Advantages of multi-arm non-randomised sequentially allocated cohort designs for Phase II oncology trials

Background Efficient trial designs are required to prioritise promising drugs within Phase II trials. Adaptive designs are examples of such designs, but their efficiency is reduced if there is a delay in assessing patient responses to treatment. Methods Motivated by the WIRE trial in renal cell carcinoma (NCT03741426), we compare three trial approaches to testing multiple treatment arms: (1) single-arm trials in sequence with interim analyses; (2) a parallel multi-arm multi-stage trial and (3) the design used in WIRE, which we call the Multi-Arm Sequential Trial with Efficient Recruitment (MASTER) design. The MASTER design recruits patients to one arm at a time, pausing recruitment to an arm when it has recruited the required number for an interim analysis. We conduct a simulation study to compare how long the three different trial designs take to evaluate a number of new treatment arms. Results The parallel multi-arm multi-stage and the MASTER design are much more efficient than separate trials. The MASTER design provides extra efficiency when there is endpoint delay, or recruitment is very quick. Conclusions We recommend the MASTER design as an efficient way of testing multiple promising cancer treatments in non-comparative Phase II trials.

The THE PHILOSOPHICAL FOUNDATION OF THE SCHOOL LITERACY MOVEMENT IN INDONESIA

The School Literacy Movement (SLM) was launched in 2015 by the Indonesian government in response to the concerns of many parties regarding the readiness of the Indonesian young generation to face the challenges of the 21st-century. This paper examined the philosophical foundations of SLM by scrutinizing the School Literacy Movement Master Design published in 2019 as the object of study. This study was a descriptive qualitative study, using the inferential content analysis method. The findings were: (1) the philosophical foundation of SLM that is portrayed in the object of study are essentialism, perennialism, progressivism, existentialism, and critical pedagogy, and (2) the object of the study is strongly influenced by the philosophy of progressivism since the writers of the SLM Master Design were more focused on the effort to prepare the students to face the 21st-century challenges. Gerakan Literasi Sekolah (GLS) atau The School Literacy Movement (SLM) atau dicanangkan pada tahun 2015 oleh pemerintah Indonesia, sebagai jawaban atas keprihatinan banyak pihak terkait kesiapan generasi muda Indonesia menghadapi tantangan abad 21. Tulisan ini mengkaji landasan filosofis SLM dengan menelaah Desain Induk Gerakan Literasi Sekolah terbitan 2019 sebagai objek kajian. Penelitian ini adalah penelitian deskriptif kualitatif yang menggunakan metode analisis isi inferensial. Temuan penelitian adalah: (1) Landasan filosofis SLM yang tergambar dalam objek kajian adalah esensialisme, perenialisme, progresivisme, eksistensialisme, dan pedagogi kritis; dan (2) Objek kajian sangat dipengaruhi oleh filosofi progresivisme karena penulis Desain Induk SLM lebih fokus pada upaya mempersiapkan siswa untuk menghadapi tantangan abad ke-21.

The Evaluation of School Literacy Movement Program in Secondary School

School Literacy Movement is a program made by the government to improve the literacy skill in elementary and secondary school level. This program is the implementation of Regulation No 23 by 2015 about growing manners. This is a descriptive evaluation study that use Discrepancy evaluation model as a tool to evaluate the program. The aims of the study is to find the gaps between planning, process and result of School Literacy Movement at Secondary School that is adjusted with the vision and mission of the school and the master design of School Literacy Movement issued by Minister of Education and Culture. The stages those are observed are design, installation, process, product, and cost and benefit. The study uses interview, observe, and document study to get the data from the principal, teacher, and students. The result shows the gaps are 1) school haven’t design any training for the teacher about literacy, 2) school hasn’t prepared an instrument to evaluate the program, 3) learning stage of literacy is implemented only for Bahasa Indonesia (should be for all subjects), 4) school hasn’t prepare any cost for the literacy program. Thus, it can be concluded that there are still some gaps happened in doing the School Literacy Movement at Secondary School based on the Master Design of School Literacy Movement issued by Ministry of Education and Culture.

Evaluation of School Literation Movement Programs in Jakarta Selatan Wilayah II High School, Kecamatan Tebet

This study aims to determine the implementation of the School Literacy Movement or “Gerakan Literasi Sekolah“ (GLS) program carried out in the South Jakarta State High School area II in Tebet sub-district. This research is a type of evaluation research with a qualitative approach using the gap evaluation model or Discrepancy Evaluation Model (DEM) developed by Malcom Provus. So that the implementation of the GLS program in terms of design, installation, process, and product. The data is obtained through observation, interviews, and study documents. Principals and teachers in these schools have implemented a school literacy movement program by the indicators of the school literacy movement contained in the master design of the school literacy movement in secondary schools. The condition of the school has fulfilled the adequacy and adequacy of facilities and infrastructure that support the school literacy movement program. The competencies of school principals and teachers have been able to develop the school literacy movement program The results of the study stated that the level of achievement of the GLS program in Tebet sub-district high schools was in the High category. This means that for the most part, even all program indicators have been implemented or are available according to criteria.

KAJIAN POTENSI LIKUIFAKSI MENGGUNAKAN METODE PENETRATION TEST DAN INDEKS KEANDALAN “STUDI KASUS BANDARA MINANGKABAU, PADANG SUMATERA BARAT”

Bandara Internasional Minangkabau (BIM) adalah infrastruktur udara yang penting di Indonesia, terletak di kota Padang. Pada 30 September 2009, terjadi gempa bumi dengan besarnya (ML) 7,9 SR. dan percepatan puncak mencapai 0,28 g. Gempa ini akan digunakan untuk referensi dalam analisa likufraksi. Likufraksi perlu di analisa untuk menidentifikasi potensi kerusakan. Mitigasi perlu dilakukan sebelum memulai pengembangan BIM pada Master Design Bandara Internasional Minangkabau. Metode analisa potensi likufraksi yang digunakan dalam penelitian ini adalah metode uji penetrasi standart (SPT) dan probabilistik/Reliabilitas index (β). Perbandingan antara rasio stres siklik (CSR) dan rasio resistensi siklik (CRR) adalah faktor keamanan. Faktor keamanan lebih besar dari satu maka tidak berpotensi likufraksi, tetapi jika faktor keamanan lebih kecil dengan satu maka berpotensi likufraksi. Hasil analisa dari potensi likufraksi menunjukkan potensi di beberapa titik di wilayah BIM, seperti area taxi Way, Apron dan terminal kargo bandara. Potensi likuifaksi rata – rata terjadi karna (FS) < 1 pada kedalaman 7-16 m, itu berarti potensi likuifaksi merupakan likuifaksi dalam.

Integrating urban analysis, generative design, and evolutionary optimization for solving urban design problems

To better support urban designers in planning sustainable, resilient, and livable urban environments, new methods and tools are needed. A variety of computational approaches have been proposed, including different forms of spatial analysis to evaluate the performance of design proposals, or the automated generation of urban design proposals based on specific parameters. However, most of these propositions have produced separate tools and disconnected workflows. In the context of urban design optimization procedures, one of the main challenges of integrating urban analytics and generative methods is a suitable computational representation of the urban design problem. To overcome this difficulty, we present a holistic data representation for urban fabrics, including the layout of street networks, parcels, and buildings, which can be used efficiently with evolutionary optimization algorithms. We demonstrate the use of the data structure implemented for the software Grasshopper for Rhino3D as part of a flexible, modular, and extensible optimization system that can be used for a variety of urban design problems and is able to reconcile potentially contradicting design goals in a semi-automated design process. The proposed optimization system aims to assist a designer by populating the design space with options for more detailed exploration. We demonstrate the functionality of our system using the example of an urban master-design project for the city of Weimar.

Rancangan Kegiatan Literasi Informasi di SMA Negeri 1 Padang

Based on the results of research that has been done, the literacy activities at SMAN1 Padang are in accordance with the activities in the Master Design Movement of the School Literacy Movement, then it can be concluded as follows. First the design of information literacy activities at SMAN 1 Padang, namely: (1) reading activity 15 minutes before learning, i.e. making a literacy journal for students; (2) reading award, namely literacy ambassador. (3) Literacy corner, holding a reading corner in the park. (4) reading books by utilizing the role of the library, holding user guidance. (5) procurement of libraries as a source of literacy, making literacy bulletin boards. Second, constraints in the utilization of information literacy at SMAN 1 Padang, namely: limited implementation time in reading activities 15 minutes before learning, lack of placement of reading corners and completeness of reading collections in the literacy corner, lack of implementing reading award activities. Third, efforts to overcome obstacles in information literacy activities at SMAN 1 Padang, namely: increasing the implementation time of reading activities 15 minutes before learning, increasing collection and placement of reading corners in the school environment, continuing reading reading activities and adding prizes to students.Keywords: design, literacy

The Reflector - Design for enriched music festival experiences through meaningful interactions at Into The Great Wide Open

This report covers research, design development and evaluation of The Reflector - a design that aims to enrich music festival experiences through meaningful interactions at Into The Great Wide Open 2016 (annual music and arts festival on Vlieland). This TU Delft Master Design for Interaction graduation project aims to deliver a spatial design that offers unique human centred experiences. The process is supported by Vision in Product Design approach, which is known for providing interaction and context centred desirable experiences. The project is carried out in cooperation with Triomf Productions who have a long lasting partnership with Into the Great Wide Open (ITGWO) in terms of providing festival identity through area designs. A goal of the project is to deliver a unique product that complies with supplier convenience guidelines and demonstrates feasibility in terms of manufacturability and costing.