scholarly journals Comparative Evaluation of Efficacy of Jasminum grandiflorum with Honey and Corticosteroids in Management of Recurrent Aphthous Stomatitis- A Study Protocol

2021 ◽  
pp. 259-263
Author(s):  
Suwarna Dangore Khasbage ◽  
Dhanashri R. Tijare ◽  
Monika Khubchandani ◽  
Surbhi Juneja
Keyword(s):  
Synergistic Effect ◽  
Study Design ◽  
Study Protocol ◽  
Comparative Evaluation ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Aphthous Ulcer ◽  
Medical Sciences ◽  
Oral Medicine ◽  
One Year

Aim: To determine the efficacy of J grandiflorum in the treatment of aphthous ulcer on the basis of reduction in size of the ulcer, erythema and pain. Study Design: Prospective, Observational. Place and Duration: Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Deemed to be University, Sawangi (Meghe), Wardha.   Duration: One year. Methodology: One Hundred and Twenty patients visiting to the dental OPD and diagnosed to have aphthous ulcer will be selected. The patients will be divided in three groups and the formulated gel will be prescribed to one group of patient and other will be given corticosteroid and monitoring will be done. Expected Results: With all the studies performed till now it is expected that the j. grandiflorum and honey together will have good synergistic effect over aphthous ulcer and will help in reduction of size, pain and erythema level of aphthous ulcer. Conclusion: J grandiflorum and honey may be effective in management of recurrent aphthous stomatitis.

scholarly journals Comparative Evaluation of The Efficacy of Topical Hyaluronic Acid ( 0.2%) and Topical Triamcinolone Acetonide( 0.1%) in The Treatment of Recurrent Aphthous Stomatitis

2020 ◽  
Vol 19 (2) ◽  
pp. 107-117
Author(s):  
Bero Nzhad Mustafa ◽  
◽  
Ali Fakhree Alzubaidee
Keyword(s):  
Hyaluronic Acid ◽  
Triamcinolone Acetonide ◽  
Surface Area ◽  
Comparative Evaluation ◽  
Acid Group ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Aphthous Ulcer ◽  
Aphthous Ulcers ◽  
Significant Difference

Background: Recurrent aphthous ulcers are the most common oral lesion. They are classified into minor, major, and herpetiform ulcers. More than 85% of recurrent aphthous stomatitis presents as a minor ulcer. Hyaluronic acid is a biomaterial and it is a major carbohydrate component that can be found in many tissues and recently introduced as an alternative approach to enhance wound healing. Triamcinolone acetonide is a synthetic corticosteroid and it has two forms for topical use cream (0.1%) and ointment (0.1%). Objective: To make a comparison between the effectiveness of hyaluronic acid (0.2%) and triamcinolone acetonide (0.1) in the management of recurrent aphthous ulcer. Patients and Methods: We recruited eighty patients who had a history of recurrent aphthous stomatitis and when presented with current oral ulcer and randomly divided into two groups, one group received hyaluronic acid, and the other group received triamcinolone acetonide. The instruction was given to all patients to apply the agent to the aphthous ulcer 4 times per day for 6 days (day 0 to day 6). The severity of pain was assessed by using VAS and the change of the ulcer surface area measured. Results: Eighty patients with aphthous ulcers have participated in the study, 43 were treated with hyaluronic acid, 37 were treated with triamcinolone acetonide. There was a significant difference between the two groups regarding ulcer surface and after three and six days, the diameter of the ulcer in the hyaluronic acid group was significantly reduced in comparison with those of the triamcinolone acetonide group (p < 0.001). Regarding VAS for pain, there was a significant difference after three and six days, hyaluronic acid group had significantly less VAS than those of the triamcinolone acetonide group (p = 0.004 and p < 0.001 respectively). Conclusion: Hyaluronic acid is more effective than triamcinolone acetonide when used in the treatment of recurrent oral ulcers in reducing pain and surface area of the ulcer. Keywords: Hyaluronic acid (HA), Triamcinolone acetonide (TA), Recurrent aphthous stomatitis (RAS), comparative evaluation

scholarly journals Distribution of oral ulceration cases in Oral Medicine Integrated Installation of Universitas Padjadjaran Dental Hospital

2020 ◽  
Vol 32 (3) ◽  
pp. 237
Author(s):  
Dewi Zakiawati ◽  
Nanan Nur'aeny ◽  
Riani Setiadhi
Keyword(s):  
Oral Mucosa ◽  
Descriptive Study ◽  
Medical Data ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Herpes Labialis ◽  
Oral Medicine ◽  
Oral Ulceration ◽  
Outpatient Unit ◽  
Dental Hospital

Introduction: Oral ulceration defines as discontinuity of the oral mucosa caused by the damage of both epithelium and lamina propria. Among other types of lesions, ulceration is the most commonly found lesion in the oral mucosa, especially in the outpatient unit. Oral Medicine Integrated Installation (OMII) Department in Universitas Padjadjaran Dental Hospital serves as the centre of oral health and education services, particularly in handling outpatient oral medicine cases. This research was the first study done in the Department which aimed to observe the distribution of oral ulceration in OMII Department university Dental Hospital. The data is essential in studying the epidemiology of the diseases. Methods: The research was a descriptive study using the patient’s medical data between 2010 and 2012. The data were recorded with Microsoft® Excel, then analysed and presented in the table and diagram using GraphPad Prism® Results: During the study, the distribution of oral ulceration cases found in OMII Department was 664 which comprises of traumatic ulcers, recurrent aphthous stomatitis, angular cheilitis, herpes simplex, herpes labialis, and herpes zoster. Additionally, more than 50% of the total case was recurrent aphthous stomatitis, with a precise number of 364. Conclusion: It can be concluded that the OMII Department in university Dental Hospital had been managing various oral ulceration cases, with the most abundant cases being recurrent aphthous stomatitis.

scholarly journals Hubungan Stres dengan Stomatitis Aftosa Rekuren pada Mahasiswa Program Studi Pendidikan Dokter Gigi Universitas Sam Ratulangi

e-GIGI ◽  
2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Yosef P. Wowor ◽  
Herdy Munayang ◽  
Aurelia Supit
Keyword(s):  
Perceived Stress ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Aphthous Ulcer ◽  
P Value ◽  
Mild Stress ◽  
Perceived Stress Scale ◽  
Chi Square ◽  
Study Program ◽  
Stress Scale

Abstract: Recurrent aphtosa stomatitis (RAS) or aphthous ulcer on the oral mucosa can be triggered by several predisposing factors, inter alia stress. This study was aimed to determine the relationship between stress and RAS among students of Dentistry Study Program of Sam Ratulangi University. This was an analytical study with a cross sectional design. Samples were obtained by using total sampling method. There were 64 students as respondents. This study was conducted by examination of the oral cavity of the respondents, and filling the SAR question list as well as the perceived stress scale (PSS) questionnaire. The results showed that 48% of respondents experienced RAS and 51.6% did not. Moreover, 25% of respondents experienced mild stress, 45.3% moderate stress, and 29.7% severe stress. The chi-square test showed a p-value of 0.000. In conlusion, there was a significant relationship between stress and recurrent aphthous stomatitis among students at Dentistry Study Program of Sam Ratulangi University.Keywords: recurrent aphthous stomatitis, stress level Abstrak: Stomatitis aftosa rekuren (sar) atau ulkus aftosa pada mukosa mulut yang bersifat rekuren dapat dipicu oleh beberapa faktor predisposisi salah satunya stres. Tujuan penelitian ini untuk mengetahui hubungan stres dengan stomatitis aftosa rekuren pada mahasiswa Program Studi Pendidikan Dokter Gigi Universitas Sam Ratulangi. Jenis penelitian ialah analitik dengan desain potong lintang. Pengambilan sampel menggunakan metode total sampling seluruh mahasiswa di Program Studi. Terdapat total 64 mahasiswa sebagai responden penelitian. Penelitian dilakukan melalui pemeriksaan rongga mulut, serta pengisian daftar pertanyaan SAR dan kuesioner perceived stress scale (PSS). Hasil penelitian menunjukkan bahwa 48% responden mengalami SAR dan 51,6% yang tidak mengalami SAR. Selain itu, 25% responden mengalami tingkat stres ringan, 45,3% sedang, dan 29,7% berat. Hasil analisis uji chi-square menunjukkan nilai p=0,000. Simpulan penelitian ini ialah terdapat hubungan bermakna antara stres dengan stomatitis aftosa rekuren pada mahasiswa Program Studi Pendidikan Dokter Gigi Universitas Sam Ratulangi.Kata kunci: stomatitis aftosa rekuren, tingkat stress

Postprandial effects of macronutrient composition meals on metabolic responses and arterial stiffness indexes in lean and obese men adults; a protocol study (Preprint)

2020 ◽  
Author(s):  
Naseh Pahlavani ◽  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Lida Jarahi ◽  
Mahsa Malekahmadi ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Study Protocol ◽  
Pulse Wave ◽  
Metabolic Response ◽  
Metabolic Responses ◽  
Medical Sciences ◽  
Three Phase ◽  
Component Pulse ◽  
Protocol Study ◽  
Meal Composition

BACKGROUND Background: Prior studies have shown that meal composition is capable of effect on metabolic response and arterial stiffness indexes. OBJECTIVE Objective: A three-phase parallel study will design to investigate the effects of meal composition on metabolic parameters and arterial stiffness indexes among lean and obese adult. The planned study protocol is presented METHODS Methods/design: This is a parallel clinical trial targeting adults (aged 18–35 years, free from any diseases) selected by inclusion and exclusion criteria at Mashhad University Medical Sciences. Each subject will complete three interventions with a washout period of one week: high carbohydrate, high protein and high fat meal. The postprandial effect will be assessed during 360 minutes from each meal including energy expenditure component, pulse wave analysis and pulse wave velocity and blood sampling. RESULTS N/A CONCLUSIONS Metabolic Responses, Macronutrients Composition, Arterial Stiffness, Study Protocol: The differences in postprandial response due to different meal composition could affect of metabolic and vascular parameters. This could provide necessary information for the establishment of new strategies in terms of nutritional education and metabolic and vascular improvement. CLINICALTRIAL Trial registration: Iranian Registry of Clinical Trials: IRCT20190818044552N1. Registered on August 26, 2019

A Critical Appraisal of Assessment and Evaluation Reforms At Datta Meghe Institute of Medical Sciences (Deemed to be University) From 2006 Till 2017: A Study Protocol (Preprint)

2020 ◽  
Author(s):  
Dr. Priyanka Jaiswal ◽  
Dr. Ved Prakash Mishra ◽  
Dr. Minal Chaudhary ◽  
Dr. Sunita Vagha ◽  
Dr. Sachin Damke ◽  
...  
Keyword(s):  
Study Protocol ◽  
Critical Appraisal ◽  
Evaluation Process ◽  
Outcome Analysis ◽  
Medical Sciences ◽  
User Friendliness ◽  
Assessment And Evaluation ◽  
Need Analysis ◽  
The University ◽  
Regulations And Guidelines

UNSTRUCTURED DattaMeghe Institute of Medical Sciences has been declared as Deemed to be University [DMIMS (DU)] under section 3 of UGC Act, 1996 in the year 2005. The University examinations are conducted as per the rules, regulations and guidelines issued by the various Apical councils of India from time to time. The first University exam was conducted in the year 2006. DMIMS (DU) has initiated various reforms by its own in assessment and evaluation process based on needs. For any system to thrive, it needs to be constantly upgraded and critically evaluated. Therefore, a study is undertaken with this in mind and thereby aimed at evaluation and validation of the assessment and evaluation reforms formulated and implemented at DMIMS (DU) since its inception (year 2006).Need analysis for the assessment and evaluation reforms will be carried out on the basis of feedbacks and reports received from respective stakeholders (Students, Faculty and External examiners) from time to time. Outcome analysis of the Feedbacks and reports will be done subsequently after the implementation of the assessment and evaluation reforms. Further based on the outcome analysis, reforms will be validated into following parameters: Objectivity, Responsiveness, User friendliness, Residual component (not covered in above 3 parameters)and a satisfactory index will be derived. If satisfactory index for reform is 100%, it will be concluded that reforms are well received and good to excellent in nature. Total 33 assessment and evaluation reforms have beenimplemented since year 2006. These reforms will be categorised into Pre-Examination (n=18), On Site Examination (n=05) and Post Examination (n=10), and in each category, they will befurther classified into academic (Total =15) and administrative (Total = 18) on the basis of their domain for the ease of structuring and implementation.All the 33 reforms will be validated on the basis of defined parameters. They will be found satisfactory.

scholarly journals Genetic and immunologic findings in children with recurrent aphthous stomatitis with systemic inflammation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Martina Girardelli ◽  
Erica Valencic ◽  
Valentina Moressa ◽  
Roberta Margagliotta ◽  
Alessandra Tesser ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Systemic Inflammation ◽  
Lupus Erythematosus ◽  
Early Onset ◽  
Disease Onset ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Monogenic Disorders ◽  
Pathogenic Variants ◽  
Targeted Treatments

Abstract Background Recurrent aphthous stomatitis with systemic signs of inflammation can be encountered in inflammatory bowel disease, Behçet’s disease (BD), Systemic Lupus Erythematosus (SLE). In addition, it has been proposed that cases with very early onset in childhood can be underpinned by rare monogenic defects of immunity, which may require targeted treatments. Thus, subjects with early onset recurrent aphthous stomatitis receiving a clinical diagnosis of BD-like or SLE-like disease may deserve a further diagnostic workout, including immunologic and genetic investigations. Objective To investigate how an immunologic, genetic and transcriptomics assessment of interferon inflammation may improve diagnosis and care in children with recurrent aphthous stomatitis with systemic inflammation. Methods Subjects referred to the pediatric rheumatologist for recurrent aphthous stomatitis associated with signs of systemic inflammation from January 2015 to January 2020 were enrolled in the study and underwent analysis of peripheral lymphocyte subsets, sequencing of a 17-genes panel and measure of interferon score. Results We enrolled 15 subjects (12 females, median age at disease onset 4 years). The clinical diagnosis was BD in 8, incomplete BD in 5, BD/SLE overlap in 1, SLE in 1. Pathogenic genetic variants were detected in 3 patients, respectively 2 STAT1 gain of function variants in two patients classified as BD/SLE overlap and SLE, and 1 TNFAIP3 mutation (A20 haploinsufficiency) in patients with BD. Moreover 2 likely pathogenic variants were identified in DNASE1L3 and PTPN22, both in patients with incomplete BD. Interferon score was high in the two patients with STAT1 GOF mutations, in the patient with TNFAIP3 mutation, and in 3 genetic-negative subjects. In two patients, the treatment was modified based on genetic results. Conclusions Although recurrent aphthous stomatitis associated with systemic inflammation may lead to a clinical diagnosis of BD or SLE, subjects with early disease onset in childhood deserve genetic investigation for rare monogenic disorders. A wider genetic panel may help disclosing the genetic background in the subset of children with increased interferon score, who tested negative in this study.

Results of Double-Blind Placebo-Controlled Challenge with Nickel Salts in Patients Affected by Recurrent Aphthous Stomatitis

2003 ◽  
Vol 131 (4) ◽  
pp. 296-300 ◽  
Author(s):  
M.L. Pacor ◽  
G. Di Lorenzo ◽  
N. Martinelli ◽  
G. Lombardo ◽  
A. Di Gregoli ◽  
...  
Keyword(s):  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind ◽  
Double Blind Placebo

Customised gold weight eyelid implantation in paralytic lagophthalmos

2008 ◽  
Vol 122 (10) ◽  
pp. 1088-1091 ◽  
Author(s):  
N Jayashankar ◽  
K P Morwani ◽  
M J Shaan ◽  
S R Bhatia ◽  
K T Patil
Keyword(s):  
Visual Acuity ◽  
Prospective Study ◽  
Study Design ◽  
Study Group ◽  
Upper Eyelid ◽  
Eyelid Closure ◽  
Gold Weight ◽  
One Year ◽  
A Prospective Study

AbstractGold eyelid implantation is widely considered the procedure of choice to reanimate the upper eyelid in paralytic lagophthalmos. Commercially supplied implants are not readily available in all places and are sometimes cumbersome to import.Objective:We aimed to devise a method whereby every surgeon performing gold eyelid implantation could have easy and quick access to the implant. Furthermore, we aimed to develop a means of creating an implant of the exact weight required for complete eyelid closure.Study design and setting:A prospective study was performed from 1997 to 2005 in a tertiary research hospital, involving 50 subjects requiring gold upper eyelid implantation and using the technique in question.Results:Only patients with a minimum follow up of one year were included in the study group. Symptoms improved in 96 per cent of subjects, who were able to dispense with eyedrops and eye ointments. Visual acuity improved in 92 per cent of patients. There were two extrusions amongst the early cases.Conclusion and significance:Customised gold eyelid implantation offers an alternative in regions where commercial implants are not easily obtained.

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