Pathology of the vertical section of the lacrimal duct continues to attract the interest of otorhinolaryngologists and ophthalmologists. With the development of new technologies, an active search began for effective and safe methods of conservative and surgical treatment of the disease of the lacrimal organs. Measures aimed at preventing scarring: various drains, differing in shape, material, method of conduction, and duration of stay in the lacrimal ducts, medical methods can not only contribute to recovery, but also extend the time and negatively affect the outcome of treatment. The problem of scarring formed dacryorrhinostomy remains unresolved to this point. The article presents the results of the examination of patients with pathology of the vertical division of the lacrimal duct after video endoscopic endonasal dacryocystorhinostomy performed in the ENT department of the Clinics of Samara State Medical University. In all patients, the stoma of 0,7–0,8 сm is formed endonasally. The data of the video endoscopic examination of the nasal cavity and lacrimal ducts after the use of stents and the preparation Antiadgesin were analyzed. Patients are divided into 2 groups. Group 1 – 17 people who, after the formation of dacryorhinostomy, used bicanalicular silicone stents that were in the lumen of the lacrimal duct for 2 to 4 weeks, group 2 – 12 people who after the formation of the dacryorrhinostomy injected the drug „Antiadhesin“ into the lacrimal duct through the upper and lower tear points with blunt cannula in the amount of 1 ml. The effectiveness of prophylactic measures aimed at eliminating stenosis of the dacryorhinostomy was evaluated. Data on the greater efficiency of surgical intervention in patients in group 2 with the use of the drug Antiadgesin compared with group 1 using stents.