Globalization is a term used widely to describe ‘homogenization’ of the world and various cultures. Although it is to do with trade, with an impact on resources, manufacture, and consumption, its impact is often seen on economics, development, international relations, and health. However, its effect on individual and population mental health across cultures deserves detailed study. The term means different things to different people and is often misused and misinterpreted in a number of ways. The geopolitical impact of globalization on social determinants of mental health of individuals and populations is of particular interest, especially because globalization affects migration and consequent changes in well-being. Cultures vary and have various dimensions, which change in response to globalization. The challenges in the global mental health agenda are of critical interest to policymakers and service planners. Often, mental health is regarded as separate from aspects of physical health and well-being, thereby creating specific problems. In the context of globalization and resulting migration, we propose a conceptual model to understand the effects of globalization on mental health and identify some action points for future research and policy-making.