API-led Connectivity Using Mulesoft For Healthcare

The API-led business model is a new way of thinking about how to engage with partners and customers through APIs. The traditional approaches were designed for business use cases having limited endpoints and speed of delivery is not critical. Traditional approaches include P2P and E2E. To overcome these drawbacks, a new approach of API-led connectivity is used. The primary aim of API-led connectivity is to allow the integration flows to be reused by means of many events and to be reused within the integration platform. This paper focuses on creating an API- led network which is agile, reusable, and fits business requirements. This network will be built for the health care system using Allscripts and Fitbit APIs. To implement API -led networks in this paper MuleSoft platform is used and API is built using the API development cycle. Depending on the business requirements on the search for API and connector already present on Anypoint App exchange. Using available component flow is created to connect EHR system systems and different devices like Fitbit. Both API are protected with OAuth 2.0 which is handled with a separate flow for initiating the communication between the system and source API. After doing the required transformation to data fetch from source API data is pushed to the Salesforce object. Using different services provided by Mulesoft, an API-led network was built in which EHR and the Fitbit device were integrated. As this development process followed agile behavior it helped in meeting business requirements for building networks. The data was successfully fetched, processed, and transferred from the EHR system and the Fitbit device to the Salesforce object.

Analytical Solutions for Gas-Water Two-Phase Flow in Multiseam Coalbed Methane Production

Multiseam coalbed methane (CBM) exploitation can not only reduce single-well investment but also increase the length of service of the well and significantly enhance the CBM economic recovery of the entire basin. To compare with and further to guide the actual project of CBM production, this study proposed a conceptual gas-water two-phase separate flow model for single coal seam considering the solubility of gas. This mathematical model was solved analytically by separation of variables and verified through history matching of the production data from the No. 3 seam of 1# test well of Jincheng and then applied to investigate the effect of gas solubility on the gas pressure. Furthermore, based on the coupled two-phase separate flow model of single seam, another two-phase separate flow model for the development of multicoal seam development was established. Similarly, the analytical solution of this model for multicoal seam layers was matched with the in situ data of TS-1 well of Liupanshui coal mine. It is found that the height difference and pressure difference between the two seams play key roles in the multiseam CBM development comprehensively.

Turbulent Mixing Process of a Round Jet With Slot Lobes

Turbulent mixing in the near region of a round jet with three slot lobes is examined via mean velocity and turbulent statistics and structures at a Reynolds number of 15,000. The design utilizes separate flow motivations upstream of each geometric feature, deviating from conventional nozzles or orifice plates. Immediate outlet velocity profiles are heavily influenced by opposing pressure gradients between the neighboring round and slot streams. Spanwise mean velocity profiles reveal the majority of the convective exchange between a given slot and the round center occurs in the immediate near field, but has lasting effects on the axial centerline profiles downstream. This is also reflected by the velocity half-widths, exhibiting asymmetry across the entirety of available measurements. Centerline turbulence intensities exhibit strong and short-lived isotropy. The increasingly anisotropic intensities found downstream are lower than similar geometries from the literature, implying that mixing development is inhibited. Reynolds stresses at the round-slot interface are significantly smaller than the round-stagnant exchange, but achieve a symmetric condition at x/D ≅ 4. Two-point spatial correlations of the fluctuating streamwise velocity exhibit stronger dependence toward the axial centerline at the round-slot interface in comparison to the nominal round radius. In contrast, spanwise velocity fluctuations exhibit nearly identical, localized behaviors on each side of the jet. Corresponding differences in streamwise integral length scale peak in the range 1.0 ≤ x/D ≤ 1.5, and so too do the turbulent structures in this area, as a result of the collated jet geometry.

An in vitro Chondro-osteo-vascular Triphasic Model of the Osteochondral Complex

The generation of engineered models of the osteochondral complex to study its pathologies and develop possible treatments is hindered by the distinctly different properties of articular cartilage and subchondral bone, with the latter characterized by vascularization. In vitro models of the osteochondral complex have been mainly engineered as biphasic constructs containing just cartilage and bone cells, a condition very dissimilar from the in vivo environment. The different cellular components of the osteochondral complex are governed by interacting biochemical signaling; hence, to study the crosstalk among chondrocytes, osteoblasts, and endothelial cells, we have developed a novel triphasic model of the osteochondral tissue interface. Wet-spun poly(ε-caprolactone) (PCL) and PCL/hydroxyapatite (HA) scaffolds in combination with a methacrylated gelatin (gelMA) hydrogel were used as the polymeric backbone of the constructs. The scaffold components were engineered with human bone marrow derived mesenchymal stem cells (hMSCs) and human umbilical vein endothelial cells (HUVECs), and differentiated using a dual chamber microphysiological system (MPS) bioreactor that allows the simultaneous, separate flow of media of different compositions for induced differentiation of each compartment towards a cartilaginous or osseous lineage. Within the engineered Microphysiological Vascularized Osteochondral System (microVOCS), hMSCs showed spatially distinct chondrogenic and osteogenic markers in terms of histology and gene expression. HUVECs formed a stable capillary-like network in the engineered bone compartment and enhanced both chondrogenic and osteogenic differentiation of hMSCs, resulting in the generation of an in vitro system that mimics a vascularized osteochondral interface tissue.

Crayfish as Bioindicators for Monitoring ClO2: A Case Study from a Brewery Water Treatment Facility

This study focuses on the use of crayfish as bioindicators in the water treatment process during operating conditions. The crayfish physiological responses to water disinfected with chlorine dioxide (ClO2) was evaluated. Monitoring was conducted at the private commercial enterprise Protivín Brewery in Czech Republic under standard operating conditions. This brewery has a water treatment facility, where ClO2 is used for water purification. A total of 25 adult signal crayfish (Pacifastacus leniusculus) were kept in separate flow-through aquaria receiving the purified water with ClO2 concentrations ranging from 0.01 to 0.29 mg L−1. Diurnal rhythms of 32% of crayfish was disturbed even at lower concentrations of ClO2 (0.01–0.2 mg L−1), while higher concentrations (>0.2 mg L−1) affected all animals. A random decline and rise of heart rate was detected. In addition, the frequent occurrence of higher levels of ClO2 significantly increased mortality. On average, mortality of crayfish occurred three to four weeks after stocking into the experimental system. Crayfish mortality is estimated to occur at concentrations exceeding 0.2 mg L−1 of ClO2. Our results suggest that long-term exposure to ClO2 adversely affects crayfish physiology. In addition, the results of this study could contribute to the use of crayfish as bioindicators in long-term water quality monitoring under industrial conditions.

Contextual adaptation of omni-channel grocery retailers’ online fulfilment centres

Purpose The purpose of this paper is to investigate how grocery retailers configure their online fulfilment centres (OFC) as they move towards an omni-channel structure and what contextual factors influence their decisions. Design/methodology/approach An exploratory case study with three grocery retailers in the Nordic countries was conducted. The study investigates the current OFC configurations and identifies nine important contextual factors. Findings This study shows the importance of understanding the changes that omni-channel retailing entails for an OFC configuration. Nine contextual factors were identified. Several of the factors are found in previous theory, but this paper extends the knowledge of how they affect the configuration of an OFC in grocery retail. The changes in, for example, order characteristics create different requirements for picking, packing, sorting and shipping when compared with traditional distribution centres (DC). Although representing a separate flow for online fulfilment, OFC configuration depends on how the other logistics flows from the DC to stores are designed. Research limitations/implications To support further theory development, nine contextual factors and their relationship to OFC configurations are proposed. Practical implications This study provides managerial value in two ways. First, grocery retailers with one or more OFCs can benchmark existing solutions using the empirical case descriptions. Second, the findings provide grocery retailers with knowledge of how to configure an OFC. Originality/value The literature lacks a holistic approach towards how grocery retailers configure their OFCs and what factors affect these decisions. This study provides the first in-depth analysis of how the omni-channel context affects the configuration of all the aspects of an OFC.

Preliminary Design Investigation of Dual Stator HE FSM using Segmental Rotor

To drop the effect of air transportation on the atmosphere as well as to advance fuel productivity more-electric aircraft (MEA) architectures is a well-known approach. As the electrical machines are competent to deliver higher torque densities and are foremost for the viability of electrical driving force for aircraft applications. For these reasons a new category of machine has been familiar and published in last decade known as flux switching machine (FSM). FSMs comprises all excitation sources on stator side without winding robust rotor structure. Additionally, FSMs are classified into three types such as permanent magnet (PM) FSMs, field excitation (FE) FSMs and hybrid excitation (HE) FSMs. PM FSM and FE FSM use PM and FE coil for their excitation sources respectively, whereas both PM and FE coil are used in HE-FSM for excitation. Afterwards, HE FSMs have shown higher torque to weight ratios with higher efficiency during research in the last decade. Yet, in existing structures of HE FSMs, there is flux cancellation between the fluxes of PMs and FE coil which causes to reduce the performance of machines. Hence, in this paper, a novel structure of dual stator (DS) HE FSM with segmented rotor has been proposed and analyzed. The main reason of dual stator is to make the separate flow fluxes in HE machines to avoid cancellations. The proposed novel DS HE FSM has a simple structure using dual stators to endorse separate dual excitations to be used in fault conditions. The proposed structure has been analyzed using commercial 2D FEA package, JMAG-designer. Initially, this paper presents the coil test analysis of proposed DS HE FSM to confirm the working principle. Besides, performance analysis has been carried out at no load and load conditions.