Mesoscopic-scale functional networks in the primate amygdala

The primate amygdala performs multiple functions that may be related to the anatomical heterogeneity of its nuclei. Individual neurons with stimulus- and task-specific responses are not clustered in any of the nuclei, suggesting that single-units may be too-fine grained to shed light on the mesoscale organization of the amygdala. We have extracted from local field potentials recorded simultaneously from multiple locations within the primate (Macaca mulatta) amygdala spatially defined and statistically separable responses to visual, tactile, and auditory stimuli. A generalized eigendecomposition-based method of source separation isolated coactivity patterns, or components, that in neurophysiological terms correspond to putative subnetworks. Some component spatial patterns mapped onto the anatomical organization of the amygdala, while other components reflected integration across nuclei. These components differentiated between visual, tactile, and auditory stimuli suggesting the presence of functionally distinct parallel subnetworks.

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Mesoscopic-scale functional networks in the primate amygdala

10.1101/2020.02.24.963587 ◽

2020 ◽

Cited By ~ 1

Author(s):

Jeremiah K Morrow ◽

Michael X Cohen ◽

Katalin M Gothard

Keyword(s):

Macaca Mulatta ◽

Auditory Stimuli ◽

Functional Networks ◽

Field Potentials ◽

Single Neurons ◽

Mesoscopic Scale ◽

Fine Grained ◽

Response Profile ◽

Shed Light ◽

And Task

AbstractThe primate amygdala performs multiple functions that may be related to the anatomical heterogeneity of its nuclei. At the level of single neurons, each function is reflected in stimulus- and task-specific responses. Given that neurons with a particular response profile are not clustered in any of the nuclei, single units may be too fine-grained to shed light on the mesoscale organization of the amygdala. We have extracted from local field potentials recorded simultaneously from multiple locations within the primate amygdala (Macaca mulatta) spatially defined and statistically separable responses to visual, tactile, and auditory stimuli. A generalized eigendecomposition-based method of source separation isolated coactivity patterns, or components, that in neurophysiological terms correspond to putative subnetworks. Some component spatial patterns mapped onto the anatomical organization of the amygdala, while other components reflected integration across nuclei. These components differentiated between visual, tactile, and auditory stimuli suggesting the presence of functionally distinct parallel subnetworks.

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Distribution of multi-unit pitch responses recorded intracranially from human auditory cortex

10.1101/2021.10.22.465330 ◽

2021 ◽

Author(s):

Joel I Berger ◽

Phillip E Gander ◽

Yukiko Kikuchi ◽

Sukhbinder Kumar ◽

Christopher K Kovach ◽

...

Keyword(s):

Auditory Cortex ◽

Spatial Resolution ◽

Local Field ◽

Unit Activity ◽

Field Potential ◽

Specific Region ◽

Auditory Stimuli ◽

Field Potentials ◽

High Impedance ◽

Clinical Purpose

The perception of pitch requires the abstraction of stimulus properties related to the spectrotemporal structure of sound. Previous studies utilizing both animal electrophysiology and human imaging have indicated the presence of a center for pitch representation in the auditory cortex. Recent data from our own group - examining local field potentials (LFPs) in humans - indicate more widely distributed pitch-associated responses within the auditory cortex (Gander et al., 2019). To probe this with greater spatial resolution, we examined multi-unit activity related to three different auditory stimuli, in seven epilepsy patients who were implanted with high-impedance electrodes in auditory cortex for the clinical purpose of localizing seizures. The stimuli were regular-interval noise (RIN) with a pitch strength that is related to the temporal regularity, and pitch value determined by repetition rate, and harmonic complexes with missing fundamentals. We demonstrated increases in spiking activity in 69 of 104 (66%) responsive multi-unit activity in auditory cortex due to pitch-associated stimuli. Importantly, these responses were distributed across the entire extent of Heschl's gyrus (HG), in both primary and non-primary areas, rather than isolated to a specific region, and this finding was evident regardless of the stimulus presented. These findings are the first multi-unit pitch responses recorded from humans, and align with a recent study in macaques (Kikuchi et al., 2019) demonstrating that both local field potential and unit responses to pitch-inducing stimuli are distributed throughout auditory cortex.

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Combined measurements of cerebellar blood flow, local field potentials and glucose utilization during climbing fibres stimulation: Effect of postsynaptic excitatory activity

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0192 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S192-S192

Author(s):

Aïcha Douhou ◽

Kirsten Caesar ◽

Nikolas Offenhauser ◽

Martin Lauritzen ◽

Gilles Bonvento

Keyword(s):

Blood Flow ◽

Local Field ◽

Glucose Utilization ◽

Local Field Potentials ◽

Field Potentials ◽

Climbing Fibres ◽

Excitatory Activity ◽

Combined Measurements

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Local field potentials of the bed nucleus of stria terminalis in patients with major depressive and obsessive compulsive disorder

Klinische Neurophysiologie ◽

10.1055/s-0033-1337276 ◽

2013 ◽

Vol 44 (01) ◽

Cited By ~ 1

Author(s):

WJ Neumann ◽

J Huebl ◽

C Brücke ◽

L Gabriëls ◽

P Brown ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Local Field ◽

Local Field Potentials ◽

Stria Terminalis ◽

Field Potentials ◽

Obsessive Compulsive ◽

Major Depressive ◽

Bed Nucleus ◽

Compulsive Disorder

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Brainwide functional networks associated with anatomically- and functionally-defined hippocampal subfields using ultrahigh-resolution fMRI

Scientific Reports ◽

10.1038/s41598-021-90364-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Wei-Tang Chang ◽

Stephanie K. Langella ◽

Yichuan Tang ◽

Sahar Ahmad ◽

Han Zhang ◽

...

Keyword(s):

Resting State ◽

Functional Organization ◽

A Priori ◽

Longitudinal Axis ◽

Functional Networks ◽

Resting State Functional Connectivity ◽

Underlying Assumption ◽

Isotropic Resolution ◽

Hippocampal Subfields ◽

Fine Grained

AbstractThe hippocampus is critical for learning and memory and may be separated into anatomically-defined hippocampal subfields (aHPSFs). Hippocampal functional networks, particularly during resting state, are generally analyzed using aHPSFs as seed regions, with the underlying assumption that the function within a subfield is homogeneous, yet heterogeneous between subfields. However, several prior studies have observed similar resting-state functional connectivity (FC) profiles between aHPSFs. Alternatively, data-driven approaches investigate hippocampal functional organization without a priori assumptions. However, insufficient spatial resolution may result in a number of caveats concerning the reliability of the results. Hence, we developed a functional Magnetic Resonance Imaging (fMRI) sequence on a 7 T MR scanner achieving 0.94 mm isotropic resolution with a TR of 2 s and brain-wide coverage to (1) investigate the functional organization within hippocampus at rest, and (2) compare the brain-wide FC associated with fine-grained aHPSFs and functionally-defined hippocampal subfields (fHPSFs). This study showed that fHPSFs were arranged along the longitudinal axis that were not comparable to the lamellar structures of aHPSFs. For brain-wide FC, the fHPSFs rather than aHPSFs revealed that a number of fHPSFs connected specifically with some of the functional networks. Different functional networks also showed preferential connections with different portions of hippocampal subfields.

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Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy

Brain Sciences ◽

10.3390/brainsci11070882 ◽

2021 ◽

Vol 11 (7) ◽

pp. 882

Author(s):

Yeon Hee Yu ◽

Seong-Wook Kim ◽

Dae-Kyoon Park ◽

Ho-Yeon Song ◽

Duk-Soo Kim ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Local Field ◽

Smooth Muscle Actin ◽

Local Field Potentials ◽

Renal Tissue ◽

Field Potentials ◽

Wild Type ◽

Sprague Dawley ◽

Rat Models

Increased prevalence of chronic kidney disease (CKD) and neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system have been reported during the natural history of CKD. Psychological distress and depression are serious concerns in patients with CKD. However, the relevance of CKD due to decline in renal function and the pathophysiology of emotional deterioration is not clear. Male Sprague Dawley rats were divided into three groups: sham control, 5/6 nephrectomy at 4 weeks, and 5/6 nephrectomy at 10 weeks. Behavior tests, local field potentials, and histology and laboratory tests were conducted and investigated. We provided direct evidence showing that CKD rat models exhibited anxiogenic behaviors and depression-like phenotypes, along with altered hippocampal neural oscillations at 1–12 Hz. We generated CKD rat models by performing 5/6 nephrectomy, and identified higher level of serum creatinine and blood urea nitrogen (BUN) in CKD rats than in wild-type, depending on time. In addition, the level of α-smooth muscle actin (α-SMA) and collagen I for renal tissue was markedly elevated, with worsening fibrosis due to renal failures. The level of anxiety and depression-like behaviors increased in the 10-week CKD rat models compared with the 4-week rat models. In the recording of local field potentials, the power of delta (1–4 Hz), theta (4–7 Hz), and alpha rhythm (7–12 Hz) was significantly increased in the hippocampus of CKD rats compared with wild-type rats. Together, our findings indicated that anxiogenic behaviors and depression can be induced by CKD, and these abnormal symptoms can be worsened as the onset of CKD was prolonged. In conclusion, our results show that the hippocampus is vulnerable to uremia.

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