scholarly journals Biological rhythms in Arctic vertebrates

Rangifer ◽  
2000 ◽  
Vol 20 (2-3) ◽  
pp. 99 ◽  
Author(s):  
B. E.H. Van Oort ◽  
N. J.C. Tyler ◽  
E. Reierth ◽  
K.-A. Stokkan

Many biological processes show regular cyclical fluctuations that persist throughout an organism's life; these range from the transcription of DNA to patterns of behaviour. Persistent, cyclical phenomena of this kind are a fundamental feature of all organisms. They are governed primarily by endogenous rhythms generated by a 'biological clock' situated in the brain. Normally, however, the expression of the clock is modulated to a greater or lesser extent by environmental cues. This paper reviews the physiological control of the temporal organisation of cycles in vertebrates and, in particular, explores their regulation in arctic species like reindeer (Rangifer tarandus L.). We emphasise how exposure to the photoperiodic conditions that characterise polar regions places special demands on timing mechanisms and how arctic species, therefore, are of particular interest for the study of biological rhythms. Thus far, behavioural and physiological studies of these species show that arctic reindeer (and ptarmigan) appear to be truly opportunistic in summer and wintet, seemingly without any active biological clock and that they are, instead, driven directly by photoperiod. This situation, if confirmed, would be unique among vertebrates.

1988 ◽  
Vol 8 (12) ◽  
pp. 5378-5385 ◽  
Author(s):  
L Saez ◽  
M W Young

The per locus influences biological rhythms in Drosophila melanogaster. In this study, per transcripts and proteins were localized in situ in pupae and adults. Earlier genetic studies have demonstrated that per expression is required in the brain for circadian locomotor activity rhythms and in the thorax for ultradian rhythmicity of the Drosophila courtship song. per RNA and proteins were detected in a restricted group of cells in the eyes and optic lobes of the adult brain and in many cell bodies in the adult and pupal thoracic ganglia. per products were also found in the pupal ring gland complex, a tissue involved in rhythmic aspects of Drosophila development. Abundant expression was seen in gonadal tissue. No biological clock phenotypes have been reported for this tissue in any of the per mutants, per protein mapped to different subcellular locations in different tissues. The protein accumulated in or around nuclei in some cells and appeared to be cytoplasmic in others.


1988 ◽  
Vol 8 (12) ◽  
pp. 5378-5385
Author(s):  
L Saez ◽  
M W Young

The per locus influences biological rhythms in Drosophila melanogaster. In this study, per transcripts and proteins were localized in situ in pupae and adults. Earlier genetic studies have demonstrated that per expression is required in the brain for circadian locomotor activity rhythms and in the thorax for ultradian rhythmicity of the Drosophila courtship song. per RNA and proteins were detected in a restricted group of cells in the eyes and optic lobes of the adult brain and in many cell bodies in the adult and pupal thoracic ganglia. per products were also found in the pupal ring gland complex, a tissue involved in rhythmic aspects of Drosophila development. Abundant expression was seen in gonadal tissue. No biological clock phenotypes have been reported for this tissue in any of the per mutants, per protein mapped to different subcellular locations in different tissues. The protein accumulated in or around nuclei in some cells and appeared to be cytoplasmic in others.


2020 ◽  
pp. 1-6

Abstract The eye is part of the sensory nervous system. However, there are a number of organ systems that also work with the eye. The retina is the only tissue in mammals that regulates photoreception due to the presence of photoreceptors, the rods and cones and performs both visual and non-visual functions Light plays a fundamental role in the behavior of almost all organisms. In addition to visual processes, light also induces important physiological responses. People with mild vascular disease that causes damage to the retina in the eye are more likely to have problems with thinking and memory skills. Everyone has a natural body clock that they are born with and all organs in the body operate according to biological rhythms. Our experiments with ophthalmic mutant rats also showed that the loss of vision also hampered their physiological activities and their rhythmicity was also disturbed. The menstrual cycle disturbances and age of menarche are regulated by many factors; nevertheless, blindness is one of the most impotent factors in regulating biological clock dependent functions. The human eyes are the only organs in the body capable of “seeing”- wavelengths of light and turning it into visual images. We can't “see” or get a visual image to the brain without eyes. The eye-like ability of skin to sense light by using a receptor (Cryptochrome) but failed to form image. Photoreceptors contain chemicals that change when they are hit by light. This causes an electrical signal, which is then sent to the brain along the optic nerve. Different types of photoreceptor allow us to see an enormous range of light and colours. There are two types of photoreceptors in the human retina, rods and cones. Rods are responsible for vision at low light levels (scotopic vision). They do not mediate colour vision and have a low spatial acuity. The blind: People who have lost their sight have different experiences. Some describe seeing complete darkness, like being in a cave. Some people see sparks or experience vivid visual hallucinations that may take the form of recognizable shapes, random shapes and colours, or flashes of light. An afterimage is an image that continues to appear in the eyes after a period of exposure to the original image. Afterimages occur because photochemical activity in the retina continues even when the eyes are no longer experiencing the original stimulus.


Author(s):  
M. Sato ◽  
Y. Ogawa ◽  
M. Sasaki ◽  
T. Matsuo

A virgin female of the noctuid moth, a kind of noctuidae that eats cucumis, etc. performs calling at a fixed time of each day, depending on the length of a day. The photoreceptors that induce this calling are located around the neurosecretory cells (NSC) in the central portion of the protocerebrum. Besides, it is considered that the female’s biological clock is located also in the cerebral lobe. In order to elucidate the calling and the function of the biological clock, it is necessary to clarify the basic structure of the brain. The observation results of 12 or 30 day-old noctuid moths showed that their brains are basically composed of an outer and an inner portion-neural lamella (about 2.5 μm) of collagen fibril and perineurium cells. Furthermore, nerve cells surround the cerebral lobes, in which NSCs, mushroom bodies, and central nerve cells, etc. are observed. The NSCs are large-sized (20 to 30 μm dia.) cells, which are located in the pons intercerebralis of the head section and at the rear of the mushroom body (two each on the right and left). Furthermore, the cells were classified into two types: one having many free ribosoms 15 to 20 nm in dia. and the other having granules 150 to 350 nm in dia. (Fig. 1).


Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 883 ◽  
Author(s):  
Debajyoti Chowdhury ◽  
Chao Wang ◽  
Ai-Ping Lu ◽  
Hai-Long Zhu

Circadian rhythms have a deep impact on most aspects of physiology. In most organisms, especially mammals, the biological rhythms are maintained by the indigenous circadian clockwork around geophysical time (~24-h). These rhythms originate inside cells. Several core components are interconnected through transcriptional/translational feedback loops to generate molecular oscillations. They are tightly controlled over time. Also, they exert temporal controls over many fundamental physiological activities. This helps in coordinating the body’s internal time with the external environments. The mammalian circadian clockwork is composed of a hierarchy of oscillators, which play roles at molecular, cellular, and higher levels. The master oscillation has been found to be developed at the hypothalamic suprachiasmatic nucleus in the brain. It acts as the core pacemaker and drives the transmission of the oscillation signals. These signals are distributed across different peripheral tissues through humoral and neural connections. The synchronization among the master oscillator and tissue-specific oscillators offer overall temporal stability to mammals. Recent technological advancements help us to study the circadian rhythms at dynamic scale and systems level. Here, we outline the current understanding of circadian clockwork in terms of molecular mechanisms and interdisciplinary concepts. We have also focused on the importance of the integrative approach to decode several crucial intricacies. This review indicates the emergence of such a comprehensive approach. It will essentially accelerate the circadian research with more innovative strategies, such as developing evidence-based chronotherapeutics to restore de-synchronized circadian rhythms.


2010 ◽  
Author(s):  
Αικατερίνη Χαραλαμποπούλου

In this study I have attempted to present a linguistic investigation into the nature and structure of time, based on proposals developed in Evans (2004). Accordingly, as linguistic structure and particularly patterns of elaboration reflect conceptual structure conventionalized into a format encodable in language, this study presents an examination of the human conceptual system for time. Indeed, an examination of the ways in which language lexicalizes time provides important insights into the nature and organization of time. That is, given the widely held assumption that semantic structure derives from and reflects, at least partially, conceptual structure, language offers a direct way of investigating the human conceptual system. However, how time is realized at the conceptual level, that is, how we represent time as revealed by the way temporal concepts are encoded in language, does not tell the whole story, if we are to uncover the nature and structure of time. Research in cognitive science suggests that phenomenological experience and the nature of the external world of sensory experience to which subjective experience constitutes a response, give rise to our pre- conceptual experience of time. In other words, as Evans (2004) says, time is not restricted to one particular layer of experience but it rather “constitutes a complex range of phenomena and processes which relate to different levels and kinds of experience” (ibid.: 5). Accordingly, while my focus in this study is on the temporal structure, which is to say the organization and structuring of temporal concepts, at the conceptual level, I have also attempted to present an examination of the nature of temporal experience at the pre-conceptual level (prior to representation in conceptual structure). In this regard, I have examined the results of research from neuroscience, cognitive psychology and social psychology. More specifically and with respect to evidence from neuroscience, it is suggested that temporal experience is ultimately grounded in neurological mechanisms necessary for regulating and facilitating perception (e.g., Pöppel 1994). That is, perceptual processing is underpinned by the occurrence of neurologically instantiated temporal intervals, the perceptual moments, which facilitate the integration of sensory information into coherent percepts. As we have seen, there is no single place in the brain where perceptual input derived from different modalities, or even information from within the same modality, can be integrated. In other words, there is no one place where spatially distributed sensory information associated with the distinct perceptual processing areas of the brain, are integrated in order to produce a coherent percept. Rather, what seems to be the case is that the integration of sensory information into coherent percepts is enabled by the phenomena of periodic perceptual moments. Such a mechanism enables us to perceive, in that the nature of our percepts are in an important sense ‘constructed’. Put another way, perception is a kind of constructive process which updates successive perceptual information to which an organism has access. The updating occurs by virtue of innate timing mechanisms, the perceptual moments, which occur at all levels of neurological processing and range from a fraction of second up to an outer limit of about three seconds. It is these timing mechanisms which form the basis of our temporal experience. As Gell says, “perception is intrinsically time-perception, and conversely, time-perception, or internal time-consciousness, is just perception itself...That is to say, time is not something we encounter as a feature of contingent reality, as if it lay outside us, waiting to be perceived along with tables and chairs and the rest of the perceptible contents of the universe. Instead, subjective time arises as inescapable feature of the perceptual process itself, which enters into the perception of anything whatsoever” (1992: 231). In other words, our experience of time is a consequence of the various innate ‘timing mechanisms' in the brain which give rise to a range of perceptual moments, which are in turn necessary for and underpin perceptual processing. In this way, time exists into the experience of everything as it is fundamental to the way in which perceptual process operates. […]


2004 ◽  
Vol 57 (5) ◽  
pp. 393 ◽  
Author(s):  
James Garner ◽  
Paul A. Keller ◽  
Adam McCluskey

Corticotrophin Releasing Hormone [CRH; also known as Corticotrophin Releasing Factor (CRF)], a 41-amino-acid hormone, is one of the body’ major modulators of the stress response. CRH coordinates the endocrine, autonomic, and behavioural responses to stress through actions in both the brain and the periphery activating the ‘fight or flight’ response. CRH is also implicated in various neurological disorders including Alzheimer’s, Parkinson’s, and anorexia nervosa, and it has been described as a biological clock controlling the length of gestation in humans and other higher-order primates. In the past decade there has been an enormous effort expended in the design and development of new therapeutic agents targetting CRHs in the central nervous and peripheral systems. In this review, we examine the chemistry and recent developments in this exciting field.


1992 ◽  
Vol 70 (5) ◽  
pp. 772-772
Author(s):  
Alastair V. Ferguson

Since the recognition in the 1970s that peptides may play more diverse physiological roles than suggested by their original recognition as circulating hormones, there has been an explosion of information regarding the potential central nervous system actions of these substances. Pharmacological binding studies have described an extensive distribution of many different groups of peptidergic receptors suggesting potential sites of action for specific peptides within the brain. Many of these receptor localizations were found within the blood brain barrier indicating that these substances were released locally and perhaps acted as neurotransmitters. Over the years, experiments demonstrating physiological effects of locally administered peptides in regions where receptors for that molecule are localized have added credibility to such a hypothesis. The explosion of interest in the peptides as potential chemical messengers within the brain has since led to the description of multiple peptidergic neuronal systems within the brain. In addition, there are now many different reports of postsynaptic effects of exogenous administration of peptides on single neurons. Similarly, many studies have reported more broad-based physiological effects resulting from actions of peptides within the central nervous system.The manuscripts that follow summarize presentations in a symposium to examine the "Central Peptidergic Mechanisms in Autonomic Control," which was part of the program at the Canadian Federation of Biological Sciences annual meeting held at Queen's University in Kingston in July of 1991. The express purpose of this symposium in its inception was to provide a forum for consideration of the CNS actions of peptides in the context of a systems physiology approach. We hoped to consider our current knowledge of the roles of peptides in the brain as they relate to the control of specific physiological systems. Therefore rather than presenting a consideration of individual peptides, and each one's multitude of potential roles, the manuscripts presented in the following section have addressed what is known of central peptidergic involvement in the physiological control of reproductive function (W. K. Samson), cardiovascular regulation (A. V. Ferguson), thermoregulatory control (Q. J. Pittman), and drinking (M. Evered).I should like to take this opportunity to thank all who contributed to this symposium, in particular the speakers without whose cooperation it would not have been possible. I am also indebted to the sponsors of the symposium: Merck Frosst, Warner Lambert, Sandoz, the Canadian Physiological Society, and the Faculty of Medicine at Queen's University, whose generous support permitted such a highly qualified group of invited speakers to attend.


2010 ◽  
Vol 6 (5) ◽  
pp. 696-698 ◽  
Author(s):  
C. A. Wyse ◽  
A. N. Coogan ◽  
C. Selman ◽  
D. G. Hazlerigg ◽  
J. R. Speakman

Biological rhythms that oscillate with periods close to 24 h (circadian cycles) are pervasive features of mammalian physiology, facilitating entrainment to the 24 h cycle generated by the rotation of the Earth. In the absence of environmental time cues, circadian rhythms default to their endogenous period called tau , or the free-running period. This sustained circadian rhythmicity in constant conditions has been reported across the animal kingdom, a ubiquity that could imply that innate rhythmicity confers an adaptive advantage. In this study, we found that the deviation of tau from 24 h was inversely related to the lifespan in laboratory mouse strains, and in other rodent and primate species. These findings support the hypothesis that misalignment of endogenous rhythms and 24 h environmental cycles may be associated with a physiological cost that has an effect on longevity.


2007 ◽  
Vol 19 (5) ◽  
pp. 721-733 ◽  
Author(s):  
Nava Levit-Binnun ◽  
Nestor Z. Handzy ◽  
Avi Peled ◽  
Ilan Modai ◽  
Elisha Moses

We study the interplay between motor programs and their timing in the brain by using precise pulses of transcranial magnetic stimulation (TMS) applied to the primary motor cortex. The movement of the finger performing a tapping task is periodically perturbed in synchronization with a metronome. TMS perturbation can profoundly affect both the finger trajectory and its kinematics, but the tapping accuracy itself is surprisingly not affected. The motion of the finger during the TMS perturbation can be categorized into two abnormal behaviors that subjects were unaware of: a doubling of the frequency of the tap and a stalling of the finger for half the period. More stalls occurred as the tapping frequency increased. In addition, an enhancement of the velocity of the finger on its way up was observed. We conclude that the timing process involved in controlling the tapping movement is separate from the motor processes in charge of execution of the motor commands. We speculate that the TMS is causing a release of the motor plan ahead of time into activation mode. The observed doubles and stalls are then the result of an indirect interaction in the brain, making use of an existing motor plan to correct the preactivation and obtain the temporal goal of keeping the beat.


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