Expression of p53 and p16 in Carcinoma Breast Tissue: Depicts Prognostic Significance or Coincidence

Background: Breast cancer is a leading cause of cancer death in women worldwide. Breast carcinoma is currently managed by assessing clinicopathological features. Elucidation of molecular mechanisms of pathogenesis of breast carcinoma may lead to the development of new targeted therapies, particularly in triple negative cancers. Literature shows a few studies on the expression of calretinin in breast carcinoma particularly in basal like type and its prognostic significance. In this study, authors are trying to assess the expression of a new marker calretinin in different molecular subtypes of invasive carcinoma breast.Methods: This study was done in 107 cases of invasive carcinoma breast specimens received in Department of Pathology, Government Medical college, Kottayam from December 2017 to May 2019.Results: Among the molecular subtypes, Basal like tumours showed 68.4% of cases with high level and 31.6% of cases with low level calretinin expression which is comparable with the study by Farrag et al. All the other molecular subgroups showed predominantly low level of calretinin expression.Conclusions: Different molecular subtypes of invasive carcinoma breast showed varied calretinin expression. High level calretinin expression was significantly associated with grade 3 (p value = 0.002), ER negativity (p = 0.004), PR negativity (p = 0.018) and Basal like molecular subtype (p : <0.001). This suggests that calretinin might play a role in pathogenesis of basal like breast carcinomas.

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Study of Clinical Profile of Carcinoma Breast and Prognostic Significance of Serum Lactate Dehydrogenase as Tumor Marker in Carcinoma Breast

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i39a32155 ◽

2021 ◽

pp. 162-167

Author(s):

Geetika Malhotra ◽

D. D. Wagh ◽

Meenakshi Yeola

Keyword(s):

Breast Cancer ◽

Tumor Marker ◽

Prospective Observational Study ◽

Breast Cancer Incidence ◽

Prognostic Significance ◽

Serum Lactate ◽

Clinical Profile ◽

Serum Lactate Dehydrogenase ◽

Carcinoma Breast ◽

Factors Associated

Background: Breast cancer is the highly prevalent malignancy and is a major killer in women around world. In India, there is substantial statistically significant increase in breast cancer incidence patterns. Women from under developed areas(883000 cases) have a significantly higher no. of cases than those from developed areas (794,000) [1]. There are various risk factors associated with breast malignancy. A variety of bio-chemical markers have been tested to determine the malignancy, for the early detection of carcinoma of different origin. LDH is the easiest and cheapest to calculate of all of these indicators. Objectives: To study the clinical profile of patient with breast To study the prognostic significance of LDH as tumor marker in breast To compare post-operative LDH level in patient undergoing surgery for carcinoma breast v/s patient undergoing neoadjuvant chemotherapy. Compare variation in preoperative baselines LDH levels and post-operative LDH levels. Methodology: It is a prospective observational study done on patients with breast cancer. It will be conducted at Dept. of General Surgery , J.N.M.C and AVBRH, Sawangi (Meghe), Wardha. The study will be conducted on patients with Carcinoma Breast. Results: To be assessed after the study. Conclusion: Serum LDH is a good prognostic marker of breast cancer.

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Activities of serum Ada, GGT and alp in carcinoma breast-a case control study for diagnostic and prognostic significance

Indian Journal of Medical Sciences ◽

10.4103/0019-5359.122740 ◽

2013 ◽

Vol 67 (5) ◽

pp. 123 ◽

Cited By ~ 7

Author(s):

Archana Choudhari ◽

Prakash Desai ◽

V Indumati ◽

Sumangala Kadi

Keyword(s):

Case Control Study ◽

Prognostic Significance ◽

Case Control ◽

Carcinoma Breast ◽

Control Study

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Expression of Calretinin in Carcinoma Breast in Correlation with Various Histological and Molecular Subtypes

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i21b31373 ◽

2021 ◽

pp. 1-11

Author(s):

M. B. Sri Hansini ◽

Hemalatha Ganapathy

Keyword(s):

Molecular Subtypes ◽

Molecular Subtype ◽

Prognostic Significance ◽

Clinicopathological Parameters ◽

High Grade ◽

Proliferative Index ◽

Carcinoma Breast ◽

Luminal B ◽

Grade Ii ◽

High Proliferative Index

Breast carcinoma is the second most common cancer following lung cancer. The incidence of cancer accounts for 24.2% and cancer death is about 15% among females. There are various prognostic and predictive factors for assessing the patient encountering carcinoma breast. Among the various prognostic factors, histological subtype and molecular subtype play a key role. The calretinin expression in carcinoma breast was seen in high-grade breast carcinomas and basal like subtype of carcinoma breast. Calretinin expression was predominantly noted in high grade II and III carcinomas as in other studies and other histological subtypes like metastatic carcinomas which are considered high grade tumours. The present study aimed to correlate the various clinicopathological parameters with the calretinin expression. The expression of Calretinin was seen mainly in grade II and grade III IDC- NST and metaplastic carcinomas. Among the molecular subtypes, the Basal like subtype and the Luminal B subtype showed calretinin expression. The calretinin expression was associated with tumours with a high proliferative index with Ki67 index >14%. This implies the importance of prognostic significance of calretinin expression, as cases with a high proliferative index are likely to have poor prognosis.

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Ultrastructural features of prognostic significance in human oral cancer

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100123490 ◽

1992 ◽

Vol 50 (1) ◽

pp. 618-619

Author(s):

Karvita B. Ahluwalia ◽

Nidhi Sharma

Keyword(s):

Oral Cancer ◽

Squamous Cell ◽

Common Knowledge ◽

Prognostic Significance ◽

Growth Control ◽

Terminal Differentiation ◽

Squamous Cell Carcinomas ◽

Effective Therapy ◽

Invasive Potential ◽

Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

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