An unusual case of breast abscess caused by Proteus mirabilis and Prevotella buccalis

A 56-year-old nulliparous woman presented to the emergency department with acute onset of redness, sensitivity, and local fever in the left breast. Mastitis with abscess was diagnosed. Unusual pathogens were identified in the culture obtained from the abscess - Proteus mirabilis and Prevotella buccalis. Keywords: breast abscess; Proteus mirabilis; Prevotella buccalis.

Mammographic Microcalcifications and Breast Cancer: A Radio-Pathological Correlation

Background: Breast cancer is the most common cancer for women, often asymptomatic, and diagnosed from combined screening using mammography and ultrasound. Abnormal findings include microcalcifications with widely variable positive predictive values (PPVs) for malignancy, ranging from 2% to 95%. PPVs for each type of microcalcification are unknown. Objective: To assess PPVs for all abnormal microcalcifications in Breast Imaging Reporting and Data System (BI-RADS) 4 and 5 as seen by mammography. Materials and Methods: The present study was a retrospective study of 62 female patients with abnormal microcalcifications that underwent mammography-guided needle localized excision between September 2011 and December 2018, at Thammasat University Hospital. Results: Of all 72 abnormal microcalcifications, PPVs were coarse heterogeneous 25%, amorphous 37.93%, fine pleomorphic 42.31%, and fine linear or linear branching 33.33%. Conclusion: Abnormal microcalcifications rated BI-RADS 4 or 5 have greatly varying malignancy risks, thus, tissue biopsies should be considered in line with microcalcification morphology and individual patient risk factors. Keywords: Breast cancer, Mammography, Microcalcification, Radio-pathologic correlation, Needle localized excision

MEMBANGUN KESADARAN DAN PERILAKU HIDUP SEHAT MAHASISWI GUNA MENCEGAH KANKER PAYUDARA

Breast cancer is the second highest prevalence after cervical cancer. In recent years cases of breast tumors that are at risk of becoming cancer are found in women aged 25 years and under. This risk will increase in adolescent girls who have a history of tumors, so there is a 4.37 times more risk of developing breast cancer. Similarly, young women who experience menarche (first menstruation) at the age of <12 years are more likely to develop breast cancer than those who experience menarche aged> 12 years. Busyness undergoing daily routine is also one of the causes of teenagers / young women paying less attention to the health of their breasts. Based on this there have been many campaigns and movements to foster women's awareness of breast cancer such as the BSE movement (Breast Self-Check) and SADANIS (aware of clinical examination). It is unfortunate that this campaign has not been able to touch all circles, especially among students who are very busy with campus life and do not have the awareness to take care of their health. This dedication activity is carried out to increase the awareness of students / young women to maintain breast health. Keywords: breast cancer, health, increase student awareness.

Factors Associated with Breast Cancer in Women of Reproductive Age at Dr. Pirngadi Hospital, Medan, North Sumatera

Background: Breast cancer has the highest prevalence in Indonesia. The objective of the research was to analyze the risk factors which influenced the incidence of breast cancer in women of reproductive age. Subjects and Method: This was a casecontrol study conducted at Dr. Pirngadi Hospital, North Sumatera. The population was all 15-49 year-old breast cancer women. Sample of 42 women of reproductive age with breast cancer and 42 women without breast cancer was selected for this study. The dependent variable was breast cancer. The independent variables were family history of breast cancer, menarche, history of breastfeeding, and history of fibrocystic disease. The data were collected by questionnaire and medical record. The data were analyzed by a multiple logistic regression. Results: History of family with breast cancer (OR= 4.93; 95% CI=1.33 to 18.28), age of menstruation (OR= 8.46; 95% CI=2.34 to 30.64), history of breastfeeding (OR= 8.46; 95% CI= 2.19 to 32.70), and history of fibrocystic disease (OR= 7.12; 95% CI=1.99 to 25.48) were associated with breast cancer. Conclusion: History of family with breast cancer, age of menstruation, history of breastfeeding, and history of fibrocystic disease are associated with breast cancer. Keywords: breast cancer, history of breastfeeding, women of reproductive age Correspondence: Mila Trisna Sari. Masters Program in Public Health, Universitas Sumatera Utara. Email: [email protected]. Mobile: 08192100- 173.

Prospect of application of artificial intelligence systems for breast cancer screening

The article presents a literature review of the databases such as PubMed, MEDLINE, Springer eLIBRARY and found via Google Scholar relevant Russian scientific articles. Articles were searched using the keywords: “breast cancer”, “artificial intelligence”, “screening”. The information obtained was then pooled, structured and analyzed in order to review the current state and problems in the field of breast cancer screening and application of artificial intelligence systems in this field in the world and in Russia. The possibility of applying artificial intelligence technologies for breast cancer screening in Russian healthcare system is discussed

Perawatan Paliatif terhadap Kualitas Hidup Pasien Kanker Payudara

This study aims to identify the effect of palliative care on breast cancer patients' quality of life. The method used in this study is a literature review. The results showed that palliative care affected breast cancer patients. In conclusion, comprehensive palliative care from various aspects of the patient's life plays a significant role in achieving the maximum quality of life in breast cancer patients and preparing for a dignified death. Keywords: Breast Cancer, Quality of Life, Palliative Care

Gynecomastia and Congenital Anomalies of the Breast

Breast and chest wall appearance is an important component of an individual’s body image that can have a profound impact on their psychological well-being. Given the inherent complexity of breast embryogenesis, multiple anomalies exist that differ with respect to their clinical management and reconstructive approach. In this review, the authors outline fundamentals of breast embryology, pathophysiology of common congenital breast and chest wall anomalies, and potential reconstructive solutions. It is the aim of this chapter to provide readers with a broad yet concise overview of the spectrum of congenital breast and chess wall disorders to aid in the proper diagnosis and management of affected patients. This review contains 7 tables, and 4 figures, and 31 references. Keywords: breast embryology, pediatric breast reconstruction, gynecomastia, juvenile hypertrophy, polythelia, athelia, Poland syndrome, congenital breast

Patient satisfaction and quality of life in breast reconstruction: assessment of outcomes of immediate, delayed, and nonreconstruction.

Objectives: This study was conducted aiming to assess the quality of life and satisfaction of mastectomized women treated with and without breast reconstruction. Results: A total of 81 patients mastectomized were included, of whom 53 (65.4%) underwent breast reconstruction. Quality of life was not significantly better in the reconstruction group than the nonreconstruction group. Satisfaction with the surgically operated breast, whether reconstructed or not, was positively correlated with quality of life (p = 0.004). There was no significant difference in quality of life between women with immediate and late reconstruction. This study showed that the satisfaction of patients with the operated breast, reconstructed or not, is more important in quality of life than whether the breast was reconstructed or not. When we analyzed the quality of life of mastectomized women who were dissatisfied with their unreconstructed breasts, we observed that nonreconstruction had a negative impact on the quality of life. Keywords: Breast cancer, Mastectomy, Breast reconstruction, Quality of life

Estimating the Risks and Benefits of Tamoxifen Chemoprevention for Breast Cancer in Brazil

Background According to the National Surgical Adjuvant Breast and Bowel Project (NSABP-P1), tamoxifen can prevent 49% of invasive breast cancers in patients who have a five-year risk of 1.67% or more. Because tamoxifen is associated with side effects (endometrial cancer and stroke), it is necessary to weight the risks and benefits of using tamoxifen for prevention of breast cancer. The aim of this paper is to calculate a risk-benefit index based on the Brazilian population to assess the feasibility of Tamoxifen as a chemopreventive agent. Results Results showed that with increasing age, the greater the five-year risk of breast cancer would have to be for a positive risk-benefit index. This shows that more risk exists in older women with the use of tamoxifen, precisely because of the values ​​of incidence and mortality of the assessed diseases that increase with age in the population. Conclusion This study presents a methodology to determine the benefits and risks associated with chemoprevention with tamoxifen in the Brazilian population. Keywords: Breast Neoplasms, Tamoxifen, Chemoprevention

Aproximación completa del genoma del cáncer de mama basal

Aproximación completa del genoma del cáncer de mama basal Whole genome approach to basal like breast cancer Mev Dominguez, Yannick Bidet Y, Maud Privat, Nancy Uhrhammer, Anne Cayre1, Ines Raoelfils, Frederick Penault-Llorca, Yves Jean Bignon Laboratoire Diagnostic Génétique et Moléculaire, Centre Jean Perrin, Clermont-Ferrand, France. Clermont Université, EA4233, Clermont-Ferrand, France. DOI: https://doi.org/10.33017/RevECIPeru2011.0007/ RESUMEN El cáncer de mama basal (BLBC) comprende hasta el 15% de los cánceres de mama. El BLBC es caracterizado por la baja o ausencia de la expresión del receptor de estrógreno (ER), receptor de progesterona (PR), ausencia de amplificación del gen HER2 y por la expresión de las citoqueratinas basales (Cks): Cks 5, 6, 14 y/o 17, receptor del factor de crecimiento epidermal (EGFR) y/o C-Kit. BLBC constituye una entidad clínica distinta y presenta un pobre prognóstico clínico (Sørlie et al. 2001). El principal objetivo de este proyecto es el mapeamiento completo y comparativo de las alteraciones genómicas en BLBC asociado o no con mutaciones en el gen BRCA1. Asi también, explorar el rol de la via de señalización de BRCA1 en BLBC. Por esta razón, utilizamos un arreglo de captura del exoma completo de 2.1M en 9 muestras congeladas de mama obtenidas del Departamento de Patología del Centre Jean Perrin-Clermont Ferrand. Actualmente, hemos identificado en un individuo (MCD-4) 11, 109 variantes, de las cuales 7,113 (64%) han sido descritas como polimorfismos (SNP) de acuerdo al algortimo conservativo HCDiff. Con relación a la distribución de estas variantes, los cromosomas 10 y 2 fueron los más afectados. Las nuevas variantes somáticas encontradas serán confirmadas por secuenciación convencional. El análisis de los pacientes remanentes está en avance. Mediante el empleo de esta medotología de nueva generación, nosotros contribuiremos en identificar nuevos marcadores o alvos terapéuticos así como ayudar a completar el catálogo de las variantes somáticas recurrentes y hereditarias asociadas con el desarrollo de BLBC. Keywords: Breast cancer, Basal like, BRCA1, genomic, mutation, next generation sequencing. ABSTRACT Basal like breast cancer (BLBC) composes up to 15% of breast cancer (BC) and is characterized by low or absent expression of estrogen receptor (ER), progesterone receptor (PR), lack of HER2 gene amplification and expression of basal cytokeratins (Cks) 5, 6, 14 and/or 17, epidermal growth factor receptor (EGFR) and/or C-Kit. BLBC constitutes a distinct clinical entity and is associated with poorer clinical outcome (Sørlie et al. 2001). The principal objective of this project is the complete and comparative mapping of genomic abnormalities in a series of BLBC associated or not to BRCA1 mutations and explores the role of the BRCA1 pathway in BLBC. For this reason, we are evaluating a 2.1 M feature human exome capture array on 9 frozen samples obtained from the Pathology Department of Centre Jean Perrin. By the time, we identified on one individual (MCD-4) 11,109 variants, of which 7,113 (64%) were described as known single nucleotide polymorphism (SNP) based on the conservative HCDiff algoritrhm. In regards to the distribution of these variations, chromosomes 10 and 2 were most affected. The novel somatic variations will be confirmed by conventional sequencing. The analyses of the remaining patients are ongoing. Using this next generation methodology, we will contribute to identify new markers or therapeutic targets and help to complete a catalogue of recurrent somatic and inherited variants associated with the development of BLBC. Keywords: Breast cancer, Basal like, BRCA1, genomic, mutation, next generation sequencing.