scholarly journals Temporal Analysis of SARS-CoV-2 Variants during the COVID-19 Pandemic in Nepal

COVID ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 423-434
Author(s):  
Samrat Paudel ◽  
Amol Dahal ◽  
Hitesh Kumar Bhattarai

Nepal has suffered two waves of SARS-CoV-2 infections, one in the year 2020 and another in the year 2021. Although the government of Nepal keeps a detailed record of daily coronavirus infections and deaths throughout the country, and publishes the result every day, genomic surveillance of mutants in the country has lagged behind. Sequencing of COVID-19 samples has been conducted sporadically during the pandemic. From the GISAID database, 127 high-quality sequences deposited by different health authorities in Nepal were collected and analyzed. From the analysis, it can be concluded that at least two variants of concern, alpha and delta, and one variant of interest, kappa, were detected in Nepal in 2021. As in other countries, the delta variant outcompeted the kappa and alpha variants and by July 2021 had established itself as the dominant variant. It can be hypothesized that the second wave in Nepal was primarily caused by the delta variant. Further, phylogenetic tree analysis suggests cases of local transmission and global transmission of coronavirus. This analysis reveals the global nature of the disease, where variants arising in one part of the world can quickly spread to other parts of the world and can also spread through individual communities. This paper highlights a need to structure public policy of Nepal to target the delta variant since it has become the predominant variant in Nepal. A further policy suggestion is to appropriately sample and sequence genomes of SARS-CoV-2 at regular intervals to understand the dynamics of variants in the population.

2021 ◽  
Vol 5 (1) ◽  
pp. 163-178
Author(s):  
Elyta Elyta ◽  
Syarifah Ema Rahmaniah ◽  
Hendra Ramdani

At the beginning of 2020, the world was shocked by the outbreak of Covid-19, which was known to have originated from Wuhan. The increase in cases of local transmission in China's border region with Russia has sparked new concerns. In writing this paper, the author uses data collection methods with literature studies from journals and electronic books, including data from trusted websites through internet searches in the form of soft files that can support the paper's explanation. From the results of this paper, the reader can see that it is divided into several essential points explaining how China's policy to close the border in Russia to prevent the spread of the Covid-19 Virus in their country, first, how the procedures carried out by China in tightening checks on Russian borders. And Second, knowing how China monitors its citizens by using cell phones.


Author(s):  
Rifat Mahmud

The first wave of the COVID- 19 disease has caused a daunting and unprecedented challenge for governments of the world. Decision-makers worldwide, including that of Bangladesh, had to initiate responses that were beyond the conventional measures. This paper offers the decision-makers in Bangladesh on the possible learning in the field of crisis management during this pandemic. The paper aims in focusing on the first phase of responses to COVID-19 (March-May) from the initial lockdown to the reopening of offices by the government of Bangladesh. Methodologically, the paper is a content analysis involving netnography approach of data collection from websites. The paper presents a finding of possible lessons of crisis responses in Bangladesh. The paper aims to create an agenda for learning lessons from the situation of the largest crisis to hit the world in centuries. The paper induces substantial value for policy-makers to be prepared for the second wave of the COVID- 19 crisis, to meet the challenges of the pandemic.


2020 ◽  
Author(s):  
Daniyar Yergesh ◽  
Shirali Kadyrov ◽  
Hayot Saydaliev ◽  
Alibek Orynbassar

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2), the cause of the coronavirus disease-2019 (COVID-19), within months of emergence from Wuhan, China, has rapidly spread, exacting a devastating human toll across around the world reaching the pandemic stage at the the beginning of March 2020. Thus, COVID-19s daily increasing cases and deaths have led to worldwide lockdown, quarantine and some restrictions. Covid-19 epidemic in Italy started as a small wave of 2 infected cases on January 31. It was followed by a bigger wave mainly from local transmissions reported in 6387 cases on March 8. It caused the government to impose a lockdown on 8 March to the whole country as a way to suppress the pandemic. This study aims to evaluate the impact of the lockdown and awareness dynamics on infection in Italy over the period of January 31 to July 17 and how the impact varies across different lockdown scenarios in both periods before and after implementation of the lockdown policy. The findings SEIR reveal that implementation lockdown has minimised the social distancing flattening the curve. The infections associated with COVID-19 decreases with quarantine initially then easing lockdown will not cause further increasing transmission until a certain period which is explained by public high awareness. Completely removing lockdown may lead to sharp transmission second wave. Policy implementation and limitation of the study were evaluated at the end of the paper. Keywords COVID-19 - Lockdown - Epidemic model - SEIR - Awareness - Dynamical systems.


2018 ◽  
Vol 73 (5) ◽  
pp. 330-337 ◽  
Author(s):  
Atadzhan Е. Ergeshov

Tuberculosis (TB) is a significant problem of public health both in Russia and abroad. About one third of the world’s population is infected with Mycobacterium tuberculosis. Every year more than 10 million new TB cases are registered in the world, and about 1.7 million people die from TB. In the Russian Federation, due to the measures taken by the Government and health authorities the epidemic TB situation has been noticeably improved since the sharp deterioration in the 90s of the last century. At the same time, the spread of drug-resistant TB and its low treatment effectiveness, the spread of combined HIV and TB infection reduces the effectiveness of anti-tuberculosis interventions. The research conducted by CTRI, the WHO Collaborating Center for TB in the Russian Federation, is aimed at solving such urgent problems as studying latent infection mechanisms, developing new test systems for accelerated diagnostics of drug resistance, clinical approbation and introduction of short effective regimens of chemotherapy, developing new antituberculosis agents. The achieved successes in the study of tuberculosis in the 21st century creates preconditions for eliminating its epidemic both in Russia and the world, though suggesting imminent breakthrough for tuberculosis is a hasty conclusion. 


2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Ryan Rachmad Nugraha ◽  
Adriana Viola Miranda ◽  
Attaullah Ahmadi ◽  
Don Eliseo Lucero-Prisno

AbstractCoronavirus disease-19 (COVID-19) has been spreading in every part of the world, putting nations at risk with its pandemic status, including Indonesia. COVID-19 vaccine has been deemed as one of the most effective interventions to date for mitigating the spread and mortality from COVID-19. Responding to the situation, the Government of Indonesia (GOI) has allocated the means necessary to procure and distribute COVID-19 vaccines; placing into consideration the unique context of the country, recently categorized as a middle-income country and archipelagic with a population over 270 million. This article aims to present the challenges associated with the distribution of COVID-19 vaccination as well as recommendations to mitigate them, to ensure a timely and effective COVID-19 vaccination program in Indonesia.


2021 ◽  
pp. 1-1
Author(s):  
Naveen Kumar

The second wave of Covid -19 in India has made us witness as to how negligence from the part of everyone of us, be it people, Government or policy makers of healthcare system might bring the unwanted disaster in the form of Covid Tsunami. This has made us to see never ending queues of patients , relatives standing for hours for the want of hospital beds, oxygen, essential medicines and lastly but unfortunate for their turn for the cremations of loved ones . But now we can see the number of active cases are declining across the country. Amidst this positive observation in regard of second wave ,there is speculation erupting about the Covid third wave. We can appreciate a similarity in the way that the noble corona virus behave with the Spanish flu that had shaken the world in 1918. It had resulted in three waves with second wave was most deadly and long lasting than the other two waves. During the first wave where the infection was mostly of mild severity we had seen the disease affecting the elderly and immune-compromised patients more. In contrast to this, second wave resulting from mutant strains affected the younger population more and it was of larger severity with high mortality rate. Scientists and experts are now anticipating the third wave , taking the lesson from the Spanish flu and we must be better prepare for it. In order to prepare ourselves from a expected third wave of Covid-19, we shouldn’t repeat mistakes that we made during previos waves. We should refrain ourselves from dismantling our enhanced healthcare facilities, there should not be any sorts of shortage of oxygen , hospital beds, and drug that we have already witnessed. We must have an aggressive containment measure comprising of a really strong and pro-active surveillance system. This can be achieved by increasing the capacity of the existing surveillance system by identifying active cases early. We must ensure that we should follow “social vaccine” of proper masking, avoid indoor gatherings, and proper sanitization. Our vaccination programme needs a boost. We should vaccinate a large section of people before any third wave hits us. The more we vaccinate, the better prepared we are. As medical professionals, it must be ensured that proper scientific protocol must be implemented while handling Covid-19 cases. And last but not the least efforts must be made to fill up vacancies seen in our public health system, especially for frontline healthcare workers. As it is anticipated that the young children are more vulnerable to the forthcoming third wave, efforts are to be sought in order to start vaccination of the younger children in our country. Trials for which has already been started in India and across the world. Till the time vaccine is made available, the resources are to be mobilized to build up healthcare facilities catering the vulnerable age group in this third wave such as building up of more paediatric wards, paediatric ICU’s , training of healthcare personals in handling the emergencies for expected third wave .In addition to these efforts , more and more paediatric covid care centers must be set up at various parts of the country. Equally important is making arrangements for rehabilitation centers for the orphans. Countries like US, Singapore and UAE have already started vaccinating the children in age group between 12 to 15 years with Pfizer-BioNTech Covid vaccine. It’s a high time that the government in India must consider for allowing “expedited approval pathway” to the companies like Pfizer for their Covid-19 vaccine for children. All these combined efforts from everyone may ensure that the country and world may remain well equipped against these subsequent waves of this deadly virus and pave the path of the triumph in the near future.


2021 ◽  
Vol 4 (1) ◽  
pp. 2
Author(s):  
Sami Ullah Mumtaz

The Corona virus (SARS-CoV2) pandemic initiated in late December 2019 in Wuhan city of Hubei, China, which has rapidly progressed involving more than 215 countries of the world. It was caused by novel SARS-COV2 coronavirus with Huanan seafood wholesale market as the possible point of origin. In past two decades, coronaviruses epidemic of Middle East Respiratory Syndrome (MERS-COV) had 37% mortality rate and Severe Acute Respiratory Syndrome (SARS-COV) had 10% affecting more than 10,000 population together. World Health Organization (WHO) declared it as the sixth Public Health Emergency of International Concern (PHEIC) on January 30, 2020 and later on March 11, 2020, the WHO labeled it as a pandemic. The first case of COVID-19 from Pakistan was reported on 26th February, 2020 and has affected over 354,000 people with a mortality of over 7000 patients.Many countries of the world have seen second wave of this pandemic. Government of Pakistan has also declared a second wave on October 28, 2020, after the rise in cases from 500 to 750 per day. Now it has crossed 2000 cases. The data released by the National Command and Operation Centre (NCOC) shows that the current percent positivity rate is close to 3 compared to the previous figure of lesser than 2 making it a bigger challenge than first wave in Pakistan. The patients now presenting in hospitals are all in critical condition. Lack of a specific vaccine or antiviral drug and non-compliance to the standard preventive measures is the major reason of initiation of a second wave of this viral infection in Pakistan. Being a nation we need to be responsible. Our country may go into economic crisis & our health facilities may choke. We have to understand how to live with this virus till the availability of vaccine or Curative antiviral drug. The Government of Pakistan is creating awareness in the public for the secondwave as the situation of pandemic is getting worse. Smart lock downs are being implemented but people are not following preventive measures that are leading to infection spread at a very alarming speed. At the moment preventive measures are the only way to stop the spread of disease. Preventive measures should be adopted to contain this deadly disease. Wearing masks, using hand sanitizers, washing hands with soap for 20 sec, keeping social distance of 6 feet are mandatory preventivestrategies. Social, political, business, recreational and religious gatherings, should be avoided. Educational institutes should follow strict standard operating procedures. Most of the people in Pakistan are not considering this disease as a matter of serious concern due to unawareness, poverty, beliefs and lack of resources. People should ignore such disbeliefs and should start considering it as a great health concern. They should follow the preventive measures in true sense.


Author(s):  
Rasheed Omobolaji Alabi ◽  
Akpojoto Siemuri ◽  
Mohammed Elmusrati

Background: The spread of the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has reached a global level, creating a pandemic. The government of various countries, their citizens, politicians, and business owners are worried about the unavoidable economic impacts of this pandemic. Therefore, there is an eagerness for the pandemic peaking. Objectives: This study uses an objective approach to emphasize the need to be pragmatic with easing of lockdowns measures worldwide through the forecast of the possible trend of COVID-19. This is necessary to ensure that the enthusiasm about SARS-CoV-2 peaking is properly examined, easing of lockdown is done systematically to avoid second-wave of the pandemic. Methods: We used the Facebook prophet on the World Health Organization data for COVID-19 to forecast the spread of SARS-CoV-2 for the 7th April until 3rd May 2020. The forecast model was further used to forecast the trend of the virus for the 8th until 14th May 2020. We presented the forecast of the confirmed and death cases. Results: Our findings from the forecast showed an increase in the number of new cases for this period. Therefore, the need for easing the lockdown with caution becomes imperative. Our model showed good performance when compared to the official report from the World Health Organization. The average forecasting accuracy of our model was 79.6%. Conclusion: Although, the global and economic impact of COVID-19 is daunting. However, excessive optimism about easing the lockdown should be appropriately weighed against the risk of underestimating its spread. As seen globally, the risks appeared far from being symmetric. Therefore, the forecasting provided in this study offers an insight into the spread of the virus for effective planning and decision-making in terms of easing the lockdowns in various countries.


2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Bahar Hassanmirzaei ◽  
Tohid Seif Barghi

: COVID-19 has stricken the world since the beginning of 2020. The pandemic is not controlled yet, and also the new variants of the virus are rapidly spreading. To reduce the virus's person-to-person transmission rate, health authorities and the government applied limitations to all activities (including sports activities). As a result, all football matches and team training worldwide were suspended for a limited period until a reduced infection risk was recognized. Even though training and competitions were gradually resuming worldwide, no spectators were allowed to attend any matches. After the successful experience of resuming football matches and tournaments following tight restrictions in keeping the players, staff, and organizers safe, it is time to let the spectators back in the stadiums and establish the needed guidelines. This commentary will highlight the most important aspects and issues that need to be addressed if the football federation and associations decide to let the spectators back into the stadiums, as football will lose its enthusiasm and financial turnover.


2020 ◽  
Vol 2 (5) ◽  
pp. 98-107
Author(s):  
Ana Karina Fonseca de Carvalho Calderan Correa ◽  
Gabriela Araújo Barros Lima e Silva ◽  
Leonardo Nogueira Tavares ◽  
Ricardo Correa de Araújo Júnior ◽  
Antonio Aparecido Celoria

Orofacial Harmonization (HOF) that has already been recognized as a dental specialty by the Brazilian Federal Council of Dentistry (CFO) through the resolution CFO-198/2019, has been showing considerable advances in health promotion and reestablishment of a complete physical, mental and social well-being of the individual. Also, it makes efforts in an attempt to strengthen and improve the biosafety protocols presented by the World Health Organization (WHO). The undertakings carried out by the government and health authorities are notorious in an attempt to adapt to the new reality presented by this pandemic caused by COVID-19. However, we cannot deny the negligence of these same authorities of not inserting this specialty as part of the essential care for the population, as the HOF is able of providing numerous benefits, as well as the dentist who was left in the gloom in its origin as a health promoting agent. In the present study, updated biosafety protocols will be shown, and also the importance of adding the inherent technologies of HOF and all the knowledge and proficiency of dentistry professionals in an attempt to concretize the real concept of health, benefiting the population that is desolated and terrified in this new post-COVID world.


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