The basis of the study is the compilation and analysis of works by domestic and foreign economists, study of the information from official websites of government bodies, methods of analysis, comparison and generalization, and mathematical modeling. Results and conclusions: in order to develop the effective approaches and directions for the research program for development and transformation of the digital economy in Russia, in addition to global processes and digitalization trends at the regional level, along with politics, economic environment, macro-processes, it is important to take into account the sum of factors of the ecosystem of the digital economy as a new economic order: economic, demographic, scientific and technical, geo-potential, state and legal factor. The scientific novelty of the study is reflected in the proposed understanding of the term “digital ecosystem” for solving the above set problem using interdisciplinary approach.