scholarly journals Hubungan Jarak Pemasangan Terapi Intravena Dari Persendian Terhadap Waktu Terjadinya Flebitis

2007 ◽  
Vol 11 (1) ◽  
pp. 1-5
Author(s):  
Dewi Gayatri ◽  
Hanny Handiyani
Keyword(s):  
Survival Analysis ◽  
Survival Rate ◽  
Infusion Therapy ◽  
Puncture Site ◽  
Cohort Design ◽  
Analysis Methods ◽  
The Relationship

AbstrakPenelitian ini bertujuan untuk mengidentifikasi hubungan jarak pemasangan terapi intravena dari persendian dengan waktu terjadinya flebitis. Desain penelitian yang digunakan adalah penelitian kohort prospektif dengan lama pengamatan 72 jam. Sampel yang diambil berjumlah 120 responden. Teknik analisis yang digunakan dalam penelitian ini adalah survival analysis. Penelitian ini menyimpulkan bahwa semakin jauh jarak pemasangan terapi intravena dari persendian maka risiko untuk terjadi flebitis akan semakin meningkat. Hal ini dapat disebabkan karena kurangnya fiksasi dan dekatnya persambungan selang kanul dengan persendian lainnya. Faktor lain yang akan meningkatkan risiko terjadinya flebitis adalah cairan dengan osmolalitas tinggi dan pemakaian balutan konvensional. Hal utama yang direkomendasikan dari penelitian ini adalah pemasangan terapi intravena sebaiknya berjarak minimal 3-7 cm dari persendian serta diperlukan penelitian lanjutan di mana jumlah sampel dan desain yang lebih baik diterapkan. AbstractThis research aimed to identify the relationship between the distance vein puncture site from joint and survival rate of phlebitis. This research used cohort design with 72 hour observation. The size sample of this research was 120 respondents. Analysis methods which using in this research was survival analysis. The conclusions of this research are the distance vein puncture which far joint can increase phlebitis probability, osmolality and types of dressing can increase phlebitis probability too. The recommendations of this research are the inserting of infusion therapy is minimum 3-7 cm from joint and use the modern dressing. Besides that, the research have been recommending the next research which is using better design and bigger samples size.

scholarly journals Is the Frequency of Smoking Affecting the Risk of Abusing Cannabis?

2020 ◽  
Vol 16 (1) ◽  
pp. 44-52
Author(s):  
Nurul Huriah Astuti ◽  
Sutanto Priyo Hastono
Keyword(s):  
Multivariate Analysis ◽  
Survival Analysis ◽  
Survival Rate ◽  
Smoking Habit ◽  
Wilcoxon Test ◽  
Test Results ◽  
Cannabis Abuse ◽  
The Relationship

The results of previous study found that teens that had a smoking habit were 14 times more likely to smoke cannabis than those who did not smoke. This study aims to determine the relationship between the frequency of smoking and cannabis abuse done through survival analysis. The research samples were 708 students of cannabis abusers who were previously preceded by smoking. The results of this study found that durability or length of time for abusing cannabis was mostly 1 – 4 years. The Wilcoxon test results concluded that there was a difference in survival to abusing cannabis among the frequency groups of smoking. Multivariate analysis also showed that the more number of cigarettes consumed, the greater the risk for abusing cannabis after being controlled by confounders. Conclusion of this study, the frequency of smoking affects the survival rate and the amount of risk to abusing cannabis.

Survival Analysis of Geriatric Patients with Low Digestive Hemorrhage Attending an Emergency Department

Gerontology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Ana Fernandez-Suárez ◽  
Oriol Yuguero Torres
Keyword(s):  
Emergency Department ◽  
Survival Analysis ◽  
Retrospective Study ◽  
Survival Rate ◽  
Life Expectancy ◽  
Antiplatelet Therapy ◽  
Geriatric Patients ◽  
Digestive Hemorrhage ◽  
Kaplan Meier ◽  
Number Of Individuals

<b><i>Background:</i></b> The increase in life expectancy and low mortality have doubled the number of individuals older than 65 in the last 30 years. <b><i>Methods:</i></b> We conducted a retrospective study of 101 patients older than 80 years of age treated by low digestive hemorrhage (LDH) in an emergency department during 2018. Sociodemographic variables were evaluated, as well as comorbidity and survival at 18 months. Survival was assessed by a Kaplan-Meier test. <b><i>Results:</i></b> 52.5% of the subjects were women. The average comorbidity of the sample was 1.97. The survival rate per year was 60%. The finding on colonoscopy shows no association with mortality. However, those patients on anticoagulant/antiplatelet therapy have a higher survival rate. <b><i>Conclusion:</i></b> Survival per year is high, so urgent colonoscopy for an LDH should be performed after evaluating the patient’s stability and functional status in a scheduled and outpatient manner.

scholarly journals Evaluation of Changes on World Stock Exchanges in Connection with the SARS-CoV-2 Pandemic. Survival Analysis Methods

Risks ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 121
Author(s):  
Beata Bieszk-Stolorz ◽  
Krzysztof Dmytrów
Keyword(s):  
Survival Analysis ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Stock Exchange ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Stock Exchanges ◽  
Analysis Methods ◽  
Hazards Model ◽  
Kaplan Meier

The aim of our research was to compare the intensity of decline and then increase in the value of basic stock indices during the SARS-CoV-2 coronavirus pandemic in 2020. The survival analysis methods used to assess the risk of decline and chance of rise of the indices were: Kaplan–Meier estimator, logit model, and the Cox proportional hazards model. We observed the highest intensity of decline in the European stock exchanges, followed by the American and Asian plus Australian ones (after the fourth and eighth week since the peak). The highest risk of decline was in America, then in Europe, followed by Asia and Australia. The lowest risk was in Africa. The intensity of increase was the highest in the fourth and eleventh week since the minimal value had been reached. The highest odds of increase were in the American stock exchanges, followed by the European and Asian (including Australia and Oceania), and the lowest in the African ones. The odds and intensity of increase in the stock exchange indices varied from continent to continent. The increase was faster than the initial decline.

scholarly journals The survival of business takeovers and new venture start-ups

2020 ◽  
Vol 29 (3) ◽  
pp. 797-826
Author(s):  
Guoqian Xi ◽  
Jörn Block ◽  
Frank Lasch ◽  
Frank Robert ◽  
Roy Thurik
Keyword(s):  
Life Cycle ◽  
Survival Rate ◽  
Firm Survival ◽  
Organizational Ecology ◽  
New Venture ◽  
Firm Characteristics ◽  
Entry Modes ◽  
Survival Patterns ◽  
Start Ups ◽  
The Relationship

Abstract Business takeovers and new venture start-ups are two important and distinct entry modes of entrepreneurship. They differ from resource-based and organizational ecology perspectives. We compare firm survival patterns and determinants associated with the two entry modes. From two large French datasets, we find that business takeovers have a higher survival rate than new venture start-ups. However, these differences in survival probability reduce over the entrepreneurship life cycle and when controlling for different entrepreneur and firm characteristics. Moreover, we identify differences in determinants of survival for the two groups, highlighting a distinction between the two entrepreneurship entry modes. This work contributes to the literature on the relationship between entrepreneurship entry and firm survival, thereby contributing to both entrepreneurship and firm survival research.

scholarly journals The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Chengquan Shen ◽  
Jing Liu ◽  
Jirong Wang ◽  
Xiaokun Yang ◽  
Haitao Niu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
T Cells ◽  
Survival Analysis ◽  
Prognostic Value ◽  
Molecular Mechanisms ◽  
Tyrosine Phosphatase ◽  
Gene Set Enrichment Analysis ◽  
Expression Level ◽  
Pathologic Features ◽  
The Relationship

PTPN6 (protein tyrosine phosphatase nonreceptor type 6), a tyrosine phosphatase, is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Previous studies have demonstrated that PTPN6 expression is relatively elevated in several malignancies. However, the role of PTPN6 in bladder cancer (BC) remains unclear. The purpose of this study was to explore the prognostic value of PTPN6 in BC. RNA-seq data from The Cancer Genome Atlas (TCGA) was used to identify the expression level of PTPN6 in BC. The relationship between clinical pathologic features and PTPN6 were analyzed with the Wilcoxon signed-rank test. The prognostic and predictive value of PTPN6 was evaluated by survival analysis and nomogram. Gene Set Enrichment Analysis (GSEA) was conducted to explore the potential molecular mechanisms of PTPN6 in BC. Finally, Tumor Immune Estimation Resource (TIMER) was applied to investigate the relationship between PTPN6 and immune cell infiltration in the tumor microenvironment. Results indicated that PTPN6 was overexpressed in BC tissues compared with normal bladder tissues and was significantly correlated with grade, stage, T, and N. Survival analysis showed that low expression of PTPN6 was significantly related to the poor overall survival (OS) in BC patients. Coexpression analysis showed that PTPN6 and TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) have a close correlation in BC. GSEA showed that multiple cancer-associated signaling pathways are differentially enriched in the PTPN6 high expression phenotype. Moreover, the expression level of PTPN6 was positively associated with the infiltration of B cells, CD4+T cells, dendritic cells, and neutrophils and negatively associated with CD8+ T cells and macrophages in BC. In conclusion, we identified that PTPN6 may be a novel prognostic biomarker in BC based on the TCGA database. Further clinical trials are needed to confirm our observations and mechanisms underlying the prognostic value of PTPN6 in BC also deserve further experimental exploration.

The relationship between Prostaglandin E1 applied area and flap survival rate

1992 ◽  
Vol 45 (6) ◽  
pp. 465-468 ◽  
Author(s):  
Yukimasa Sawada ◽  
Takatoshi Yotsuyanagi ◽  
Ichiro Hatayama ◽  
Ken Sone
Keyword(s):  
Survival Rate ◽  
Prostaglandin E1 ◽  
Flap Survival ◽  
The Relationship

Overexpression of UBE2C in Esophageal Squamous Cell Carcinoma Tissues and Molecular Analysis

2021 ◽  
Author(s):  
Rong Li ◽  
xingfeng pang ◽  
Zhiguang Huang ◽  
Lihua Yang ◽  
Zhigang Peng ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Survival Analysis ◽  
Survival Rate ◽  
Comprehensive Evaluation ◽  
Synergistic Effects ◽  
Comprehensive Treatment ◽  
Rna Seq ◽  
Mrna Expression Data ◽  
Risk Of Recurrence ◽  
Lower Survival Rate

Abstract Background: The treatment of esophageal cancer is mainly based on a combination of traditional surgery and radiotherapy/chemotherapy. Some new progress has been made in multidisciplinary comprehensive treatment and imaging diagnosis in recent years, but the 5-year survival rate for esophageal cancer is much lower than 30% due to its invasiveness and pronounced metastasis ability, as well as the difficulty in early diagnosis. This study aimed to elucidate the molecular mechanism of UBE2C in ESCC.Methods: In this study, we conducted a comprehensive evaluation of the UBE2C expression in ESCC by collecting the protein and mRNA expression data (including in house RNA- seq, in hosue IHC, TCGA-GTEx RNA-seq and tissue microarray) to calculate a combined SMD and sROC. K-M method was used for survival analysis. We also explored the mechanism of UBE2C in ESCC by combing the DEGs of ESCC, related-genes of UBE2C in ESCC and the putative miRNAs and lncRNAs which may regulate UBE2C.Results: UBE2C protein and mRNA were highly expressed in ESCC tissues. The pooled SMD of UBE2C expression values was 1.98 (95% CI: 1.51–2.45, P < 0.001), and the the AUC of the sROC was 0.93 (95% CI: 0.90–0.95). The results of survival analysis suggested an association between high expression of UBE2C and a poor prognosis and a higher risk of recurrence. Pathways anaylsis showed that UBE2C mainly influenced the biological function of esophageal cancer by synergistic effects with CDK1, PTTG1 and SKP2. We also constructed a potential UBE2C-related ceRNA network for ESCC (HCP5/hsa-mir-139-5p/UBE2C).Conclusion: UBE2C mRNA and protein level were highly expressed in ESCC and a higher UBE2C expression generally predicts a lower survival rate and a higher risk of recurrence.

Calibration of reliability-based safety factors for sand boiling in excavations

2020 ◽  
Vol 57 (5) ◽  
pp. 742-753
Author(s):  
Ignatius Tommy Pratama ◽  
Chang-Yu Ou ◽  
Jianye Ching
Keyword(s):  
Factor Of Safety ◽  
Probability Of Failure ◽  
Reliability Theory ◽  
Design Codes ◽  
Test Results ◽  
Safety Factors ◽  
Target Probability ◽  
Analysis Methods ◽  
Actual Factor ◽  
The Relationship

This study calibrated the required factors of safety of five analysis methods for sand boiling using reliability theory. The factors of safety computed by the five analysis methods were compared with the results of a series of sand boiling model tests. The comparison shows that rigorous methods (Terzaghi’s and Harza’s methods) were more accurate in predicting the factors of safety compared to the simplified methods (Harr’s, simplified Terzaghi’s, and simplified Harza’s methods). The statistics of the model factor for each method, defined as the actual factor of safety divided by the computed one, was calibrated by the model test results. These statistics were then used to establish the relationship between the target probability of failure and the required factor of safety by reliability theory. Verification using a full-scale sand boiling case history shows that the required factor of safety calibrated by the reliability theory was more reasonable than the required factors of safety in references and design codes.

scholarly journals Eight-Gene Metabolic Signature Related with Tumor-Associated Macrophages Predicting Overall Survival for Hepatocellular Carcinoma

2020 ◽  
Author(s):  
Junyu Huo ◽  
Yunjin Zang ◽  
Hongjing Dong ◽  
Xiaoqiang Liu ◽  
Fu He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Survival Analysis ◽  
Risk Score ◽  
Risk Group ◽  
Cancer Genome ◽  
Metabolic Reprogramming ◽  
Tumor Associated Macrophages ◽  
Kaplan Meier ◽  
The Relationship

Abstract Background: In recent years, the relationship between tumor associated macrophages (TAMs) and solid tumors has become a research hotspot. The study aims at exploring the close relationship of TAMs with metabolic reprogramming genes in hepatocellular carcinoma(HCC), in order to provide a new way of treatment for HCC.Materials and methods: The study selected 343 HCC patients with complete survival information(survival time >= 1month) in the Cancer Genome Atlas (TCGA) as the study objects. Kaplan-Meier survival analysis assisted in figuring out the relationship between macrophage infiltration level and overall survival (OS), and Pearson correlation test to identify metabolic reprogramming genes(MRGs) related to tumor macrophage abundance. Lasso regression algorithm were conducted on prognosis related MRGs screened by Univariate Cox regression analysis and Kaplan-Meier survival analysis to construct the riskscore, another independent cohort (including 228 HCC patients) from the International Cancer Genome Consortium (ICGC) were used for external validation regarding the prognostic signature.Results: A risk score composed of 8 metabolic genes can accurately predict the OS of training cohort(TCGA) and testing cohort(ICGC). It is important that the risk score could widely used for people with different clinical characteristics, and is an independent predictor independent of other clinical factors affecting prognosis. As expected, high-risk group exhibited an obviously higher macrophage abundance relative to low-risk group, and the risk score presented a positive relation to the expression level of three commonly used immune checkpoints(PD1,PDL1,CTLA4).Conclusion: Our study constructed and validated a novel eight‑gene signature for predicting HCC patients’ OS, which possibly contributed to making clinical treatment decisions.

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