scholarly journals Amelioration of Cell Phone and Wi Fi induced Pancreatic Damage and Hyperglycemia (Diabetes Mellitus) with Pomegranate and Vit E in Rats

2021 ◽  
pp. 204-215
Author(s):  
Hadiya Sibghatullah ◽  
Sibghatullah Muhammad Ali Sangi ◽  
Elsamoual Ibrahim Ahmedani ◽  
Ali Alqahtani ◽  
Abdulhakim Bawadekji ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Ionizing Radiation ◽  
Cell Phone ◽  
Histopathological Examination ◽  
Cell Damage ◽  
Cell Phones ◽  
Albino Rats ◽  
Pancreatic Cell ◽  
Rat Pancreas ◽  
Wistar Albino Rats

Background: Type 2 Diabetes Mellitus has become a global concern. To date numerous studies have been conducted but little literature is available to explain the effects of mobile phone radiation on pancreas, where from Insulin is secreted. In Some studies, effects of ionizing radiation have been examined and established the relationship between cell phone exposure and cell damage. Objectives: Objectives of study were to observe the effects of mobile phones, connected with WiFi on the pancreas. Methods: 40 male Wistar Albino rats were exposed tomobile phones connected with Wi-Fi for eight weeks. Results: The histopathological examination of the rat pancreas revealed that, exposure of rats to cell phones and Wi-Fi causes significant damage to the rat pancreas. Conclusion: The ionizing radiation emitted from cell phones and WiFi causes increase in oxidative stress leading to inflammation and pancreatic cell death that may affect glucose homeostasis.

scholarly journals The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats

2017 ◽  
Vol 95 (11) ◽  
pp. 1343-1350
Author(s):  
Aleksandra Vranic ◽  
Stefan Simovic ◽  
Petar Ristic ◽  
Tamara Nikolic ◽  
Isidora Stojic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systolic Function ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Albino Rats ◽  
Acute Administration ◽  
Rat Hearts ◽  
Patients With Diabetes ◽  
Streptozotocin Induced Diabetes ◽  
Wistar Albino Rats

Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts. The present study was carried out on 40 adult male Wistar albino rats (8 weeks old). Rats were randomly divided into 4 groups (10 animals per group): healthy rats treated with 0.1 μmol/L of spironolactone, diabetic rats treated with 0.1 μmol/L of spironolactone, healthy rats treated with 3 μmol/L of spironolactone, and diabetic rats treated with 3 μmol/L of spironolactone. Different, dose-dependent, acute responses of spironolactone treatment on isolated, working diabetic and healthy rat heart were observed in our study. In healthy rats, better systolic function was achieved with higher spironolactone dose, while in diabetic rats, similar effects of low and high spironolactone dose were observed.

scholarly journals Biochemical and histological changes in liver and kidney in male Wistar albino rats following exposure to Solignum®: a permethrincontaining wood preservative

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Kingsley C. Patrick-Iwuanyanwu ◽  
Iniobong A. Charles
Keyword(s):  
Body Weight ◽  
Chronic Exposure ◽  
Histopathological Examination ◽  
Wood Preservative ◽  
Inflammatory Cells ◽  
Male Rats ◽  
Albino Rats ◽  
Dependent Manner ◽  
Histological Changes ◽  
Wistar Albino Rats

The present investigation was aimed to determine the effect of sub-chronic exposure to Solignum<sup>®</sup>, a permethrin-containing wood preservative on biochemical and histological changes in liver and kidneys of male Wistar albino rats. Thirty-two male rats were randomly divided into four groups: control and three treatment concentrations containing 8 rats each. The treatment groups were exposed to Solignum<sup>®</sup> at dose rates of 100, 200 and 400 mg/kg body weight (BW) respectively per day orally for four weeks. Data obtained from the study showed a progressive increase in the body weight of rats in control whereas, rats treated with different concentrations (100, 200 and 400 mg/kg BW) of Solignum<sup>®</sup> decreased significantly (≤0.05) especially at the end of the second and fourth week when compared with control. On the other hand, there was a significant decrease in the relative liver weights of rats treated with 100 and 200 mg/kg BW Solignum<sup>®</sup> while rats treated with 400 mg/kg BW showed a significant increase when compared with control. The relative weight of kidneys in experimental groups increased significantly when compared with control. Biochemical analysis results illustrated that there was a significant increase in marker enzymes namely alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activity at the end of the fourth week. Similarly, total bilirubin, serum urea, creatinine and electrolytes (Na<sup>+</sup>, K<sup>+</sup> and Cl<sup>-</sup>) levels increased in a dose dependent manner in treated rats when compared with untreated control group. Serum total protein decreased significantly in experimental rats when compared with control. However, cholesterol and triglycerides showed no significant difference when compared with control. Histopathological examination of hepatocytes in treated rats was characterized by mild periportal inflammatory cells and cytoplasmic degeneration. Furthermore, histopathological examination of rat kidneys revealed inflammatory cells, congested vessel and interstitial hemorrhage in rats treated with Solignum<sup>®</sup>. Therefore, this present study is aimed to evaluate the hepatotoxic and nephrotoxic potentials associated with sub-chronic exposure to the commercial pesticide Solignum<sup>®</sup>.

scholarly journals Evaluation of the Hepatoprotective And Nephroprotective Activities of Vitamin C and E in Paracetamol induced toxicity in Wistar Albino Rats

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1405-1409
Author(s):  
Omodamiro O.D ◽  
Ewa-ibe C ◽  
Jimoh M.A ◽  
Ajah O
Keyword(s):  
Ascorbic Acid ◽  
Vitamin E ◽  
Vitamin C ◽  
Cell Damage ◽  
Concomitant Administration ◽  
Hepatic Cell ◽  
Albino Rats ◽  
High Doses ◽  
Paracetamol Toxicity ◽  
Wistar Albino Rats

Free radical-mediated cell damage can be prevented by well-known antioxidant vitamins such as Vitamins E and C, and it has been reported that Paracetamol can cause hepatotoxicity at high doses. This study evaluated the efficacy of the combination of Vitamin C and Vitamin E in the prevention of renal and hepatic cell damage caused by paracetamol toxicity. Twenty-eight male albino rats were grouped into seven of four rats per group. Vitamin C at prophylactic dosage; (200mg, 150mg, 100mg, 50mg, 25mg) and Vitamin E at prophylactic dosage; (500iu, 400iu, 300iu, 200iu, 100iu) were administered orally to the rats in groups 1 through 5, respectively with concomitant administration 1000mg/kg bw of paracetamol twice daily for seven days. Group 6 was administered 1000mg/kg of paracetamol only (untreated), and Group 7 served as the normal control. The results revealed a significantly (P < 0.05) increase in serum ALT, AST, ALP, Urea and Creatinine of the group administered 1000mg/kg of paracetamol only. The prophylactic doses of ascorbic acid and α-tocopherol significantly (P < 0.05) decrease serum ALT, AST, ALP, Urea and Creatinine level compared to the untreated rats. This study validates that co-administration of ascorbic acid and α-tocopherol at the proposed prophylactic dosages could be used in the prevention of renal and hepatic cell damage caused by paracetamol toxicity.

scholarly journals The Neuroprotective and Anti-Inflammatory Effects of Annona Muricata (Graviola) on Radiation-Induced Rat Sciatic Nerve Injury.

2021 ◽  
Author(s):  
Emrah Keskin ◽  
Özlem Elmas ◽  
Havva Hande Keser Şahin ◽  
Çağhan Tönge ◽  
Ahmet Günaydın
Keyword(s):  
Sciatic Nerve ◽  
Ionizing Radiation ◽  
Nerve Injury ◽  
Sciatic Nerve Injury ◽  
Albino Rats ◽  
Annona Muricata ◽  
Leaf Extracts ◽  
Normal Tissues ◽  
Radiation Induced ◽  
Wistar Albino Rats

Abstract Background: In radiotherapy (RT) exposure area, normal tissues are also affected that may cause serious complications in the patients. This study aimed to evaluate Annona muricata’s radioprotective effects on sciatic nerve injury due to ionizing radiation (IR). Methods and Results: 32 adult female Wistar albino rats separated into 4 equal groups; Control (C), Annona muricata leaf extracts (AME), radiation (RAD), radiation and Annona muricata leaf extracts (AME+RAD). In groups AME and AME+RAD, Annona muricata leaf extracts were administered at a dose of 300 mg/kg for the first day and 50 mg/kg everyday for following one week intraperitoneally. In RAD and AME+RAD, rats were exposed to a single dose of 20 Gray IR to their right legs. All the subjects were sacrified at the end of the first month. Oxidative stress biochemical parameters (SOD, CAT and GPx) from blood samples were analyzed. Right sciatic nerves extracted and histomorphology evaluated. Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME (p<0,01). Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of CAT (p<0,01), SOD (p<0,01) and GPx (p<0,05) in AME+RAD group compared to RAD group were found to be statistically significant.Conclusion: Our study unveiled that AM could have a potential of biochemically and histomorphology healing on sciatic nerve injury due to ionizing radiation.

scholarly journals Tubular Necrosis, Acid-Base and Electrolyte Abnormalities Associated with Gasoline Vapour-induced Nephrotoxicity

2020 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Renal Function ◽  
Biochemical Markers ◽  
Histopathological Examination ◽  
Albino Rats ◽  
Renal Vasculature ◽  
Tubular Necrosis ◽  
Serum Biochemical ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Electrolyte Abnormalities

Introduction: This study aimed to assess the effect of exposure to gasoline vapor (GV) on the histomorphology and biochemical markers of renal function in rats. Methods: Twenty-four mature Wistar Albino rats weighing 180–200 g were randomly divided into two groups (n = 12 per group). Animals in group 1 (G1) served as unexposed controls, while animals in group 2 (G2) were exposed to GV for 35 days. At the end of the exposure, the animals were sacrificed, and blood samples were collected for biochemical analysis while the kidneys were removed and processed for histopathological evaluation. Results: Serum biochemical markers of renal function in the exposed group differed significantly (p< 0.05) from the unexposed group in urea (45.16 ± 1.00mg/dl versus(vs) 13.20 ± 0.69 mg/dl), creatinine (1.16 ± 0.27mg/dl vs 0.38 ± 0.10mg/dl), uric acid (3.66 ± 0.82mmol/L vs 1.96 ± 0.08mmol/L), potassium (6.90 ± 0.27mmol/L vs 3.57 ± 0.26mmol/L), sodium (182.60 ± 3.21mmol/L vs 141.33 ± 10.46mmol/L), chloride (119.00 ± 1.58mmol/L vs 103.33 ± 2.07mmol/L), pH (6.82 ± 0.22 vs 7.38 ± 0.25), bicarbonate (16.60 ± 5.03mmol/L vs 26.50 ± 3.45mmol/L), and glucose (125.60 ± 16.23mg/ dl vs 83.33 ± 4.46mg/dl). Histopathological examination of kidney sections revealed areas of degenerative and necrotic changes in the glomerulus, tubules, and renal vasculature, particularly in the cortical portion of the kidney. Conclusion: Chronic exposure to gasoline compounds may be associated with significant structural and biochemical derangements in kidney function.

Can curcumin modulate allergic rhinitis in rats?

2016 ◽  
Vol 130 (12) ◽  
pp. 1103-1109 ◽  
Author(s):  
M Acar ◽  
N Bayar Muluk ◽  
S Yigitaslan ◽  
B P Cengiz ◽  
P Shojaolsadati ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Goblet Cell ◽  
Histopathological Examination ◽  
Nasal Congestion ◽  
Control Group ◽  
Albino Rats ◽  
Epithelial Surface ◽  
Vascular Proliferation ◽  
Wistar Albino Rats ◽  
Goblet Cell Metaplasia

AbstractObjectives:This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats.Methods:Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21–28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21–28. Allergy symptoms and histopathological features of the nasal mucosa were examined.Results:The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria.Conclusion:Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.

scholarly journals Neuro-protective role of seeds of Mucuna pruriens BEK and Mucuna monosperma DC in wistar albino rats

2016 ◽  
Vol 4 (6) ◽  
pp. 276-281
Author(s):  
Desai Yogesh Hareshchandra ◽  
◽  
Ravi Mundugaru ◽  
Shridhara Bairy T ◽  
S Ravikrishna ◽  
...  
Keyword(s):  
Granular Layer ◽  
Histopathological Examination ◽  
Neuromuscular Disorders ◽  
Brain Regions ◽  
Neuroprotective Activity ◽  
Mucuna Pruriens ◽  
Control Group ◽  
Albino Rats ◽  
Anti Oxidant ◽  
Wistar Albino Rats

Mucuna pruriens Bek. and Mucuna monosperma DC. seeds were extensively used in Ayurveda for neuromuscular disorders. The objective of present study was to screen the neuroprotective activity of the test drugs in wistar albino rats. The cerebral ischemia was induced by bilateral common carotid artery occlusion for 60 minutes followed by reperfusion. At the end of the experiments under anaesthesia animals were sacrificed and brain was removed. Anti oxidant and histopathological examination was carried out of the brain tissue. Both test drugs have been shown considerable anti oxidant activity in comparison to BCCAO control group. Histopathological examination revealed there is a decreased cellularity and predominance of immature neurons in the granular layer was observed in hypothalamus in control rats while the test drug has shown normal cytoarchitecture. The sections of hippocampus from Mucuna monosperma DC group exhibited decreased cellularity of the granular layer and vacuolization was observed and Mucuna pruriens Bek treated group exhibited almost normal cytoarchitecture. In conclusion the test drugs possess moderate anti oxidant and cellular integrity maintaining potential in different brain regions and hence it supports its therapeutic claim in neuromuscular disorders.

scholarly journals DOES THE INTRATYMPANIC APPLICATION OF MESNA PREVENT THE CHOLESTEATOMA? AN EXPERIMENTAL RATS STUDY

2021 ◽  
Author(s):  
BİLAL SİZER ◽  
Aylin Gül ◽  
Songül Karababa Demir
Keyword(s):  
Propylene Glycol ◽  
Histopathological Examination ◽  
Salt Water ◽  
Statistical Significance ◽  
Control Group ◽  
Albino Rats ◽  
Microscopic Evaluation ◽  
Wistar Albino Rats ◽  
The Right ◽  
Experimental Group

Purpose Studying the effect of Mesna on middle ear otitis media and cholesteatoma induced by propylene glycol on an experimental animal model. Methods The study was designed to consist of sixteen Wistar albino rats, their right ears being the control group and left ears being the experiment group. %50 propylene glycol, gentamicinsulfate and physiologic salt water were applied to the right ear and %50 propylene glycol, gentamicinsulfate and %20 Mesna were administered to the left ear through intratympanic injections on days 1, 3, 8, 15 and 21. The rats were sacrificed 45 days after the first injection and underwent histopathological examination. Results It was seen that cholesteatoma and fibrosis were less common in the experiment group in microscopic evaluation. A statistically significant decrease was observed when the average and maximum thicknesses of the tympanic membranes and the minimum thicknesses of the tympanic bulla of the control group and the experiment group were compared. (p< 0.05) Conclusion In the experimental cholesteatoma model created in rats, no statistical significance was observed, indicating that Mesna, which was applied intratympanically, completely prevented the formation of cholesteatoma. However, it was found that the prevalence of cholesteatoma formation was microscopically less in the experimental group.

scholarly journals Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes

2016 ◽  
Vol 19 (6) ◽  
pp. 464-470 ◽  
Author(s):  
Amel Mahmoud Soliman ◽  
Ayman Saber Mohamed ◽  
Mohamed-Assem Said Marie
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Diabetic Complication ◽  
Albino Rats ◽  
Glutathione S Transferase ◽  
Wistar Albino Rats

Background. The main complication of diabetes mellitus is diabetic nephropathy in both types, which is a main reason for renal failure. Echinochrome substance present in sea urchin shells and spines and possesses high antioxidant activity.Aim. is to evaluate the ability of Ech to suppress the progression of diabetic complication in kidney.Materials and methods. Thirty-six male Wistar albino rats were divided into two main groups, type 1 diabetes mellitus and type 2 diabetes mellitus. Both groups divided into control, diabetic and echinochrome subgroups. Type 1 diabetes was induced by single dose of streptozotocin (60 mg/kg, i.p), while type 2 was induced by high fat diet for 4 weeks before the injection with streptozotocin (30 mg/kg, i.p). The treated groups were administrated by echinochrome (1mg/kg body weight in 10% DMSO) daily for 4 weeks.Results. Echinochrome groups showed reduction in the concentrations of glucose, malondialdehyde, urea, uric acid and creatinine. While it caused general increase in glutathione-S-transferase, superoxide dismutase, catalase, glutathione reduced, nitric oxide and creatinine clearance. The histopathological investigation showed clear improvement in the kidney architecture.Conclusion. Administration of echinochrome improves renal function and ameliorates renal histopathological changes possibly by improvement of glucose metabolism and inhibition of lipid peroxidation process.

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