Translational Value of Exercise in Routine Care Following Hematopoietic Stem Cell Transplantation: A Retrospective Analysis

Purpose: Exercise is an effective adjuvant therapy to address many of the symptoms experienced by Hematopoietic Stem Cell Transplant (HSCT) recipients. However, there is little translational research examining meaningful clinical effects. A retrospective analysis of a community-embedded exercise program based at a large urban comprehensive cancer hospital was conducted, with the aim of establishing the translational value of exercise in a clinical setting. A secondary aim was to determine the impact of baseline function on exercise response. Methods: The Living Well Program is an evidence-based program supervised by Accredited Exercise Physiologists, delivered through the Chris O’Brien Lifehouse. HSCT recipients are prescribed individualised, once-weekly 1-hour aerobic, resistance and balance training. Changes in physical function (6-minute walk distance, strength, and balance), fatigue, and quality of life measures from baseline to post-intervention were analysed, and also assessed in relation to session attendance. Participants were then stratified as low- or high-function for each measure of physical function. Results: Data from 48 participants (male n=27, age=54.3±11.7-years) was included in the analysis. Significant improvements were found for all outcome measures, with improvements exceeding minimal clinically important differences for 6-minute walk distance (6MWD) and 30-second sit-to-stand. Greater session attendance correlated with improvements in 6MWD and strength outcomes. Exercise response was greater among those with lower baseline scores for 6MWD only (p<0.001).Conclusions: An existing exercise program embedded in cancer care was successful in eliciting improvements that are both significant and clinically relevant. Further investigations into key factors that influence the efficacy of these programs are required.

Causal inference under interference with prognostic scores for dynamic group therapy studies

Group therapy is a common treatment modality for behavioral health conditions. Patients often enter and exit groups on an ongoing basis, leading to dynamic therapy groups. Examining the effect of high versus low session attendance on patient outcomes is a research question of interest. However, there are several challenges to identifying causal effects in this setting, including the lack of randomization, interference among patients, and the interrelatedness of patient participation. Dynamic therapy groups motivate a unique causal inference scenario, as the treatment statuses are completely defined by the patient attendance record for the therapy session, which is also the structure inducing interference. We adopt the Rubin causal model framework to define the causal effect of high versus low session attendance of group therapy at both the individual patient and peer levels. We propose a strategy to identify individual, peer, and total effects of high attendance versus low attendance on patient outcomes by the prognostic score stratification. We examine performance of our approach via simulation and apply it to data from a group cognitive behavioral therapy trial for treating depression among patients in a substance use disorders treatment setting.

Social Skills Training Using the Thai Version of UCLA PEERS® in Thai Adolescents with Autism Spectrum Disorder

Objective: To study the feasibility and effectiveness of the Thai version of UCLA PEERS® in Thai adolescents with autism spectrum disorder (ASD).Materials and Methods: The UCLA PEERS® was modified to fit with Thai culture. Twelve adolescents, aged 11-19 years old, with ASD participated in this modified 10-session weekly group intervention during March to October 2015 at Siriraj Hospital, Bangkok, Thailand. Feasibility was assessed by parent satisfaction and session attendance rate. Effectiveness was assessed by social skills improvement rated by parents, Vineland Adaptive Behavior Scales (VABS), the Children’s Depression Inventory (CDI), and the Clinical Global Impression-Improvement Scale (CGI-I).Results: All enrolled participants completed the study. Parents’ satisfaction with the program was 81.92%. The session attendance rates ranged from 83.3 to 100%. At the end of intervention, all of the skills trained in the program were rated as improved by at least half of parents. At 4-month follow-up, all but two skills (entering conversation and handling bullying) were still reported as improved by more than 50% of parents. VABS raw scores significantly increased in the domain of communication (95% confidence interval (CI): -2.25 to -0.89; p=0.036), daily living skills (95% CI: -3.70 to -0.47; p=0.016), and socialization (95% CI: -1.77 to -0.40; p=0.005), and significantly decreased in maladaptive behaviors domain (95% CI: 0.24 to 2.10; p=0.002). Six adolescents had CGI-I scores of very much improved or much improved.Conclusion: The Thai version of UCLA PEERS® is a feasible and effective social skills intervention for Thai adolescents with ASD.

Impact of Maintenance Session Attendance and Early Weight Loss Goal Achievement on Weight Loss Success in a Community-Based Diabetes Prevention Program Intervention

Purpose The purpose of this study was to examine how maintenance session attendance and 6-month weight loss (WL) goal achievement impacted 12-month 5% WL success in older adults participating in a community-based Diabetes Prevention Program (DPP) lifestyle intervention. Methods Data were combined from 2 community trials that delivered the 12-month DPP-based Group Lifestyle Balance (GLB) to overweight/obese adults (mean age = 62 years, 76% women) with prediabetes and/or metabolic syndrome. Included participants (n = 238) attended ≥4 core sessions (months 0-6) and had complete data on maintenance attendance (≥4 of 6 sessions during months 7-12) and 6- and 12-month WL (5% WL goal, yes/no). Multivariate logistic regression was used to estimate the odds of 12-month 5% WL associated with maintenance attendance and 6-month WL. Associations between age (Medicare-eligible ≥65 vs <65 years) and WL and attendance were examined. Results Both attending ≥4 maintenance sessions and meeting the 6-month 5% WL goal increased the odds of meeting the 12-month 5% WL goal. For those not meeting the 6-month WL goal, maintenance session attendance did not improve odds of 12-month WL success. Medicare-eligible adults ≥65 years were more likely to meet the 12-month WL goal (odds ratio = 3.03, 95% CI, 1.58-5.81) versus <65 years. Conclusions The results of this study provide important information regarding participant attendance and WL for providers offering DPP-based lifestyle intervention programs across the country who are seeking Medicare reimbursement. Understanding Medicare reimbursement-defined success will allow these providers to focus on and develop strategies to enhance program effectiveness and sustainability.

Update in the World of COVID-19

This brief chapter incorporates some of our team’s observations about practicing TFPP during the COVID-19 pandemic. For many of our patients, access to care became more fractured, whereas for other patients, session attendance became easier and even resulted in better access to their inner lives. The impact of the necessity to switch to telehealth is discussed, as well as the effects of isolation on the one hand and tensions surrounding quarantine situations on the other. The chapter discusses one case of a Vietnam war Veteran for whom the experience of the lockdown exacerbated anger and mistrust he had experienced during the war. In a second case the patient experienced being infected with COVID as yet another experience of abuse, and struggled with his angry response. Patients’ responses are necessarily filtered through their developmental histories, traumatic experiences, and individual dynamics. TFPP helps to delineate how patients’ symptoms and relationships are affected, creating opportunities for further therapeutic work.

Abstract P185: Paradoxical Outcomes Among Group Lifestyle Balance Participants In Real-world Clinical Practice

Introduction: The CDC established the National Diabetes Prevention Program (NDPP) initiative in 2010, leading to implementation of numerous group-based lifestyle interventions, such as the 12-month Group Lifestyle Balance (GLB) program, in community and clinical settings. Heterogeneity in weight outcomes is common. While evidence suggests that session attendance is associated with greater weight loss, some participants do not achieve weight loss even with high session attendance. Conversely, some may achieve clinically significant weight loss (≥5%) with lower attendance. In this study, we sought to identify and characterize such paradoxical interventional outcomes. (i.e., high session attendance and <5% weight loss compared with low attendance and ≥5% weight loss). Hypothesis: No a priori hypotheses. Methods: We conducted a longitudinal descriptive analysis of overweight/obese GLB participants using electronic health record data from an integrated healthcare delivery system in Northern California (2010-2017). We focused on the 12-week intensive core phase of the curriculum because prior studies show that weight loss outcomes achieved during this period are highly correlated with long-term weight loss. We categorized patients into 4 mutually exclusive groups by session attendance (<9/≥9 session) and weight change from baseline to 12-weeks follow-up (<5%/≥5% weight loss). The threshold of 9 sessions corresponds to 75% adherence, a quality metric used by Medicare. Results: Among 1,818 evaluable participants, we identified 870 (47.9%) with paradoxical outcomes. Of these, 104 (12.0%) achieved ≥5% weight loss with <9 sessions attended (paradoxical responders) and 766 (88.0%) achieved <5% weight loss despite attending ≥9 sessions (paradoxical non-responders). The remaining 948 participants (52.1%) achieved weight loss consistent with a dose response, based on number of sessions attended. Conclusions: Nearly half of all GLB participants in this integrated health system had paradoxical outcomes, with more than 40% classified as paradoxical non-responders. These results suggest that session attendance may not be as sensitive a predictor of weight outcomes as previously thought, and other approaches are needed to understand the complex factors influencing goal attainment in behavioral lifestyle programs.

Feasibility and acceptability of a culturally tailored physical activity intervention for Arab-Australian women

Background Despite being one of the largest migrant groups in Australia, few physical activity interventions exist for Arab-Australians. The primary aim of this study was to test the feasibility and acceptability of a 12-week culturally tailored physical activity intervention for Arab-Australian women. Methods This study used a single-group pretest–posttest design, and was informed by extensive formative research and consultation involving the Arab-Australian community. Participants were insufficiently active Arab-Australian women aged 35–64 with no current illness or injury that would limit physical activity participation. The intervention comprised 6 face-to-face physical activity and education sessions over 12 weeks. The intervention was conducted at 2 separate intervention sites in Western Sydney, Australia. Feasibility outcomes included recruitment, session attendance, and retention. The acceptability of the intervention was assessed through a process evaluation questionnaire completed post-intervention. Accelerometers and the short-form International Physical Activity Questionnaire were used to measure physical activity at baseline and post-intervention. Descriptive statistics were used for feasibility and acceptability outcomes, and changes in physical activity were examined using Wilcoxon signed-rank tests. Results Of the 53 women who were contacted or expressed interest, 22 were eligible and enrolled in the study. Participants were primarily recruited through direct contact by Arab-Australian community workers and by word-of-mouth. Average session attendance was 63% and the retention rate post-intervention was 68%. The culturally-related intervention components, such as the appropriateness of content, and women-only setting, were rated highly favourably (4.33 to 4.87/5). General intervention elements, such as the face-to-face delivery, knowledge and approachability of facilitators, and session structure, were also rated favourably (4.33 to 4.93/5), and the lowest scored item was the intervention session frequency (3.2/5). There were no statistically significant changes in physical activity post-intervention. Conclusions The findings from this study highlighted factors related to recruitment and delivery that need to be considered when developing physical activity interventions for Arab-Australian women. Further research is required using a larger sample and a randomised controlled trial design to examine the longer-term impact on physical activity, and to also examine ways of increasing intervention engagement and retention among Arab-Australian women. Trial Registration: ANZCTR, ACTRN12618001392257. Registered 20 August 2018, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=375636.

Extension for Community Healthcare Outcomes (ECHO) Telementoring in the Military: Where We Are Now, Opportunities and Challenges

ABSTRACT Introduction In collaboration with the ECHO (Extension for Community Healthcare Outcomes) Institute since 2012, the Army, Navy, and Air Force have developed medical teleECHO programs to address various health and safety issues affecting military personnel. This article describes and compares the current state of military teleECHOs as well as the growth and change over time. Materials and Methods This study evaluated continuing education units (CEUs) offered, average session attendance, and number of spoke sites for current military teleECHO programs across the service branches. Results Between 2012 and 2019, the military teleECHO initiative grew from one program to seven different teleECHO programs, covering topics from pain to diabetes to amputee care. Military ECHOs now provide training to 10 countries and 27 states in the United States. Between October 2018 and September 2019, the military ECHO programs provided a total of 51,769 continuing medical education (CME) hours to a total of 3,575 attendees from 223 spoke sites. Conclusions The military has successfully used the ECHO model to improve the health and safety of active-duty military, retirees, and dependents.

A Behavioral Lifestyle Intervention to Improve Frailty in Overweight or Obese Older Adults with Type 2 Diabetes: A Feasibility Study

Background: Older adults with Type 2 diabetes (T2D) are more likely to be frail, which increases the risk for disability and mortality. Objectives: To determine the feasibility of a behavioral lifestyle intervention, enhanced with mobile health technology for self-monitoring of diet and activity, to improve frailty in overweight/obese older adults (≥65 years) diagnosed with T2D. Design, Setting, and Participants: Single arm, 6-month study of a behavioral lifestyle intervention in 20 overweight/obese (BMI>25) older adults (≥ 65 years) with self-reported T2D diagnosis who owned a smartphone. A Fitbit tracker was provided to all participants for self-monitoring of diet and physical activity. Our primary outcome of feasibility was measured by session attendance, adherence to Fitbit usage to self-monitor diet and physical activity, and study retention. Secondary outcomes included the preliminary efficacy of the intervention on frailty, physical function, quality of life, and T2D-related outcomes. Results: Eighteen participants completed the study. The mean age was 71.5 (SD ± 5.3) years, 56% were female, and half were Hispanic. At baseline, 13 (72%) were pre-frail, 4 (22%) were frail, and 1 (6%) were non-frail. At follow-up, frailty scores improved significantly from 1.61 ± 1.15 to 0.94 ± 0.94 (p=0.01) and bodyweight improved from 205.66 ± 45.52 lbs. to 198.33 ± 43.6 lbs. (p=<0.001). Conclusion: This study provides evidence for the feasibility of a behavioral lifestyle intervention in overweight/obese older adults with T2D and preliminary results support its potential efficacy in improving frailty score.