽

Antioxidant Agents ◽

Long Time ◽

Male Wistar Rats ◽

Plasma Alkaline Phosphatase

The use of medicinal plants in treating various disease has been reported since long time ago, including for hepatic disease. Corn silk contains phytochemicals of medical benefit such as flavonoids compounds which act as antioxidant agents and has been widely reported possess hepatoprotective effect. Using a model of carbon tetrachloride (CCl4)-induced hepatotoxicity in 36 male Wistar rats, this study investigated the effect of corn silk infusion and assessed using enzymes produced by the liver in plasma [alkaline phosphatase (ALP) and liver glutathione (GSH)]. The corn silk infusion (in 50, 100, and 200 mg/kg BW doses) were administered 24 hours after CCl4-induction liver damage with 3ml/kg BW CCl4 in olive oil (1:1, v/v), intraperitoneally for seven days. Along with corn silk groups, distilled water (0.2 mL/kg BW) and Curcumin (100 mg/kg BW) were given for induction and drug control, respectively. In the end of the study (8th day), the level of both ALP dan GSH were measured. The differences among groups for GSH and ALP level were statistically calculated using ANOVA method. The result showed that the corn silk infusion is active at 200 mg/kg BW based on both ALP (18.74% decreased) and GSH (5-7% increased) level. Moreover, the flavonoid compound was detected on the infusion that may contribute on its hepatoprotective activity. In conclusion, corn silk infusion owned hepatoprotective effect in male Wistar rats.

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EVALUATION OF HEPATOPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF PHYSALI IXOCARPA AGAINST RIFAMPICIN-ISONIAZID INDUCED HEPATOTOXICITY IN WISTAR RATS

International Research Journal of Pharmacy ◽

10.7897/2230-8407.111085 ◽

2020 ◽

Vol 11 (10) ◽

pp. 17-22

Author(s):

N Delhiraj ◽

M K Jaganathan ◽

A R Vijayakumar

Keyword(s):

Adult Male ◽

Wistar Rats ◽

Ethanolic Extract ◽

Hepatoprotective Activity ◽

Group V ◽

Group Iii ◽

Group I ◽

Male Wistar Rats ◽

Histopathological Studies ◽

Tuberculosis Therapy

The liver is the primary organ that metabolizes the majority of the drug. Toxicity caused by these drugs to the liver is called hepatotoxicity. Hepatotoxicity is a major concern in tuberculosis therapy, especially Rifampicin - Isoniazid (R-H). Studies showed that these drugs induce oxidative stress in the liver. This study attempts to determine whether the ethanolic extract of Physalis ixocarpa (EEPI) protects against R-H induced hepatotoxicity in adult male Wistar rats. Adult male Wistar rats were divided into five groups (each group n=6 animals). Group I, control treated with normal saline (5ml/kg, b/w, p.o.). Group II, Hepatotoxicity induced by combination of R-H (each 50mg/kg, i.p.) administered up to 14 days. Group III and IV, EEPI (100 mg/kg & 200 mg/kg, b/w) were administered orally one hour before the R-H inducing agent up to 14 days. Group V, Silymarin (25 mg /kg, b/w., p.o.) was served as standard. After 14th days animals were allowed fast overnight and blood was collected through orbital puncture and animal was sacrificed then liver tissue was collected for biochemical analysis and histopathological studies. Our results show a significant reduction in the level of alkaline phosphate (ALP), alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin. Treatment with EEPI also showed a significant increase in the activity of antioxidant enzymes and decreased levels of malondialdehyde (MDA) in the liver. EEPI also reduced the macrovesicular steatosis and ballooning caused by the R-H. The present study demonstrates that administration of ethanolic extract of Physalis ixocarpa ameliorating hepatoprotective activity as evidenced by the biochemical and histopathological parameters.

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Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010014333x ◽

1986 ◽

Vol 44 ◽

pp. 342-343

Author(s):

I. Stachura ◽

M. Pardo ◽

J. Costello ◽

D.M. Landwehr

Keyword(s):

Wistar Rats ◽

Renal Damage ◽

Standard Diet ◽

Experimental Conditions ◽

Phosphate Intake ◽

Dietary Restrictions ◽

Severe Reduction ◽

Male Wistar Rats ◽

Unrestricted Diet ◽

Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

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Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000654 ◽

2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Masoud Nasiri ◽

Saja Ahmadizad ◽

Mehdi Hedayati ◽

Tayebe Zarekar ◽

Mehdi Seydyousefi ◽

...

Keyword(s):

Lipid Peroxidation ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Wistar Rats ◽

Enzymatic Antioxidants ◽

Acute Response ◽

Total Antioxidant ◽

Male Wistar Rats ◽

Exercise Induced ◽

And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

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