Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy

Diabetic retinopathy has recently been defined as a highly specific neurovascular complication of diabetes. The chronic progression of the impairment of the interdependence of neurovascular units (NVUs) is associated with the pathogenesis of diabetic retinopathy. The NVUs consist of neurons, glial cells, and vascular cells, and the interdependent relationships between these cells are disturbed under diabetic conditions. Clinicians should understand and update the current knowledge of the neurovascular impairments in diabetic retinopathy. Above all, neuronal cell death is an irreversible change, and it is directly related to vision loss in patients with diabetic retinopathy. Thus, neuroprotective and vasoprotective therapies for diabetic retinopathy must be established. Understanding the physiological and pathological interdependence of the NVUs is helpful in establishing neuroprotective and vasoprotective therapies for diabetic retinopathy. This review focuses on the pathogenesis of the neurovascular impairments and introduces possible neurovascular protective therapies for diabetic retinopathy.

Dynamics Of Organizational Communications In Sharing Fantasy Themes To Maintain The Solidarity And Existence Of Community Organizations

The purpose of this study is to explain the organizational communication aspect of a community organization, Forum Betawi Rempug (FBR), and to reveal the interaction patterns and dynamics of various fantasies of dramatically exchanged symbols. Organizational communication can be defined as the process of creating and exchanging messages in a network of interdependent relationships to cope with an uncertain or changing environment. This research approach uses a subjectivist in the interpretive category. This study uses a qualitative method by using a Symbolic Convergence approach which is subjectivist. The results show that the dynamics of sharing fantasy patterns on the theme of leadership and Betawi figures of FBR community organization depart from the rhetorical vision of the issue of the revival of Betawi in the past, the era before the formation of the State and long before the Dutch colonial era existed. Betawi is a culture that is noble and needs to be fought for. In the organization’s context, FBR is a forum for the struggle to unite the Betawi people by evoking Betawi cultural values and the struggle for the Betawi people’s lives. From the narrative analysis of the FBR community organization, the present storytellers are the leaders in the ranks of the FBR. The latter is considered the primary source of information for delivering the message of the existing dramatic stories. The meaning of leadership in a metaphorical context often gives rise to stories of Betawi’s character and leadership as village guards in the sense of an essential struggle that contains sincerity and loyalty to the area where they live.

Being Popular or Having Popular Friends, Which Is Better? A Longitudinal Social Network Analysis of Depressive Symptoms among Chinese Adolescents under Major Chronic Stress

Background: Previous studies have found that adolescents’ depressive symptoms are influenced by social networks in a stressful context, especially focusing on the processes of social selection and social influence. The current study aimed to explore the coevolution of sociometric popularity and depressive symptoms among adolescents suffering from the stress attached to the Chinese gaokao. Methods: The analytical sample comprised 1062 Chinese adolescents who were under significant pressure to return to school for an additional year (returnees) to prepare for college entrance examinations. Students were assessed for depressive symptoms and asked to nominate up to five friends within their classes across four waves (six months). We employed stochastic actor-oriented models to investigate the interdependent relationships between popularity and depressive symptoms. Results: Adolescents’ depressive symptoms negatively predicted future friendship popularity in this stressful situation, but not vice versa. The results of this study also highlighted the importance of friends’ popularity, indicating that adolescents who nominated popular peers as friends tended to subsequently have lower depressive symptoms. Conclusion: These findings suggested that friends’ popularity may serve as a protective factor against depressive symptoms under major chronic stress. Network-based interventions may have practical implications for reducing depressive symptoms under major chronic stress.

Modelling the blockchain adoption barriers in the AEC industry

PurposeIn the era of digitalisation, blockchain has the potential to fundamentally change the architecture, engineering and construction (AEC) industry's workflow, trust and procurement environments. However, few studies have investigated blockchain adoption barriers in the AEC industry in detail. Therefore, the study aims to provide a comprehensive understanding of these barriers and their interdependent relationships in the context of the AEC industry.Design/methodology/approachBased on a review of the literature, industry reports and expert feedback, 11 barriers towards adopting the blockchain were identified. Then, the authors investigated the interdependencies amongst the factors by adopting a two-stage integrated interpretive structural modelling (ISM) and decision-making trial and evaluation laboratory (DEMATEL) method.FindingsThe findings show that the lack of information technology infrastructure (BC4) and legal and regulatory uncertainty (BC11) are the most prominent barriers towards blockchain adoption in the AEC industry.Practical implicationsThe research contributes in providing a clearer understanding of related barriers and potential solutions for practitioners in this area. Subsequently, the identification of adoption barriers can enable an important knowledge foundation and suggest possible solutions for adopting blockchain techniques successfully and effectively in the AEC industry.Originality/valueThe study lays an essential research foundation for the effective adoption and use of blockchain in the AEC industry.

278 Understanding Biosecurity Perceptions in Pennsylvania Pig Producers

The group mental model of swine-related biosecurity for producers and experts was assessed and compared using network analysis. The proper implementation of biosecurity plans reduces the risk of biological hazards that could cripple the industry. Recently collected survey data show producer motivation to adopt a biosecurity protocol is not driven solely by the value of the operation (Hines and Falcone, unpublished). Other motivating factors exist for how producers perceive risk relating to biosecurity management. To identify how pig producers and experts conceptualize biosecurity, open-ended survey questions were asked. Survey responses (n = 123) were coded using a newly developed codebook. Intercoder reliability was established using Krippendorff’s a. Code co-occurrence was used to build a network diagram showing producer and expert mental models, or depiction of the interdependent relationships among values, beliefs, behavior, and cognitive processes of decision making. Analyses of code co-occurrence revealed differences between producers and experts. The results suggest PA-based producers think of biosecurity relating to the protection of their property (ie. inward protection) which was closely associated with limiting access of “outsiders.” Also, the mental model diagram suggests producers think about biosecurity more broadly due to less clustering of ideas. Whereas experts think about biosecurity more specifically relating to two to three themes. Specifically, the expert biosecurity diagram revealed record keeping as an important component of biosecurity, which was strongly related to how experts think about cleanliness and limiting outsider access. Regarding strategies to address biohazard risks, both producers and experts recognize several options. However, experts proved to have stronger connections between concepts. Specifically, the diagrams revealed experts see all strategies as connected. From an expert perspective, strategies to address biohazard risks should be implemented simultaneously. These findings are the first step to designing communication to bridge the gaps between expert and producer understanding of biosecurity.

Examining the Subjugation of Indigenous Women through Community Partnerships with Extractive Industries

Integration into the capitalist market creates an opportunity for Indigenous communities to relinquish interdependent relationships with the Canadian state by commodifying natural resources to subsidize funding. Corporate partnerships offer Indigenous communities an opportunity for economic development to help alleviate conditions of poverty; however, the potential benefits are not reaching all members of the communities equally. Rather, extractive developments on Indigenous territories are creating new and complex challenges for Indigenous women. This paper examines the current and historical legacies of colonization within Canada that have excluded and oppressed Indigenous women, and have made Indigenous communities dependent on colonial processes to improve socioeconomic disparities. The legacies of colonization, the patriarchal foundations of capitalism, and the transient nature of extractive developments disproportionately harm Indigenous women, making corporate partnerships an unsustainable option to maintain Indigenous independence from the Canadian State.

Reverse the Lens, Set Focus on the Followers: A Theoretical Framework of Resource Dependence, Upward Influence, and Leadership

Leadership theories predominantly focus on the top-down managerial influence on employees. Recent theoretical developments, however, have accentuated the call for scholarly attention on holistic models comprising both leadership and followership. In the present study, the author developed a theoretical framework of upward influence and leadership construction by drawing on resource dependence theory. Specifically, the author proposed a novel outlook illuminating upward influence in hierarchical relationships whereby employees, as the hosts of tacit resources, inculcate interdependent relationships with their managers. Considering the dependence of employees and managers on each other for tangible and intangible resources, relationships with a (a) power imbalance and (b) joint or embedded dependence emerge. The author further explained the role of leadership construction in power-imbalanced and embedded relationships and elaborated on organizational and team structural boundary conditions. By revitalizing upward influence, the proposed theoretical framework offered new insights into leadership and followership literature, with the potential to change the conversation from a foundational thesis assuming the managerial capacity to lead and bestow resources on their subordinates to a two-way resource-dependence perspective, which has been scarcely considered in contemporary management research.

SYSTEMIC APPROACH FOR CRITICAL INFRASTRUCTURES, HIDDEN VULNERABILITIES OF INTERDEPENDENCIES

The growing scientific interest in the field of critical infrastructure protection has been determined by society's growing dependence on the essential services provided by these infrastructures. Critical infrastructures do not work isolated, they establish complex and dynamic networks of interdependencies. A critical infrastructure is itself a system with its own components and operating principles, a system connected to a system of systems based on multiple determinations. Critical infrastructure systems are built based on interdependent relationships between infrastructures, manifesting itself as an open system that relates to the macro-social system. Critical infrastructure systems behave dynamically and react to external stimuli represented by threats. Interdependencies between critical infrastructures generate new vulnerabilities and threats, based on the spread of effects and consequences. A comprehensive approach for critical infrastructure risks requires a systemic approach, taking into account that the interconnection of critical infrastructure objectives also involves the interconnection of threats and vulnerabilities.

Direct Punishment and Indirect Reputation-Based Tactics to Intervene Against Offenses

Punishment and reputation-based mechanisms play a major role in supporting the evolution of human cooperation. Theoretical accounts and field observations suggest that humans use multiple tactics to intervene against offenses—including confrontation, gossip, and ostracism—which have unique benefits and costs. Here, we draw a distinction between direct punishment tactics (i.e., physical and verbal confrontation) and indirect reputation-based tactics (i.e., gossip and ostracism). Based on this distinction, we sketch the common and unique social functions that different tactics are tailored to serve and describe information-processing mechanisms that potentially underlie decisions concerning how to intervene against offenses. We propose that decision rules guiding direct and indirect tactics should weigh information about the benefits of changing others’ behavior versus the costs of potential retaliation. Based on a synthesis of existing evidence, we highlight the role of situational, relational, and emotional factors in motivating distinct punishment tactics. We suggest that delineating between direct and indirect tactics can inform debates about the prevalence and functions of punishment, and the reputational consequences of third-party intervention against offenses. We emphasize the need to study how people use reputation-based tactics for partner recalibration and partner choice, within interdependent relationships and social networks, and in daily life situations.