NEW GENERATION CRAFT: IKEA HACK AND ITS TAXONOMY

In this research, IKEA-hacks are examined according to their main characteristics and classified according to these examinations. In the study, IKEA-hack and Do-It-Yourself (DIY) and the IKEA Effect subjects are included to expose the IKEA-hack issue comprehensively. The IKEA-hacks examined in the classification were selected from the studies on the ikeahackers.net website. At first, a pilot study was carried out and a review table was created as a result of some improvements during the pilot study. The classification includes; the information about the intended use of products before and after the hack, to which hack category they belong to, how many IKEA products have been used in process, the instruments used in procedure, and which spaces the product has been prepared. The hack categories were divided into two main categories as visual and functional modifications. These modifications are discussed under 2 categories and 8 sub-categories. The first category is visual changes that includes only-colour modification (A), material change (B), colour and material change (C) as sub- categories. The second category is dedicated to functional changes and includes sub-categories such as; the products used without any modification but for a purpose other than specified by IKEA (D), improved functionality (E), those with added functionalities (F), modifications on the indented use specified by the company by making some modifications on the product (G), and creating a new product by combining independent parts (H). Among 6313 works presented on the ikeahackers.net website published between 2006 and 2018, 378 works involved in the sample were examined; the analyses were separately performed for every year and the changes were compared between the years. Examining the outcomes, only 21% of the practices were conducted for visual purposes only, %79 is about functionality. In visual based practices, category C comes front in which colour and material change performed at the same time. Whereas in the functional practices, people mostly performed Category G in which hackers redefine the context of usage of the IKEA products.

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NEW GENERATION CRAFT: IKEA HACK AND ITS TAXONOMY

The Turkish Online Journal of Design Art and Communication ◽

10.7456/11101100/013 ◽

2021 ◽

Vol 11 (1) ◽

pp. 232-246

Author(s):

Sena BERKTAŞ ◽

Renk DİMLİ ORAKLIBEL

Keyword(s):

Pilot Study ◽

New Product ◽

Functional Changes ◽

Material Change ◽

Before And After ◽

Do It Yourself ◽

New Generation ◽

Second Category ◽

Intended Use ◽

Visual Changes

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A pilot study on the effect of ulipristal acetate on myoma angiogenesis, measured by 2D ultrasound and VEGF serum levels

10.36811/ojgor.2020.110015 ◽

2020 ◽

pp. 19-29

Author(s):

Patricia Diaz Ortega ◽

Manuel García Manero

Keyword(s):

Pilot Study ◽

Power Doppler ◽

Uterine Fibroids ◽

Premenopausal Women ◽

Serum Levels ◽

Ulipristal Acetate ◽

Before And After ◽

Angiogenesis Process ◽

2D Ultrasound ◽

Average Size

Introduction: Symptomatic uterine fibroids can cause symptoms that can be disabling. There are many treatments, including ulipristal acetate, whose role in reducing symptoms and decreasing the size of the fibroid is well known. With this preliminary study, we also try to evaluate the correlation between myoma vascularization measured by ultrasound (Power Doppler 2D) and serum VEGF levels, before and after treatment with ulipristal acetate; in patients diagnosed with symptomatic uterine fibroids. Materials and Methods: A preliminary, prospective observational pilot study was designed. Twenty-four premenopausal women, diagnosed with symptomatic uterine fibroids, were included and all of them completed the study. Four cycles of ulipristal acetate were administered according to the dose and indications specified in the data sheet. In order to assess the influence of this treatment on the angiogenesis process of the fibroids, measurements of VEGF serum levels were made and their vascularization was assessed by means of 2D power doppler ultrasound; at the beginning and the end of treatment. In addition, several determinations of the same parameters were made throughout the successive visits. Endpoints were defined as the decrease in VEGF levels from previous levels, the decrease in myoma vascularization on ultrasound, and the reduction in myoma size. Result: 24 patients who met the inclusion criteria were enrolled (n=24). The average size of myomas was reduced from 45,08 ? 24,02mm to 29?16,96mm after treatment. The average VEGF serum level significantly decreased after the first treatment cycle (from 147,17 ? 153,51 pg/ml to 102,04 ? 186,08pg/ml). Vascularization of myomas after treatment with ulipristal acetate was analyzed, and a significantly decrease was achieved in 83,3% of cases. Conclusion: There is a correlation between myoma vascularization and treatment with Ulipristal acetate. SPRMs may provide effective treatment for women with symptomatic fibroids by two ways: supports selective progesterone receptor modulators and reduced angiogenesis. Keywords: Angiogenesis; Ulipristal Acetate; Uterine fibroids; VEGF

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THU0642-HPR EVOLUTION OF THE PERCEPTIONS OF RA PATIENTS AFTER EDUCATION PATIENT SESSION TEACHING METHOTREXATE SELF-INJECTION A PROSPECTIVE PILOT STUDY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.5505 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 566.1-566

Author(s):

S. Afilal ◽

H. Rkain ◽

B. Berchane ◽

J. Moulay Berkchi ◽

S. Fellous ◽

...

Keyword(s):

Pilot Study ◽

Patient Education ◽

Median Duration ◽

Large Scale ◽

Education Session ◽

Prospective Pilot Study ◽

Mean Delay ◽

Lack Of Information ◽

Level Of Satisfaction ◽

Before And After

Background:Methotrexate is a gold standard for treatment of RA. In our context, RA patients prefer to be injected by paramedics rather than self-injecting. This can be explained by patients’ bad perceptions of self-injection or lack of information. Appropriate self-injection education can therefore be an important element in overcoming these obstacles and improving disease self-management.Objectives:Compare the RA patients’ perceptions on methotrexate self-injection before and after a patient education session.Methods:Prospective pilot study that included 27 consecutive patients (81.5% female, mean age 44.4 years, illiteracy rate 40.7%) with RA (median duration of progression of 4 years, mean delay in referral for specialist of 6 months, median duration of methotrexate use of 1 year). The patients benefited from an individual patient education session to learn how to self-inject with methotrexate subcutaneously. The patient education session was supervised by a nurse and a rheumatologist with a control a week later. Perceptions of the reluctance to self-inject and the difficulties encountered by patients were assessed before the patient education session, after the 1st and 2nd self-injection of methotrexate using a 10 mm visual analog scale. Patients also reported their level of satisfaction (10 mm VAS) after the 1st and 2nd self-injection.Results:The mean duration of patient education session is 13 min.Table I compares the evolution of the degrees of reluctance to self-injection, the difficulties encountered, and the satisfaction experienced by the patients.Table 1.Evolution of RA patients’ perceptions on the methotrexate self-injection. (N = 27)BeforeAfter the 1stself-injectionAfter the 2end self-injectionpVAS reluctance (0-10mm)6,5 ± 3,62,2 ± 2,91,0 ± 2,3<0,0001VAS difficulty (0-10mm)7,5 ± 2,62,5 ± 2,71,0 ± 1,9<0,0001VAS satisfaction (0-10mm)-8,9 ± 1,89,5 ± 1,50,002Conclusion:This study suggests the effectiveness of a methotrexate self-injection patient education session in RA patients. It also highlights the value of patient education in rheumatologic care. A large-scale study is necessary to better interpret and complete these preliminary results from this pilot study.Disclosure of Interests:None declared

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Plasma Exosomal miRNA Levels after Radiotherapy Are Associated with Early Progression and Metastasis of Cervical Cancer: A Pilot Study

Journal of Clinical Medicine ◽

10.3390/jcm10102110 ◽

2021 ◽

Vol 10 (10) ◽

pp. 2110

Author(s):

Oyeon Cho ◽

Do-Wan Kim ◽

Jae-Youn Cheong

Keyword(s):

Cervical Cancer ◽

Pilot Study ◽

Biological Functions ◽

Patients With Cancer ◽

Initial Stage ◽

Exosomal Mirnas ◽

Early Progression ◽

Before And After ◽

Microenvironmental Factors ◽

Exosomal Mirna

Plasma exosomal miRNAs are key regulators of cell-cell interactions associated with several biological functions in patients with cancer. This pilot study aimed to investigate the log2 fold change (log2FC) of the expression of exosomal miRNAs and related mRNAs in the blood of patients with cervical cancer to identify prognostic markers better than those currently available. We sequenced plasma exosomal RNA from 56 blood samples collected from 28 patients with cervical cancer, who had been treated with concurrent chemoradiotherapy (CCRT). Changes in the expression of miRNAs and mRNAs before and after CCRT were represented as log2FC. Their biological functions were studied by miRNA-mRNA network analysis, using ingenuity pathway analysis, after the selection of two groups of miRNAs, each associated with early progression (EP) and metastasis, also described as initial stage. Seven patients experienced EP, three of whom died within four months after progression. Reduced levels of miR-1228-5p, miR-33a-5p, miR-3200-3p, and miR-6815-5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A. Increased levels of miR-605-5p, miR-6791-5p, miR-6780a-5p, and miR-6826-5p and decreased levels of miR-16-1-3p (or 15a-3p) were associated with the degree of metastasis and led to the systemic activation of myeloid, endothelial, and epithelial cells, as well as neurons, phagocytes, and platelets. Log2FCs in the expression of miRNAs and mRNAs from plasma exosomes after CCRT are associated with EP and metastasis, reflecting unresolved inflammation and systemic microenvironmental factors, respectively. However, this study, supported by preliminary data insufficient to reach clear conclusions, should be verified in larger prospective cohorts.

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Fecal Metaproteomics Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following Lifestyle-Induced Weight Loss

Biomolecules ◽

10.3390/biom11050726 ◽

2021 ◽

Vol 11 (5) ◽

pp. 726

Author(s):

Ronald Biemann ◽

Enrico Buß ◽

Dirk Benndorf ◽

Theresa Lehmann ◽

Kay Schallert ◽

...

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Gut Microbiome ◽

Taxonomic Composition ◽

Low Grade ◽

Gut Inflammation ◽

Functional Changes ◽

Microbiome Composition ◽

Before And After ◽

Human Proteins

Gut microbiota-mediated inflammation promotes obesity-associated low-grade inflammation, which represents a hallmark of metabolic syndrome. To investigate if lifestyle-induced weight loss (WL) may modulate the gut microbiome composition and its interaction with the host on a functional level, we analyzed the fecal metaproteome of 33 individuals with metabolic syndrome in a longitudinal study before and after lifestyle-induced WL in a well-defined cohort. The 6-month WL intervention resulted in reduced BMI (−13.7%), improved insulin sensitivity (HOMA-IR, −46.1%), and reduced levels of circulating hsCRP (−39.9%), indicating metabolic syndrome reversal. The metaprotein spectra revealed a decrease of human proteins associated with gut inflammation. Taxonomic analysis revealed only minor changes in the bacterial composition with an increase of the families Desulfovibrionaceae, Leptospiraceae, Syntrophomonadaceae, Thermotogaceae and Verrucomicrobiaceae. Yet we detected an increased abundance of microbial metaprotein spectra that suggest an enhanced hydrolysis of complex carbohydrates. Hence, lifestyle-induced WL was associated with reduced gut inflammation and functional changes of human and microbial enzymes for carbohydrate hydrolysis while the taxonomic composition of the gut microbiome remained almost stable. The metaproteomics workflow has proven to be a suitable method for monitoring inflammatory changes in the fecal metaproteome.

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Gamma entrainment frequency affects mood, memory and cognition: an exploratory pilot study

Brain Informatics ◽

10.1186/s40708-020-00119-9 ◽

2020 ◽

Vol 7 (1) ◽

Author(s):

Ryan L. S. Sharpe ◽

Mufti Mahmud ◽

M. Shamim Kaiser ◽

Jianhui Chen

Keyword(s):

Pilot Study ◽

Correlation Analysis ◽

Negative Correlation ◽

Cognitive Abilities ◽

Statistical Significance ◽

Assessment Scores ◽

Frequency Group ◽

Before And After ◽

Mood Score ◽

40 Hz

AbstractHere we provide evidence with an exploratory pilot study that through the use of a Gamma 40 Hz entrainment frequency, mood, memory and cognition can be improved with respect to a 9-participant cohort. Participants constituted towards three binaural entrainment frequency groups: the 40 Hz, 25 Hz and 100 Hz. Participants attended a total of eight entrainment frequency sessions twice over the duration of a 4-week period. Additionally, participants were assessed based on their cognitive abilities, mood as well as memory, where the cognitive and memory assessments occurred before and after a 5-min binaural beat stimulation. The mood assessment scores were collected from sessions 1, 4 and 8, respectively. With respect to the Gamma 40 Hz entrainment frequency population, we observed a mean improvement in cognitive scores, elevating from 75% average to 85% average upon conclusion of the experimentation at weak statistical significance ($$\alpha$$ α = 0.10, p = 0.076). Similarly, memory score improvements at a greater significance ($$\alpha$$ α = 0.05, p = 0.0027) were noted, elevating from an average of 87% to 95%. In pertinence to the mood scores, a negative correlation across all populations were noted, inferring an overall increase in mood due to lower scores correlating with elevated mood. Finally, correlation analysis revealed a stronger R$$^2$$ 2 value (0.9838) within the 40 Hz group between sessions as well as mood score when compared across the entire frequency group cohort.

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Serum testosterone and testicular hemodynamics before and after infection with SARS-COV-2 (pilot study)

Urologiia ◽

10.18565/urology.2021.5.5-9 ◽

2021 ◽

Vol 5_2021 ◽

pp. 5-9

Author(s):

Kh.S. Ibishev Ibishev ◽

E.A. Mamedov Mamedov ◽

Z.R. Gusova Gusova ◽

A.I. Palenyy Palenyy ◽

Y.O. Prokop Prokop ◽

...

Keyword(s):

Pilot Study ◽

Serum Testosterone ◽

Before And After

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Abstract WP21: Primary Thrombectomy Within 3 Hours of Onset in Acute Ischemic Stroke From Large Artery Occlusion (PAST3-LAO)- A Pilot Study

Stroke ◽

10.1161/str.47.suppl_1.wp21 ◽

2016 ◽

Vol 47 (suppl_1) ◽

Author(s):

Yahia M Lodi ◽

Varun Reddy ◽

George Petro ◽

Anas Hourani ◽

Chun-An Chou

Keyword(s):

Pilot Study ◽

Artery Occlusion ◽

Primary Objective ◽

Stent Retriever ◽

Large Artery ◽

Good Outcome ◽

Randomized Controlled ◽

Randomized Controlled Studies ◽

New Generation ◽

Number Of Passes

Background: Based on recent trials, AIS due to large artery occlusion (LAO) is resistant to IV thrombolysis and adjunctive stent retriever thrombectomy (SRT) is associated with better recanalization rates and outcomes.Despite the benefit with endovascular therapy 39% to 68% of patients were either disabled or dead.Thrombectomy in AIS with LAO within 3 hours (IV t-PA window) is performed as secondary therapy after IV thrombolysis, which may be associated with delay in enrollment and recanalization. Objective: Primary objective is to evaluate the safety, feasibility and recanalization rate of primary SRT (without IV tPA) within 3 hours in AIS with NIHSS >10 from LAO.Secondary objective is to determine the functional outcome in 30-days and 90-days. Methods: Based on institutionally approved protocol patients with LAO with LCB within 3 hours were offered primary SRT alone as an alternative to IV rtPA, after informed consent.Consecutive patients who underwent primary SRT for LAO within 3 hours from 2012 to 2014 were enrolled.Outcomes were measured using modified Rankin Scale. Results: 18 patients with LAO; mean age 62.8±15.3 years and mean NIHSS 16±5; chose primary SRT after informed consent.Thrombectomy was performed using new generation stent-retriever device in addition to small intra-arterial rtPA (2-10 mg).Number of passes was 1.6±0.9.Near complete (TICI2b in 1) and complete (TICI3 in 17) recanalization was observed in all (100%) patients.Mean time to recanalization from symptoms onset was 188.5±82.7 and from groin puncture was 64.61±40.14 minutes.Immediate post-thrombectomy, 24 hour and 30 day NIHSS score was 4.4±3.7, 1.9±3.2 and 0.3±0.9 respectively.There was no procedure related complication.Asymptomatic perfusion related hemorrhage developed in 6 patients (33%).30 days good outcome was observed in all cases (mRS0= 38.9%, mRS1=44.4%, mRS2=16.7%). 90 days good outcome was observed as follows (mRS0= 50.0%, mRS1=44.4%, mRS2=5.6%). Conclusion: Our pilot study demonstrates that primary SRT in AIS due LAO occlusion with LCB is not only safe and feasible, but associated with complete recanalization and good functional outcome.Larger randomized controlled studies are needed.

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Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson’s Disease: A Pilot Study

Parkinson s Disease ◽

10.1155/2018/8691495 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6

Author(s):

Oriol De Fabregues ◽

Alex Ferré ◽

Odile Romero ◽

Manuel Quintana ◽

José Álvarez-Sabin

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Pilot Study ◽

Sleep Quality ◽

Rem Sleep ◽

Rating Scale ◽

Sleep Problems ◽

Periodic Leg Movements ◽

Before And After ◽

Hamilton Anxiety Rating Scale

Background. Sleep problems in patients with advanced Parkinson’s disease (PD) have a deleterious impact on quality of life. Objective. To assess the effect of levodopa-carbidopa intestinal gel (LCIG) infusion on sleep quality in advanced PD patients. Methods. Seven patients participated in a prospective pilot study. Before and after 6 months of LCIG infusion, an overnight polysomnography was performed and the Epworth Sleepiness Scale, fatigue scale, Pittsburgh Sleep Quality Index, Beck Depression Inventory, and the Hamilton Anxiety Rating Scale were administered. Results. PSG showed low sleep efficiency. REM sleep without atony was found in 5 patients. After 6 months of LCIG infusion, the percentage of REM sleep decreased as well as the number of arousals especially due to reduction of spontaneous arousals and periodic leg movements during REM sleep, but differences were not statistically significant. Also, scores of all study questionnaires showed a tendency to improve. Conclusion. The results show a trend toward an improvement of sleep quality after 6 months of LCIG infusion, although differences as compared to pretreatment values were not statistically significant. The sleep architecture was not modified by LCIG. Further studies with larger study samples are needed to confirm these preliminary findings.

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Pilot Test of the Trisensor, A New Generation Sonar Sensory Aid

Journal of Visual Impairment & Blindness ◽

10.1177/0145482x8307700906 ◽

1983 ◽

Vol 77 (9) ◽

pp. 446-449 ◽

Cited By ~ 2

Author(s):

Randolph D. Easton ◽

Richard M. Jackson

Keyword(s):

Pilot Study ◽

High Resolution ◽

Object Localization ◽

Pilot Test ◽

Angle Error ◽

Space Object ◽

Near Space ◽

Side Channels ◽

Center Channel ◽

New Generation

This report describes the results of a pilot study undertaken to assess systematically the usability of the Trisensor in near space, object localization tasks. In general, findings support the contention that the high resolution, center channel reduces the degree of angle error when reaching for targets in near space. It was also found that the degree of angle error associated with the binaural side channels could be reduced if targets were moved from the periphery into place during localization.

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