Low FXIII activity levels in intensive care unit hospitalized COVID-19 patients

Background COVID-19 infection is associated with a hypercoagulable state. Severe COVID-19 patients present with high plasma fibrinogen levels, continuous deposition of fibrin and the presence of microthrombi in their lungs, accompanied by significant fibrinolysis, resulting in high D-dimer levels. Due to the role of FXIII in fibrin crosslinking and clot stabilization, we analyzed its activity levels and dynamics in COVID-19 patients hospitalized in the intensive care unit (ICU). Methods FXIII levels were measured in thirty four COVID-19 patients hospitalized in the ICU and in fourteen non-severe COVID-19 patients. FVIII levels were measured for comparison. Laboratory data and clinical variables were recorded. Results The average FXIII activity level in 34 ICU hospitalized COVID-19 patients was 69.9±33 %, significantly lower compared to an average of 120±20.9 % FXIII activity in 14 non-severe COVID-19 patients. FXIII activity levels were below the low normal value (< 79 % FXIII activity) in 74 % of the ICU hospitalized COVID-19 patients. In contrast, high FVIII activity was measured among all severe COVID-19 patients. Consecutive measurements, performed in fourteen ICU hospitalized COVID-19 patients, pointed to a significant decrease in FXIII activity from the average of 85.7±28.2 %, (which is in the normal range), to an average of 68.0±20.4 %, below the low normal range, within 6.4±3.4 days of ICU hospitalization. Liver functions did not differentiate between patients with low and normal FXIII activity. No inhibitor to FXIII activity was found in the plasma of severe COVID-19 patients. Levels of FXIII-A antigen correlated with FXIII activity, and were low in severe COVID-19 patients. Conclusions Low FXIII activity levels were found in COVID-19 patients hospitalized in the ICU, with gradual decline during their hospitalization. A mechanism of consumption may account for the low FXIII activity in these patients.

Biostratigraphy, Age, and Paleoenvironment of the Pliocene Beaufort Formation on Meighen Island, Canadian Arctic Archipelago

The Beaufort Formation records extraordinary details of Arctic environments and amplified temperatures at approximately modern levels of atmospheric CO2. It was deposited during the Neogene on the western side of what is now the Canadian Arctic Archipelago. Meighen Island is a key locality for studying this formation because marine sediments there are interbedded with terrestrial fossiliferous sands. The biostratigraphic succession, fossils from the marine beds, and paleomagnetic data from the Bjaere Bay region of the island suggest two potential ages for the studied exposures: either continuous deposition at ca. 3.0 Ma, or a sequence of deposits at ca. 4.5 Ma and 3.4 Ma. The sediments appear to encompass at least two eustatic highstands of sea level and a particularly warm climate interval of the Pliocene Arctic.

Muographic monitoring of hydrogeomorphic changes induced by post-eruptive lahars and erosion of Sakurajima volcano

Post-eruptive destabilization of volcanic edifices by gravity driven debris flows or erosion can catastrophically impact the landscapes, economies and human societies surrounding active volcanoes. In this work, we propose cosmic-ray muon imaging (muography) as a tool for the remote monitoring of hydrogeomorphic responses to volcano landscape disturbances. We conducted the muographic monitoring of Sakurajima volcano, Kyushu, Japan and measured continuous post-eruptive activity with over 30 lahars per year. The sensitive surface area of the Multi-Wire-Proportional-Chamber-based Muography Observation System was upgraded to 7.67 m$$^2$$ 2 ; this made it possible for the density of tephra within the crater region to be measured in 40 days. We observed the muon flux decrease from 10 to 40% through the different regions of the crater from September 2019 to October 2020 due to the continuous deposition of tephra fallouts. In spite of the long-term mass increase, significant mass decreases were also observed after the onsets of rain-triggered lahars that induced the erosion of sedimented tephra. The first muographic observation of these post-eruptive phenomena demonstrate that this passive imaging technique has the potential to contribute to the assessment of indirect volcanic hazards.

In-Process Height Displacement Measurement Using Crossed Line Beams for Process Control of Laser Wire Deposition

We propose the use of the line section method with crossed line beams for the process control of laser wire deposition. This method could be used to measure the height displacement in front of a laser spot when the processing direction changes. In laser processing, especially laser deposition of metal additive manufacturing, the laser process control technique that controls the processing parameters based on the measured height displacement in front of a laser processing spot is indispensable for high-accuracy processing. However, it was impossible to measure the height displacement in front of a processing laser spot in a processing route in which the processing direction changes as the measurement direction of the conventional light-section method comprising the use of a straight-line beam is restricted although the configuration is simple. In this paper, we present an in-process height displacement measurement system of the light-section method using two crossed line beams. This method could be used to measure the height displacement in a ±90° direction by projecting two crossed line beams from the side of a laser processing head with a simple configuration comprising the addition of one line laser to the conventional light-section method. The height displacement can be calculated from the projected position shift of the line beams irrespective of the measurement direction by changing the longitudinal position on the crossed line beams according to the measurement direction. In addition, the configuration of our proposed system is compact because the imaging system is integrated into the processing head. We could measure the height displacement at 2.8–4 mm in front of a laser processing spot according to the measurement direction by reducing the influence of intense thermal radiation. Moreover, we experimentally evaluated the height displacement measurement accuracy for various measurement directions. Finally, we evaluated continuous deposition in an “L” shape wherein the deposition direction was changed while using a laser wire direct energy deposition machine for the laser process control based on the in-process height displacement measurement result. We achieved highly accurate continuous deposition at the position wherein the processing direction changes despite the acceleration and deceleration of the stage by laser process control.

Thermal evolution of Los Cuervos formation in the southern area of the Cesar sub-basin (Colombia), based on geochemical and petrophysical data

The tectonic complexity to which the post-Cretaceous Cesar-Ranchería basin has been subjected has generated alterations in the evolution of its oil system, evidence of this is the lack of stratigraphic record in the Cesar sub-basin belonging to ages ranging from the Eocene to the Early Miocene. These units that are no longer present could have been deposited and eroded during this period of time, leaving their mark on the closest overlying units. Previously mentioned hypothesis oriented this research to study how the basin filling was in the time range from the Eocene to the early Miocene based on both organic (24 Tmax and 14 %Ro data) and inorganic (514 data of porosity) paleo-geothermometer data of Paleocene age formations present in two new wells ANH-LA LOMA-2 and ANH-CR-LOS CEREZOS-1X. In addition to the data provided by the wells drilled for this study, 31 published Tmax and 13 %Ro data from Los Cuervos Formation in the Calenturitas and La Jagua Mines were used. The results obtained indicate that the continuous deposition of sedimentary units did occur from the Paleocene to the middle Eocene and it is expected that the Sedimentitas del Eoceno Formation has reached a thickness between 2.5 to 3.5km with characteristics of quartz sandstones (density and compaction). This thickness of rock began to be eroded in the late Eocene to the Miocene according to recent thermo-chronological studies. The evidence obtained allow to improve the thermal evolution models of the oil system, to establish when the greatest advances were made in the transformation ratios and to estimate how the oldest source rocks of the Cesar sub-basin are currently in the studied area.

Strength Enhancement in Fused Filament Fabrication via the Isotropy Toolpath

The fused filament fabrication (FFF) process deposits thermoplastic material in a layer-by-layer manner, expanding the design space and manufacturing capability compared with traditional manufacturing. However, the FFF process is inherently directional as the material is deposited in a layer-wise manner. Therefore, the in-plane material cannot reach the isotropy character when performing the tensile test. This would cause the strength of the print components to vary based on the different process planning selections (building orientation, toolpath pattern). The existing toolpaths, primarily used in the FFF process, are linear, zigzag, and contour toolpaths, which always accumulate long filaments and are unidirectional. Thus, this would create difficulties in improving the mechanical strength from the existing toolpath strategies due to the material in-plane anisotropy. In this paper, an in-plane isotropy toolpath pattern is generated to enhance the mechanical strength in the FFF process. The in-plane isotropy can be achieved through continuous deposition while maintaining randomized distribution within a layer. By analyzing the tensile strength on the specimens made by traditional in-plane anisotropy toolpath and the proposed in-plane isotropy toolpath, our results suggest that the mechanical strength can be reinforced by at least 20% using our proposed toolpath strategy in extrusion-based additive manufacturing.

Muographic Monitoring of Hydrogeomorphic Changes Induced by Post-Eruptive Lahars and Erosion of Sakurajima Volcano

Post-eruptive destabilization of volcanic edifices by gravity driven debris flows or erosion can catastrophically impact the landscapes, economies and human societies surrounding active volcanoes. In this work, we propose muography as a tool for the remote monitoring of hydrogeomorphic responses to volcano landscape disturbances. We conducted the muographic monitoring of Sakurajima volcano, Kyushu, Japan and measured continuous post-eruptive activity with over 30 lahars per year. The sensitive surface area of the Multi-Wire-Proportional-Chamber-based Muography Observation System was upgraded to 7.67 m2 ; this made it possible for the density of tephra within the crater region to be measured in 40 days. We observed the muon flux decrease from 10 % to 40 % through the different regions of the crater from September 2019 to October 2020 due to the continuous deposition of tephra fallouts. In spite of the long-term mass increase, significant mass decreases were also observed after the onsets of rain-triggered lahars that induced the erosion of sedimented tephra. The first muographic observation of these post-eruptive phenomena demonstrate that this passive imaging technique has the potential to contribute to the assessment of indirect volcanic hazards.

Designing an Interchangeable Multi-Material Nozzle System for 3D Bioprinting Process

Three-dimensional bioprinting is a rapidly growing field attempting to recreate functional tissues for medical and pharmaceutical purposes. Development of functional tissue requires deposition of multiple biomaterials encapsulating multiple cell types i.e. bio-ink necessitating switching ability between bio-inks. Existing systems use more than one print head to achieve this complex interchangeable deposition, which decreases efficiency, structural integrity, and accuracy. In this research, we developed a nozzle system capable of switching between multiple bio-inks with continuous deposition ensuring the minimum transition distance so that precise deposition transitioning can be achieved. Finally, the effect of rheological properties of different bio-material compositions on the transition distance is investigated by fabricating the sample scaffolds.

Efficiency enhancement in stoichiometrically stable CdS/TiO2 nanotube heterostructure electrode for sunlight driven hydrogen generation

A stoichiometrically stable CdS/TiO2 heterostructured electrode was developed via electrochemical deposition for efficient photoelectrochemical conversion. Continuous deposition of CdS over TiO¬2 leads to enhanced photocurrent and reduction of carrier recombination....