scholarly journals The Effect of a One-Year Lifestyle Intervention Program on Carotid Intima Media Thickness

2011 ◽  
Vol 176 (7) ◽  
pp. 798-804 ◽  
Author(s):  
Debra Marshall ◽  
Elaine Walizer ◽  
Marina Vernalis
Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Praveen Veerabhadrappa ◽  
Abul Kashem ◽  
Priya Kothapalli ◽  
Keith Diaz ◽  
Chenyi Ling ◽  
...  

Background: African Americans tend to have greater carotid intima-media thickness (IMT), and are 60% more likely to have a stroke than Caucasians. Data on the effects of lifestyle intervention on carotid IMT in African Americans does not exist. The aim of our study was to assess the efficacy of 6 months of diet and exercise intervention on carotid IMT in sedentary African American adults. Methods: Nineteen African American subjects (15F/4M, 52 ± 6yrs) who were sedentary, non smoking, non diabetic, free of cardiovascular disease, not on antihypertensive or cholesterol medications underwent 6 weeks of dietary counseling under the supervision of a registered dietician and were required to follow an AHA low fat, low salt diet for the duration of the study. Compliance was assessed by a diet log (3 days/week). Subjects completed 6 months of supervised aerobic exercise training (3 days/week, 40 minutes/session at 65% of their estimated VO 2max ). Common carotid artery IMT was assessed using high resolution ultrasonography. Results: At baseline, IMT significantly correlated with age (r = 0.58, P = 0.003) and total cholesterol (r = 0.41, P = 0.04). At 6 months, there were significant changes in basal metabolic index (ΔBMI, -0.83 kg/m 2 , P = 0.01); Δtriglycerides (-13.7 mg/dL, P = 0.03) and Δfasting glucose (-7.2 mg/dL, P = 0.01). On repeated measures ANCOVA, the mean IMT were statistically significantly different (F (1, 15) = 7.999, P = 0.013) between before vs. after training (Mean ± SD; 0.617 ± 0.092mm vs. 0.572 ± 0.068mm), after adjusting for changed variables (ΔBMI, Δtotal cholesterol and Δmean arterial pressure) as covariates. Conclusion: Our preliminary study showed that 6 months of diet and exercise intervention reduced carotid IMT by ∼7.3% and improved the cardio-metabolic profile in sedentary African Americans. Reduction in IMT from early and effective lifestyle modification strategies may help to improve cerebrovascular health and prevent stroke in this at-risk stroke population.


2016 ◽  
Vol 8 (9) ◽  
pp. 322 ◽  
Author(s):  
Mariam Kashani ◽  
Arn H Eliasson ◽  
Elaine M Walizer ◽  
Clarie E Fuller ◽  
Renata J Engler ◽  
...  

<p><strong>BACKGROUND:</strong> Self-efficacy, defined as confidence in the ability to carry out behavior to achieve a desired goal, is considered to be a prerequisite for behavior change. Self-efficacy correlates with cardiovascular health although optimal timing to incorporate self-efficacy strategies is not well established. We sought to study the effect of an empowerment approach implemented in the introductory phase of a multicomponent lifestyle intervention on cardiovascular health outcomes.</p><p><strong>DESIGN:</strong> Prospective intervention cohort study.</p><p><strong>METHODS:</strong> Patients in the Integrative Cardiac Health Project Registry, a prospective lifestyle change program for the prevention of cardiovascular disease were analyzed for behavioral changes by survey, at baseline and one year, in the domains of nutrition, exercise, stress management and sleep. Self-efficacy questionnaires were administered at baseline and after the empowerment intervention, at 8 weeks.</p><p><strong>RESULTS:</strong> Of 119 consecutive registry completers, 60 comprised a high self-efficacy group (scoring at or above the median of 36 points) and 59 the low self-efficacy group (scoring below median).  Self-efficacy scores increased irrespective of baseline self-efficacy but the largest gains in self-efficacy occurred in patients who ranked in the lower half for self-efficacy at baseline. This lower self-efficacy group demonstrated behavioral gains that erased differences between the high and low self-efficacy groups. <strong></strong></p><p><strong>CONCLUSIONS:</strong> A boost to self-efficacy early in a lifestyle intervention program produces significant improvements in behavioral outcomes.  Employing empowerment in an early phase may be a critical strategy to improve self-efficacy and lower risk in individuals vulnerable to cardiovascular disease.</p>


2019 ◽  
Vol 12 (3) ◽  
pp. 1317-1328
Author(s):  
Inas R. El- Alameey ◽  
Hanaa H. Ahmed ◽  
Mones M. Abushady

Brain derived neurotrophic factor (BDNF) is a neurotrophin probably concerned in the pathophysiology of obesity and metabolic syndrome (MS) in adults. The aim was to explore serum BDNF relationship with metabolic syndrome components before and after one-year of the lifestyle intervention program in obese children. Forty obese children and forty age and gender-matched lean controls were studied. Anthropometric parameters, blood pressure, fasting blood glucose, serum insulin, lipid profile, insulin resistance (HOMA-IR), and serum BDNF, before and after one year of diet control and physical activity were measured. At baseline, fasting glucose, insulin, HOMA-IR, cholesterol, LDL, triglycerides were significantly higher in obese children relative to controls (P=0.00). Serum BDNF concentration was significantly lower in obese children than in lean controls (P=0.00), and its mean concentration of the subjects with MS was significantly lower than those without MS, and control group (P< 0.001). Linear regression analysis suggested that high waist: hip ratio, body adiposity index, fat percentage, diastolic BP, fasting blood glucose, LDL and HOMA-IR are good predictors for decreased serum BDNF concentration in obese children. After one-year intervention program, the obese group showed a significant increase in serum BDNF, and HDL, paralleled by a significant decline in fasting glucose, insulin, HOMA-IR, cholesterol, LDL, triglycerides as compared to the baseline (P =0.00). Serum BDNF was lower in obese children than in lean controls, and seemed to be linked with the metabolic syndrome components. One-year lifestyle intervention program succeeded to enhance BDNF serum concentration in these children.


2020 ◽  
Vol 25 ◽  
pp. 19-36
Author(s):  
Gerd L. Nordbotten ◽  
Leif I. Tjelta ◽  
Merete H. Helland

The aims of this study were to: 1) investigate to what extent participants in a lifestyle intervention program, including nutritional guidance and two weekly intensive running sessions, maintain improvements in aerobic capacity and health parameters one year after the end of an intervention; and 2) identify common determinants for those participants who succeeded in weight loss maintenance. A total of 51 participants completed the 33-week intervention. One year after the end of the intervention period (1YA) 34 participants completed anthropometric measurements, 12 (8 women) in the training group (TG) and 22 (13 women) in the nutritional guidance and training group (NTG). A total of 13 participants (9 women) in the TG and 11 participants (7 women) in the NTG completed a 3000 m running test. There were no significant differences in body mass index, 3000 m running time or waist circumference between the groups 1YA. There was however, substantial variation in both groups as to what extent participants had maintained their weight loss. Higher self-efficacy and self-control in relation to food and exercise characterized those who best maintained their weight loss.


Stroke ◽  
1993 ◽  
Vol 24 (12) ◽  
pp. 1779-1783 ◽  
Author(s):  
W J Mack ◽  
R H Selzer ◽  
H N Hodis ◽  
J K Erickson ◽  
C R Liu ◽  
...  

2020 ◽  
Vol 8 (11) ◽  
pp. 560-568
Author(s):  
Rintu Barman ◽  
◽  
Tridip Kumar Das ◽  

Introduction: Diabetes mellitus is one of the commonest endocrine disorder with multiple organ dysfunction as its complication .The early detection of atherosclerotic changes in the pre diabetic state would help us to take measures to prevent overt complication in later part of life. Aim: To study the association of carotid intima media thickness in individuals with impaired fasting glucose. Material and Method: A prospective study,a total of 30 patient and equally matched control were taken from patient attending at Medicine OPD for a period of one year. Routine lab investigation, lipid profile and B-mode Ultra sonography of the carotid intima media thickness of the selected cases as well as the control groups were done, thickening of the Intima-Media C omplex greater than 0.8mm is considered abnormal, and represents the earliest changes of atherosclerotic disease. Result: 18 individuals from cases and 5 individuals from control have significant increase in thickness of the common carotid intima-media thickness i.e. ≥0.8mm.


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