scholarly journals Insights from an awareness survey on oral submucous fibrosis (OSMF)

2020 ◽  
Vol 16 (12) ◽  
pp. 999-1006
Author(s):  
Harippriya Karthikeyan ◽  
Keyword(s):  
General Population ◽  
Sample Size ◽  
Inflammatory Infiltrate ◽  
Oral Submucous Fibrosis ◽  
P Value ◽  
Tobacco Products ◽  
Associated Diseases ◽  
Submucous Fibrosis ◽  
Epithelial Inflammation ◽  
Number Of Males

Oral Submucous Fibrosis (OSMF) is characterized by Juxta-epithelial inflammation with oedema, fibroblasts, neutrophil and eosinophil inflammatory infiltrate. Therefore, it is of interest to gain insights from an awareness survey on ORAL SUBMUCOUS FIBROSIS (OSMF). The sample size was 100 patients who had participated in this survey in Tamilnadu, India where 93% of the subjects used tobacco products. 81% of the patients were not aware of the malignancy caused by OSMF. A significant number of males use more tobacco than females (p value = 0.006 (<0.05) in the sample dataset. Thus, there is a need to create awareness on OSMF among the general population to combat the associated diseases.

scholarly journals Association of Blood Groups with Oral Submucous Fibrosis and if any of the Blood Group is Related with an Increased Risk for Oral Submucous Fibrosis

2021 ◽  
Vol 15 (10) ◽  
pp. 2776-2778
Author(s):  
Sobia Siddique ◽  
Syed Muhammad Razi Zaidi ◽  
Shahida Maqbool ◽  
Madiha Insha ◽  
Muhammad Abul Hasan Ali ◽  
...  
Keyword(s):  
Blood Group ◽  
Oral Submucous Fibrosis ◽  
Malignant Lesion ◽  
Oral Pathology ◽  
Blood Groups ◽  
P Value ◽  
Blood Group System ◽  
Increased Risk ◽  
Submucous Fibrosis ◽  
B Blood Group

Objective: To assess any association of blood groups with oral submucous fibrosis and if any of the blood group is related with an increased risk for oral submucous fibrosis. Study Design: Comparative study Place and Duration of Study: Department Of Oral Pathology, Fatima Jinnah Dental College & Hospital Karachi, Pakistan from Jan to Dec 2018. Patients and Methods: Total 100 patients were enrolled in the study in which half were cases where oral sub mucous fibrosis had been diagnosed clinically while remaining half were the controls that were involved in the habit of using tobacco/nuts but had no oral pre malignant lesion. For investigation of blood, samples of blood were taken from both the groups. Odd ration and chi-square test was used to analyze data. A p-value of <0.05 was considered statistically significant. Results: Majority of the individuals in experimental group had “B” blood group followed by “O” “AB” and “A” blood groups. Conclusion: This study showed that ABO blood groups have considerable relation with oral submucous fibrosis. Individuals having “B” blood group had 2.18 times increased tendency of having oral submucous fibrosis in contrast with patients who belong to any other blood group. Keywords: ABO blood group system, Oral Submucous fibrosis, Oral lesions, Oral Squamous Cell Carcinoma

scholarly journals Prevalence of OSMF cases in various age groups correlating with habits and treatment outcomes in Saveetha Dental College: A prevalence study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1799-1804
Author(s):  
Aklesha Behera ◽  
Abilasha R ◽  
Pratibha Ramani ◽  
Gheena S ◽  
Hannah R
Keyword(s):  
Indian Subcontinent ◽  
Oral Submucous Fibrosis ◽  
Age Groups ◽  
Mouth Opening ◽  
Study Groups ◽  
Patient Records ◽  
Tobacco Products ◽  
Precancerous Condition ◽  
Male Preponderance ◽  
Submucous Fibrosis

Oral submucous fibrosis is a chronic, progressive, scarring precancerous condition of the oral cavity seen predominantly in the Indian subcontinent and southeast Asia. OSMF is caused by consumption of areca nuts and tobacco products. Patients suffer from trismus and other related problems. Interincisal mouth opening ranges between 24 to 55 mm in this study, hence making the study groups between I to III. The aim of the study is to find a correlation between age, habits and treatment outcome in OSMF patients. Data was procured from patient records of 86000 patients who visited from between June 2019 and March 2020 and analysis was done. Age is between 21 to 64 years. Male preponderance is seen 92.4% pan chewing is common (35.9%) Interincisal opening is between 24 to 55 mm, making the OSMF grade I and II. OSMF affects people aged 21 to 64 years and the interincisal mouth opening is between 24 to 55 mm, making the grades I and II.

scholarly journals Application of injection Kenacort, intradermal route in oral submucous fibrosis

2020 ◽  
Vol 6 (2) ◽  
pp. 316
Author(s):  
Manjunath K. ◽  
Amardeep Singh ◽  
Manjunatha Rao S. V.
Keyword(s):  
Soft Tissues ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Cost Effective ◽  
Intradermal Injection ◽  
Research Centre ◽  
P Value ◽  
Medical College ◽  
History Of ◽  
Submucous Fibrosis

<p class="abstract"><strong>Background:</strong> Oral submucous fibrosis is a potentially pre-malignant disease, that results in progressive juxta-epithelial fibrosis of oral soft tissues, resulting in increased loss of tissue mobility, marked rigidity and inability to open the mouth. Actual treatment includes iron, multi vitamins, lycopene, pentoxifyline, steroid injections and human placental extracts. Currently available treatment with intradermal injection of Kenacort with hyaluronidase is effective to some extent.</p><p class="abstract"><strong>Methods:</strong> This study was conducted at Basaveshwara Medical College and Hospital, Research Centre, Chitradurga, Karnataka, in the Otorhinolaryngology Department from February 2019 to August 2019 for 6 months duration. A total of 40 patients were included in this study. Mouth opening was recorded from baseline to 6 weeks. Cases were followed up for 6 months thereafter. Patients with positive history of chewing of betel-nuts, pan, gutkha and age from 18-50 years males and females were included in this study. Patients undergoing any surgery, allergic conditions, age more than 50 years were excluded. Mouth opening was assessed by objective type and subjective type.</p><p class="abstract"><strong>Results:</strong> There was significant increase in mouth opening in patients after administration of intra-dermal Kenacort injection and oral lycopene. The results were statistically significant and patients responded better and p value &lt;0.001.</p><p class="abstract"><strong>Conclusions:</strong> Management of moderate oral submucous fibrosis should include counselling of patients along with oral lycopene with intradermal injection of Kenacort with hyaluronidase, is highly efficacious and cost- effective in improving the mouth opening and reducing other symptoms in patients with OSMF, whereas advanced stages should be treated surgically.</p>

scholarly journals Audiometry Analysis for the Assessment of Hearing Deficit in Patients with Oral Submucous Fibrosis

2021 ◽  
Author(s):  
Ashwini Desai ◽  
Nikkhiel Diwaan ◽  
Rashmi Sapkal ◽  
Siddesh Shenoy ◽  
Niranjan Desai ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Eustachian Tube ◽  
Oral Submucous Fibrosis ◽  
Bone Conduction ◽  
Pure Tone Audiometry ◽  
Study Groups ◽  
Control Group ◽  
P Value ◽  
Submucous Fibrosis ◽  
Group D

Introduction: Oral Submucous Fibrosis (OSMF) is a slowly progressive chronic fibrotic disease of the oral cavity extending to pharynx. Function and patency of eustachian tube gets altered when the palatal and paratubal muscles which regulate the patency of pharyngeal orifice gets affected. This leads to pain in ear along with mild to moderate conductive loss of hearing. Aim: To evaluate hearing deficit in OSMF patients and to correlate clinical stages of OSMF with degree of hearing deficits in patients. Materials and Methods: It was a cross-sectional study. The study comprised of a total of 50 subjects (100 ears). Forty patients diagnosed with OSMF who reported to Department of Oral Medicine and Radiology constituted the study group. Ten normal individuals with no deleterious habits and without any previously diagnosed ear disorders constituted the control group. Pure Tone Audiometry (PTA) was used for evaluating all the subjects for air conduction and bone conduction hearing loss. Values on qualitative characteristics were shown as n (% prevalence) across five study groups. Values on quantitative variables were shown as Mean±SD across five study groups. Inter group comparison for qualitative and quantitative variables was done using chi-square test and analysis of variance (ANOVA) test respectively with Post-Hoc Bonferroni’s correction for multiple group comparisons. Results: The OSMF group showed a marked degree of hearing loss compared to the control group. The distribution of mean PTA in quantitative assessment was significantly higher in group D compared to group A and group B (p-value<0.05 for both) and also the distribution of qualitative hearing loss was significantly higher in group C and group D (p-value<0.05). Conclusion: There was a significant association between OSMF and hearing deficit in this study. Fibrosis of the oropharynx and palatal/paratubal muscles which are affected in OSMF and theses muscles are attached to eustachian tube, the patency of the eustachian tube gets affected. As a result, patients with mainly advanced cases of OSMF should be assessed for hearing deficit.

scholarly journals Tulasi a magical herb and a boon for management of oral submucous fibrosis: a clinical study

2017 ◽  
Vol 5 (11) ◽  
pp. 4719 ◽  
Author(s):  
G. Madhulatha ◽  
N. Vijayalaxmi ◽  
T. Harshavardhan
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Modern Medicine ◽  
Burning Sensation ◽  
Rank Test ◽  
P Value ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Submucous Fibrosis

Background: Plants are a good source of drugs in traditional and modern medicine. One among these plants is “tulasi” The queen of herbs” which is used in ayurveda for its diverse properties like antioxidant, analgesic, anti-inflammatory, antidiabetic, and others. It belongs to labiate family and is the most sacred and valued in traditional culture of India. AIMS of the study was to evaluate the efficacy of Tulasi in the treatment of OSMF.Methods: The study included 20 individuals, females and males of age group 20-50yrs who visited the outpatient department who were diagnosed clinically as having OSMF, categorized according to pindborg’s classification. Patients were asked to apply 500mg of Tulasi medicine paste (Tulasi powder mixed with glycerine) twice daily for 1month and were recalled for follow up every week for 1month. All the clinical parameters - mouth opening, burning sensation, pain with the lesion and others were evaluated and recorded in specially designed proforma.Results: Friedman test and wilcoxon signed rank test was used for statistical evaluation. Significant improvement with P value <0.05 was noticed in burning sensation, mouth opening and pain associated with the lesion.Conclusions: The study concludes that Tulasi can be used as a main treatment modality in the management of patients with OSMF.

scholarly journals Inverse correlation of Serum Lactate Dehydrogenase and Haemoglobin Levels in patients with Oral Submucous Fibrosis

2019 ◽  
Vol 12 (04) ◽  
pp. 1755-1759
Author(s):  
Jimson Sudha ◽  
Amaladas Julius ◽  
Samson Jimson ◽  
Kesavaram Padmavathy
Keyword(s):  
Lactate Dehydrogenase ◽  
Biochemical Marker ◽  
Quantitative Estimation ◽  
Oral Submucous Fibrosis ◽  
Venous Blood ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
P Value ◽  
Healthy Individuals ◽  
Submucous Fibrosis

Serum lactate dehydrogenase (LDH) is a marker of cellular necrosis and is elevated in oral potentially malignant disorders, Oral Submucous Fibrosis (OSMF). Serum LDH levels have been used as a valuable biochemical marker in diagnosis of OSMF. To evaluate and compare the levels of serum LDH and haemoglobin in OSMF with normal healthy individuals. Two mL of venous blood was collected by under aseptic conditions and serum was separated from the normal healthy control subjects (Group 1, n= 22) and the OSMF (clinically and histopathologically confirmed cases) patients (Group 2, n= 22). Quantitative estimation of serum LDH and haemoglobin was performed. Significant rise was observed in the serum LDH levels (518.14 ± 48.62 IU/L) while the mean Hb levels (11.3 ± 1.14) were decreased in patients with OSMF in comparison with normal healthy individuals (LDH: 189.77 ± 28.30 IU/L, Hb: 12.94± 0.98 gm%) (P value < 0.0001, < 0.0001). Serum LDH and Hb estimation would serve as a valuable biochemical marker in the diagnosis of OSMF

scholarly journals ORAL SUBMUCOUS FIBROSIS

2018 ◽  
Vol 25 (04) ◽  
pp. 520-525
Author(s):  
Muhammad Zeeshan ◽  
Ayesha Shakeel ◽  
Hafiz Yasir Mahmood ◽  
Muhammad Zeeshan
Keyword(s):  
Oral Submucous Fibrosis ◽  
Computer Software ◽  
Mouth Opening ◽  
Cross Sectional Study ◽  
P Value ◽  
Areca Nut ◽  
Chi Square ◽  
Cross Sectional ◽  
Submucous Fibrosis ◽  
Intralesional Steroids

Objectives: In this study we investigate the effectiveness of lycopene in themanagement of oral submucous fibrosis (OSF) when intralesional steroids also given incombination. Study Design: Cross sectional study. Setting: Dental Section Allied Hospital,Faisalabad. Period: Eight months from September 2016 to April 2017. Methodology: This crosssectional study was initiated after approval from hospital ethical board. Collected Informationwas entered in SPSS computer software version 23 and analyzed for possible results. Meanand SD was calculated and presented for quantitative data like age, VAS score and mouthopening. Frequency (percentages) were calculated and presented for qualitative data such asgender. Post stratification statistical chi square test was used to see effect modification. P value≤ 0.05 was considered as significant. Results: Overall, there were 100% (n=354) patients.Total patients who were selected for the study had the habit of chewing areca nut either innatural form or in the form of Pan Masala, gutkha or mawa. Gutkha is the most common formof areca nut used, i.e. 65.8% (n=233) patients were using it. In our study average increase inmouth opening from baseline (before treatment) was 5.12±1.03 mm in group A. 4.20±1.26mm in group B and 3.40±0.19 mm in group C at six week. Conclusion: When Lycopene usedcombined with intralesional steroids and Hyaluronidase its effectiveness is better in improvingthe mouth opening its symptoms in patients with Oral Submucous Fibrosis (OSF). It was alsofound that there was no side effects.

scholarly journals Soft palate morphology in OSMF patients: Radiographic evaluation

2021 ◽  
Vol 7 (2) ◽  
pp. 74-79
Author(s):  
Himali A Shah ◽  
Jigna S Shah
Keyword(s):  
Soft Palate ◽  
Oral Submucous Fibrosis ◽  
Common Type ◽  
Cone Beam ◽  
Radiographic Evaluation ◽  
P Value ◽  
Lateral Cephalogram ◽  
Length Width ◽  
Submucous Fibrosis

Oral submucous fibrosis (OSMF) is a chronic progressive, scarring disorder of oral cavity, which includes buccal mucosa, tongue, lips, anterior faucial pillars, soft palate, and oropharynx. Changes in soft palate morphology will start even before the OSMF, present itself clinically. These changes can lead to sleep apnea, difficulty in speech, swallowing & respiration. Various radiographs are good diagnostic aid to assess the soft palate and its morphology or any changes in morphology. To evaluate and compare soft palate morphology and dimensions in various stages of OSMF with control by radiographic evaluation.: 60 patients were evaluated and compared for soft palate morphology, its length, width and angle by using lateral cephalogram and Cone beam computed tomography (CBCT). Most common type of soft palate was found to be type 1 (leaf shaped) in both groups as well as by both radiographic techniques. Significant decrease in length and increase in width with increasing grades of OSMF group. As per p value CBCT gave more precise result. As the OSMF progresses soft palate becomes stout and bulky and significant changes occur in soft palate dimensions and are better evaluated by CBCT. As involvement of the soft palate is the earliest change to be noticed, radiographs should be used as one of the diagnostic aids in OSMF patients.

scholarly journals Oral Submucous Fibrosis – A Clinicopathological Correlation

2021 ◽  
pp. 589-594
Author(s):  
R. Sudarshan
Keyword(s):  
Early Stage ◽  
Oral Submucous Fibrosis ◽  
Correlation Study ◽  
Clinical Staging ◽  
P Value ◽  
Histopathological Correlation ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Group 2 ◽  
Group 1

Objective: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder of the oral mucosa and collagen metabolic disorder caused by betel nut use. Diagnosis of this condition can be made clinically, but ascertaining its malignant transformation histopathology is mandatory. So, the correlation between the clinical and histopathology was conducted. Materials and Methods: The correlation study was conducted on 20 OSMF patients. Clinical diagnosis with histopathological confirmation was based on the standard approach. Study structure included gender, duration, frequency, and quid placement correlated with clinical and histopathological staging. Results: The current study has included most of the subjects being males and was below 25 years. Habit duration, frequency, and quid placement were correlated with clinical and histopathological staging and were directly related. Six subjects of (30%) Group 1 cases associated with 3 (42.9%) in the histologically early stage of the disease. Further, 14 (70%) cases in Group 2 clinical staging correlated with 8 (88.9%) cases in moderately advanced histological staging. Conclusion: The clinical and histopathological correlation was not obtained in the present study. The negative p-value could be because of certain factors like biopsy site selection and decreased study subjects. However, factors like frequency and quid keeping had a positive histopathological correlation.

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